Researchers investigated the antiepileptic potential of Pergularia daemia, a medicinal plant used in Cameroon to treat epilepsy. Traditional healers claim the hydro-ethanolic extract of its roots is more effective than an aqueous extract on refractory seizures. This study aimed to test that claim using mice models of epilepsy. The findings suggest that the hydro-ethanolic extract may have better anticonvulsant activity than the aqueous extract, indicating P. daemia's potential as a source for new antiepileptic drugs. However, further studies are needed to validate these findings.
Researchers investigated the potential anti-inflammatory effects of Pergularia daemia in temporal lobe epilepsy, a drug-resistant form of epilepsy. P. daemia is traditionally used in Cameroon to treat various ailments. There are currently no scientific reports on its anti-inflammatory activity during epileptogenesis. The study found that P. daemia extract reduced inflammation and may have antiepileptic effects. This suggests that P. daemia could be a potential source of new antiepileptic drugs and warrants further investigation.
Researchers investigated the effects of a plant extract called PDR on epilepsy and neuroprotection. They conducted experiments on mice and rat brain cells and found that chronic oral administration of PDR increased the time it took for seizures to occur and improved memory. PDR also increased antioxidant and acetylcholinesterase activities in the hippocampus and increased survival rates of primary cortical neurons after being exposed to a toxin. These results suggest that PDR may have potential in treating epilepsy and protecting the brain from damage.