Perilla frutescens

Common Names: purple mint, beefsteak mint, beefsteak plant

Ethnobotanical Studies

Studies

Astragalus membranaceus, Nigella sativa, and Perilla frutescens as Immunomodulators-Molecular Mechanisms and Clinical Effectiveness in Allergic Diseases.

Review
Bival Štefan M et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46080533
PubMed:
39194750

Perilla frutescens leaf extracts alleviate acute lung injury in mice by inhibiting KAT2A.

Guo J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118730
PubMed:
39181280

Multivariate Data Analysis Assisted Mining of Nutri-rich Genotypes from North Eastern Himalayan Germplasm Collection of Perilla (Perilla frutescens L.).

Kaur S et al (2024).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-024-01220-8
PubMed:
39153163

Changes in polyphenolic compounds and antioxidant activity of Japanese pickled apricot with salted red perilla leaf during pickling and digestion process.

Immunology
Suwannachot J and Ogawa Y (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114752
PubMed:
39147533

Impact of Irpex lenis and Schizophyllum commune endophytic fungi on Perilla frutescens: enhancing nutritional uptake, phytochemicals, and antioxidant potential.

Immunology
Sharma K et al (2024).
Microb Cell Fact.
DOI:
10.1186/s12934-024-02491-1
PubMed:
39127680

Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice.

Tang BX et al (2024).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-024-01351-3
PubMed:
39103531

Identification of High Linoleic Acid Varieties in Tetraploid Perilla Through Gamma-ray Irradiation and CRISPR/Cas9.

Genetics
Park ME et al (2024).
Plant Cell Physiol.
DOI:
10.1093/pcp/pcae084
PubMed:
39092550

The Antiviral Potential of Perilla frutescens: Advances and Perspectives.

Summary

In this systematic review, researchers found that has strong antiviral properties. Its active ingredients may inhibit virus replication and spread, offering potential for new antiviral drugs.

Review Antimicrobial
Chen J et al (2024).
Molecules.
DOI:
10.3390/molecules29143328
PubMed:
39064906

Bamboo vinegar regulates the phytoremediation efficiency of Perilla frutescens (L.) Britt. by reducing membrane lipid damage and increasing cadmium retention.

Li Z et al (2024).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2024.135155
PubMed:
38991637

The Effects of Exogenous Benzoic Acid on the Physicochemical Properties, Enzyme Activities and Microbial Community Structures of Perilla frutescens Inter-Root Soil.

Phytochemistry
Xue T et al (2024).
Microorganisms.
DOI:
10.3390/microorganisms12061190
PubMed:
38930572

Anti-Obesity Activities of the Compounds from Perilla frutescens var. acuta and Chemical Profiling of the Extract.

Summary

Researchers found compounds in var. that inhibit fat cell formation and promote fat burning. This could lead to new treatments for obesity.

Obesity
Youn I et al (2024).
Molecules.
DOI:
10.3390/molecules29112465
PubMed:
38893341

Improving the Traits of Perilla frutescens (L.) Britt Using Gene Editing Technology.

Summary

Researchers used genome editing techniques like CRISPR/Cas9 to improve plant traits in Perilla, a valuable oil and functional food crop with health benefits. This technology has potential to enhance production and functional substances, but regulation is still developing.

Review Genetics
Karthik S et al (2024).
Plants (Basel).
DOI:
10.3390/plants13111466
PubMed:
38891275

Macrogenomics reveal the effects of inter-cropping perilla on kiwifruit: impact on inter-root soil microbiota and gene expression of carbon, nitrogen, and phosphorus cycles in kiwifruit.

GastroenterologyGenetics
Gao N et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1349305
PubMed:
38887707

Insights into structure, codon usage, repeats, and RNA editing of the complete mitochondrial genome of Perilla frutescens (Lamiaceae).

Genetics
Wang R et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-64509-3
PubMed:
38886463

Comparative analysis of macro- and micro-nutrients of Perilla frutescens var. crispa f. viridis microgreens and germinated seeds.

Bhaswant M et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139858
PubMed:
38850981

Differences in Airway Remodeling and Emphysematous Lesions between Rats Exposed to Smoke from New-Type and Conventional Tobacco Varieties.

Wei K et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13050511
PubMed:
38790616

Green and efficient extraction of flavonoids from Perilla frutescens (L.) Britt. leaves based on natural deep eutectic solvents: Process optimization, component identification, and biological activity.

Phytochemistry
Wang Z et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139508
PubMed:
38733681

Combined effects of micron-sized polyvinyl chloride particles and copper on seed germination of perilla.

Sun F et al (2024).
Environ Geochem Health.
DOI:
10.1007/s10653-024-01976-7
PubMed:
38696028

PfbZIP85 Transcription Factor Mediates ω-3 Fatty Acid-Enriched Oil Biosynthesis by Down-Regulating PfLPAT1B Gene Expression in Plant Tissues.

Genetics
Huang X et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25084375
PubMed:
38673960

Recent trends in extraction, purification, structural characterization, and biological activities evaluation of Perilla frutescens (L.) Britton polysaccharide.

Review
Zhu L et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1359813
PubMed:
38585610

Rosmarinic Acid-Rich Perilla frutescens Extract-Derived Silver Nanoparticles: A Green Synthesis Approach for Multifunctional Biomedical Applications including Antibacterial, Antioxidant, and Anticancer Activities.

Summary

Study synthesizes silver nanoparticles using rosmarinic acid extract, showing antibacterial, antioxidant, and anticancer properties with potential for drug delivery. Promising as therapeutic agents with high stability and biocompatibility for various applications in medicine.

CancerImmunology
Netala VR et al (2024).
Molecules.
DOI:
10.3390/molecules29061250
PubMed:
38542889

Association mapping analysis for cultivated and weedy types of Perilla crop collected from South Korea using morphological characteristics and SSR markers.

Jang SJ et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26720
PubMed:
38455579

Effects of Perilla frutescens Var. Acuta in Busulfan-Induced Spermatogenesis Dysfunction Mouse Model.

Nam HJ et al (2024).
World J Mens Health.
DOI:
10.5534/wjmh.230254
PubMed:
38449453

GBF family member PfGBF3 and NAC family member PfNAC2 regulate rosmarinic acid biosynthesis under high light.

Xie G et al (2024).
Plant Physiol.
DOI:
10.1093/plphys/kiae036
PubMed:
38441888

Therapeutic Potential and Mechanisms of Rosmarinic Acid and the Extracts of Lamiaceae Plants for the Treatment of Fibrosis of Various Organs.

Review
Boo YC et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13020146
PubMed:
38397744

Perillaldehyde ameliorates lipopolysaccharide-induced acute lung injury via suppressing the cGAS/STING signaling pathway.

Wei J et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.111641
PubMed:
38368770

Corrigendum: From function to metabolome: metabolomic analysis reveals the effect of probiotic fermentation on the chemical compositions and biological activities of Perilla frutescens leaves.

Wang Z et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1357379
PubMed:
38282959

Genome-wide characterization and expression analysis of MADS-box transcription factor gene family in Perilla frutescens.

Genetics
Liang M et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1299902
PubMed:
38259943

Intranasal administration of the essential oil from Perillae Folium ameliorates social defeat stress-induced behavioral impairments in mice.

Summary

Researchers investigated the antidepressant mechanism of essential oil from Perillae Folium (PFEO). PFEO is commonly used in traditional Chinese medicine to treat depression. The study aims to uncover the specific mechanism behind its antidepressant effects.

Phytochemistry
Nguyen LTH et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117775
PubMed:
38224793

First Report of Leaf Spot Caused by Arthrinium arundinis on Amaranthus hybridus in Korea.

Lee JA, Park JH and Choi YJ (2024).
Plant Dis.
DOI:
10.1094/PDIS-07-23-1381-PDN
PubMed:
38190364

Network pharmacology and experimental evidence: MAPK signaling pathway is involved in the anti-asthma roles of Perilla frutescens leaf.

Summary

PF leaf, a traditional Chinese medicine, improves lung function and reduces inflammation in a mouse model of allergic asthma. It targets 50 core proteins and the MAPK signaling pathway, potentially offering a treatment option for allergic asthma.

AsthmaImmunology
Cao M et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22971
PubMed:
38163225

Exploring the metabolomic landscape: Perilla frutescens as a promising enhancer of production, flavor, and nutrition in Tan lamb meat.

Yu Y et al (2023).
Meat Sci.
DOI:
10.1016/j.meatsci.2023.109419
PubMed:
38154372

Diversity and correlation analysis of different root exudates on the regulation of microbial structure and function in soil planted with Panax notoginseng.

Shi H et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1282689
PubMed:
38125568

Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice.

Immunology
Park SH et al (2023).
Nutr Res Pract.
DOI:
10.4162/nrp.2023.17.6.1099
PubMed:
38053825

Role of mitochondrial farnesyltransferase gene in the prevention of the food spoilage fungi Aspergillus flavus by the antimicrobial natural preservative perillaldehyde.

Summary

Researchers investigated the role of Cox10, an enzyme in the heme A synthesis pathway, in the growth and drug resistance of Aspergillus flavus. Deletion of cox10 affects growth and development, increases drug resistance, and triggers stress responses. Understanding these molecular mechanisms could help develop antifungal agents against A. flavus contamination.

AntimicrobialGenetics
Zhuo Q et al (2024).
Food Microbiol.
DOI:
10.1016/j.fm.2023.104422
PubMed:
38049276

Perillaldehyde: A promising antibacterial agent for the treatment of pneumonia caused by Acinetobacter baumannii infection.

Chu ZY et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.111311
PubMed:
38043271

Ultrasonic-Assisted Extraction of Antioxidants from Perilla frutescens Leaves Based on Tailor-Made Deep Eutectic Solvents: Optimization and Antioxidant Activity.

Summary

Researchers found that extracting antioxidants from Perilla leaves using choline chloride-based deep eutectic solvents (DESs) had high antioxidant activity. This eco-friendly method could have various applications, but its cytotoxicity and biodegradability need further investigation.

Immunology
Jiao P et al (2023).
Molecules.
DOI:
10.3390/molecules28227554
PubMed:
38005276

Biochemical changes and enhanced accumulation of phenolic compounds in cell culture of Perilla frutescens (L.) by nano-chemical elicitation.

Phytochemistry
Tavan M, Hanachi P and Mirjalili MH (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108151
PubMed:
37931559

Integrated analysis of miRNA, transcriptome, and degradome sequencing provides new insights into lipid metabolism in perilla seed.

Genetics
Zou X et al (2023).
Gene.
DOI:
10.1016/j.gene.2023.147953
PubMed:
37925118

Genome-Wide Analysis of Glycerol-3-Phosphate Acyltransferase (GPAT) Family in Perilla frutescens and Functional Characterization of PfGPAT9 Crucial for Biosynthesis of Storage Oils Rich in High-Value Lipids.

Genetics
Zhou Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015106
PubMed:
37894786

On-Site Evaluation of Constituent Content and Functionality of Perilla frutescens var. crispa Using Fluorescence Spectra.

Sano H et al (2023).
Molecules.
DOI:
10.3390/molecules28207199
PubMed:
37894678

Determination of Luteolin 7-Glucuronide in Perilla frutescens (L.) Britt. Leaf Extracts from Different Regions of China and Republic of Korea and Its Cholesterol-Lowering Effect.

Wu Z et al (2023).
Molecules.
DOI:
10.3390/molecules28207007
PubMed:
37894485

Investigation of the Molecular Mechanism Underlying the Therapeutic Effect of Perilla frutescens L. Essential Oil on Acute Lung Injury Using Gas Chromatography Mass Spectrometry and Network Pharmacology.

Phytochemistry
Chen H et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073244521231003071900
PubMed:
37818572

Exogenous nanoselenium alleviates imidacloprid-induced oxidative stress toxicity by improving phenylpropanoid metabolism and antioxidant defense system in Perilla frutescens (L.) Britt.

Summary

Pesticides reduce important metabolites in Perilla frutescens, but the application of nano selenium can increase them, improving the plant's quality. NSe can also alleviate oxidative stress caused by pesticides and enhance overall plant quality.

Immunology
Dong Q et al (2023).
J Plant Physiol.
DOI:
10.1016/j.jplph.2023.154095
PubMed:
37741053

Genome-wide comprehensive characterization and Transcriptomic analysis of AP2/ERF gene family revealed its role in seed oil and ALA formation in Perilla (Perilla frutescens).

Summary

Researchers identified 212 AP2/ERF genes in perilla involved in oil accumulation. They found 36 AP2/ERFs correlated with 90 lipid metabolism genes, and identified 12 as important hub genes. Three AP2/ERFs (WRI, ABI4, and RAVI) were highlighted for their potential role in regulating oil accumulation, improving our understanding of oil accumulation in perilla and other oilseed crops.

Genetics
Wu D et al (2023).
Gene.
DOI:
10.1016/j.gene.2023.147808
PubMed:
37722611

Endophytic Streptomyces sp. NEAU-ZSY13 from the leaf of Perilla frutescens, as a promising broad-spectrum biocontrol agent against soil-borne diseases.

Wang Z et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1243610
PubMed:
37692391

Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using Perilla frutescens Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells.

Summary

Biomimetic synthesis of silver nanoparticles (AgNPs) using a flavonoid extract as a reducer and capper. PFFE-AgNPs showed cytotoxic effects against cancer cells, inhibition of bacteria, and antioxidant activity. Promising potential for biomedical applications, but further research needed for safety and efficacy.

CancerGastroenterologyImmunologyPhytochemistry
Hou T et al (2023).
Molecules.
DOI:
10.3390/molecules28176431
PubMed:
37687260

An In Vitro Evaluation and Network Pharmacology Analysis of Prospective Anti-Prostate Cancer Activity from Perilla frutescens.

Summary

L. Britt. leaf extracts contain rosmarinic acid, which exhibits potent cytotoxic effects on prostate cancer cells and interacts with multiple targets and pathways involved in prostate cancer. These findings suggest a potential use of L. Britt. leaves or their metabolites in prostate cancer treatment and prevention.

Cancer
Garcia PJB et al (2023).
Plants (Basel).
DOI:
10.3390/plants12163006
PubMed:
37631218

Applying quantitative spatial phenotypes analysis to the investigation of peltate glandular trichomes development pattern in Perilla frutescens.

Jiang Z et al (2023).
Plant Methods.
DOI:
10.1186/s13007-023-01072-4
PubMed:
37626389

The Role and Mechanism of Perilla frutescens in Cancer Treatment.

Summary

In this review, the authors explore the chemical composition and mechanisms of for cancer treatment. They found that certain components, such as perilla aldehyde and rosmarinic acid, have therapeutic effects. Perilla seed oil has a preventive effect on colorectal cancer. This review offers new ideas for scientific innovation and clinical applications.

Review Cancer
Huang S et al (2023).
Molecules.
DOI:
10.3390/molecules28155883
PubMed:
37570851

Yield performance, mineral profile, and nitrate content in a selection of seventeen microgreen species.

Di Gioia F et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1220691
PubMed:
37546245

The balanced unsaturated fatty acid supplement constituted by woody edible oils improved lipid metabolism and gut microbiota in high-fat diet mice.

Gastroenterology
Chen X et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1203932
PubMed:
37545586

The Effects of Perilla frutescens Extracts on IgA Nephropathy: A Systematic Review and Meta-Analysis.

Review
Adam G et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16070988
PubMed:
37513901

Overexpression of the Purple Perilla (Perilla frutescens (L.)) FAD3a Gene Enhances Salt Tolerance in Soybean.

Genetics
Li Z et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241310533
PubMed:
37445708

The revealing of a novel double bond reductase related to perilla ketone biosynthesis in Perilla frutescens.

Zhou P et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04345-1
PubMed:
37391700

Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study.

Chen L et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241210122
PubMed:
37373270

Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway.

Summary

A new study explores the potential of Perilla frutescens as a treatment for depression. Traditional Chinese medicine suggests that depression is caused by affect-mind ill-being and stagnation of Qi movement. Perilla frutescens has shown promise in regulating Qi and relieving depressive symptoms. However, the mechanism behind its antidepressant effects through inhalation is still not fully understood. This research highlights the importance of alternative therapies in treating neuropsychiatric diseases and further understanding their mechanisms for better treatment options.

NeurosciencePhytochemistry
Zhong Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116840
PubMed:
37355083

Bioefficacy of Nga-Mon (Perilla frutescens) Fresh and Dry Leaf: Assessment of Antioxidant, Antimutagenicity, and Anti-Inflammatory Potential.

Immunology
Tantipaiboonwong P et al (2023).
Plants (Basel).
DOI:
10.3390/plants12112210
PubMed:
37299189

Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes.

Genetics
Xu YD et al (2023).
Chin Med.
DOI:
10.1186/s13020-023-00772-2
PubMed:
37280712

Perillaldehyde Functions as a Potential Antifungal Agent by Triggering Metacaspase-Independent Apoptosis in Botrytis cinerea.

Antimicrobial
Wang G et al (2023).
Microbiol Spectr.
DOI:
10.1128/spectrum.00526-23
PubMed:
37191530

Comparative transcriptome sequencing analysis to postulate the scheme of regulated leaf coloration in Perilla frutescens.

Genetics
Liu X et al (2023).
Plant Mol Biol.
DOI:
10.1007/s11103-023-01342-8
PubMed:
37155022

Enhancing the potential for cadmium phytoremediation by introducing Perilla frutescens genes in tobacco.

Genetics
Wei K and Guo T (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-27392-5
PubMed:
37147538

Engineering the Staple Oil Crop Brassica napus Enriched with α-Linolenic Acid Using the Perilla FAD2-FAD3 Fusion Gene.

Genetics
Xue YF et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c09026
PubMed:
37130169

Perilla oil and α-linolenic acid ameliorated thrombosis in rats induced by collagen and epinephrine.

Kim JT et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-022-01241-6
PubMed:
37123064

The Effect of Light and Dark Treatment on the Production of Rosmarinic Acid and Biological Activities in Perilla frutescens Microgreens.

Lee S et al (2023).
Plants (Basel).
DOI:
10.3390/plants12081613
PubMed:
37111837

An Ethanol Extract of Perilla frutescens Leaves Suppresses Adrenergic Agonist-Induced Metastatic Ability of Cancer Cells by Inhibiting Src-Mediated EMT.

Cancer
Jeong JH et al (2023).
Molecules.
DOI:
10.3390/molecules28083414
PubMed:
37110648

Inhibition of Perilla frutescens Essential Oil on Pellicle Formation of Candida tropicalis and Pichia kluyveri and Its Effect on Volatile Compounds in Sichuan Pickles.

Phytochemistry
Cai T et al (2023).
Foods.
DOI:
10.3390/foods12081593
PubMed:
37107388

Comparative assessment of the biological activity of the green synthesized silver nanoparticles and aqueous leaf extract of Perilla frutescens (L.).

Tavan M et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-33625-x
PubMed:
37076588

Toxic Effects of Perilla frutescens (L.) Britt. Essential Oil and Its Main Component on Culex pipiens pallens (Diptera: Culicidae).

Phytochemistry
Zhang R et al (2023).
Plants (Basel).
DOI:
10.3390/plants12071516
PubMed:
37050142

Case study of clinical improvement of atopic dermatitis in a patient treated with herbal-based parapharmaceuticals.

Dermatology
Maraschio A, Wulhfard K and Monsellato L (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2023-0005
PubMed:
37043584

Sphaerisporangium perillae sp. nov., isolated from the root of Perilla frutescens (Linn.) Britt.

Wang T et al (2023).
Int J Syst Evol Microbiol.
DOI:
10.1099/ijsem.0.005773
PubMed:
37042836

Efficacy of Perilla frutescens (L.) Britton var. frutescens extract on mild knee joint pain: A randomized controlled trial.

Summary

This study tested the efficacy and safety of PE extracts for relieving knee joint pain and improving function. Results showed that PFE intake for 8 weeks was more effective than placebo without major safety concerns.

Pain
Kim N et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1114410
PubMed:
36998613

Comprehensive HPLC fingerprint analysis based on a two-step extraction method for quality evaluation of Perilla frutescens (L.) Britt.

Zhou G et al (2023).
Anal Methods.
DOI:
10.1039/d3ay00172e
PubMed:
36988039

Leaf Extract of Perilla frutescens (L.) Britt Promotes Adipocyte Browning via the p38 MAPK Pathway and PI3K-AKT Pathway.

Immunology
Chen F et al (2023).
Nutrients.
DOI:
10.3390/nu15061487
PubMed:
36986217

Applications of Perilla frutescens Extracts in Clinical Practice.

Review
Adam G et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12030727
PubMed:
36978975

Ectopic Expression of Perilla frutescens WRI1 Enhanced Storage Oil Accumulation in Nicotiana benthamiana Leaves.

Kim S, Lee KR and Suh MC (2023).
Plants (Basel).
DOI:
10.3390/plants12051081
PubMed:
36903941

The Extract of Perilla frutescens Seed Residue Attenuated the Progression of Aberrant Crypt Foci in Rat Colon by Reducing Inflammatory Processes and Altered Gut Microbiota.

Immunology
Chantana W et al (2023).
Foods.
DOI:
10.3390/foods12050988
PubMed:
36900505

Characterization of a Group of 2,3-Oxidosqualene Cyclase Genes Involved in the Biosynthesis of Diverse Triterpenoids of Perilla frutescens.

Genetics
Huang R et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c07716
PubMed:
36705014

Investigation of microsatellite loci for the identification of registered varieties of Perilla frutescens and a discussion on the ancestor species of P. frutescens.

Deguchi Y and Ito M (2023).
J Nat Med.
DOI:
10.1007/s11418-022-01676-5
PubMed:
36640243

Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.

Matsuzaki K et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7728
PubMed:
36637040

Polyphenols of Perilla frutescens of the family Lamiaceae identified by tandem mass spectrometry.

Phytochemistry
Razgonova MP et al (2022).
Vavilovskii Zhurnal Genet Selektsii.
DOI:
10.18699/VJGB-22-78
PubMed:
36532628

Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation.

Yong C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7684
PubMed:
36420586

Microwave-ultrasonic technique development coupled with natural deep eutectic solvents in anthocyanin extraction from perilla leaves (Perilla frutescens var. Acuta).

Han X et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.12343
PubMed:
36397264

Metabolites and chemometric study of Perilla (Perilla frutescens) from different varieties and geographical origins.

Li Y et al (2022).
J Food Sci.
DOI:
10.1111/1750-3841.16376
PubMed:
36382855

Perilla (Perilla frutescens) leaf extract inhibits SARS-CoV-2 via direct virus inactivation.

Summary

A study looked at the use of traditional Chinese medicine (TCM) to find new anti-SARS-CoV-2 agents. While most cases of COVID-19 are mild, some become critical. Remdesivir has been approved, but as a mono-therapy it hasn't lowered mortality rates significantly. TCM has been successful in treating other diseases, leading to this investigation.

COVID-19
Tang WF et al (2021).
Biomed J.
DOI:
10.1016/j.bj.2021.01.005
PubMed:
34119448

Perilla frutescens Extracts Enhance DNA Repair Response in UVB Damaged HaCaT Cells.

Genetics
Lee H and Park E (2021).
Nutrients.
DOI:
10.3390/nu13041263
PubMed:
33921322

Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway.

Summary

A study investigated the sedative and hypnotic effects of Perilla frutescens essential oil (PFEO) through inhalation administration for insomnia treatment, as traditional Chinese medicine suggests depression syndrome is a core pathogenesis of insomnia. Results showed that PFEO exhibited sedative and hypnotic effects, increased total sleep time, and decreased wake time, which suggest it may have therapeutic potential for insomnia treatment. These findings provide insight into the pharmacology and mechanism of PFEO and support the use of traditional Chinese medicine for treating insomnia.

NeurosciencePhytochemistry
Zhong Y et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113627
PubMed:
33246117