Petiveria alliacea

Common Names: guinea henweed

Ethnobotanical Studies

Studies

Triple negative breast cancer migration is modified by mitochondrial metabolism alteration induced by natural extracts of C. spinosa and P. alliacea.

Summary

Researchers studied natural extracts P2Et and Anamu-SC from plants for their anticancer properties on 4T1 breast cancer cells. Anamu-SC showed promising results by decreasing glucose consumption and ATP production, affecting mitochondrial function and cell migration. This study highlights the potential of natural products in modulating tumor metabolism.

Cancer
Carlosama C et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-70550-z
PubMed:
39215068

Toxicity of Mucura (Petiveria alliacea) extracts from the peruvian amazon against Daphnia magna for environmental protection and sustainable development.

Bracho-Pérez JC et al (2024).
Braz J Biol.
DOI:
10.1590/1519-6984.278758
PubMed:
39140498

Exploring the Therapeutic Potential of Petiveria alliacea L. Phytochemicals: A Computational Study on Inhibiting SARS-CoV-2's Main Protease (Mpro).

Summary

Researchers investigated the potential of L. (L.)-mediated phytocompounds for treating SARS-CoV-2. Top candidates myricitrin, engeletin, astilbin showed stable binding and favorable pharmacokinetics in silico, suggesting potential as safe COVID-19 therapies.

COVID-19
Ali MA et al (2024).
Molecules.
DOI:
10.3390/molecules29112524
PubMed:
38893400

The secretome from human-derived mesenchymal stem cells augments the activity of antitumor plant extracts in vitro.

Summary

Scientists studied how mesenchymal stem cells (MSCs) interact with cancer cells in the tumor microenvironment (TME) using natural plant extracts. MSC secretome combined with extracts inhibited cancer cell viability and migration, showing potential for cancer treatment.

Cancer
Ramirez JA et al (2024).
Histochem Cell Biol.
DOI:
10.1007/s00418-024-02265-1
PubMed:
38402366

Plant extracts modulate cellular stress to inhibit replication of mouse Coronavirus MHV-A59.

Summary

Plant extracts P2Et and Anamu SC were tested for their ability to inhibit murine hepatitis virus replication. P2Et reduced virus replication and cellular stress, while Anamu SC inhibited infection but induced some negative effects. These findings suggest the potential of plant extracts as antiviral therapies.

COVID-19
Prieto K et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e23403
PubMed:
38169850

Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells.

Summary

Scientists investigated the impact of on the metabolism of leukemic cells. They discovered that the extract reduced cell proliferation, altered metabolism, and decreased oxygen consumption and ATP levels, suggesting its potential as an anti-tumor agent. Care because it reveals the mechanisms behind its anti-tumor and antiproliferative effects.

Cancer
Rojas L et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242417418
PubMed:
38139247

Influence of Carboxymethyl Cellulose on the Green Synthesis of Gold Nanoparticles Using Gliricidia sepium and Petiveria alliacea Extracts: Surface-Enhanced Raman Scattering Effect Evaluation.

Horta-Piñeres S et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c03813
PubMed:
38107913

Natural Products Induce Different Anti-Tumor Immune Responses in Murine Models of 4T1 Mammary Carcinoma and B16-F10 Melanoma.

Summary

Anamu-SC extract reduces tumor growth in breast cancer but not melanoma, while P2Et extract reduces both and enhances immune response. Co-treatment of P2Et with doxorubicin reduces tumor size by 70%. Both extracts affect immune cell populations and have potential as polymolecular drugs, but further research is needed.

Cancer
Lasso P et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242316698
PubMed:
38069022

Amazonian Plants: A Global Bibliometric Approach to Petiveria alliacea L. Pharmacological and Toxicological Properties.

Review
Conceição BCD et al (2023).
Plants (Basel).
DOI:
10.3390/plants12183343
PubMed:
37765507

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model.

Summary

Alcoholic extract from Esperanza plant shows promising antitumor effects on AML by reducing cell proliferation, improving blood parameters, reducing tumor infiltration, and increasing cytokine production. Potential safer and more effective therapeutic option.

Cancer
Murillo N et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241612972
PubMed:
37629156

Exploring the safety and efficacy of phytomedicine Petiveria alliacea extract (Esperanza) in patients with metastatic gastrointestinal tumors and acute leukemias: study protocol for a phase Ib/randomized double blind phase II trial (PA001).

Ballesteros-Ramírez R et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04109-2
PubMed:
37563608

Neuroprotective effects of Petiveria alliacea on scopolamine-induced learning and memory impairment mouse model.

Summary

Researchers studied the medicinal plant Petiveria alliacea L., commonly used in the Caribbean and Central America to treat central nervous system issues like poor memory.

Neuroscience
Zavala-Ocampo LM et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116881
PubMed:
37460029

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia.

Summary

This study examined the impact of natural product extracts from P2Et and Anamú-SC plants on tumor cells, endothelial cells, and mesenchymal stem cells. The results revealed that the extracts selectively targeted tumor cells and were independent of intracellular ROS modulation. Additionally, the complexity of the extracts and the expression of Pgp influenced their interaction with chemotherapy drug doxorubicin. Interestingly, multicellular spheroids with MSC and EC showed modified effects on leukemia cell viability when treated with the extracts. This research provides insights into how botanical drugs can affect tumor microenvironments and contribute to understanding their pharmacodynamics.

Cancer
Corzo Parada L et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15061690
PubMed:
37376139

Cytotoxicity of Extracts from Petiveria alliacea Leaves on Yeast.

Cal BBF et al (2022).
Plants (Basel).
DOI:
10.3390/plants11233263
PubMed:
36501303

In Vivo and In Silico Study of the Antinociceptive and Toxicological Effect of the Extracts of Petiveria alliacea L. Leaves.

Summary

This study investigated the pain-relieving properties of extracts from L. leaves and conducted a chemical analysis. The extracts reduced pain response and showed no toxicity, suggesting potential therapeutic use.

Pain
Cruz-Salomón KDC et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15080943
PubMed:
36015091

The repellent activity evaluation of the ethanolic extract of the tipi herb against the Bothrops moojeni serpents.

Trevisan M, Seibert CS and Santos MG (2022).
Braz J Biol.
DOI:
10.1590/1519-6984.258041
PubMed:
35674601

In Silico Design and SAR Study of Dibenzyl Trisulfide Analogues for Improved CYP1A1 Inhibition.

Clarke N and Irvine W (2022).
ChemistryOpen.
DOI:
10.1002/open.202200016
PubMed:
35610057

Dibenzyl trisulfide induces caspase-independent death and lysosomal membrane permeabilization of triple-negative breast cancer cells.

Cancer
Wooten J et al (2022).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105203
PubMed:
35489582

Acetylcholinesterase inhibition and antioxidant activity properties of Petiveria alliacea L.

Summary

Extracts from Petiveria alliacea L., a traditional folk medical herb, have been shown to improve memory and the learning process. This herb has been used to treat various ailments, including those relating to the central nervous system, in different regions of the world.

Neuroscience
Zavala-Ocampo LM et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115239
PubMed:
35358623

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models.

Cancer
Mustika A, Fatimah N and Meinar Sari G (2021).
Vet World.
DOI:
10.14202/vetworld.2021.3229-3234
PubMed:
35153417

Medicinal plants used in traditional Mayan medicine for the treatment of central nervous system disorders: An overview.

Summary

This study discusses the use of natural resources in traditional Mayan medicine to treat neurological and psychological conditions. The experimenters highlight the importance of cultural and ethnopsychiatric interpretations in Mayan medicine and recognize the role of herbs in Mayan treatments. This study shows the potential for natural resources to treat CNS disorders in non-Western medicinal practices.

Neuroscience
Castañeda R et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114746
PubMed:
34656668

Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor.

Wauchope S et al (2021).
Toxicol Appl Pharmacol.
DOI:
10.1016/j.taap.2021.115502
PubMed:
33774063

Preferential Activity of Petiveria alliacea Extract on Primary Myeloid Leukemic Blast.

Ballesteros-Ramírez R et al (2020).
Evid Based Complement Alternat Med.
DOI:
10.1155/2020/4736206
PubMed:
33488744

Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages.

Immunology
Gutierrez RMP and Hoyo-Vadillo C (2017).
Pharmacogn Mag.
DOI:
10.4103/pm.pm_479_16
PubMed:
28808377

Antiamoebic Activity of Petiveria alliacea Leaves and Their Main Component, Isoarborinol.

Zavala-Ocampo LM et al (2017).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.1705.05003
PubMed:
28621111

A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism.

Hernández JF et al (2014).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2014.03.013
PubMed:
24637191

Potential behavioral and pro-oxidant effects of Petiveria alliacea L. extract in adult rats.

de Andrade TM et al (2012).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2012.07.020
PubMed:
22890225