Phyllanthus emblica

Common Names: emblic

Ethnobotanical Studies

Clinical Trials

Phyllanthus emblica fruit extract alleviates halitosis and reduces the inflammatory response to oral bacteria.

Researchers tested Phyllanthus emblica extract for treating bad breath and reducing inflammation caused by bacteria. It could lead to improved oral health products.

Lu C, Qing L and Yina L (2024).
J Appl Oral Sci.
PubMed:
38922243

Studies

Recent advances in the potential of Phyllanthus emblica L. and its related foods for combating metabolic diseases through methylglyoxal trapping.

Review
Chen SY et al (2024).
Food Res Int.
PubMed:
39232532

Key role of Phyllanthus emblica L. fruit extract promotes ZVI/H(2)O(2) process: rich titratable acid, suitable chelating ability, and antioxidant capacity.

Summary

PFE improves ZVI/HO technology for Norfloxacin removal by enhancing efficiency and decreasing iron sludge. Key mechanism involves ROS attack, pH lowering, chelation, and antioxidant capacity. UPR concept introduced.

Lu B, Fang Z and Tsang PE (2024).
Environ Sci Pollut Res Int.
PubMed:
39230818

Vicia faba L. Pod Valves: A By-Product with High Potential as an Adjuvant in the Treatment of Parkinson's Disease.

Summary

Researchers studied lucan broad bean pod valves (BPs) rich in L-dopa and polyphenols for Parkinson's treatment. BP extracts showed higher L-dopa content than seeds, with neuroprotective polyphenols, antioxidants, and no harmful metabolites. BP extracts were more effective than synthetic L-dopa in preventing oxidative stress.

Tesoro C et al (2024).
Molecules.
PubMed:
39203021

Penicillides from Penicillium and Talaromyces: Chemical Structures, Occurrence and Bioactivities.

Review
Salvatore MM et al (2024).
Molecules.
PubMed:
39202967

Comprehensive phytochemical profiling of Phyllanthus emblica L. flowers on UHPLC/MS quadrupole time of flight, HPTLC, HPLC, and NMR analytical platforms reveals functional metabolites with potent anti-inflammatory effects in human (THP-1) macrophages.

Balkrishna A et al (2024).
Phytochem Anal.
PubMed:
39160136

Extraction, Phytochemical profile, and neuroprotective activity of Phyllanthus emblica fruit extract against sodium valproate-induced postnatal autism in BALB/c mice.

Summary

Study evaluated EAFA extract's effect on VPA-induced autism in mice, showing improved behavior, antioxidant activity, reduced inflammation, and neuroprotection. EAFA extract may be a potential treatment for autism.

Gouda B et al (2024).
Heliyon.
PubMed:
39157403

The inhibitory effects of free and bound phenolics from Phyllanthus emblica Linn. on α-amylase: a comparison study.

Xing M et al (2024).
J Sci Food Agric.
PubMed:
39132987

Extract of Phyllanthus emblica L. fruit stimulates basal glucose uptake and ameliorates palmitate-induced insulin resistance through AMPK activation in C2C12 myotubes.

Li HY et al (2024).
BMC Complement Med Ther.
PubMed:
39095777

Phytochemicals-linked food safety and human health protective benefits of the selected food-based botanicals.

Christopher A and Shetty K (2024).
PLoS One.
PubMed:
39074098

Discovery of quality markers of Phyllanthus emblica by integrating chromatographic fingerprint, serum pharmacochemistry and network pharmacology.

Xu YH and Chen J (2024).
J Pharm Biomed Anal.
PubMed:
39018721

How can dry tropical forests respond to climate change? Predictions for key Non-Timber Forest Product species show different trends in India.

Saraf PN et al (2024).
Environ Monit Assess.
PubMed:
38995471

Fruit Extract and Phenolic Compounds of Phyllanthus emblica Fruits as Bioactivity Enhancer of Chloramphenicol Against Bacterial Species.

Saini R et al (2024).
Plant Foods Hum Nutr.
PubMed:
38951374

The Ethyl Acetate Extract of Phyllanthus emblica L. Alleviates Diabetic Nephropathy in a Murine Model of Diabetes.

Summary

Study examined the protective effects of Oil-Gan fruit extract on diabetic nephropathy in mice, improving kidney function and reducing inflammation and fibrosis. EPE may be a potential treatment for renal dysfunction.

Lin CH and Shih CC (2024).
Int J Mol Sci.
PubMed:
38928391

The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review.

Summary

Researchers conducted a systematic review on herbal medicines as adjuvant therapy for COVID-19, analyzing clinical trials from various countries. Results focused on Length of Stay, Negative Conversion Time, and Negative Conversion Rate. Important for potential alternative treatment options.

Latarissa IR et al (2024).
Front Pharmacol.
PubMed:
38873430

Recent Insights into the Antimicrobial Properties of Phyllanthus emblica L.: A Comprehensive Review of Wonder Berry.

Summary

The plant Phyllanthus emblica (Amla) has shown antiviral, antibacterial, and antifungal effects against various pathogens. Its bioactive compounds can be used for therapeutic purposes in treating infectious diseases.

Begum MA et al (2024).
Chem Biodivers.
PubMed:
38808441

The effect of Phyllanthus emblica (Amla) fruit supplementation on the rumen microbiota and its correlation with rumen fermentation in dairy cows.

Tilahun M et al (2024).
Front Microbiol.
PubMed:
38803380

Microbiome-Metabolome Analysis Insight into the Effects of the Extract of Phyllanthus emblica L. on High-Fat Diet-Induced Hyperlipidemia.

Wang J et al (2024).
Metabolites.
PubMed:
38786734

Silver sulphide nanoparticles (Ag(2)SNPs) synthesized using Phyllanthus emblica fruit extract for enhanced antibacterial and antioxidant properties.

Renuka R et al (2024).
Microsc Res Tech.
PubMed:
38752356

Inhibitory activities and mechanisms of free and bound phenolics on α-glucosidase in fresh fruits of Phyllanthus emblica Linn. using spectroscopy and molecular docking.

Xing M et al (2024).
Food Funct.
PubMed:
38752307

Exploration of Polysaccharides from Phyllanthus emblica: Isolation, Identification, and Evaluation of Antioxidant and Anti-Glycolipid Metabolism Disorder Activities.

Summary

Researchers studied the polysaccharides of a medicinal herb for their anti-glycolipid metabolic disorder activity. The study found potential for treating diabetes and other metabolic disorders.

Guo P et al (2024).
Molecules.
PubMed:
38675571

Herbal Spices as Food and Medicine: Microscopic Authentication of Commercial Herbal Spices.

Khan A et al (2024).
Plants (Basel).
PubMed:
38674476

Acaricidal Efficacy of Thirty-Five Egyptian Plants Against the Camel Tick, Hyalomma Dromedarii.

Khater HF et al (2024).
Acta Parasitol.
PubMed:
38671280

Phyllanthus emblica Fruit Improves Obesity by Reducing Appetite and Enhancing Mucosal Homeostasis via the Gut Microbiota-Brain-Liver Axis in HFD-Induced Leptin-Resistant Rats.

Summary

Researchers found that a water extract of L. fruit effectively reduced leptin resistance in high-fat diet fed rats by improving gut barrier function, appetite regulation, and lipid metabolism. This may help in managing obesity and related complications.

Chang HY et al (2024).
J Agric Food Chem.
PubMed:
38659208

Green synthesis, characterization and applications of Phyllanthus emblica fruit extract mediated chromium oxide nanoparticles.

Fatima E et al (2024).
Discov Nano.
PubMed:
38625606

Haplotype-resolved genomes of octoploid species in Phyllanthaceae family reveal a critical role for polyploidization and hybridization in speciation.

Li F et al (2024).
Plant J.
PubMed:
38606539

Effect of Indian gooseberry extract on improving methylglyoxal-associated leptin resistance in peripheral tissues of high-fat diet-fed rats.

Chen SY et al (2024).
J Food Drug Anal.
PubMed:
38526590

Recent Insights into the Morphological, Nutritional and Phytochemical Properties of Indian Gooseberry (Phyllanthus emblica) for the Development of Functional Foods.

Summary

Review of Indian gooseberry (aonla) fruit shows diverse health benefits including antioxidant, anti-inflammatory properties. Valuable potential for improving human health, worth considering for lab research and product development.

Avinash PG et al (2024).
Plants (Basel).
PubMed:
38475421

Phyllanthus emblica Linn: A comprehensive review of botany, traditional uses, phytonutrients, health benefits, quality markers, and applications.

Review
Ma QG et al (2024).
Food Chem.
PubMed:
38432135

Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia.

Summary

A study examined the impact of quercetin and various fruit and leaf extracts on platelet recovery in rats with chemo-induced thrombocytopenia. Enhanced platelet recovery can minimize chemotherapy disruptions and decrease the need for dosage changes or treatment discontinuation, thus improving cancer treatment outcomes.

Chawansuntati K et al (2024).
Heliyon.
PubMed:
38312709

Debittering of Emblica (Phyllanthus emblica L.) fruit powder: Preparation and biological activity.

Zhang L et al (2024).
Food Chem X.
PubMed:
38282828

Combined Effects of Clarifying Agents Improve Physicochemical, Microbial and Sensorial Qualities of Fresh Indian Gooseberry (Phyllanthus emblica L.) Juice during Refrigerated Storage.

Jafari S et al (2024).
Foods.
PubMed:
38254591

A novel deep eutectic solvent modified magnetic covalent organic framework for the selective separation and determination of trace copper ion in medicinal plants and environmental samples.

Liu Y et al (2024).
Anal Chim Acta.
PubMed:
38246739

Canal disinfection using photo-chemically activated micro-bubble emulsion, Emblica officinalis, and Nd: YAP laser on smear layer and push-out bond strength of resin-based root canal sealer to the radicular dentin.

Alkahtany MF and Almadi KH (2024).
Photodiagnosis Photodyn Ther.
PubMed:
38242188

Study on the white frost formation mechanism during storage of Phyllanthus emblica Linn. fruit based on component analysis and spatial metabolomics.

Lin J et al (2024).
J Pharm Biomed Anal.
PubMed:
38237545

Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis.

Summary

Osthole, a compound from Cnidium monnieri, shows promise as a natural antifungal agent to control blue mold in Phyllanthus emblica fruit by inhibiting mold growth and inducing autophagy in fungal cells.

Lai D et al (2024).
Pestic Biochem Physiol.
PubMed:
38225092

Screening herbal extracts as biostimulant to increase germination, plant growth and secondary metabolite production in wheatgrass.

Yadav A, Singh S and Yadav V (2024).
Sci Rep.
PubMed:
38182633

Tannins in Phyllanthus emblica L. improves cisplatin efficacy in lung cancer cells by boosting endoplasmic reticulum stress to trigger immunogenic cell death.

Summary

Tannins in Phyllanthus emblica L. (PTF) can inhibit tumor growth and have cytotoxic effects on lung cancer cells in vitro. This suggests PTF may be a potential immunotherapy for lung cancer treatment.

Hu Q et al (2023).
Phytomedicine.
PubMed:
38056150

Phyllanthi Tannin Loaded Solid Lipid Nanoparticles for Lung Cancer Therapy: Preparation, Characterization, Pharmacodynamics and Safety Evaluation.

Summary

Researchers developed PTF-loaded solid lipid nanoparticles (PTF-SLNs) for treating lung cancer. PTF-SLNs showed stronger anti-tumor efficacy and reduced harm to normal organs compared to PTF alone. This study offers a potential nanoparticle delivery system to enhance lung cancer treatment.

Wang B et al (2023).
Molecules.
PubMed:
37959818

Phyllanthus emblica: a comprehensive review of its phytochemical composition and pharmacological properties.

Summary

The review explores the various health benefits of the Balakka fruit, which include antioxidant, anti-aging, anti-cholesterol, anti-diabetic properties, among others. It also examines the different bioactive compounds present in the fruit.

Prananda AT et al (2023).
Front Pharmacol.
PubMed:
37954853

Scrutinizing the therapeutic response of Phyllanthus exmblica's different doses to restore the immunomodulation potential in immunosuppressed female albino rats.

Riasat A et al (2023).
Eur Rev Med Pharmacol Sci.
PubMed:
37916352

"Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment".

Summary

Study explores amla phytochemicals as potential inhibitors of Top1 protein in cancer. Aims to find alternative treatment without side effects from acetylcholinesterase inhibition. New medications could reduce irinotecan's side effects.

Ritu, Chandra P and Das A (2023).
J Biomol Struct Dyn.
PubMed:
37885319

Antidiabetic and antihyperlipidemic activities of Phyllanthus emblica L. extract in vitro and the regulation of Akt phosphorylation, gluconeogenesis, and peroxisome proliferator-activated receptor α in streptozotocin-induced diabetic mice.

Summary

Researchers investigated the potential benefits of L. fruits in diabetes and hyperlipidemia management. The study highlights the need for a safe and efficient drug for these conditions.

Huang SM et al (2023).
Food Nutr Res.
PubMed:
37850072

De novo transcriptome profiling and development of novel secondary metabolites based genic SSRs in medicinal plant Phyllanthus emblica L. (Aonla).

Kapoor B et al (2023).
Sci Rep.
PubMed:
37828031

Antibacterial Activity of Selected Fruit Juices against Multidrug-Resistant Bacterial Pathogens Involved in Urinary Tract and Sexually Transmitted Infections among Tribal Women in Madhya Pradesh, India.

Sharma P et al (2023).
J Pharmacopuncture.
PubMed:
37799616

Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis.

Zhang D et al (2023).
Chin Med.
PubMed:
37779204

Effect of Extraction Methods on the Antioxidant Potential and Cytotoxicity of the Combined Ethanolic Extracts of Daucus carota L., Beta vulgaris L., Phyllanthus emblica L. and Lycopersicon esculentum against Gastric Adenocarcinoma Cells.

Chauhan M et al (2023).
Molecules.
PubMed:
37764365

Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of Phyllanthus emblica: A Study Supported by Spectroscopic and Computational Investigations.

Summary

This research investigates the potential value of a specific plant as food and medicine. It contains minerals, vitamins C and E, and polyphenolic phytochemicals that may help treat infectious diseases and prevent/treat oxidative-damage-related illnesses like Alzheimer's disease.

Orabi MAA et al (2023).
Metabolites.
PubMed:
37755293

Genome of Phyllanthus emblica: the medicinal plant Amla with super antioxidant properties.

Summary

Scientists sequenced the genome of Indian gooseberry (amla), a medicinal plant rich in antioxidants. They identified ascorbate biosynthesis pathways and analyzed evolutionary insights into fruit formation and flavonoid biosynthesis. This information has potential applications in horticulture, medicine, diet, cosmetics, and comparative genomics.

Mahajan S et al (2023).
Front Plant Sci.
PubMed:
37727852

Production of tannase from a newly isolated yeast, Geotrichum cucujoidarum using agro-residues.

Thangavelu N et al (2023).
Prep Biochem Biotechnol.
PubMed:
37698943

Two pyrrole acids isolated from Phyllanthus emblica L. and their bioactivities.

Wang SH et al (2023).
Nat Prod Bioprospect.
PubMed:
37639046

BDMediLeaves: A leaf images dataset for Bangladeshi medicinal plants identification.

Islam S et al (2023).
Data Brief.
PubMed:
37636130

Phyllanthus emblica (Amla) methanolic extract regulates multiple checkpoints in 15-lipoxygenase mediated inflammopathies: Computational simulation and in vitro evidence.

Sharif MA et al (2023).
Saudi Pharm J.
PubMed:
37576860

Integrating traditional ecological knowledge into habitat restoration: implications for meeting forest restoration challenges.

Haq SM et al (2023).
J Ethnobiol Ethnomed.
PubMed:
37559120

Erratum: Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods.

(2023).
J Vis Exp.
PubMed:
37540670

Phyllanthi Fructus: A modal medicinal and food homologous item in quality evaluation.

Review
Li G et al (2023).
Chin Herb Med.
PubMed:
37538854

Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management.

Summary

The fruit of Linn. has medicinal and nutritional properties with potential for oral health management, including preventing oral pathogens and promoting wound healing. It can enhance periodontitis treatment and alleviate discomfort caused by oral cancer and high blood glucose levels. Future research on its chemical composition is needed.

Li G et al (2023).
Food Funct.
PubMed:
37529983

Synergistic antibacterial activity of Phyllanthus emblica fruits and its phytocompounds with ampicillin: a computational and experimental study.

Saini R et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
37522914

The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: A randomized controlled trial.

Akhbari M et al (2023).
J Ethnopharmacol.
PubMed:
37487962

Antidiabetic and Immunoregulatory Activities of Extract of Phyllanthus emblica L. in NOD with Spontaneous and Cyclophosphamide-Accelerated Diabetic Mice.

Summary

The study investigated the effects of emblica fruit extract on type 1 diabetes in mice, finding that it decreased blood glucose levels and increased insulin levels. It also regulated cytokine expression and showed potential as a therapeutic option for preventing diabetes.

Lin CH, Kuo YH and Shih CC (2023).
Int J Mol Sci.
PubMed:
37373070

Clinical effects of Emblica officinalis fruit consumption on cardiovascular disease risk factors: a systematic review and meta-analysis.

Summary

This study reviewed and analyzed previous research on Emblica officinalis (EO) fruit consumption and its effects on cardiovascular disease (CVD) risk factors. EO was found to have a positive impact on CVD risk factors in preliminary trials.

Meta-Analysis Cardiology
Brown PDS et al (2023).
BMC Complement Med Ther.
PubMed:
37296402

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods.

Huang H et al (2023).
J Vis Exp.
PubMed:
37125797

Dextran-Sulfate-Sodium-Induced Colitis-Ameliorating Effect of Aqueous Phyllanthus emblica L. Extract through Regulating Colonic Cell Gene Expression and Gut Microbiomes.

Li X et al (2023).
J Agric Food Chem.
PubMed:
37102314

Protective effect and mechanism research of Phyllanthus emblica Linn. fruit extract on UV-induced photodamage in keratinocytes.

Qu L, Wang F and Chen Y (2023).
Photochem Photobiol Sci.
PubMed:
37076760

Effect of amla and ginger powders on quality criteria of African catfish (Clarias gariepinus) fingers.

Zaghlool A et al (2023).
Braz J Biol.
PubMed:
37075379

Optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study.

Poomanee W et al (2023).
Sci Rep.
PubMed:
37024608

Topical combined Phyllanthus emblica Linn. and simvastatin improves wound healing in diabetic mice by enhancing angiogenesis and reducing neutrophil infiltration.

Liao TT et al (2023).
Biomed Rep.
PubMed:
37009310

Characterization and metabolomic profiling of two pigment producing fungi from infected fruits of Indian Gooseberry.

Dutta M et al (2023).
Arch Microbiol.
PubMed:
36964798

Preventive Effect of Indian Gooseberry (Phyllanthus emblica L.) Fruit Extract on Cognitive Decline in High-Fat Diet (HFD)-Fed Rats.

Summary

The study investigated the mechanism by which Indian gooseberry fruit prevents obesity-induced cognitive decline. It was found that methylglyoxal (MG)-derived advanced glycation end products (AGEs) bind to a receptor, worsening obesity and cognitive decline. Indian gooseberries have antiobesity properties, but the mechanism by which they prevent cognitive decline was not known.

Chen YY et al (2023).
Mol Nutr Food Res.
PubMed:
36738163

Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review.

Review
Gul M et al (2022).
Antioxidants (Basel).
PubMed:
35624683

Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging.

Chaikul P et al (2021).
J Tradit Complement Med.
PubMed:
34522633

Traditional uses, bioactive composition, pharmacology, and toxicology of Phyllanthus emblica fruits: A comprehensive review.

Review
Saini R et al (2022).
J Ethnopharmacol.
PubMed:
34480995

Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer.

Review Cancer
Baliga MS and Dsouza JJ (2011).
Eur J Cancer Prev.
PubMed:
21317655

Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder.

Review
Krishnaveni M and Mirunalini S (2010).
J Basic Clin Physiol Pharmacol.
PubMed:
20506691