Phyllanthus niruri

Common Names: gale of the wind

Ethnobotanical Studies

Studies

Phyllanthus niruri Linn.: Antibacterial Activity, Phytochemistry, and Enhanced Antibiotic Combinatorial Strategies.

Summary

Study investigated antibacterial activity of Linn. plant extracts against resistant pathogens. Aqueous and methanolic extracts showed promise in inhibiting bacterial growth, indicating potential for novel antibiotic development. Further research needed.

AntimicrobialPhytochemistry
Tiwana G, Cock IE and Cheesman MJ (2024).
Antibiotics (Basel).
DOI:
10.3390/antibiotics13070654
PubMed:
39061336

Bioguided Fractionation of Phyllanthus spp.: Unveiling Anticancer Potential through Metabolomic Correlation and ADMETox Insights.

Summary

Scientists studied plants from the Phyllanthus genus for potential cancer treatments. They identified bioactive compounds using advanced analytical techniques and found promising results, suggesting the potential for future drug development. This research highlights the importance of natural products in cancer therapy.

Cancer
Silva FS et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400670
PubMed:
38747034

Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV.

Summary

PNE from Linn. plant showed strong antioxidant and antidiabetic properties in mice. Phytochemicals in PNE may inhibit DPP-IV, making it a potential antidiabetic agent.

Diabetes
Bhushan V et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2337108
PubMed:
38590294

Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.

Rosidah I et al (2024).
J Toxicol.
DOI:
10.1155/2024/9445226
PubMed:
38571743

Bio-stimulants from medicinally and nutritionally significant plant extracts mitigate drought adversities in Zea mays through enhanced physiological, biochemical, and antioxidant activities.

Immunology
Bhowmick S et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108396
PubMed:
38310727

Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models.

Summary

Phyllanthus niruri L., a medicinal plant, and its compounds were found to enhance glucose uptake, reduce ROS levels, and have potential for treating type 2 diabetes.

Diabetes
Swargiary D et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105803
PubMed:
38171388

Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells.

Summary

Hypophyllanthin and phyllanthin from a plant enhance doxorubicin's effectiveness against breast cancer cells through various mechanisms, making them potential chemomodulators.

Cancer
Abdel-Sattar OE et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c02953
PubMed:
37576627

Antiplasmodial and interferon-gamma-modulating activities of the aqueous extract of stone breaker (Phyllanthus niruri Linn.) in malaria infection.

Jeje TO et al (2023).
Parasitol Int.
DOI:
10.1016/j.parint.2023.102789
PubMed:
37473798

Corrigendum: Phyllanthus niruri L. exerts protective effects against the calcium oxalate-induced renal injury via ellgic acid.

Li MT et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1207268
PubMed:
37361230

Effects of one-year supplementation with Phyllanthus niruri on fibrosis score and metabolic markers in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial.

Abu Hassan MR et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e16652
PubMed:
37313177

Combination Curcuma longa and Phyllanthus niruri Extract Potentiate Antiproliferative in Triple Negative Breast Cancer MDAMB-231 Cells.

Summary

Researchers investigated the effects of combining Curcuma longa extract (CL) and Phyllanthus niruri extract (PN) on the proliferation of triple negative breast cancer cells (TNBC). TNBC cells are highly metastatic and have the ability to renew themselves uncontrollably. CL and PN are known to have anti-proliferative effects on cancer cells. This study aims to determine if the combination of CL and PN can effectively inhibit TNBC cell proliferation. Understanding this could lead to potential treatment options for TNBC patients.

Cancer
Hermansyah D et al (2023).
Asian Pac J Cancer Prev.
DOI:
10.31557/APJCP.2023.24.5.1495
PubMed:
37247268

Physiological Impact of the Non-Nutritive Artificial Sweetener, Aspartame, and the Therapeutic Potential of Aqueous Extract of Phyllanthus niruri.

Naik AQ, Zafar T and Shrivastava VK (2023).
J Med Food.
DOI:
10.1089/jmf.2022.K.0136
PubMed:
37204311

Efficacy of a Multicomponent Nutraceutical Formulation for the Prevention and Treatment of Urinary Tract Stones.

Maisto M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24098316
PubMed:
37176022

Delivery of Apoplastic Extracellular Vesicles Encapsulating Green-Synthesized Silver Nanoparticles to Treat Citrus Canker.

Gaurav I et al (2023).
Nanomaterials (Basel).
DOI:
10.3390/nano13081306
PubMed:
37110891

Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia.

Review Cancer
Prieto JM and Hanafi MMM (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45020099
PubMed:
36826044

Cytotoxic and chemomodulatory effects of Phyllanthus niruri in MCF-7 and MCF-7(ADR) breast cancer cells.

Cancer
Abdel-Sattar OE et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-29566-0
PubMed:
36792619

Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague-Dawley Rats.

Murwanti R et al (2023).
J Toxicol.
DOI:
10.1155/2023/7511397
PubMed:
36636256

Use of Cheminformatics to Determine Potential Drug Interactions between Popular Barbadian Botanical Medicines and Antihypertensive Drugs.

Evadgian A, Bharatha A and Cohall D (2022).
ACS Omega.
DOI:
10.1021/acsomega.2c02446
PubMed:
36530331

Bioefficacy of Composite Medicinal Plant Extracts and Gum Arabic on Improving Postharvest Quality in Dragon Fruit.

Bordoh PK et al (2022).
Int J Food Sci.
DOI:
10.1155/2022/3889563
PubMed:
36329708

The Efficient and Easy Micropropagation Protocol of Phyllanthus niruri.

Suraya AA, Misran A and Hakiman M (2021).
Plants (Basel).
DOI:
10.3390/plants10102141
PubMed:
34685949

Causes and prevention of kidney stones: separating myth from fact.

Review
Garbens A and Pearle MS (2021).
BJU Int.
DOI:
10.1111/bju.15532
PubMed:
34192414

Phyllanthus niruri (stone breaker) herbal therapy for kidney stones; a systematic review and meta-analysis of clinical efficacy, and Google Trends analysis of public interest.

Meta-Analysis
Dhawan S and Olweny EO (2020).
Can J Urol.
PubMed:
32333735

Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy.

Paula VG et al (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.112728
PubMed:
32145330

Herbal remedies for urinary stones used in India and China: A review.

Review
Kasote DM et al (2017).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2017.03.038
PubMed:
28344029

The pharmacological potential of Phyllanthus niruri.

Review
Lee NY et al (2016).
J Pharm Pharmacol.
DOI:
10.1111/jphp.12565
PubMed:
27283048

Phyllanthus niruri as a promising alternative treatment for nephrolithiasis.

Review
Boim MA, Heilberg IP and Schor N (2010).
Int Braz J Urol.
PubMed:
21176271