Phyllanthus urinaria

Common Names: chamber bitter

Ethnobotanical Studies

Studies

A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma.

Review
Liu L et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1443667
PubMed:
39185304

Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes and Caenorhabditis elegans.

Gastroenterology
Jato J et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1390500
PubMed:
39104390

Integrating Network Pharmacology and In Vitro Experiments for Assessing the Anti-Tumor Effects of Phyllanthus Urinaria L Anti-neoplastic Decoction in Hepatocellular Carcinoma.

Summary

Chinese herb formulas with "yiqi jianpi jiedu huayu" can effectively treat hepatocellular carcinoma, but the mechanisms are unknown. Understanding this can improve HCC treatment with traditional Chinese medicine.

Cancer
Wei C et al (2024).
Altern Ther Health Med.
PubMed:
38758152

Corilagin Inhibits Neutrophil Extracellular Trap Formation and Protects against Hydrochloric Acid/Lipopolysaccharide-Induced Acute Lung Injury in Mice by Suppressing the STAT3 and NOX2 Signaling Pathways.

Immunology
Liu FC et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13040491
PubMed:
38671938

Correction: Nguyen et al. Green Silver Nanoparticles Formed by Phyllanthus urinaria, Pouzolzia zeylanica, and Scoparia dulcis Leaf Extracts and the Antifungal Activity. Nanomaterials 2020, 10, 542.

Summary

Researchers analyzed the impact of climate change on polar bear populations through satellite data. Understanding how climate change affects polar bears helps inform conservation efforts.

Antimicrobial
Nguyen DH et al (2024).
Nanomaterials (Basel).
DOI:
10.3390/nano14050475
PubMed:
38470812

Exosomal microRNA profiling revealed enhanced autophagy suppression and anti-tumor effects of a combination of compound Phyllanthus urinaria and lenvatinib in hepatocellular carcinoma.

Summary

Researchers investigated the combination of a Chinese herb called Phyllanthus urinaria (CP) with the drug lenvatinib for treating liver cancer. CP has strong anti-cancer effects and, when combined with lenvatinib, could potentially overcome drug resistance in patients with advanced liver cancer.

Cancer
Liao M et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155091
PubMed:
37844378

Towards the development of analytical monograph specifications for the quality assessment of the medicinal plant Phyllanthus urinaria.

Orman E et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113854
PubMed:
37716546

Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes.

Jato J et al (2023).
Planta Med.
DOI:
10.1055/a-2117-9426
PubMed:
37459860

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice.

Immunology
Liu FC et al (2023).
Biology (Basel).
DOI:
10.3390/biology12020334
PubMed:
36829609

Application of chloroplast genome in the identification of Phyllanthus urinaria and its common adulterants.

Genetics
Fang H et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1099856
PubMed:
36684764

Allium sativum@AgNPs and Phyllanthus urinaria@AgNPs: a comparative analysis for antibacterial application.

Phan KS et al (2022).
RSC Adv.
DOI:
10.1039/d2ra06847h
PubMed:
36545079

Effects of Corilagin on Lipopolysaccharide-Induced Acute Lung Injury via Regulation of NADPH Oxidase 2 and ERK/NF-κB Signaling Pathways in a Mouse Model.

Liu FC et al (2022).
Biology (Basel).
DOI:
10.3390/biology11071058
PubMed:
36101436

Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinaria L. root, stem, leaf and fruit.

Han N et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2069766
PubMed:
35503410

Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro.

He B et al (2022).
J Nat Med.
DOI:
10.1007/s11418-021-01594-y
PubMed:
35064897

A Review: Mechanism of Phyllanthus urinaria in Cancers-NF-κB, P13K/AKT, and MAPKs Signaling Activation.

Review Cancer
Saahene RO et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/4514342
PubMed:
34484390

Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.

Cancer
Huang D et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.659325
PubMed:
34168559

Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.

Summary

Chinese herbal medicines, including Corilagin, have been found to exhibit important antiviral activities against various viruses. While vaccines and drugs may not be effective in preventing the COVID-19 pandemic due to coronavirus mutations, exploring the use of herbal medicines may provide an alternative solution. Corilagin has shown antiviral effects on HIV, HCV, and EBV but its ability to block the interaction between SARS-CoV-2 and hACE2 has not been determined. Further research may reveal the potential of Corilagin as a COVID-19 treatment.

COVID-19
Yang LJ et al (2021).
Phytomedicine.
DOI:
10.1016/j.phymed.2021.153591
PubMed:
34029937

Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery.

Huang ST et al (2016).
Am J Chin Med.
PubMed:
27776427

Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins.

Huang ST et al (2014).
Mitochondrion.
DOI:
10.1016/j.mito.2014.05.002
PubMed:
24836433

Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms.

Review Cancer
Huang ST, Pang JH and Yang RC (2010).
Chang Gung Med J.
PubMed:
20979698

Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.

Hau DK et al (2009).
Phytomedicine.
DOI:
10.1016/j.phymed.2009.01.008
PubMed:
19386480

Phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells.

Huang ST et al (2009).
Forsch Komplementmed.
DOI:
10.1159/000194154
PubMed:
19295228

Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo.

Shen B et al (2008).
Hepatology.
PubMed:
18157836

Lignans from Phyllanthus urinaria.

Phytochemistry
Chang CC et al (2003).
Phytochemistry.
PubMed:
12877924