Physalis angulata

Common Names: cut-leaf ground-cherry, cutleaf groundcherry, lanceleaf groundcherry

Ethnobotanical Studies

Gongcheng County, Guangxi, China

Uses: Sphagitis, typhoid, enteroptosis

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

Society archipelago, French Polynesia

Uses: Sinusitis

DOI:: 10.1186/s13002-023-00617+0
PubMed:: 37853377

Mizoram, India

Uses: Diabetes, toothache, and inflammation

DOI:: 10.1186/s13002-023-00642-z
PubMed:: 38172927

Studies

The fate of Salmonella enterica and Listeria monocytogenes in the pulp of eight native Brazilian and exotic fruits.

Silva BS et al (2024).; Int J Food Microbiol.
DOI:: 10.1016/j.ijfoodmicro.2024.110783
PubMed:: 38851046

In vitro inhibition of 5-α reductase and in vivo suppression of benign prostatic hyperplasia by Physalis angulata ethyl acetate extract.

Nguyen NP et al (2024).; Fitoterapia.
DOI:: 10.1016/j.fitote.2024.105950
PubMed:: 38599338

Folk Knowledge and Perceptions about the Use of Wild Fruits and Vegetables-Cross-Cultural Knowledge in the Pipli Pahar Reserved Forest of Okara, Pakistan.

Jabeen S et al (2024).; Plants (Basel).
DOI:: 10.3390/plants13060832
PubMed:: 38592859

Causal agents of Stemphylium-induced foliar diseases of tomatoes and other Solanaceae hosts in Brazil.

Torres TB et al (2024).; J Appl Microbiol.
DOI:: 10.1093/jambio/lxae038
PubMed:: 38373804

Physalis angulata Linn. as a medicinal plant (Review).

Review

Novitasari A, Rohmawaty E and Rosdianto AM (2024).; Biomed Rep.
DOI:: 10.3892/br.2024.1735
PubMed:: 38357237

The Effect of Physalis angulata L. Administration on Gene Expressions Related to Lung Fibrosis Resolution in Mice-Induced Bleomycin.

Genetics

Imaduddin UK, Berbudi A and Rohmawaty E (2024).; J Exp Pharmacol.
DOI:: 10.2147/JEP.S439932
PubMed:: 38317831

Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.

Wang FR et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.117830
PubMed:: 38301983

Withanolides from Physalis angulata var. villosa and the Relative Configurational Revision of Some Known Analogs.

Zhang JF et al (2024).; J Nat Prod.
DOI:: 10.1021/acs.jnatprod.3c00725
PubMed:: 38207331

Target Separation and Potential Anticancer Activity of Withanolide-Based Glucose Transporter Protein 1 Inhibitors from Physalis angulata var. villosa.

Summary

Researchers discovered a new potential inhibitor of the glucose transporter 1 (GLUT1) protein, called physagulide Y, from the plant Mao-Ku-Zhi. This inhibitor showed strong antitumor activity and could be used to develop targeted cancer treatments.

Cancer

Zhang J et al (2023).; J Nat Prod.
DOI:: 10.1021/acs.jnatprod.3c00613
PubMed:: 38117981

10.

UPLC-Q-Orbitrap-MS/MS-Guided Isolation of Bioactive Withanolides from the Fruits of Physalis angulata.

Wang P et al (2023).; J Agric Food Chem.
DOI:: 10.1021/acs.jafc.3c04311
PubMed:: 37897427

11.

The Efficacy of Topical Formulation Containing Ciplukan (Physalis angulata Linn.) in Modulating Interleukin-17 and Interferon Gamma Expression in Mice (Mus musculus) Psoriasis Model.

Summary

Researchers studied the potential of Linn. (Ciplukan) as an alternative topical therapy for psoriasis vulgaris. It possesses anti-inflammatory properties that could replace long-term use of corticosteroids with associated side effects.

Dermatology Immunology

Suwarsa O et al (2023).; J Exp Pharmacol.
DOI:: 10.2147/JEP.S427615
PubMed:: 37842316

12.

Identification of P450 Candidates Associated with the Biosynthesis of Physalin-Class Compounds in Physalis angulata.

Hua C et al (2023).; Int J Mol Sci.
DOI:: 10.3390/ijms241814077
PubMed:: 37762378

13.

Inhibition Effect of Physalis angulata Leaf Extract on Viability, Collagen Type I, and Tissue Inhibitor of Metalloproteinase 1 (TIMP-1) but Not Plasminogen Activator Inhibitor-1 (PAI-1) of Keloid Fibroblast Culture.

Widiatmoko A et al (2023).; Clin Cosmet Investig Dermatol.
DOI:: 10.2147/CCID.S425036
PubMed:: 37667736

14.

Development of Chloroplast Microsatellite Markers and Evaluation of Genetic Diversity and Population Structure of Cutleaf Groundcherry (Physalis angulata L.) in China.

Feng S et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12091755
PubMed:: 37176816

15.

Withanolides from Physalin angulata and their inhibitory effects on nitric oxide production.

Tan YH et al (2023).; Chem Biodivers.
DOI:: 10.1002/cbdv.202300195
PubMed:: 36932465

16.

Complete Plastome of Physalis angulata var. villosa, Gene Organization, Comparative Genomics and Phylogenetic Relationships among Solanaceae.

Genetics

Zhan X et al (2022).; Genes (Basel).
DOI:: 10.3390/genes13122291
PubMed:: 36553558

17.

RNAi of Sterol Δ24-Isomerase Implicated Its Involvement in Physalin Biosynthesis in Physalis angulata L.

Genetics

Yang J et al (2022).; Front Plant Sci.
DOI:: 10.3389/fpls.2022.850711
PubMed:: 35310660

18.

Chemical Composition Analysis, Cytotoxic, Antimicrobial and Antioxidant Activities of Physalis angulata L.: A Comparative Study of Leaves and Fruit.

Antimicrobial

Ramakrishna Pillai J et al (2022).; Molecules.
DOI:: 10.3390/molecules27051480
PubMed:: 35268579

19.

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production.

Yang J, Li C and Zhang Y (2021).; Biomolecules.
DOI:: 10.3390/biom11111710
PubMed:: 34827708

20.

Traditionally used edible Solanaceae plants of Mizoram, India have high antioxidant and antimicrobial potential for effective phytopharmaceutical and nutraceutical formulations.

Antimicrobial Immunology

Ralte L, Bhardwaj U and Singh YT (2021).; Heliyon.
DOI:: 10.1016/j.heliyon.2021.e07907
PubMed:: 34522805

21.

Withanolides from Physalis angulata L.

Okmanov RY et al (2021).; Acta Crystallogr E Crystallogr Commun.
DOI:: 10.1107/S205698902100709X
PubMed:: 34422305

22.

Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo.

Arruda JCC et al (2021).; Biomed Pharmacother.
DOI:: 10.1016/j.biopha.2021.112006
PubMed:: 34392085

23.

Physalin B inhibits cell proliferation and induces apoptosis in undifferentiated human gastric cancer HGC-27 cells.

Cancer

Fang C et al (2022).; Asia Pac J Clin Oncol.
DOI:: 10.1111/ajco.13593
PubMed:: 34161670

24.

Species diversity, novel interactions and absence of well-supported host-guided phylogenetic groupings of Neotropical Alternaria isolates causing foliar lesions in Solanaceae.

Genetics

Peixoto CC et al (2021).; J Appl Microbiol.
DOI:: 10.1111/jam.15115
PubMed:: 33891782

25.

Physalis angulata reduces the progression of chronic experimental periodontitis by immunomodulatory mechanisms.

Immunology

Vieceli PS et al (2021).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2021.113986
PubMed:: 33675915

26.

A new squalene derivative from Physalis angulata L. (Solanaceae).

Odusina BO and Onocha PA (2022).; Nat Prod Res.
DOI:: 10.1080/14786419.2020.1844691
PubMed:: 33222550

27.

Bioactive compounds from Physalis angulata and their anti-inflammatory and cytotoxic activities.

Immunology

Tuan Anh HL et al (2021).; J Asian Nat Prod Res.
DOI:: 10.1080/10286020.2020.1825390
PubMed:: 33030034

28.

Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways.

Immunology Pain

do Espírito Santo RF et al (2021).; Nat Prod Res.
DOI:: 10.1080/14786419.2019.1705812
PubMed:: 31872780

29.

A new 22,26-seco physalin steroid from Physalis angulata.

Boonsombat J et al (2020).; Nat Prod Res.
DOI:: 10.1080/14786419.2018.1550766
PubMed:: 30616378

30.

Cytotoxic withanolides from Physalis angulata.

Gao C et al (2018).; Nat Prod Res.
DOI:: 10.1080/14786419.2017.1338281
PubMed:: 28617049

31.

A new phenol glycoside from Physalis angulata.

Phytochemistry

Sun CP et al (2017).; Nat Prod Res.
DOI:: 10.1080/14786419.2016.1269102
PubMed:: 28033720

32.

Unprecedent aminophysalin from Physalis angulata.

Men RZ et al (2014).; Steroids.
DOI:: 10.1016/j.steroids.2014.06.016
PubMed:: 24973634