Pimpinella anisum

Common Names: anise burnet saxifrage

Ethnobotanical Studies

Clinical Trials

The effect of Pimpinella Anisum herbal tea on human milk volume and weight gain in the preterm infant: a randomized controlled clinical trial.

Khalili S et al (2023).
BMC Complement Med Ther.
PubMed:
36681821

Studies

Effectiveness of Green Cupric Oxide Nanoparticles for Walnut Storage Pest Management.

Rodriguez MR et al (2024).
Chem Biodivers.
PubMed:
39235587

Investigating the Endophyte Actinomycetota sp. JW0824 Strain as a Potential Bioinoculant to Enhance the Yield, Nutritive Value, and Chemical Composition of Different Cultivars of Anise (Pimpinella anisum L.) Seeds.

Mahmoud AM et al (2024).
Biology (Basel).
PubMed:
39194491

Therapeutic Effects of Pimpinella anisum Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress.

Summary

Researchers studied the role of inflammation in PCOS development. Inflammation may contribute to symptoms, offering new treatment possibilities. Important for understanding and treating this common condition.

Dadkhah M et al (2024).
Iran J Pharm Res.
PubMed:
39005731

Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial.

Summary

MPR, a traditional Persian herbal formula, improves anxiety and depression in IBS-C patients. Supports potential natural treatment for mental health symptoms in IBS sufferers.

Azimi M et al (2024).
Explore (NY).
PubMed:
38937193

Impact of silver nanoparticles on secondary metabolite composition and toxicity in anise (Pimpinella anisum L.) callus culture.

Ulusoy E et al (2024).
BMC Plant Biol.
PubMed:
38702604

Chemical composition and biological activities of essential oils of seven Cultivated Apiaceae species.

Önder S et al (2024).
Sci Rep.
PubMed:
38698117

Efficacy of fennel (Foeniculum vulgare) and anise (Pimpinella anisum) essential oils as anaesthesics in common carp (Cyprinus carpio L. 1758).

Metin S et al (2024).
Fish Physiol Biochem.
PubMed:
38630160

Plant extract mediated synthesis of ZnO and CeO(2) nanoparticles for spectrofluorometric assay of omeprazole and domperidone in pharmaceuticals.

Alarfaj NA et al (2024).
Heliyon.
PubMed:
38390119

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria.

Tazi LA et al (2024).
Libyan J Med.
PubMed:
38369815

Nutritional Value and in vitro Antigiardial Activity of Anise (Pimpinella anisum L.) Seeds.

Alrasheid AA et al (2024).
Chem Biodivers.
PubMed:
38334183

Efficacy and safety of aniseed powder for treating gastrointestinal symptoms of COVID-19: a randomized, placebo-controlled trial.

Summary

Aniseed powder may help improve abdominal pain, anorexia, and diarrhea in COVID-19 patients. It has multiple beneficial properties, including inhibiting SARS-CoV-2. Larger trials are needed to confirm these findings.

Mosaffa-Jahromi M et al (2024).
Front Pharmacol.
PubMed:
38292939

Examining the Antioxidant and Superoxide Radical Scavenging Activity of Anise, (Pimpinella anisum L. Seeds), Esculetin, and 4-Methyl-Esculetin Using X-ray Diffraction, Hydrodynamic Voltammetry and DFT Methods.

Rossi M et al (2023).
Pharmaceuticals (Basel).
PubMed:
38256900

Chemoprofiling and antimicrobial activity of medicinal herbs used in the treatment of inflammatory bowel disease.

Summary

This study evaluated the antimicrobial activity of five herbs used to treat inflammatory bowel disease (IBD) in Saudi Arabia. The herbs showed good activity against E. coli and S. aureus, suggesting their potential as natural remedies for IBD.

Alshahrani A, Ali A and Abdelwahab SF (2023).
Cell Mol Biol (Noisy-le-grand).
PubMed:
38158691

Anise (Pimpinella anisum L.) attenuates azoxymethane-induced colorectal cancer by antioxidant, anti-inflammatory, and anti-apoptotic pathways in rats.

Summary

The study investigated the toxic effect and chemoprotective potential of Pimpinella anisum L. seeds (PAS) against colon cancer. Results suggest that PAS at 400 mg/kg can inhibit aberrant crypto foci incidence and decrease oxidative stress, making it a potential additive for colorectal cancer pharmaceuticals.

Almaimani G et al (2023).
Environ Sci Pollut Res Int.
PubMed:
38103135

Unveiling the bioactive potential of Pimpinella anisum L. leaf extracts: Chromatographic profiling, antimicrobial efficiency, and cytotoxicity analysis.

Summary

This study looked at extracts from Pimpinella anisum and found that it has potential antimicrobial properties against oral pathogens. The presence of antioxidants, antimicrobials, and cytotoxicity was determined using chromatographic testing methods. The results suggest that P. anisum could be a novel agent to combat various bacteria and oral pathogens.

Dawoud T and Ameen F (2023).
Biomed Chromatogr.
PubMed:
37674346

Pimpinella anisum L. Essential Oil a Valuable Antibacterial and Antifungal Alternative.

Summary

Anise essential oil contains compounds with antimicrobial properties. It has high activity against both bacteria and fungi, making it a potential natural remedy.

Dumitrescu E et al (2023).
Plants (Basel).
PubMed:
37446993

The synergistic effects of four medicinal plant seeds and chelated minerals on the growth, immunity, and antioxidant capacity of rainbow trout (Oncorhynchus mykiss).

Rashidian G et al (2023).
Fish Shellfish Immunol.
PubMed:
37419436

Protective effectiveness of anise against testicular ischemia and reperfusion injury: An experimental study in rats.

Summary

This study investigated the effects of Anise in treating testicular torsion. Anise was found to have protective effects against ischemia and reperfusion injury in rat testicles.

Yildizhan E et al (2023).
Pol J Vet Sci.
PubMed:
37389431

Water deficit stress changes in physiological, biochemical and antioxidant characteristics of anise (Pimpinella anisum L.).

Mehravi S et al (2023).
Plant Physiol Biochem.
PubMed:
37379658

Chemical profiling and quantitative analysis on the aqueous extract of Pimpinella anisum fruit by liquid chromatography-tandem mass spectrometry.

Yang J et al (2023).
Biomed Chromatogr.
PubMed:
37186388

Exploring the quantitative genetics of traits associated with drought tolerance and yield in Pimpinella anisum L. under different water regimes.

Mehravi S et al (2023).
Planta.
PubMed:
37093410

Safety and efficacy of feed additives obtained from the fruit of Pimpinella anisum L.: anise oil for use in poultry and horses and anise tincture for use in poultry, dogs, cats and horses (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).
EFSA J.
PubMed:
37089173

Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Pimpinella anisum L. (anise tincture) for use in all animal species (FEFANA asbl).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).
EFSA J.
PubMed:
37077302

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain.

Summary

This study investigated the antioxidant and anti-amnesic activities of L. plant. Aqueous extract of dried seeds was fractionated and the active fraction (P.aAF) was analyzed. Behavioral and biochemical studies on mice showed significant results, including an increase in inflexion ratio and reduction in MDA and AChE levels, as well as promotion of CAT, SOD, and GSH levels in the brain. The LD for P.aAF was calculated as 95 mg/Kg/p.o. The findings suggest that the plant's oxadiazole compounds contribute to its beneficial effects.

Mushtaq A et al (2023).
Molecules.
PubMed:
36903462

Essential Oils from Apiaceae, Asteraceae, Cupressaceae and Lamiaceae Families Grown in Serbia: Comparative Chemical Profiling with In Vitro Antioxidant Activity.

Gladikostić N et al (2023).
Plants (Basel).
PubMed:
36840093

Chemical composition and insecticidal activity of essential oils from cultivated and native aromatic plants of Argentina against Carpophilus dimidiatus (Fabricius) (Nitidulidae) and Oryzaephilus mercator (L.) (Silvanidae).

Denett GO et al (2023).
Nat Prod Res.
PubMed:
36622895

Biosynthesis of dillapiole/apiole in dill (Anethum graveolens): characterization of regioselective phenylpropene O-methyltransferase.

Koeduka T et al (2023).
Plant J.
PubMed:
36534115

Gas chromatography/mass spectrometry with chemometric methods for the determination of fatty acid profiles in herbal oils.

Tajabadi F et al (2023).
Biomed Chromatogr.
PubMed:
36515666

Effects of Heat Treatments on Various Characteristics of Ready-to-Eat Zucchini Purees Enriched with Anise or Fennel.

Tănase Butnariu LA et al (2022).
Molecules.
PubMed:
36432071

The possible protective role of pimpinella anisum oil versus selenium on aspartame induced changes in rat cerebellar cortex: histological, immunohistochemical and electron microscopic study.

Shrief AI et al (2022).
Ultrastruct Pathol.
PubMed:
36273246

In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2.

Summary

Scientists synthesized zinc oxide nanoparticles using olive and black seed essential oils and investigated 27 bioactive compounds, including ZnO, as potential inhibitors for the SARS-CoV-2 main protease. The study optimized dithymoquinone, δ-hederin, oleuropein, and ZnO, which showed promising results in molecular docking studies and molecular dynamics simulations. Further experimental validation of these compounds is required before considering them for clinical trials as a potent inhibitor of COVID-19.

Hendi AA et al (2022).
Molecules.
PubMed:
35807545

The Effect of Pimpinella Anisum and Origanum Vulgare Extracts Against Streptococcus Sanguinis, Streptococcus Mutans, and Streptococcus Salivarius.

Lavaee F et al (2022).
J Dent (Shiraz).
PubMed:
35783492

A comparison of the performance of conventional and eco-friendly extraction methods in the evaluation of total phenolics, antioxidant activity, and chemical composition of anise.

Nasir A et al (2023).
Int J Environ Health Res.
PubMed:
35723173

Immunostimulatory effects of a polysaccharide from Pimpinella anisum seeds on RAW264.7 and NK-92 cells.

Tabarsa M et al (2022).
Int J Biol Macromol.
PubMed:
35660044

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

Summary

The current self-management recommendations for COVID-19 involve rest, hydration, and the use of NSAIDs for high fever. Many patients may also use herbal medicines.

Review COVID-19
Silveira D et al (2020).
Front Pharmacol.
PubMed:
33071794

Anise.

Review
(2022).
PubMed:
30000835

A review of effective herbal medicines in controlling menopausal symptoms.

Review
Kargozar R, Azizi H and Salari R (2017).
Electron Physician.
PubMed:
29403626

Pimpinella anisum L. ethanolic extract ameliorates the gentamicin- induced nephrotoxicity in rats.

Changizi-Ashtiyani S et al (2017).
Nephrology (Carlton).
PubMed:
27860049