Piper betle

Common Names: betel pepper

Ethnobotanical Studies

Studies

Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans.

Summary

Encapsulating Piper betle oil in nanoparticles improved Alzheimer's symptoms in Caenorhabditis elegans, increasing lifespan and cognitive function while reducing Aβ deposits and neurotoxicity. The DAF-16 pathway was implicated in reducing Aβ toxicity.

NeurosciencePhytochemistry
Velumani M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.135323
PubMed:
39241994

The anti-quorum sensing and biofilm inhibitory potential of Piper betle L. leaf extract and prediction of the roles of the potent phytocompounds.

Sikdar B et al (2024).
Microb Pathog.
DOI:
10.1016/j.micpath.2024.106864
PubMed:
39153575

Synthesis of zero valent copper/iron nanoparticles using Piper betle leaves for the removal of pharmaceutical contaminant atorvastatin.

Shanmuganathan R, Nguyen ND and Al-Ansari MM (2024).
Environ Res.
DOI:
10.1016/j.envres.2024.119334
PubMed:
38838750

Inhibitory and anti-adherent effects of Piper betle L. leaf extract against Acanthamoeba triangularis in co-infection with Staphylococcus aureus and Pseudomonas aeruginosa: A sustainable one-health approach.

Kwankaew P et al (2024).
Vet World.
DOI:
10.14202/vetworld.2024.848-862
PubMed:
38798284

Effects of montmorillonite on the loading and release of Piper betle L. extract applied for wound dressing based on chitosan/polyvinyl alcohol.

Tran TNT, Le NH and Tran QM (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132531
PubMed:
38777011

Effects of Drying Methods on the Antioxidant Properties of Piper betle Leaves.

Summary

Sun-dried leaf powder showed highest antioxidant properties and lower alkaloid content compared to other drying methods. Aqueous extracts contain biologically active compounds with potential applications.

Immunology
Ramarao KDR et al (2024).
Molecules.
DOI:
10.3390/molecules29081762
PubMed:
38675582

Larvicidal potential of plant-based extracts against dengue vector: A short review.

Review
Noorazlan NAA et al (2024).
Med J Malaysia.
PubMed:
38555906

Expression of Concern: Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance.

(2024).
Cancer Sci.
DOI:
10.1111/cas.16155
PubMed:
38538295

Screening of growth inhibitors for epithelial-mesenchymal transition-induced cells by TGF-β from plant-based sources identified the active compound hydroxychavicol from Piper bitle.

Matsuo H et al (2024).
J Nat Med.
DOI:
10.1007/s11418-024-01785-3
PubMed:
38418720

Towards a replacement therapy for stimulant betel quid dependence: A proof of concept study.

Osborne PG et al (2024).
Addict Biol.
DOI:
10.1111/adb.13371
PubMed:
38380696

Exploring gender-based diversity for phenolic and organic acid profiles in the genetic resource of betel vine (Piper betle L.) from India as revealed through high-performance liquid chromatography (HPLC-DAD).

Summary

Twenty genotypes of betel vine were characterized for bio-compounds. Phenolic compounds and organic acids were identified, with male genotypes having higher content. Some genotypes had the highest phenolic content, making the chemical profile useful for gender differentiation and commercial cultivation.

Phytochemistry
Narayanappa MG et al (2024).
3 Biotech.
DOI:
10.1007/s13205-023-03907-2
PubMed:
38351909

Benign-by-design plant extract-mediated preparation of copper oxide nanoparticles for environmentally related applications.

Ahmad A et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.118048
PubMed:
38160981

A novel off-line multi-dimensional high-speed countercurrent chromatography strategy for preparative separation of bioactive neolignan isomers from Piper betle. L.

Phytochemistry
Xiao CY et al (2023).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2023.123965
PubMed:
38109812

Piper betle extract and its application in bovine teat dipping solution inhibit and eliminate biofilms in bovine mastitis-inducing staphylococci.

Sungkatavat P et al (2023).
Vet World.
DOI:
10.14202/vetworld.2023.2135-2142
PubMed:
38023268

A Scoping Review on Medicinal Properties of Piper betle (Sirih) Based on Malay Medical Manuscripts and Scientific Literatures.

Review
Zamri NFI et al (2023).
Malays J Med Sci.
DOI:
10.21315/mjms2023.30.5.3
PubMed:
37928797

Efficacy of copper oxide nanoparticles using Piper longum and Piper betle.

Ambati T et al (2023).
Bioinformation.
DOI:
10.6026/97320630019964
PubMed:
37928485

In Vitro Antibacterial Activity and Mode of Action of Piper betle Extracts against Soft Rot Disease-Causing Bacteria.

Charirak P et al (2023).
Scientifica (Cairo).
DOI:
10.1155/2023/5806841
PubMed:
37766936

Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention.

Summary

The study examines the effects of betel quid consumption on oral health and cancer development. It highlights the dysbiosis caused by betel quid in the oral microbiota and suggests that restoring the microbiota could be a potential therapy for oral cancer.

Review Cancer
Diwan P et al (2023).
Pathogens.
DOI:
10.3390/pathogens12080996
PubMed:
37623956

Development, characterization and application of starch-based film containing polyphenols of piper betle L. waste in chicken meat storage.

Nandi S and Guha P (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137103
PubMed:
37572483

Natural Product BO-1 as an Inner Responsive Molecule Inhibits Antimicrobial-Resistant Staphylococcus aureus via Synergism.

Summary

Chinese medicinal herb L. contains 6 benzoate esters, including one distinct inner responsive molecule (IRM), that can enhance antibiotic activity against multidrug-resistant bacteria by inhibiting efflux activity. This approach shows promise in treating difficult-to-treat infections.

Antimicrobial
Xiao CY et al (2023).
ACS Infect Dis.
DOI:
10.1021/acsinfecdis.3c00066
PubMed:
37417322

Development and characterization of edible films based on flaxseed gum incorporated with Piper betle extract.

Manzoor A, Ahmad S and Yousuf B (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125562
PubMed:
37379948

Antibacterial and Antifungal Fabrication of Natural Lining Leather Using Bio-Synthesized Silver Nanoparticles from Piper Betle L. Leaf Extract.

Summary

Scientists modified pig leather with silver nanoparticles to create antimicrobial leather, which effectively kills bacteria, yeast, and mold without affecting its physical properties, making it suitable for hygienic shoes.

Antimicrobial
Nguyen NT, Vu TH and Bui VH (2023).
Polymers (Basel).
DOI:
10.3390/polym15122634
PubMed:
37376280

Potential natural antimicrobial and antibiofilm properties of Piper betle L. against Staphylococcus pseudintermedius and methicillin-resistant strains.

Antimicrobial
Jantorn P et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116820
PubMed:
37369337

Effects of Piper betle Extracts against Biofilm Formation by Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Dogs.

Leesombun A et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16050741
PubMed:
37242523

Taxonomic and phylogenomic assessment identifies phyto-pathogenicity potential of Stenotrophomonas maltophilia complex.

Singh A et al (2023).
Phytopathology.
DOI:
10.1094/PHYTO-11-22-0434-SC
PubMed:
37202377

Areca Nut.

Review
(2023).
PubMed:
37043595

Utilization of Piper betle L. Extract for Inactivating Foodborne Bacterial Biofilms on Pitted and Smooth Stainless Steel Surfaces.

Ruengvisesh S et al (2023).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2212.12052
PubMed:
36959178

Targeting bone cancer with 4-Allylbenzene-1,2-diol purified from Piper betle L.: an in silico and cytotoxicity scrutiny.

Cancer
Sekar V et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2188952
PubMed:
36905677

Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo.

Alam MB et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12020374
PubMed:
36829933

Why is Nicotiana tabacum leaf extract more effective than Piper betle leaf extract on mortality of Aedes aegypty larvae ?

Destrianto PD et al (2023).
Exp Parasitol.
DOI:
10.1016/j.exppara.2023.108479
PubMed:
36754195

Technique for order preference by similarity to ideal solution (TOPSIS): a MCDM approach for selecting suitable solvent considering biochemical profiles and in vitro antibacterial efficacy of petioles of betel leaf (Piper betle L.).

Nandi S and Guha P (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25485-9
PubMed:
36715795

DNA barcoding and nutritional profiling of underutilized native indigenous plant species of Karnataka, India.

Genetics
Ramasetty BT, Kumar RM and S PH (2023).
Mol Biol Rep.
DOI:
10.1007/s11033-022-08155-w
PubMed:
36692675

Hydroxychavicol as a potential anticancer agent (Review).

Review Cancer
Mohamad NA, Rahman AA and Sheikh Abdul Kadir SH (2022).
Oncol Lett.
DOI:
10.3892/ol.2022.13620
PubMed:
36589673

Anti-inflammatory and antioxidant activities of methanol extract of Piper betle Linn. (Piper betle L.) leaves and stems by inhibiting NF-κB/MAPK/Nrf2 signaling pathways in RAW 264.7 macrophages.

Immunology
Seo J et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2022.113734
PubMed:
36152408

Herbal Products and Their Active Constituents Used Alone and in Combination with Antibiotics against Multidrug-Resistant Bacteria.

Review Antimicrobial
Herman A and Herman AP (2023).
Planta Med.
DOI:
10.1055/a-1890-5559
PubMed:
35995069

Potential of 24-Propylcholestrol as Immunity Inducer against Infection of COVID-19 Virus: In Silico Study Immunomodulatory Drugs.

Summary

Researchers investigated the potential of Betel leaf as an immune-modulator to combat the spread of COVID-19. Betel leaf has antibacterial, antioxidant, and anti-viral properties, making it a possible candidate against SARS-CoV-2. An in silico approach was used to search for compounds that inhibit three crucial proteins of the virus. This study shows promise in finding specific drugs for SARS-CoV-2 infection.

COVID-19Immunology
Kurnia D et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207325666220509184838
PubMed:
35538835

Betelvine (Piper betle L.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes.

Review EthnobotanyPhytochemistry
Biswas P et al (2022).
J Cell Mol Med.
DOI:
10.1111/jcmm.17323
PubMed:
35502487

Therapeutic antigout and antioxidant activity of Piper betle L. in gout-induced broilers.

Vikrama Chakravarthi P et al (2022).
Br Poult Sci.
DOI:
10.1080/00071668.2021.1998365
PubMed:
34859728

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications.

Review Antimicrobial
Nayaka NMDMW et al (2021).
Molecules.
DOI:
10.3390/molecules26082321
PubMed:
33923576

Antibacterial activity of betle leaf (Piper betle l.) extract on inhibiting Staphylococcus aureus in conjunctivitis patient.

Lubis RR, Marlisa and Wahyuni DD (2020).
Am J Clin Exp Immunol.
PubMed:
32211224

Potential of Piper betle extracts on inhibition of oral pathogens.

Phumat P et al (2017).
Drug Discov Ther.
DOI:
10.5582/ddt.2017.01061
PubMed:
29332888

The underlying mechanism of action for various medicinal properties of Piper betle (betel).

Review
Haslan H et al (2015).
Clin Ter.
DOI:
10.7417/CT.2015.1880
PubMed:
26550811