Common Names: Indian long pepper
TL;DR: Piperlongumine (PL) from Piper longum L. fruits improved MAFLD in mice by reducing hepatic gluconeogenesis, lipogenesis, and insulin resistance. PL targets CRTC2, CREB, and Srebp-1c, and antagonizes TP receptor to combat MAFLD induced by HFD. Potential therapeutic strategy.
Study used network pharmacology and omics to identify bioactive compounds in for potential lung cancer therapy. Key targets include CTNNB1, STAT3, HIF1A, HSP90AA1, and ERBB2. Compounds like 6-alpha-diol show promise for treatment.
Study shows green-synthesized ZnO nanostructures degrade pollutants efficiently under UV/visible radiation. Strong potential for environmental remediation. Nanostructures crucial for stability and radiation absorption in various scientific fields.
Piperine, from black and long pepper, shows promise as an anticancer agent for colorectal cancer. Further research needed to understand its molecular mechanisms for potential use in treatment.
Researchers studied chemoresistance in colorectal cancer cells treated with 5-FU, finding various resistance mechanisms. Curcumin and piperine enhance 5-FU sensitivity, showing promise for improving chemotherapy effectiveness.
Formulation of and shows strong antimicrobial activity against oral pathogens, antioxidants, and anti-inflammatory properties. Could be alternative to pharmaceuticals for oral health.
Researchers studied Piperlongumine (PL) derivatives for anticancer activity. Modifications can improve potency, solubility, and bioavailability. Important for developing less toxic and cost-effective anticancer drugs.
Study evaluated the efficacy of L. [Piperaceae] in inhibiting pain and joint destruction in osteoarthritis (OA). Network analysis and molecular docking predicted potential targets and pathways. Results showed that L. [Piperaceae] may be a disease-modifying OA drug candidate.
Piperlongumine (PLN) shows potential as an anticancer agent. It increases ROS levels and DNA damage, inhibits antioxidant enzymes, and induces genotoxicity. It inhibits DDR proteins, leading to cell death in non-tumor cells and reduced cell viability in breast cancer cells.
Scientists studied the herb Piper longum and its main compound, piperine, to understand how it protects against Parkinson's disease. They found that piperine promotes a process called autophagy, which helps degrade harmful proteins in the gut and brain. This research may lead to new treatments for Parkinson's disease.
Kuanxiong Aerosol (KXA) is a mixture of plant oils that can alleviate chest pain symptoms and be used as an additional treatment for prehospital chest pain in the emergency department. You should care because it may help in managing chest pain effectively.
Researchers found that TC + PL extract reduced insulin resistance and liver weight in mice, while Saroglitazar reversed body weight and lipid level changes. These extracts hold promise for preventing obesity-related complications.
Piperlongumine inhibits breast cancer cells, induces apoptosis, and impacts signaling pathways. Its potential in cancer treatment is enhanced by nanotechnology. Future research is needed to understand its chemistry, bioavailability, and toxicity.
A mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) improved blood glucose levels, protected neurons, and improved memory in diabetic rats by reducing oxidative stress, inflammation, and acetylcholinesterase activity.
Researchers studied the ethanolic root extract of Piper longum and identified piperlonguminine as a potential medicine for colorectal cancer. Hub genes SRC, MTOR, EZH2, and MAPK3 were found to be involved in cancer-related pathways that could be targeted for treatment. Piperlonguminine shows promise as a future CRC medicine.
Piplartine, a compound found in Linn, has shown promising antitumor activity against different types of cancer. Further research and development of synthetic derivatives could lead to new and improved anticancer drugs.
This study investigated the anticancer effects of piperlongumine (PL) in human oral cancer cell lines. PL inhibits cell proliferation by inducing apoptosis and autophagy, and combining an autophagy inhibitor with PL treatment can have effective anticancer properties.
Scientists screened 271 phytochemicals from 25 medicinal plants against SARS-CoV-2, targeting nine virus proteins. Cepharadione A showed potential as a lead candidate for developing therapeutic drugs against the virus.
Scientists identified six compounds from Piper longum L., including licarin A and neopomatene, which showed lower toxicity and increased hABCG2 gene expression in Caco-2 cells, potentially aiding renal protection strategies.
Piper longum extract, specifically pipernonaline, shows potential as a new anti-austerity agent for pancreatic cancer treatment. It selectively kills cancer cells in low-nutrient conditions, inhibits cell migration, and targets the Akt/mTOR/autophagy pathway. Promising for future therapy.
Piperine, found in black pepper, improves growth, immunity, disease resistance, and digestion in olive flounder. Optimum supplementation level is 0.5 g/kg.
Researchers investigated the effects of a plant extract on locomotor activity in diabetic rats. The extract improved locomotor function and had antioxidant, anti-inflammatory, and neuroprotective properties, suggesting its potential use in managing diabetes and associated complications.
New compounds with anti-inflammatory properties were found in the roots of L. These compounds showed even better effectiveness than a commonly used anti-inflammatory drug. Additionally, five of these compounds helped to enhance the effects of certain chemotherapeutic drugs against cervical cancer cells, including those resistant to paclitaxel. The combination of one particular compound and paclitaxel successfully promoted cancer cell death through a specific cellular pathway. This research could lead to new treatments for inflammatory diseases and cancer, offering hope for improved patient outcomes.
Researchers have developed a new approach for treating breast cancer using a compound called piperine (PIP). PIP has shown promise as a chemotherapeutic agent, but its toxicity has limited its use. To overcome this, the researchers created a nanotechnology-based treatment by encapsulating PIP within an organic metal-organic framework (MOF) called MIL-100(Fe). They further enhanced the treatment by coating the MOFs with macrophage membranes (MM) to improve immune system evasion. Through laboratory experiments, the researchers confirmed the successful synthesis of MM@PIP@MIL-100(Fe) nanoparticles and demonstrated their increased cytotoxicity against breast cancer cells compared to free PIP. This innovative approach shows potential for effective breast cancer therapy and warrants further exploration and optimization.
Piperlongumine (PL) and piperine (PP) are alkaloids with anti-cancer potential. PL is highly toxic and affects heart development, while PP is safe. Careful strategies are needed when developing PL as a medicine.
A study evaluated a plant, Piper longum, for its ability to protect DNA from the harmful effects of the chemotherapy drug cyclophosphamide. The plant was tested in laboratory experiments using plasmid DNA and human blood cells. It was also tested in rats to confirm its effectiveness in preventing genomic instability, oxidative stress, and organ damage. The plant was found to protect DNA, reduce chromosome damage, prevent DNA damage, and reduce organ damage without causing toxicity. This promising finding could lead to future therapies to reduce side effects of chemotherapy.
The study investigated the use of trihydroxy piperlongumine (THPL) as an antioxidant therapy for aluminium (Al) induced neurotoxicity in zebrafish. Fish exposed to Al showed increased oxidative stress, altered behavior and anxiety comorbid with depression. THPL effectively reduced free radicals and lipid peroxidation caused by Al and improved behavior deficits and anxiety-like behavior in adult fish. THPL also reduced the histological alterations caused by Al exposure. These results indicate that THPL is a promising candidate for treating Al-induced neurodegeneration.
Researchers synthesized four analogs of piperlongumine, an alkaloid found in Piper longum, and tested their anti-platelet aggregation activity. Compound 8 showed the strongest activity, so it was studied further and found to have good binding affinity to stroke-related protein targets. Animal experiments showed that compound 8 could significantly improve brain tissue damage after ischemia, potentially reducing injury from ischemic stroke by inhibiting apoptosis and structural disorders. This suggests piperlongumine analogs could be developed into treatments for ischemic stroke.
The study examined the effects of natural compounds found in Piper longum and Ocimum sanctum on proteins important for SARS-CoV2 entry into host cells. Using computer tools to analyze protein interactions and drug properties, vicenin 2, rosmarinic acid, and orientin were identified as the most effective compounds. These findings suggest the potential for natural compounds to target ACE2 and TMPRSS2 as a strategy for developing future COVID-19 treatments.