Common Names: black pepper
Researchers studied clove and black pepper extracts for their potential as alternative antimicrobial agents due to increasing antibiotic resistance. The extracts have a history of traditional medicinal and culinary use.
Piperine from black pepper shows potential in overcoming drug resistance in cancer cells by targeting key pathways and enhancing drug bioavailability. It can improve the effectiveness of chemotherapy when used with other agents.
PIP, a compound from black pepper, enhances DOX sensitivity in TNBC cells by suppressing PI3K/Akt/mTOR signaling and CSCs. Potential for decreasing chemoresistance. Important for developing new treatment strategies.
Piperine, from black and long pepper, shows promise as an anticancer agent for colorectal cancer. Further research needed to understand its molecular mechanisms for potential use in treatment.
Turmeric and black pepper extracts have a synergistic effect on lung cancer cells, potentially reducing side effects of synthetic drugs. Further research is needed to understand specific mechanisms.
Piperine from black pepper shows potential as an anticancer agent for head and neck cancer. It inhibits cell growth, triggers apoptosis, and reduces inflammation and migration. It may be effective in regulating signaling pathways associated with cancer development.
Scientists tested 37 Piper nigrum compounds for lung cancer treatment. Clarkeinol A showed strongest binding to EGFR, with potential as a specific inhibitor with fewer side effects. Further research is warranted.
Study dissected pepper metabolome using H-NMR, identified 18 metabolites including piperine. Aroma profiling showed abundance of β-caryophyllene. Autoclaving improved pepper aroma and revealed antimicrobial activity against food-borne bacteria.
Researchers synthesized isoxazole derivatives from piperic acid to inhibit STAT3 in breast cancer cells. Studies show potential as effective anticancer agents, offering promise for developing new chemotherapy drugs.
Piperine in black pepper has potent health benefits, including antioxidant, anticancer, and drug-enhancing properties. Incorporating it into diets and medications can improve overall health and enhance treatment effectiveness, particularly in chemotherapy.
The researchers looked at a mix of plants to see if it has antioxidant and antidiabetic effects in a diabetes model. This information may be useful for managing diabetes and exploring natural remedies.
This study investigates a traditional Siddha medicine called Swasa Kudori Tablet for treating asthma. The active compounds are identified and their gene targets are determined. Pinocembrin is found to have strong binding affinity with a target protein. Traditional medicines could be useful in developing new asthma treatments.
This study found that rattan pepper polysaccharide (RPP) can reduce intestinal inflammation and depression-like behavior in mice with inflammatory bowel disease (IBD). RPP improves gut microbiota balance, reduces brain inflammation, and enhances synaptic function. This suggests that RPP may have potential therapeutic effects for IBD and associated depression.
The study shows that multicomponent crystals of piperine-nicotinic acid reduced total cholesterol, triglyceride, and LDL cholesterol levels while increasing HDL cholesterol levels in high-fat diet-fed rats.
Piperine, derived from black pepper, has potential for breast cancer therapy. To improve its effectiveness, we created PPN-encapsulated nanoparticles. The optimized nanoparticles showed increased stability, sustained release, and exceptional cytotoxic effects on breast tumor cells. You should care because this formulation could enhance breast cancer treatment.
Researchers investigated the defense response of pepper roots to Phytophthora capsici infection, a destructive disease in pepper production. Understanding this molecular mechanism can help develop effective strategies for disease management.
Researchers investigated the effect of a plant extract (PNE) on colorectal cancer (CRC) cells. PNE was found to inhibit cell proliferation, induce apoptosis, and inhibit tumor growth by regulating p53 and activating the caspase-3 pathway. PNE could be a potential natural anti-CRC drug candidate.
Various plant extracts were examined for their ability to reduce oxidative stress in brain cells. Elderberry, Queen Garnet plum, and clove showed neuroprotective effects, while elderberry also demonstrated treatment effects. Further research is needed to explore their potential as therapies for oxidative stress-related disorders.
This study used plants to create copper nanoparticles with antioxidant, antibacterial, and cytotoxic properties. The nanoparticles showed potential for scavenging free radicals, inhibiting bacteria, and being toxic to breast cancer cells. Certain components of the plant extract exhibited promising properties as inhibitors of selected proteins.
Piper nigrum essential oil has a pleasant aroma, unique flavor, and many bioactivities. Its potential role against colitis needs further investigation.
Piperine, found in black pepper, improves growth, immunity, disease resistance, and digestion in olive flounder. Optimum supplementation level is 0.5 g/kg.
Scientists have developed reliable, low-cost methods to extract piperine from black pepper. Piperine has shown good cytotoxic activity against aggressive gastric cancer cells, and can enhance the effectiveness of traditional chemotherapeutic drugs. It is a promising molecule for therapy investigations.
Research explores dysbiosis in gut microbiota, genetic, immunological, and environmental factors in ulcerative colitis & Crohn's disease. Medicinal plants/compounds regulate NLRP3 inflammasome & reduce inflammation, offering treatment potential. Clinical validation and effective treatments development necessary.
Review finds that plant-based drugs, particularly herbs, used as add-on therapy for COVID-19 show efficacy and safety, potentially enhancing the immune system for treating the virus. (37 words)
GBA1 variants are the primary genetic risk factor for Parkinson's disease. However, their impact on the disease is not fully known and their occurrence is different across populations.
This review examines the potential benefits of combining taurine and black pepper extract for reducing cardiovascular disease risk factors and improving heart health.
A new dietary supplement, PFPE-CH, made from a mixture of cold-pressed coconut oil and honey, has shown promising results in reducing the risk of tumor formation and minimizing the side effects of chemotherapeutic drugs in breast cancer treatment. The toxicity study revealed no harmful effects at a high dosage, and long-term use did not impact kidney or liver function. In a cancer prevention study, PFPE-CH significantly decreased tumor incidence by up to 71.4% without adverse effects. Furthermore, PFPE-CH enhanced the effectiveness of chemotherapy while reducing its toxicity. These findings suggest that PFPE-CH is a safe and effective option for breast cancer treatment.
The brain is highly affected by the production and accumulation of ROS, which is a common factor in almost all neurodegenerative diseases. Researchers evaluated extracts of black pepper for their neuroprotective potential in human neuroblastoma cells. The extracts exhibited neuroprotection by decreasing oxidative stress and restoring mitochondrial membrane potential in cells, as well as displaying potent anti-glycation and significant anti-Aβ fibrilization activities. The extracts' multitarget neuroprotective mechanism makes them a potential candidate for treating neurodegenerative diseases.
Age-related neurological disorders (ANDs) are multifactorial diseases whose risk increases with age, characterized by oxidative stress, impaired mitochondrial function, and neuronal cell death. Black pepper has many health benefits, including neuroprotective properties, due to its active compound piperine. Recent studies have shown that piperine effectively prevents AND symptoms by modulating cell survival signaling and death. Novel nanodelivery systems are being developed to improve the efficacy and bioavailability of black pepper in experimental models, including clinical trials. Black pepper and its active ingredients have therapeutic potential for ANDs.
Essential oils (EOs) have been used for a long time in traditional medicine and aromatherapy to manage various diseases. Researchers worldwide have studied the neuroprotective and anti-aging potentials of EOs and their possible mechanisms of action. This review summarizes the current findings on EOs tested against neurodegenerative disorders such as Alzheimer's disease and dementia, as well as anxiety, depression, and cognitive dysfunction. EOs have been effective on several pathological targets and improved cognitive performance in animal models and humans. Therefore, EOs may be developed as multi-potent agents against neurological disorders with better efficacy, safety, and cost-effectiveness.