Pistacia lentiscus

Common Names: mastic tree

Ethnobotanical Studies

Clinical Trials

Real-world safety and effectiveness of Pistacia lentiscus (mastic gum) in patients with diabetic gastroparesis: 24-week interim analysis postintervention.

Diabetic patients often have gut nerve problems. Understanding this could lead to better treatment options for gastrointestinal issues in diabetes.

Kant R et al (2024).
Indian J Pharmacol.
DOI:
10.4103/ijp.ijp_555_23
PubMed:
38454582

Studies

Chios gum mastic enhance the proliferation and odontogenic differentiation of human dental pulp stem cells.

Baek HS et al (2024).
Korean J Physiol Pharmacol.
DOI:
10.4196/kjpp.2024.28.5.423
PubMed:
39198223

Scent of relief: Mastic resin scent recovers salivation in chronic dry mouth patients.

Faruque MRJ et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117245
PubMed:
39111079

Seven New Noroleanane Triterpenoids from Mastic and their NO Inhibitory and Cytotoxic Activities.

An XR et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202401585
PubMed:
39078810

Lentisk (Pistacia lentiscus) Oil Nanoemulsions Loaded with Levofloxacin: Phytochemical Profiles and Antibiofilm Activity against Staphylococcus spp.

Phytochemistry
Maurizi L et al (2024).
Pharmaceutics.
DOI:
10.3390/pharmaceutics16070927
PubMed:
39065624

Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications.

Efentakis P et al (2024).
Nutrients.
DOI:
10.3390/nu16132152
PubMed:
38999899

Pistacia lentiscus: Phytochemistry and Antidiabetic Properties.

Summary

Scientists studied the Mediterranean shrub L. (), which is rich in bioactive compounds. It has antibacterial, anti-inflammatory, and antioxidant properties. Of particular interest is its potential in treating type 2 diabetes. Its multifaceted benefits make it a promising candidate for drug development.

Review DiabetesPhytochemistry
Floris S et al (2024).
Nutrients.
DOI:
10.3390/nu16111638
PubMed:
38892571

Teaching Green Chemistry and Engineering through the Epoxidation of Poly-β-myrcene.

Review
Anastasiou DE et al (2024).
Chempluschem.
DOI:
10.1002/cplu.202400167
PubMed:
38837684

Exploring the healing power of Pistacia lentiscus stems: insights into extraction methods, polyphenolic composition, and health-promoting activities.

Beraich A et al (2024).
Int J Environ Health Res.
DOI:
10.1080/09603123.2024.2359070
PubMed:
38801327

Identification of Sex-Associated Genetic Markers in Pistacia lentiscus var. chia for Early Male Detection.

Stavridou E et al (2024).
Genes (Basel).
DOI:
10.3390/genes15050632
PubMed:
38790261

Pistacia lentiscus L. revealed in vitro anti-proliferative activity on MCF-7 breast cancer cells and in vivo anti-mammary cancer effect on C57BL/6 mice through necrosis, anti-inflammatory and antioxidant enhancements.

Summary

Pistacia lentiscus essential oil inhibits breast cancer growth in vitro and in vivo by reducing inflammation and oxidative stress, suggesting potential as a preventive and therapeutic agent.

CancerImmunology
Abidi O et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0301524
PubMed:
38635559

Efficacy of Pistacia lentiscus Plant (Rumi Mastagi) in Comparison to Levosulpiride in Patients with Diabetic Gastroparesis: A Double-Blind Non-Inferior Randomised Control Trial Study.

Summary

Study compared mastic gum and levosulpiride for treating diabetic gastroparesis. Mastic gum showed similar efficacy to levosulpiride in improving symptoms and gastric emptying. Potential new treatment option for DG.

Diabetes
Singh A et al (2024).
Indian J Endocrinol Metab.
DOI:
10.4103/ijem.ijem_84_23
PubMed:
38533281

Antimicrobial Activities of Pistacia lentiscus Essential Oils Nanoencapsulated into Hydroxypropyl-beta-cyclodextrins.

Summary

Essential oils from were encapsulated in HPβCD to improve solubility and stability. The resulting inclusion complexes showed enhanced antibacterial activity against various pathogens. This encapsulation method could lead to more effective natural antimicrobials for food safety.

Antimicrobial
Alabrahim OAA and Azzazy HME (2024).
ACS Omega.
DOI:
10.1021/acsomega.3c07413
PubMed:
38524461

Systematic qualitative analysis of terpenes in mastic (Pistacia lentiscus L.) extract and their fragmentations by UHPLC-Q-Orbitrap-HRMS.

Phytochemistry
Kahaer G et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3342
PubMed:
38500403

The Phenolic Content of Pistacia lentiscus Leaf Extract and Its Antioxidant and Antidiabetic Properties.

Summary

This study examined the polyphenolic profile of leaves and their potential antioxidant and antidiabetic activities. The extract showed high levels of phenolic and flavonoid compounds and demonstrated significant inhibition of pancreatic alpha-amylase activity. This suggests potential benefits for diabetes treatment.

DiabetesImmunologyPhytochemistry
Bouakline H et al (2024).
ScientificWorldJournal.
DOI:
10.1155/2024/1998870
PubMed:
38356989

Synergistic anticancer effect of Pistacia lentiscus essential oils and 5-Fluorouracil co-loaded onto biodegradable nanofibers against melanoma and breast cancer.

Summary

A nanoformulation combining Pistacia lentiscus essential oil and 5-Fluorouracil showed improved stability, targeting abilities, and antioxidant properties, resulting in stronger anticancer effects against breast and melanoma cells compared to free compounds. It may be a promising treatment for localized breast cancer and melanoma.

Cancer
Alabrahim OAA and Azzazy HME (2024).
Discov Nano.
DOI:
10.1186/s11671-024-03962-5
PubMed:
38353827

Metal phytostabilization by mastic shrub (Pistacia lentiscus L.) and its root-associated bacteria in different habitats of Sardinian abandoned mining areas (Italy).

Tamburini E et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-30776-2
PubMed:
37964146

Chemical Characteristics and Biological Activity Screening of Pistacia lentiscus Mastic Gum and Leaves from Turkiye.

Sarikahya NB et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.13056
PubMed:
37870092

Combination of sweet orange, lentisk and lemon eucalyptus essential oils: Optimization of a new complete antimicrobial formulation using a mixture design methodology.

Summary

The study analyzed the essential oils of sweet orange, lentisk, and lemon eucalyptus for their antimicrobial activity. The oils showed promise in inhibiting various microorganisms and could potentially be used as natural food preservatives. However, more research is needed to understand their mechanisms of action and efficacy.

Antimicrobial
Al-Mijalli SH et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e19814
PubMed:
37809691

Expediting Multiple Biological Properties of Limonene and α-Pinene: Main Bioactive Compounds of Pistacia lentiscus L., Essential Oils.

El Omari N et al (2023).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2809229
PubMed:
37796709

Analysis of the Chemical Composition and Evaluation of the Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties of Pistacia lentiscus from Boulemane as a Natural Nutraceutical Preservative.

Summary

The study analyzed the chemical profile of L. leaves and its effects. The leaves contain germacrene D, spathulenol, bicyclogermacrene, and terpinen-4-ol. L. is rich in phenolic compounds, has antioxidant and antimicrobial properties, and has potential as an anticoagulant and antidiabetic agent.

AntimicrobialDiabetesImmunology
Drioiche A et al (2023).
Biomedicines.
DOI:
10.3390/biomedicines11092372
PubMed:
37760813

Pistacia lentiscus essential oil and its pure active components as acaricides to control Dermanyssus gallinae (Acari: Mesostigmata).

Summary

Pistacia lentiscus essential oil and 4-Terpineol show promise as natural alternatives for controlling red poultry mites. Further in vivo trials are needed to confirm safety and effectiveness.

Phytochemistry
Alimi D et al (2023).
Vet Parasitol.
DOI:
10.1016/j.vetpar.2023.110028
PubMed:
37748374

Tackling local ecological homogeneity: Finding intraspecific trait variability in local populations of Mediterranean plants.

Iozia LM and Varone L (2023).
Ecol Evol.
DOI:
10.1002/ece3.10550
PubMed:
37732284

Morphological performance and seasonal pattern of water relations and gas exchange in Pistacia lentiscus plants subjected to salinity and water deficit.

Álvarez S, Acosta-Motos JR and Sánchez-Blanco MJ (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1237332
PubMed:
37731979

Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia.

Summary

An improved formulation from Traditional Persian Medicine (TPM) containing a mixture of plants exhibits antioxidant and anti-cholinesterase properties, potentially making it a useful natural remedy for dementia. Further studies are needed for safety and efficacy.

ImmunologyNeuroscience
Peron G et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115674
PubMed:
37634357

Chios Mastic Gum: Chemical Profile and Pharmacological Properties in Inflammatory Bowel Disease: From the Past to the Future.

Summary

This review examines the effects of Chios mastic gum on inflammatory bowel disease, which has been used in Greek medicine for years. It summarizes its components and potential mechanisms of action, highlighting the need for further research.

Review Immunology
Ottria R et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241512038
PubMed:
37569412

Phytochemical investigation of Pistacia lentiscus L. var. Chia leaves: A byproduct with antimicrobial potential.

Summary

This study investigated the phytochemicals in Pistacia lentiscus L. var. Chia leaves for antimicrobial properties. The extracts and compounds showed selective activity against pathogenic Mucorales. Important for pharmaceutical industry.

AntimicrobialPhytochemistry
Anagnostou C et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105648
PubMed:
37562489

Leaf Morphological and Epidermal Traits Variability along an Environmental Gradients in Ten Natural Populations of Pistacia lentiscus.

Doghbage A et al (2023).
Life (Basel).
DOI:
10.3390/life13071617
PubMed:
37511992

Comparison of Phytochemical Composition, Antibacterial, and Antifungal Activities of Extracts from Three Organs of Pistacia lentiscus from Saudi Arabia.

Summary

This study found that methanolic extracts of stems, roots, and leaves of the lentisk tree have antimicrobial properties and are rich in polyphenols. They can be useful in treating infections and as food preservatives.

AntimicrobialPhytochemistry
Al-Zaben M et al (2023).
Molecules.
DOI:
10.3390/molecules28135156
PubMed:
37446818

Biological properties of extracts from the mixture of honey and berries of Pistacia lentiscus.

Ayad R et al (2023).
Nutr Health.
DOI:
10.1177/02601060231183734
PubMed:
37408433

Antimicrobial Efficiency of Pistacia lentiscus L. Derivates against Oral Biofilm-Associated Diseases-A Narrative Review.

Summary

This review highlights the antimicrobial potential of PlL extracts against oral biofilm-associated diseases. These extracts are more effective than other PlL derivates and could be useful in preventing and reversing intraoral dysbiosis. They can be incorporated into toothpaste, mouthwashes, and local delivery devices for clinical management.

Review Antimicrobial
Milia EP, Sardellitti L and Eick S (2023).
Microorganisms.
DOI:
10.3390/microorganisms11061378
PubMed:
37374880

Pharmacological Properties of Chemically Characterized Extracts from Mastic Tree: In Vitro and In Silico Assays.

Ouahabi S et al (2023).
Life (Basel).
DOI:
10.3390/life13061393
PubMed:
37374175

Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial.

Summary

Chios Mastiha Essential Oil (CMEO) improved blood lipid profile, blood pressure, weight, body fat, and quality of life in individuals with abdominal obesity and metabolic abnormalities. It may have anti-obesity effects through inflammation and antioxidant modulation.

ObesityPhytochemistry
Gioxari A et al (2023).
Pharmacol Res.
DOI:
10.1016/j.phrs.2023.106821
PubMed:
37329633

7β-hydroxycholesterol and 7-ketocholesterol: new oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes.

Immunology
Ghzaiel I et al (2023).
J Steroid Biochem Mol Biol.
DOI:
10.1016/j.jsbmb.2023.106345
PubMed:
37286110

Mastic (Pistacia lentiscus) gum and oral health: a state-of-the-art review of the literature.

Review
Alwadi MAM et al (2023).
J Nat Med.
DOI:
10.1007/s11418-023-01704-y
PubMed:
37147480

Regulation of Energy Metabolism and Anti-Inflammatory Activities of Mastiha Fractions from Pistacia lentiscus L. var. chia.

Immunology
Kalousi FD et al (2023).
Foods.
DOI:
10.3390/foods12071390
PubMed:
37048208

The Effect of Mastic Chios Supplementation in Inflammatory Bowel Disease: A Systematic Literature Review.

Immunology
Mavroudi A et al (2023).
J Med Food.
DOI:
10.1089/jmf.2022.0116
PubMed:
37001176

Co-delivering of oleuropein and lentisk oil in phospholipid vesicles as an effective approach to modulate oxidative stress, cytokine secretion and promote skin regeneration.

Immunology
Sklenarova R et al (2023).
Eur J Pharm Biopharm.
DOI:
10.1016/j.ejpb.2023.02.018
PubMed:
36871904

Comparison of the Allelopathic Potential of Non-Native and Native Species of Mediterranean Ecosystems.

Chaves Lobón N, González Félix M and Alías Gallego JC (2023).
Plants (Basel).
DOI:
10.3390/plants12040972
PubMed:
36840320

Metabolomics-Based Profiling via a Chemometric Approach to Investigate the Antidiabetic Property of Different Parts and Origins of Pistacia lentiscus L.

Diabetes
Sehaki C et al (2023).
Metabolites.
DOI:
10.3390/metabo13020275
PubMed:
36837894

Triterpenoid and Steroid Content of Lipophilic Extracts of Selected Medicinal Plants of the Mediterranean Region.

Gadouche L et al (2023).
Molecules.
DOI:
10.3390/molecules28020697
PubMed:
36677757

Heat and Cold-Stressed Individuals of Pistacia lentiscus (Mastic Tree) Do Modify Their Secreting Profile.

Stefi AL et al (2022).
Plants (Basel).
DOI:
10.3390/plants11233290
PubMed:
36501332

Use of Pistacia lentiscus mastic for sustained-release system of chlorocresol and benzoic acid for in vitro prevention of bacterial colonization of silicon urinary catheter.

(2022).
Lett Appl Microbiol.
DOI:
10.1111/lam.13784
PubMed:
36281521

Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells.

Giordo R et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2130304
PubMed:
36200704

Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases.

Review
Rezig L et al (2022).
Steroids.
DOI:
10.1016/j.steroids.2022.109093
PubMed:
36029811

Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages.

Review
Starace M et al (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.15302
PubMed:
35962760

1,2,3,4,6-Pentagalloyl glucose of Pistacia lentiscus can inhibit the replication and transcription processes and viral pathogenesis of SARS-COV-2.

Summary

Researchers examined the effects of five active compounds from Pistacia sp. on key targets of the SARS-COV-2 virus. 1,2,3,4,6-pentagalloyl glucose (PG) was found to be the most effective, with strong binding affinities to helicase, RdRp, E protein, and 3CLpro, and was able to inhibit the replication and transcription processes, making it a potential antiviral treatment. The study suggests PG could also have anti-inflammatory and antioxidant properties.

COVID-19Genetics
Samandar F et al (2022).
Mol Cell Probes.
DOI:
10.1016/j.mcp.2022.101847
PubMed:
35843391

Efficient Neural Differentiation of Mouse Embryonic Stem Cells by Mastic Gum.

Yazdian-Robati R et al (2023).
Biopreserv Biobank.
DOI:
10.1089/bio.2021.0130
PubMed:
35446125

РАЗРАБОТКА РЕЦЕПТУРЫ И ТЕХНОЛОГИИ ПЕНООБРАЗОВАТЕЛЯ ИЗ МАСТИЧНОЙ (PISTACIA LENTISCUS L.) КАМЕДИ.

Zazadze R et al (2022).
Georgian Med News.
PubMed:
35417884

Pistacia lentiscus L. fruits showed promising antimutagenic and antigenotoxic activity using both in-vitro and in-vivo test systems.

Genetics
Bouguellid G et al (2022).
J Toxicol Environ Health A.
DOI:
10.1080/15287394.2022.2057885
PubMed:
35387576

Overview of Chios Mastic Gum (Pistacia lentiscus) Effects on Human Health.

Review
Soulaidopoulos S et al (2022).
Nutrients.
DOI:
10.3390/nu14030590
PubMed:
35276949

Diverse Triterpenoids from Mastic Produced by Pistacia lentiscus and Their Anti-Inflammatory Activities.

Immunology
Yu YH et al (2022).
Chem Biodivers.
DOI:
10.1002/cbdv.202101012
PubMed:
35170187

Pistacia lentiscus L. Distilled Leaves as a Potential Cosmeceutical Ingredient: Phytochemical Characterization, Transdermal Diffusion, and Anti-Elastase and Anti-Tyrosinase Activities.

Phytochemistry
Elloumi W et al (2022).
Molecules.
DOI:
10.3390/molecules27030855
PubMed:
35164116

Interventions of Unani medicine for maintenance of health with special reference to air quality: an evidence-based review.

Review
Akhlaq S et al (2021).
Rev Environ Health.
DOI:
10.1515/reveh-2021-0116
PubMed:
34883008

Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology.

Review Dermatology
Poljšak N, Kreft S and Kočevar Glavač N (2020).
Phytother Res.
DOI:
10.1002/ptr.6524
PubMed:
31657094

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.

Meta-Analysis
Nirumand MC et al (2018).
Int J Mol Sci.
DOI:
10.3390/ijms19030765
PubMed:
29518971

Effect of Pistacia lentiscus oil on experimental pulmonary fibrosis.

Abidi A et al (2016).
Tunis Med.
PubMed:
28051231