Plantago major

Common Names: broadleaf plantain, great plantain, buckhorn plantain, rippleseed plantain, common plantain

Ethnobotanical Studies

Clinical Trials

Efficacy of Aloe vera/ Plantago Major Gel in Diabetic Foot Ulcer: A Randomized Double-Blind Clinical Trial.

This study investigates the use of Aloe vera/Plantago major gel (Plantavera gel) in healing diabetic foot ulcers, a common and serious complication in diabetic patients. The results could potentially provide a new and effective alternative treatment option.

Najafian Y et al (2019).
Curr Drug Discov Technol.
DOI:
10.2174/1570163815666180115093007
PubMed:
29336265

Studies

The healing effect of nano emulsified Plantago major L extract on oral wounds in a wistar rat model.

Jahanimoghadam F et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04621-z
PubMed:
39227926

Single host plant species may harbour more than one species of Peronospora - a case study on Peronospora infecting Plantago.

Mu M et al (2024).
Persoonia.
DOI:
10.3767/persoonia.2024.52.04
PubMed:
39161633

Total Mineral Content in Raw Materials of Ten Medicinal Plants from Roadside Biotopes of Voronezh Oblast.

Dyakova NA et al (2024).
Dokl Biol Sci.
DOI:
10.1134/S0012496624701126
PubMed:
39128956

Plantago major and Plantago lanceolata Exhibit Antioxidant and Borrelia burgdorferi Inhibiting Activities.

Immunology
Laanet PR et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25137112
PubMed:
39000214

Investigation of biological-rhythm patterns: physiological and biochemical effects in herbaceous plants exposed to low-level chronic radiation - part 1: nonirradiated seeds.

Antonova EV and Pozolotina VN (2024).
Int J Radiat Biol.
DOI:
10.1080/09553002.2024.2348076
PubMed:
38805607

Efficacy and safety of Plantago major seeds in patients with diabetic nephropathy: A randomized open-labeled controlled clinical trial.

Summary

Study aims to investigate the efficacy of Plantago major seed powder in diabetic nephropathy patients. Plantain may help improve albuminuria and GFR decline in these individuals.

Diabetes
Haider R et al (2024).
Explore (NY).
DOI:
10.1016/j.explore.2024.05.003
PubMed:
38797623

Aloe vera jelly dessert supplemented with Lactobacillus curvatus encapsulated in Plantago major mucilage and sodium alginate: Characterization of physicochemical, sensory properties and survivability against low pH, salt, heat, and cold storage.

Phytochemistry
Sekhavatizadeh SS et al (2024).
Food Sci Nutr.
DOI:
10.1002/fsn3.4003
PubMed:
38726455

Separation of crude methanol extract of Plantago major root: identification of phytochemicals and assessment of biological activities.

Rahamouz-Haghighi S and Sharafi A (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2326993
PubMed:
38470177

Phytochemical evaluation and exploration of some biological activities of aqueous and ethanolic extracts of two species of the genus Plantago L.

Summary

TL;DR: Plantago species from Tunisia have antioxidant, anticancer, and antibacterial properties. Roots of P. lagopus contain high levels of polyphenols. P. lagopus extracts inhibit cancer cell proliferation and have antibacterial activity against E. coli and K. pneumoniae.

Phytochemistry
Bouali A et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0298518
PubMed:
38421979

Ethnobotany and phytochemistry of plants used to treat musculoskeletal disorders among Skaw Karen, Thailand.

Summary

Karen farmers use medicinal plants to treat musculoskeletal system disorders (MSD), which are common among farmers. Understanding the efficacy of these plants could potentially benefit the health and well-being of farmers worldwide.

EthnobotanyPhytochemistry
Kantasrila R et al (2024).
Pharm Biol.
DOI:
10.1080/13880209.2023.2292261
PubMed:
38131672

Antioxidant, Anti-Inflammatory Effects and Ability to Stimulate Wound Healing of a Common-Plantain Extract in Alginate Gel Formulations.

Immunology
Bâldea I et al (2023).
Gels.
DOI:
10.3390/gels9110901
PubMed:
37998991

In vitro anti-inflammatory activity of Plantago major L. and Piper aduncum L. on phospholipase A2 from the venom of snake Lachesis muta muta.

Immunology
Yarleque-Chocas M et al (2023).
Rev Peru Med Exp Salud Publica.
DOI:
10.17843/rpmesp.2023.403.12191
PubMed:
37991036

Immunosuppressive effect of Plantago major on the innate immunity of Galleria mellonella.

Kaya S et al (2023).
PeerJ.
DOI:
10.7717/peerj.15982
PubMed:
37753175

Antimicrobial and Other Biomedical Properties of Extracts from Plantago major, Plantaginaceae.

Summary

Scientists have studied the medicinal properties of a particular herb called [herb name]. The review highlights its antimicrobial, antiviral, antifungal, anti-inflammatory effects, and wound-healing properties. These findings suggest that [herb name] has potential as a valuable natural medicine.

Review Antimicrobial
Zhakipbekov K et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16081092
PubMed:
37631007

Multiannual Assessment of Quality of Plantago major L. Seed Progeny from Kyshtym Radiation Accident Area: Weather-Dependent Effects.

Shimalina NS, Antonova EV and Pozolotina VN (2023).
Plants (Basel).
DOI:
10.3390/plants12132528
PubMed:
37447088

Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21(st) century: A systematic review.

Summary

DFU is a common and serious problem for diabetics. Treating it is difficult, particularly for people with weak immune systems.

Diabetes
Narzary I et al (2023).
World J Clin Cases.
DOI:
10.12998/wjcc.v11.i17.4035
PubMed:
37388781

Update on the treatment of chemotherapy and radiotherapy-induced buccal mucositis: a systematic review.

Summary

Chemotherapy and radiotherapy often lead to oral mucositis (OM), causing inflammation of the mouth lining. This condition can have serious repercussions, including difficulty eating and speaking, as well as increased susceptibility to infections. OM is a common problem among cancer patients, and finding effective treatments is crucial to improve their quality of life during treatment.

Cancer
Wen S et al (2023).
Acta Odontol Latinoam.
DOI:
10.54589/aol.36/1/3
PubMed:
37314054

In vitro effects of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in normal and malignant human skin cells.

Gjörloff Wingren A et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e16480
PubMed:
37292297

Genome assembly of the pioneer species Plantago major L. (Plantaginaceae) provides insight into its global distribution and adaptation to metal-contaminated soil.

Genetics
Lyu S et al (2023).
DNA Res.
DOI:
10.1093/dnares/dsad013
PubMed:
37228100

Effectiveness of natural-based products for radiation-induced oral mucositis therapy: A systematic review.

Review
Pranadwista ZF and Nur'aeny N (2023).
Cancer Treat Res Commun.
DOI:
10.1016/j.ctarc.2023.100720
PubMed:
37209466

Role of Medicinal Herbs in Periodontal Therapy: A Systematic Review.

Review
Pasupuleti MK et al (2023).
J Int Soc Prev Community Dent.
DOI:
10.4103/jispcd.JISPCD_210_22
PubMed:
37153928

Electrospun Nanofibers Loaded with Plantago major L. Extract for Potential Use in Cutaneous Wound Healing.

Anaya-Mancipe JM et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15041047
PubMed:
37111535

Keeping Healthy in Your Skin-Plants and Fungi Used by Indigenous Himalayan Communities to Treat Dermatological Ailments.

Dermatology
Haq SM et al (2023).
Plants (Basel).
DOI:
10.3390/plants12071575
PubMed:
37050200

Pro-Apoptotic and Anti-Cancer Activity of the Vernonanthura Nudiflora Hydroethanolic Extract.

Cancer
Nadir A et al (2023).
Cancers (Basel).
DOI:
10.3390/cancers15051627
PubMed:
36900417

Antibacterial activity of ethanolic extracts of Plantago major leaves against Pseudomonas aeruginosa from burn infections.

Turki Monawer A and Mohammed Abdulkahar Mammani I (2023).
J Infect Dev Ctries.
DOI:
10.3855/jidc.17576
PubMed:
36897894

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review.

Review
Ouchi JD, Pereira RMS and Okuyama CE (2023).
Adv Skin Wound Care.
DOI:
10.1097/01.ASW.0000911996.22146.51
PubMed:
36812084

Topical Intervention of Natural Products Applied in Patients with Pressure Injuries: A Scoping Review.

Ouchi JD, Pereira RMS and Okuyama CE (2023).
Adv Skin Wound Care.
DOI:
10.1097/01.ASW.0000911996.22146.51
PubMed:
36806281

In vivo anti-inflammatory activities of Plantago major extract and fractions and analysis of their phytochemical components using a high-resolution mass spectrometry.

ImmunologyPhytochemistry
Triastuti A et al (2022).
Res Pharm Sci.
DOI:
10.4103/1735-5362.359433
PubMed:
36704431

Stress memory in two generations of Plantago major from radioactive and chemical contaminated areas after the cessation of exposure.

Shimalina NS, Pozolotina VN and Orekhova NA (2022).
Int J Radiat Biol.
DOI:
10.1080/09553002.2023.2146232
PubMed:
36353750

Natural Deep Eutectic Extracts of Propolis, Sideritis scardica, and Plantago major Reveal Potential Antiageing Activity during Yeast Chronological Lifespan.

Vasileva B et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/8368717
PubMed:
36082083

Traditional Uses of Medicinal Plants in South-Western Part of Lithuania.

Karpavičienė B et al (2022).
Plants (Basel).
DOI:
10.3390/plants11162093
PubMed:
36015397

A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy.

Review Antimicrobial
Saifulazmi NF et al (2022).
Life (Basel).
DOI:
10.3390/life12081287
PubMed:
36013466

Therapeutic Efficacy of Great Plantain (Plantago major L.) in the Treatment of Second-Degree Burn Wounds: A Case-Control Study.

Keshavarzi A et al (2022).
Int J Clin Pract.
DOI:
10.1155/2022/4923277
PubMed:
35966146

Evaluation of anti-inflammatory effects of leaf and seed extracts of Plantago major on acetic acid-induced ulcerative colitis in rats.

Immunology
Farid A et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115595
PubMed:
35934192

Medicinal Plants Used Traditionally for Skin Related Problems in the South Balkan and East Mediterranean Region-A Review.

Review
Tsioutsiou EE et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.936047
PubMed:
35865952

Green pharmacy at the tips of your toes: medicinal plants used by Setos and Russians of Pechorsky District, Pskov Oblast (NW Russia).

Belichenko O et al (2022).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-022-00540-w
PubMed:
35715815

In vitro elicitation and detection of apigenin, catalpol and gallic acid in hairy root culture of Plantago major L. and assessment of cytotoxicity and anti-bacterial activity of its methanolic extract.

Rahamouz-Haghighi S, Bagheri K and Sharafi A (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2068543
PubMed:
35503010

The Effect of Plantago major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial.

Diabetes
Ghanadian M et al (2022).
Int J Low Extrem Wounds.
DOI:
10.1177/15347346211070723
PubMed:
35044254

The Effect of Plantago major on Wound Healing in Preclinical Studies: A Systematic Review.

Cardoso FCI et al (2021).
Wound Manag Prev.
PubMed:
33448940

Using Plantago major and Plantago lanceolata in environmental pollution research in an urban area of Southern Poland.

Skrynetska I et al (2019).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-019-05535-x
PubMed:
31201696

Plantago major protects against cisplatin-induced renal dysfunction and tissue damage in rats.

Parhizgar S et al (2018).
Saudi J Kidney Dis Transpl.
DOI:
10.4103/1319-2442.243960
PubMed:
30381501

Plantago major in Traditional Persian Medicine and modern phytotherapy: a narrative review.

Review
Najafian Y et al (2018).
Electron Physician.
DOI:
10.19082/6390
PubMed:
29629064

Renoprotective Effect of Plantago Major Against Nephrotoxicity and Oxidative Stress Induced by Cisplatin.

Parhizgar S et al (2016).
Iran J Kidney Dis.
PubMed:
27514764

The Effects of Plantago major on the Activation of the Neutrophil Respiratory Burst.

Reina E et al (2013).
J Tradit Complement Med.
DOI:
10.4103/2225-4110.119706
PubMed:
24716188