Platycodon grandiflorus

Common Names: balloon-flower, Chinese-bellflower

Ethnobotanical Studies

Studies

Efficient enrichment and characterization of triterpenoid saponins from Platycodon grandiflorus roots.

Summary

Study optimized extraction and purification of triterpenoid saponins from Platycodon grandiflorum roots for pharmaceutical potential. Results show increased content and variations in compounds, supporting future drug development.

Phytochemistry
Li W et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.465332
PubMed:
39241405

Effects of soil microplastic heterogeneity on plant growth vary with species and microplastic types.

Zhang XM et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.175940
PubMed:
39218083

Genome-Wide Identification of the CYP716 Gene Family in Platycodon grandiflorus (Jacq.) A. DC. and Its Role in the Regulation of Triterpenoid Saponin Biosynthesis.

GeneticsPhytochemistry
Zhang W et al (2024).
Plants (Basel).
DOI:
10.3390/plants13141946
PubMed:
39065473

Genome-wide identification of bZIP transcription factors and their expression analysis in Platycodon grandiflorus under abiotic stress.

Genetics
Wang Z et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1403220
PubMed:
38863542

Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in drought stress of Platycodon grandiflorus.

Genetics
Chen B et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1363251
PubMed:
38742211

Cloning, Expression Characteristics of Farnesyl Pyrophosphate Synthase Gene from Platycodon grandiflorus and Functional Identification in Triterpenoid Synthesis.

Genetics
Liu M et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c09293
PubMed:
38738769

RNA sequencing analysis reveals PgbHLH28 as the key regulator in response to methyl jasmonate-induced saponin accumulation in Platycodon grandiflorus.

GeneticsPhytochemistry
Zhang W et al (2024).
Hortic Res.
DOI:
10.1093/hr/uhae058
PubMed:
38716227

Genome-wide analysis of bZIP transcription factors and their expression patterns in response to methyl jasmonate and low-temperature stresses in Platycodon grandiflorus.

Genetics
Fan J et al (2024).
PeerJ.
DOI:
10.7717/peerj.17371
PubMed:
38708338

Population identification and genetic diversity analysis of Fritillaria ussuriensis (Fritillaria) based on chloroplast genes atpF and petB.

Genetics
Wang X et al (2024).
J Appl Genet.
DOI:
10.1007/s13353-024-00874-z
PubMed:
38684618

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.

Wu Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1162883
PubMed:
38549665

Determination of higenamine in common natural spices by ultrahigh-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry
Du J et al (2024).
Drug Test Anal.
DOI:
10.1002/dta.3672
PubMed:
38440922

An outlook on the versatility of plant saponins: A review.

Summary

Saponin-rich plants are eco-friendly alternatives to synthetic surfactants and medications. Studies show high potential for sustainable, ethical, and economical use in commercial products, benefiting human health and the environment.

Review Phytochemistry
Jolly A, Hour Y and Lee YC (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105858
PubMed:
38365071

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

Liu M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117701
PubMed:
38185258

Preparation methods, structural characteristics, and biological activity of polysaccharides from Platycodon grandiflorus.

Review
Ma JQ et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.129106
PubMed:
38161010

Genome-wide identification and expression profiling of the WRKY gene family reveals abiotic stress response mechanisms in Platycodon grandiflorus.

Genetics
Yu H et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128617
PubMed:
38070802

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Shahrajabian MH and Sun W (2023).
Curr HIV Res.
DOI:
10.2174/011570162X271199231128092621
PubMed:
38047360

Investigation of the response of Platycodongrandiflorus (Jacq.) A. DC to salt stress using combined transcriptomics and metabolomics.

Genetics
Zhang M et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04536-w
PubMed:
38001405

Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus.

Yu H et al (2023).
Planta.
DOI:
10.1007/s00425-023-04273-2
PubMed:
37943378

Heterologous Expression of Platycodon grandiflorus PgF3'5'H Modifies Flower Color Pigmentation in Tobacco.

Ma L et al (2023).
Genes (Basel).
DOI:
10.3390/genes14101920
PubMed:
37895269

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid.

Dong Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117110
PubMed:
37673198

Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota.

Summary

Researchers found that polysaccharides from Platycodon grandiflorus root reduced weight gain in mice, altered expression of lipid metabolism genes, and changed gut microbiota, suggesting potential as an anti-obesity treatment.

GastroenterologyObesity
Ke W et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115318
PubMed:
37572640

Histone Deacetylase Inhibitor, Sodium Butyrate-Induced Metabolic Modulation in Platycodon grandiflorus Roots Enhances Anti-Melanogenic Properties.

Ahn MA, Lee J and Hyun TK (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241411804
PubMed:
37511563

Comparative analysis of the molecular response characteristics in Platycodon grandiflorus irradiated with heavy ion beams and X-rays.

Liu X et al (2023).
Life Sci Space Res (Amst).
DOI:
10.1016/j.lssr.2023.07.001
PubMed:
37481313

Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways.

Liu M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116745
PubMed:
37336335

Protective effect of Platycodon grandiflorus polysaccharide on apoptosis and mitochondrial damage induced by pseudorabies virus in PK-15 cells.

Xing Y et al (2023).
Cell Biochem Biophys.
DOI:
10.1007/s12013-023-01141-4
PubMed:
37310618

Physiological and sucrose metabolic responses to waterlogging stress in balloon flower (Platycodon grandiflorus (Jacq.) A. DC).

Ji HS and Hyun TK (2023).
Physiol Mol Biol Plants.
DOI:
10.1007/s12298-023-01310-y
PubMed:
37181045

Ameliorative Effects of Flavonoids from Platycodon grandiflorus Aerial Parts on Alloxan-Induced Pancreatic Islet Damage in Zebrafish.

Phytochemistry
Nam YH et al (2023).
Nutrients.
DOI:
10.3390/nu15071798
PubMed:
37049638

Aqueous extract of Platycodon grandiflorus attenuates lipopolysaccharide-induced apoptosis and inflammatory cell infiltration in mouse lungs by inhibiting PI3K/Akt signaling.

Immunology
Zhou Y et al (2023).
Chin Med.
DOI:
10.1186/s13020-023-00721-z
PubMed:
37016413

Genome-Wide Identification and Expression Profiling Analysis of the Trihelix Gene Family and response of PgGT1 under Abiotic Stresses in Platycodon grandiflorus.

Genetics
Liu M et al (2023).
Gene.
DOI:
10.1016/j.gene.2023.147398
PubMed:
36990256

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice.

GastroenterologyImmunology
Fan X et al (2023).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2022.10.016
PubMed:
36970196

Effect of Chinese herbal medicine therapy on risks of all-cause mortality, infections, parasites, and circulatory-related mortality in HIV/AIDS patients with neurological diseases.

Chiou JS et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1097862
PubMed:
36937878

An evaluation of the qualitative superiority of the Mongolian medicinal herb hurdan-tsagaan (Platycodi Radix) from five different geographic origins based on anti-inflammatory effects.

Immunology
Si Q et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116331
PubMed:
36931411

The chromosome-level genome assembly of lance asiabell (Codonopsis lanceolata), a medicinal and vegetable plant of the Campanulaceae family.

Genetics
Jang W et al (2023).
Front Genet.
DOI:
10.3389/fgene.2023.1100819
PubMed:
36816041

Enrichment of Wheat Bread with Platycodon grandiflorus Root (PGR) Flour: Rheological Properties and Microstructure of Dough and Physicochemical Characterization of Bread.

Phytochemistry
Liu Y et al (2023).
Foods.
DOI:
10.3390/foods12030580
PubMed:
36766109

PlgMYBR1, an R2R3-MYB transcription factor, plays as a negative regulator of anthocyanin biosynthesis in Platycodon grandiflorus.

Kim E and Hyun TK (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03490-6
PubMed:
36748016

Platycodon grandiflorus root extract activates hepatic PI3K/PIP3/Akt insulin signaling by enriching gut Akkermansia muciniphila in high fat diet fed mice.

Gastroenterology
Luo Z et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154595
PubMed:
36610135

Platycodon grandiflorus Polysaccharides Alleviate Cr(VI)-Induced Apoptosis in DF-1 Cells via ROS-Drp1 Signal Pathway.

Zhang Z et al (2022).
Life (Basel).
DOI:
10.3390/life12122144
PubMed:
36556509

Platycodin D inhibits the proliferation and migration of hypertrophic scar-derived fibroblasts and promotes apoptosis through a caspase-dependent pathway.

Yu Z et al (2023).
Arch Dermatol Res.
DOI:
10.1007/s00403-022-02513-1
PubMed:
36526799

Ligand fishing of monoamine oxidase B inhibitors from Platycodon grandiflorus (Jacq.) A.DC. roots by the enzyme functionalised magnetic nanoparticles.

Yuan H et al (2023).
Phytochem Anal.
DOI:
10.1002/pca.3180
PubMed:
36254558

Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of "the lung and intestine are related".

Gastroenterology
Liu Y et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.927384
PubMed:
36160385

Transcriptome-wide identification of WRKY transcription factors and their expression profiles in response to methyl jasmonate in Platycodon grandiflorus.

Genetics
Li J et al (2022).
Plant Signal Behav.
DOI:
10.1080/15592324.2022.2089473
PubMed:
35730590

Identification and Functional Characterization of FLOWERING LOCUS T in Platycodon grandiflorus.

Kim G et al (2022).
Plants (Basel).
DOI:
10.3390/plants11030325
PubMed:
35161306

Comparative Transcriptomic Analysis on White and Blue Flowers of Platycodon grandiflorus to Elucidate Genes Involved in the Biosynthesis of Anthocyanins.

Genetics
Lv Y et al (2021).
Iran J Biotechnol.
DOI:
10.30498/ijb.2021.239899.2811
PubMed:
34825015

Platycodon grandiflorus polysaccharides inhibit Pseudorabies virus replication via downregulating virus-induced autophagy.

Xing Y et al (2021).
Res Vet Sci.
DOI:
10.1016/j.rvsc.2021.08.004
PubMed:
34391058

The Pharmacological Effects and Health Benefits of Platycodon grandiflorus-A Medicine Food Homology Species.

Review
Ji MY et al (2020).
Foods.
DOI:
10.3390/foods9020142
PubMed:
32023858