Plumbago zeylanica

Common Names: wild leadwort

Ethnobotanical Studies

Studies

Ayurveda Detoxification Process Reduces Plumbagin from the Roots of Plumbago zeylanica L. - A RP-UFLC Analysis.

Ankad GM, Hegde H and Kotturshetti IB (2024).
J Chromatogr Sci.
DOI:
10.1093/chromsci/bmae048
PubMed:
39237121

Plumbagin's Antiproliferative Mechanism in Human Cancer Cells: A Copper-Dependent Cytotoxic Approach.

Summary

Plumbagin from Plumbago zeylanica inhibits tumor growth by targeting copper-dependent apoptosis in pancreatic cancer cells. Plumbagin prevents copper efflux, induces ROS production, and suppresses specific genes, suggesting its potential as a cancer treatment.

Cancer
El Oirdi M et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14606
PubMed:
39147940

Plumbagin ameliorates LPS-induced acute lung injury by regulating PI3K/AKT/mTOR and Keap1-Nrf2/HO-1 signalling pathways.

Liu Z et al (2024).
J Cell Mol Med.
DOI:
10.1111/jcmm.18386
PubMed:
38990057

In-vitro Studies of Extracts of Plumbago Zeylanica in Cancer Cell Lines.

Cancer
Usman FN and Sharma S (2024).
Zhongguo Ying Yong Sheng Li Xue Za Zhi.
DOI:
10.62958/j.cjap.2024.010
PubMed:
38979580

Plumbagin accelerates serum albumin amyloid aggregation kinetics and generates fibril polymorphism by inducing non-native β-sheet structures.

Chauhan C et al (2024).
Biochim Biophys Acta Proteins Proteom.
DOI:
10.1016/j.bbapap.2024.141028
PubMed:
38849109

Development and efficacy assessment of polyherbal phytosomal gel for accelerated wound healing.

Shukla B et al (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2346400
PubMed:
38700423

The complete chloroplast genome of the medicinally important plant Plumbago zeylanica L. (plumbaginaceae) and phylogenetic analysis.

Genetics
Zhou H and Zhang H (2024).
Mitochondrial DNA B Resour.
DOI:
10.1080/23802359.2024.2333574
PubMed:
38586506

Plumbagin Induces Reactive Oxygen Species and Endoplasmic Reticulum Stress-related Cell Apoptosis in Human Oral Squamous Cell Carcinoma.

Chen PH et al (2024).
Anticancer Res.
DOI:
10.21873/anticanres.16912
PubMed:
38423664

TLC and HPLC methods for the determination of plumbagin for the diagnosis of poisoning by Plumbago scandens L.

Teixeira CJR et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.107634
PubMed:
38307130

Purification and structural characterization of two polysaccharides with anti-inflammatory activities from Plumbago zeylanica L.

Summary

This study purified two water-soluble polysaccharides from Plumbago zeylanica L. and found that they have significant anti-inflammatory effects in THP-1 cells. These compounds could be potential anti-inflammatory agents.

Immunology
Zhang X et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129455
PubMed:
38232876

Screening herbal extracts as biostimulant to increase germination, plant growth and secondary metabolite production in wheatgrass.

Yadav A, Singh S and Yadav V (2024).
Sci Rep.
DOI:
10.1038/s41598-023-50513-6
PubMed:
38182633

Plumbago Zeylanica (Chitrak) leaf image dataset: A comprehensive collection for botanical studies, herbal medicine research, and environmental analyses.

Patil K et al (2023).
Data Brief.
DOI:
10.1016/j.dib.2023.109929
PubMed:
38161654

Preliminary data on cytotoxicity and functional group assessment of a herb-mineral combination against colorectal carcinoma cell line.

Gastroenterology
Jayakumar R et al (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2023-0221
PubMed:
38016708

Network pharmacology analysis of Plumbago zeylanica to identify the therapeutic targets and molecular mechanisms involved in ameliorating hemorrhoids.

Nandi A et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2280681
PubMed:
37948311

Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin.

Summary

Researchers studied the effectiveness of plumbagin in inhibiting cell growth, tumor metastasis, and inducing apoptosis in tongue squamous cell carcinoma. Findings may lead to new therapies for this type of cancer with a poor prognosis.

Cancer
Xin Y et al (2023).
Aging (Albany NY).
DOI:
10.18632/aging.205175
PubMed:
37925175

First report of acaricidal efficacy from plumbagin on larvae of Rhipicephalus microplus and Rhipicephalus sanguineus resistant to conventional acaricides.

Gutiérrez-Wong JR, Rosado-Aguilar JA and Rodríguez-Vivas RI (2023).
Exp Parasitol.
DOI:
10.1016/j.exppara.2023.108632
PubMed:
37832775

Medicinal Plants Used in the Management of Sexual Dysfunction, Infertility and Improving Virility in the East African Community: A Systematic Review.

Review
Kyarimpa C et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/6878852
PubMed:
37600549

Plumbagin induces apoptosis, cell cycle arrest, and inhibits protein synthesis in LoVo colon cancer cells: A proteomic analysis.

Summary

Plumbagin, extracted from Plumbago zeylanica L., inhibits growth and induces apoptosis in LoVo colon cancer cells. Mechanisms include cell cycle arrest and disruption of protein synthesis. Potential therapeutic for colon cancer.

CancerGastroenterology
Shu J et al (2023).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14305
PubMed:
37558615

Concept of dementia (Nisy ā n) in Unani system of medicine and scientific validation of an important Unani pharmacopoeial preparation 'Majoon Vaj' for its management: a review.

Summary

This review examines the Unani system's understanding of dementia, focusing on phytochemistry, nootropic, and CNS activities. It suggests potential directions for future research and enhances our understanding of dementia.

Neuroscience
Aleem M and Khan MI (2023).
J Complement Integr Med.
DOI:
10.1515/jcim-2021-0447
PubMed:
37384842

Sustainable production of plumbagin via meta-topolin-mediated high frequency regeneration of genetically true-to-type Plumbago zeylanica L.

Santra I and Ghosh B (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03642-8
PubMed:
37304405

Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells.

CancerImmunology
Liu H et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24076279
PubMed:
37047251

Development and Validation of HPLC Method for Quantification of Plumbagin in Plumbago Zeylanica L. Roots.

Shukla B and Kushwaha P (2023).
Drug Res (Stuttg).
DOI:
10.1055/a-2019-4985
PubMed:
36822215

Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma.

Cancer
Pan ST et al (2023).
J Oncol.
DOI:
10.1155/2023/8306514
PubMed:
36814557

Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.

Cancer
Lin CL et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154655
PubMed:
36689858

Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson's Disease.

Summary

Plumbagin, a molecule extracted from a medicinal herb, has been studied for its potential to treat Parkinson's disease (PD). This study found that plumbagin partially repairs the loss of dopaminergic neurons and improves behavioral impairment in mice with PD. It also inhibits inflammatory pathways and enhances autophagy. These results suggest that plumbagin has promise as a treatment agent for PD, but further studies are needed to confirm its effectiveness.

Neuroscience
Su Y et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/1837278
PubMed:
36589679

Functional genomics-enabled characterization of CYP81B140 and CYP81B141 from Plumbago zeylanica L. substantiates their involvement in plumbagin biosynthesis.

Genetics
Vasav AP et al (2022).
Planta.
DOI:
10.1007/s00425-022-04014-x
PubMed:
36282353

Artificial microRNA mediated silencing of cyclase and aldo-keto reductase genes reveal their involvement in the plumbagin biosynthetic pathway.

Genetics
Vasav AP et al (2023).
J Plant Res.
DOI:
10.1007/s10265-022-01415-7
PubMed:
36227455

Ethnoveterinary Practices and Ethnobotanical Knowledge on Plants Used against Cattle Diseases among Two Communities in South Africa.

Ethnobotany
Chakale MV et al (2022).
Plants (Basel).
DOI:
10.3390/plants11131784
PubMed:
35807736

Comparative hepatoprotective activity of detoxified roots of Plumbago zeylanica L. and Plumbago rosea L. in Wistar rats.

Akhilraj AR et al (2021).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2021.04.002
PubMed:
34366166

Interference of quorum sensing regulated bacterial virulence factors and biofilms by Plumbago zeylanica extract.

Qais FA et al (2021).
Microsc Res Tech.
DOI:
10.1002/jemt.23872
PubMed:
34268833

Molecular cloning and characterization of type III polyketide synthase from Plumbago zeylanica.

Sakamoto S et al (2021).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2020.1754399
PubMed:
32400171

Fungal endophytes of Plumbago zeylanica L. enhances plumbagin content.

Andhale NB, Shahnawaz M and Ade AB (2019).
Bot Stud.
DOI:
10.1186/s40529-019-0270-1
PubMed:
31494810

Methanolic Extract of Plumbago Zeylanica - A Remarkable Antibacterial Agent Against Many Human and Agricultural Pathogens.

Singh MK et al (2017).
J Pharmacopuncture.
DOI:
10.3831/KPI.2017.20.004
PubMed:
28392958

Comparative toxicity profiles of Plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats.

Kumar D et al (2015).
Ayu.
DOI:
10.4103/0974-8520.182750
PubMed:
27313422