Podophyllum peltatum

Common Names: Indian-apple, May apple, mayapple, pomme de mai, wild-mandrake

Ethnobotanical Studies

Studies

Interactions between developmental phenology, carbon movement, and storage constrain demography in the understory clonal herb Podophyllum peltatum L.

Genetics
Watson MA and Vuorisalo T (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1325052
PubMed:
38988638

Polycarbonate-Based Copolymer Micelles as Biodegradable Carriers of Anticancer Podophyllotoxin or Juniper Extracts.

Summary

Researchers discovered efficient production of Podophyllotoxin (PPT) from genus Juniperus for anticancer drugs. Polymer micelles increase PPT solubility and reduce toxicity, showing promising anticancer activity for future nanomedicine applications.

Cancer
Kalinova RG et al (2024).
J Funct Biomater.
DOI:
10.3390/jfb15030053
PubMed:
38535246

Molecular phylogeography and historical demography of a widespread herbaceous species from eastern North America, Podophyllum peltatum.

Wang C et al (2023).
Am J Bot.
DOI:
10.1002/ajb2.16254
PubMed:
37938809

Anticancer Podophyllotoxin Recovery from Juniper Leaves at Atmospheric and High Pressure Using Eco-Friendly Solvents.

Cancer
Ivanova D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12071526
PubMed:
37050153

Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives.

Review
Shen S et al (2022).
Nat Prod Rep.
DOI:
10.1039/d2np00028h
PubMed:
35913409

Podophyllin in Dermatology: Revisiting a Historical Drug.

Singh A, Choudhary R and Ganguly S (2022).
Indian Dermatol Online J.
DOI:
10.4103/idoj.idoj_225_21
PubMed:
35198500

Phylogenomics and diversification drivers of the Eastern Asian - Eastern North American disjunct Podophylloideae.

Genetics
Ye WQ et al (2022).
Mol Phylogenet Evol.
DOI:
10.1016/j.ympev.2022.107427
PubMed:
35131422

Podophyllotoxin Induces ROS-Mediated Apoptosis and Cell Cycle Arrest in Human Colorectal Cancer Cells via p38 MAPK Signaling.

Cancer
Lee SO et al (2021).
Biomol Ther (Seoul).
DOI:
10.4062/biomolther.2021.143
PubMed:
34642263

Potential interactive effects between invasive Lumbricus terrestris earthworms and the invasive plant Alliaria petiolata on a native plant Podophyllum peltatum in northeastern Ohio, USA.

Cope CG et al (2020).
AoB Plants.
DOI:
10.1093/aobpla/plaa073
PubMed:
33604015

Assembly of Plant Enzymes in E. coli for the Production of the Valuable (-)-Podophyllotoxin Precursor (-)-Pluviatolide.

Decembrino D et al (2020).
ACS Synth Biol.
DOI:
10.1021/acssynbio.0c00354
PubMed:
33095000

The Effect of p53-R249S on the Suppression of Hepatocellular Carcinoma Cells Survival Induced by Podophyllum Derivatives.

Cancer
Chen H et al (2020).
Anticancer Agents Med Chem.
DOI:
10.2174/1871520620666200218110047
PubMed:
32067620

Application of medicinal plants in several dermatovenerological entities.

Review
Maleš Ž et al (2019).
Acta Pharm.
DOI:
10.2478/acph-2019-0045
PubMed:
31639095

Podophyllum peltatum and observations on the Creek and Cherokee Indians: William Bartram's preservation of Native American pharmacology.

Ray LE et al (2009).
Yale J Biol Med.
PubMed:
19325943

In vitro propagation of Podophyllum peltatum.

Moraes-Cerdeira RM et al (1998).
Planta Med.
PubMed:
17253216

Evaluation of Podophyllum peltatum accessions for podophyllotoxin production.

Moraes RM et al (2002).
Planta Med.
PubMed:
11988859

High yield of podophyllotoxin from leaves of Podophyllum peltatum by in situ conversion of podophyllotoxin 4- O-beta-D-glucopyranoside.

Canel C et al (2001).
Planta Med.
PubMed:
11270736

Podophyllotoxin.

Review
Canel C et al (2000).
Phytochemistry.
PubMed:
10872202

An investigation of the antiviral activity of Podophyllum peltatum.

Antimicrobial
Bedows E and Hatfield GM (1982).
J Nat Prod.
PubMed:
6298369