Polygala fallax

Ethnobotanical Studies

Studies

Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway.

Shih-Wei C et al (2024).
Arch Physiol Biochem.
DOI:
10.1080/13813455.2024.2392298
PubMed:
39221837

Quality markers of Polygala fallax Hemsl decoction based on qualitative and quantitative analysis combined with network pharmacology and chemometric analysis.

Li Y et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3380
PubMed:
38750654

Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.

Guan G et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118108
PubMed:
38574780

Extract identification and evaluation of the cytotoxic activity of Polygala fallax Hemsl in Heilongjiang ethnic medicine against tumors.

Yang G and Lang Y (2023).
Technol Health Care.
DOI:
10.3233/THC-236050
PubMed:
37066951

Total flavonoids of Polygala fallax Hemsl induce apoptosis of human ectopic endometrial stromal cells through PI3K/AKT/Bcl-2 signaling pathway.

Phytochemistry
Zhong C et al (2023).
Gynecol Obstet Invest.
DOI:
10.1159/000530104
PubMed:
36934719

Effects of light intensity on the growth of Polygala fallax Hemsl. (Polygalaceae).

Liang H et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.985628
PubMed:
36092442

The extract of Polygala fallax Hemsl. slows the progression of diabetic nephropathy by targeting TLR4 anti-inflammation and MMP-2/9-mediated anti-fibrosis in vitro.

Immunology
Wang M et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154251
PubMed:
35717806

Research on anti-hepatocellular carcinoma activity and mechanism of Polygala fallax Hemsl.

Yao Z et al (2020).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113062
PubMed:
32512042

Polygala fallax Hemsl combined with compound Sanqi granules relieves glomerulonephritis by regulating proliferation and apoptosis of glomerular mesangial cells.

Chao S et al (2020).
J Int Med Res.
DOI:
10.1177/0300060519894124
PubMed:
32000547

Inhibitory effect of reinioside C on vascular smooth muscle cells proliferation induced by angiotensin II via inhibiting NADPH oxidase-ROS-ENK1/2-NF-kappaB-AP-1 pathway.

Summary

The study investigated the effect of reinioside C on the proliferation of vascular smooth muscle cells (VSMCs) induced by angiotensin II (Ang II), which plays a role in arteriosclerosis and restenosis. Treatment with reinioside C inhibited the proliferative effect of Ang II in a concentration-dependent manner. The possible mechanism was found to involve attenuation of Ang II-induced NADPH oxidase mRNA expression, generation of ROS, ERK1/2 phosphorylation, activation of NF-kappaB, and mRNA expression of AP-1 and c-myc in VSMCs. The study suggests that reinioside C inhibits the proliferation of VSMCs induced by Ang II by inhibiting the NADPH oxidase-ROS-ERK1/2-NF-kappaB-AP-1 pathway.

COVID-19
Hong D et al (2014).
Pharmazie.
PubMed:
25272943

Inhibitory effect of reinioside C on monocyte-endothelial cell adhesion induced by oxidized low-density lipoprotein via inhibiting NADPH oxidase/ROS/NF-kappaB pathway.

Bai YP et al (2009).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-009-0450-8
PubMed:
19730822

Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C.

Zhang GG et al (2008).
Vascul Pharmacol.
DOI:
10.1016/j.vph.2008.01.004
PubMed:
18295546

[Study on the antihyperlipidemia effective constituent of Polygala fallax Hemsl].

Xu KP et al (2006).
Zhong Yao Cai.
PubMed:
16722311

[Chemical constituents in roots of Polygala fallax and their anti-oxidation activities in vitro].

Lin LL et al (2005).
Zhongguo Zhong Yao Za Zhi.
PubMed:
16110862

[Blood-activating and anti-inflammatory actions of Polygala fallax].

Immunology
Kou J et al (2003).
Zhong Yao Cai.
PubMed:
14528694

Oligosaccharide polyesters from roots of Polygala fallax.

Zhang D et al (1997).
Phytochemistry.
PubMed:
9195762

Nine new triterpene saponins, polygalasaponins XXXIII--XLI from the roots of Polygala fallax Hemsl.

Phytochemistry
Zhang D et al (1996).
Chem Pharm Bull (Tokyo).
PubMed:
8945775