Polygala tenuifolia

Ethnobotanical Studies

Studies

Serum metabolomics combined with gut microbiota reveals the effects of Polygala tenuifolia polysaccharide on the metabolic and microbial profiles in SAMP8 mouse.

Gastroenterology
Li Z et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116442
PubMed:
39197206

Pharmacometabolomics and mass spectrometry imaging approach to reveal the neurochemical mechanisms of Polygala tenuifolia.

Li Q et al (2024).
J Pharm Anal.
DOI:
10.1016/j.jpha.2024.100973
PubMed:
39175609

Saponin components in Polygala tenuifolia as potential candidate drugs for treating dementia.

Summary

The study found that saponin from Polygala Willd can help with dementia. It provides new evidence for using these components in dementia treatment.

Review NeurosciencePhytochemistry
Li S et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1431894
PubMed:
39050746

Polygala tenuifolia willd. Extract alleviates LPS-induced acute lung injury in rats via TLR4/NF-κB pathway and NLRP3 inflammasome suppression.

Immunology
Guo S et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155859
PubMed:
38972239

Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.

Zeng Q et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13060675
PubMed:
38929114

Polygalae Radix: review of metabolites, pharmacological activities and toxicology.

Review
Liu M, Wang X and Gao D (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1420853
PubMed:
38873413

Phytochemical determination and mechanistic investigation of Polygala tenuifolia root (Yuanzhi) extract for bronchitis: UPLC-MS/MS analysis, network pharmacology and in vitro/in vivo evaluation.

Summary

Researchers studied the effectiveness of Polygala tenuifolia in treating bronchitis. Results suggest it may help relieve cough and remove phlegm. Further research needed on its molecular mechanisms.

Phytochemistry
Chen T et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118418
PubMed:
38838926

Magnolia Officinalis Alcohol Extract Alleviates the Intestinal Injury Induced by Polygala Tenuifolia Through Regulating the PI3K/AKT/NF-κB Signaling Pathway and Intestinal Flora.

GastroenterologyImmunology
Liu S et al (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S461152
PubMed:
38799799

Preparation, structural characteristics and pharmacological activity of polysaccharides from Polygala tenuifolia: A review.

Li Y et al (2024).
Carbohydr Res.
DOI:
10.1016/j.carres.2024.109117
PubMed:
38626569

Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice.

Kong H et al (2024).
Behav Brain Res.
DOI:
10.1016/j.bbr.2024.114974
PubMed:
38554850

Combination of tenuigenin-based Polygala tenuifolia willd. root extract and forsythoside a improved Alzheimer's disease.

Summary

Tenuigenin and forsythoside A extracts from specific plants show neuro-protective effects individually. When combined in a 2:1 ratio, they synergistically protect against Alzheimer's disease symptoms in cell models. Shows potential for future treatment development.

Neuroscience
Liang G et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2332945
PubMed:
38529756

Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS/MS combined with multivariate statistical analysis.

Immunology
Luo Y et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27622
PubMed:
38515733

Glycyrrhizae radix et rhizoma processing ameliorates adverse reactions of polygalae radix in zebra fish and rabbit models.

Chen SH et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118020
PubMed:
38458341

The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials.

Summary

TL;DR: Chinese herbal medicine (CHM) shows potential in improving cognitive function for mild cognitive impairment (MCI) patients, supported by moderate evidence. Most studies had some bias concerns, but CHM was generally safe with common gastrointestinal side effects.

Neuroscience
Liu L et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1341074
PubMed:
38425647

Polygalacic acid attenuates cognitive impairment by regulating inflammation through PPARγ/NF-κB signaling pathway.

Summary

Researchers studied how polygalacic acid from Polygala tenuifolia treats Alzheimer's disease. Understanding its mechanism can lead to new treatments for AD.

ImmunologyNeuroscience
Zhao T and Jia J (2024).
CNS Neurosci Ther.
DOI:
10.1111/cns.14581
PubMed:
38421141

Network pharmacology and experimental validation to investigate the mechanism of Nao-Ling-Su capsule in the treatment of ischemia/reperfusion-induced acute kidney injury.

Summary

NLSC, a traditional herbal capsule, may have potential in treating acute kidney injury. Its ingredients have brain-strengthening and kidney-protecting effects, showing promise in clinical use.

Cardiology
Lin Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117958
PubMed:
38395179

Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer's disease: a systematic review and meta-analysis.

Summary

Researchers evaluated the clinical efficacy and safety of a combination of two Chinese herbal formulas, PT and AT, for the treatment of Alzheimer's disease. The combination showed potential in improving cognition and functioning without increasing adverse events, but the quality of evidence is low.

Neuroscience
Zhang Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1268000
PubMed:
38283842

Hydroxysafflor Yellow A and Tenuigenin Exhibit Neuroprotection Effects Against Focal Cerebral Ischemia Via Differential Regulation of JAK2/STAT3 and SOCS3 Signaling Interaction.

Summary

Combining natural compounds in Chinese medicine, hydroxysafflor yellow A (HSYA) and tenuigenin (TEN), shows promise in treating ischemic stroke by improving various aspects of brain function and suppressing cell apoptosis. This combination modulates signaling pathways, leading to synergistic effects against stroke.

CardiologyImmunology
Yu L et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-023-03896-6
PubMed:
38214838

Polysaccharide from Polygala tenuifolia alleviates cognitive decline in Alzheimer's disease mice by alleviating Aβ damage and targeting the ERK pathway.

Summary

Polygala tenuifolia, a key herb in Chinese medicine for treating dementia, contains polysaccharides. Understanding the role and effects of these compounds can help make better decisions for dementia treatment and research in the lab.

Neuroscience
Li Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117564
PubMed:
38081400

Attenuating effect of Polygala tenuifolia Willd. seed oil on progression of MAFLD.

Xin M et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1253715
PubMed:
37869756

Tenuigenin promotes non-rapid eye movement sleep via the GABA(A) receptor and exerts somnogenic effect in a MPTP mouse model of Parkinson's disease.

Neuroscience
Zhang D et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115259
PubMed:
37531785

Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.

Summary

PTAT decoction, a traditional medicine, showed significant antiepileptic and anxiolytic effects in mice through modulation of GABA neurotransmission and reduction of inflammation, suggesting potential as a natural treatment for epilepsy.

ImmunologyNeuroscience
Xie Y et al (2023).
Pak J Pharm Sci.
PubMed:
37530166

Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis.

Neuroscience
Li C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7930
PubMed:
37364988

Tenuigenin activates the IRS1/Akt/mTOR signaling by blocking PTPN1 to inhibit autophagy and improve locomotor recovery in spinal cord injury.

Zang L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116841
PubMed:
37355079

Development of an online UPLC-PDA-ESI-Q-TOF-MS-LOX-FLD system for rapid screening of anti-inflammatory compounds in Polygala tenuifolia Willd.

Immunology
Sun M et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115353
PubMed:
36965376

Elucidating the promising role of traditional Chinese medicine in neuroprotection against oxidative stress encompassing Alzheimer's disease.

Summary

Traditional Chinese Medicine (TCM) has shown potential in managing Alzheimer's disease (AD) by breaking the vicious cycle of oxidative stress and neurodegeneration. The active constituents of various herbs in TCM have a long history in managing oxidative stress and have highlighted therapeutic potential. Chinese herbs provide a multiple-target approach, which can target multiple pathways involved in AD, and untangle the issues in the current therapy regimen of AD. This review suggests that TCM is a promising candidate for breaking the vicious cycle of oxidative stress in AD therapy.

Review ImmunologyNeuroscience
Arora A et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25800-4
PubMed:
36790717

Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation.

Summary

Kaixin San (KXS) is a traditional Chinese medicine used for emotion-thought diseases. Researchers investigated whether it benefits hippocampal neurons and myocardial cells of mice with paradoxical sleep deprivation (PSD) and its mechanism. KXS was found to effectively improve PSD-induced damage to the hippocampus and myocardium, likely due to its anti-inflammatory and antioxidant properties. These findings suggest KXS may be a potential treatment for sleep deprivation-related diseases.

CardiologyNeuroscience
Cao Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116034
PubMed:
36529245

Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia.

Review Neuroscience
Chen Z et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.937333
PubMed:
35924058

Sugar easters and xanthones from the roots of Polygala tenuifolia Willd. and their cytoprotective activity.

Yang BB et al (2022).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105256
PubMed:
35870664

Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer's Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway.

Neuroscience
Huang Q et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.817213
PubMed:
35295332

Nature against depression.

Review Neuroscience
El-Alfy AT, Abourashed EA and Matsumoto RR (2012).
Curr Med Chem.
PubMed:
22414105