Polygonatum sibiricum

Ethnobotanical Studies

Studies

Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review.

Summary

Review explores how polysaccharide from a Chinese herb can help prevent and manage conditions like type 2 diabetes and Alzheimer's by restoring the intestinal barrier. Potential for treating complex diseases and improving clinical outcomes.

Review Gastroenterology
Ren Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1421607
PubMed:
39224782

Polygonatum sibiricum Polysaccharides Alleviate Depressive-like Symptoms in Chronic Restraint Stress-Induced Mice via Microglial Regulation in Prefrontal Cortex.

Summary

PSP, a polysaccharide extracted from natural sources, shows potential as an antidepressant by regulating microglial activity and neuroinflammatory pathways in mice under chronic restraint stress. This study highlights the importance of PSP in treating depression.

Neuroscience
Yuan ZY et al (2024).
Polymers (Basel).
DOI:
10.3390/polym16162358
PubMed:
39204578

Research on the anti-oxidant and anti-aging effects of Polygonatum kingianum saponins in Caenorhabditis elegans.

Summary

Saponins in show anti-aging effects in nematodes through SKN-1 pathway, reducing ROS levels and up-regulating antioxidant genes. Potential clinical interventions against aging.

Phytochemistry
Huang Y et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e35556
PubMed:
39170193

Ball Milling Improves Physicochemical, Functionality, and Emulsification Characteristics of Insoluble Dietary Fiber from Polygonatum sibiricum.

Phytochemistry
Ke J et al (2024).
Foods.
DOI:
10.3390/foods13152323
PubMed:
39123514

Polygonatum sibiricum polysaccharide regulation of gut microbiota: A viable approach to alleviate cognitive impairment.

Summary

Polygonatum sibiricum polysaccharide (PSP) improves gut health, reduces inflammation, and may alleviate cognitive impairment by modulating gut-brain axis communication. Important for understanding and treating neurological diseases.

Review GastroenterologyNeuroscience
Jiang Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134494
PubMed:
39111476

Antitumor activity of Polygonatum sibiricum polysaccharides.

Summary

Scientists studied Polygonatum sibiricum polysaccharide (PSP) for its potential in cancer treatment due to its diverse pharmacological activities. PSP shows promise as an immunomodulatory, antitumor, antioxidant, and anti-aging agent, but further research is needed to understand its complex mechanisms.

Review Cancer
Lai W et al (2024).
Arch Pharm Res.
DOI:
10.1007/s12272-024-01511-3
PubMed:
39060656

Polygonati Rhizoma varieties and origins traceability based on multivariate data fusion combined with an artificial intelligence classification algorithm.

Chen P et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140350
PubMed:
39032291

Surface-Engineered Polygonatum Sibiricum Polysaccharide CaCO(3) Microparticles as Novel Vaccine Adjuvants to Enhance Immune Response.

He J et al (2024).
Mol Pharm.
DOI:
10.1021/acs.molpharmaceut.4c00295
PubMed:
39017595

Structural characterization and hypoglycemic effect of polysaccharides of Polygonatum sibiricum.

Summary

Researchers extracted and analyzed Polygonatum sibiricum polysaccharide (PSP) for its potential benefits in diabetes treatment. PSP inhibits enzymes, improves insulin sensitivity, and repairs tissue damage in diabetic mice. PSP shows promise as a natural therapeutic agent for type II diabetes.

Diabetes
Wang X et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17243
PubMed:
38992877

Multiomics reveals the ameliorating effect and underlying mechanism of aqueous extracts of polygonatum sibiricum rhizome on obesity and liver fat accumulation in high-fat diet-fed mice.

Summary

PSRwe from Polygonatum sibiricum may prevent obesity and non-alcoholic fatty liver disease. Further research needed to assess its potential benefits on fat accumulation and liver health.

Obesity
Ou X et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155843
PubMed:
38971026

Polygonatum sibiricum component liquiritigenin restrains breast cancer cell invasion and migration by inhibiting HSP90 and chaperone-mediated autophagy.

Summary

Liquiritigenin inhibits HSP90-mediated chaperone-mediated autophagy, reducing BC cell growth and invasion. Important for potential breast cancer treatment.

Cancer
Xu S et al (2024).
Korean J Physiol Pharmacol.
DOI:
10.4196/kjpp.2024.28.4.379
PubMed:
38926844

Polygonatum sibiricum polysaccharides protect against knee osteoarthritis by inhibiting the TLR2/NF-κB signaling pathway in vivo and in vitro.

Immunology
Kuang S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133137
PubMed:
38901508

Corrigendum to "Microparticulated Polygonatum sibiricum polysaccharide shows potent vaccine adjuvant effect" [Int. J. Pharm. 652 (2024) 123802].

Shen K et al (2024).
Int J Pharm.
DOI:
10.1016/j.ijpharm.2024.124296
PubMed:
38866627

Identification of the inhibition mechanism of carbonic anhydrase II by fructooligosaccharides.

Mu Y et al (2024).
Front Mol Biosci.
DOI:
10.3389/fmolb.2024.1398603
PubMed:
38863966

Anti-aging mechanism and effect of treatment with raw and wine-steamed Polygonatum sibiricum on D-galactose-induced aging in mice by inhibiting oxidative stress and modulating gut microbiota.

GastroenterologyImmunology
Zhong R et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1335786
PubMed:
38774211

Study on the active components and mechanism of Atractylodis Macrocephalae Rhizoma for invigorating the spleen and tonifying qi based on spectrum-effect relationship and network pharmacology.

Li Y et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5870
PubMed:
38664069

The impact of dietary supplementation of polysaccharide derived from Polygonatum sibiricum on growth, antioxidant capacity, meat quality, digestive physiology, and gut microbiota in broiler chickens.

GastroenterologyImmunology
Yang B et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.103675
PubMed:
38593546

Study on the components changes of polysaccharides and saponins during nine steaming and drying of Polygonatum sibiricum.

Phytochemistry
Zhang Q, Lin X and Su W (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13516
PubMed:
38587108

Polygonatum sibiricum polysaccharide ameliorates skeletal muscle aging via mitochondria-associated membrane-mediated calcium homeostasis regulation.

Chen W et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155567
PubMed:
38579644

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate-protein kinase G signaling in diabetic mice.

Summary

Researchers studied the potential benefits of Polygonatum sibiricum polysaccharide (PSP) in treating diabetic cardiomyopathy (DCM) in mice. Results may lead to new treatments for this common condition in diabetic individuals.

CardiologyDiabetes
Lei S et al (2024).
J Diabetes Investig.
DOI:
10.1111/jdi.14192
PubMed:
38553792

Research progress on medicinal components and pharmacological activities of polygonatum sibiricum.

Review
Liu R et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118024
PubMed:
38484952

Effect of Polygonatum sibiricum saponins on gut microbiota of mice with ulcerative colitis.

Summary

Polygonatum sibiricum saponins (PSS) improved symptoms and pathology in colitis mice induced with dextran sulfate sodium (DSS). PSS restored intestinal microbial balance, reduced pathogenic bacteria, and increased beneficial bacteria, suggesting its potential therapeutic role in ulcerative colitis.

GastroenterologyPhytochemistry
Cao R et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105855
PubMed:
38354822

Review of studies on polysaccharides, lignins and small molecular compounds from three Polygonatum Mill. (Asparagaceae) spp. in crude and processed states.

Review
Zhang Q, Yang Z and Su W (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129511
PubMed:
38242391

A breakthrough in periodontitis treatment: Revealing the pharmacodynamic substances and mechanisms of Kouqiangjie formula.

Wu Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117738
PubMed:
38199336

Antibacterial Activity and Mechanism of Polygonatum sibiricum Extract Against Bacillus cereus and Its Application in Pasteurized Milk.

Fei P et al (2023).
Foodborne Pathog Dis.
DOI:
10.1089/fpd.2023.0110
PubMed:
38079263

Transcriptome analysis of three medicinal plants of the genus Polygonatum: identification of genes involved in polysaccharide and steroidal saponins biosynthesis.

Summary

Study on the synthesis of active components in Polygonati Rhizoma found differentially expressed genes and transcription factors related to polysaccharides and saponins. Provides a transcriptome dataset and lays foundation for improving active component content using molecular methods.

GeneticsPhytochemistry
Lu J et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1293411
PubMed:
38046616

Optimized acid hydrolysis conditions for better characterization the structure of inulin-type fructan from Polygonatum sibiricum.

Zong X et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128030
PubMed:
37981289

Research on the Impact of Deep Eutectic Solvent and Hot-Water Extraction Methods on the Structure of Polygonatum sibiricum Polysaccharides.

Zhang C et al (2023).
Molecules.
DOI:
10.3390/molecules28196981
PubMed:
37836822

A New Method of Extracting Polygonatum sibiricum Polysaccharide with Antioxidant Function: Ultrasound-Assisted Extraction-Deep Eutectic Solvents Method.

Immunology
Sun C et al (2023).
Foods.
DOI:
10.3390/foods12183438
PubMed:
37761147

Insights into the mechanisms of microbiome and metabolome changes mediated by understory interplanting mode in Polygonatum sibiricum.

Wang Y et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1232846
PubMed:
37637191

Effects of Polygonatum sibiricum on Physicochemical Properties, Biological Compounds, and Functionality of Fermented Soymilk.

Phytochemistry
Wan P et al (2023).
Foods.
DOI:
10.3390/foods12142715
PubMed:
37509807

Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model.

Summary

A complex extract of PS and NS improves menopause symptoms in rats without side effects like endometriosis. It increases estrogen receptors and improves blood-lipid metabolism and osteoporosis.

Endocrinology
Park D et al (2023).
Nutrients.
DOI:
10.3390/nu15112443
PubMed:
37299404

Effects of Extraction Methods on the Physicochemical Properties and Biological Activities of Polysaccharides from Polygonatum sibiricum.

Phytochemistry
Jing Y et al (2023).
Foods.
DOI:
10.3390/foods12102088
PubMed:
37238906

Metabolome and transcriptome signatures shed light on the anti-obesity effect of Polygonatum sibiricum.

Summary

Researchers found that older rhizomes of a medicinal plant contain higher levels of phloretin, linoleic acid, and α-linolenic acid, contributing to an anti-obesity effect. Genetic pathways controlling metabolite accumulation were identified, providing insights for future research.

GeneticsObesity
Ou X et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1181861
PubMed:
37143889

Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis.

Wang R et al (2023).
J Microbiol.
DOI:
10.1007/s12275-023-00042-8
PubMed:
37052796

Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum Sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats.

Diabetes
Zhang H et al (2023).
Curr Drug Metab.
DOI:
10.2174/1389200224666230406114012
PubMed:
37038712

Polygonum sibiricum polysaccharides exert the antidepressant-like effects in chronic unpredictable mild stress-induced depressive mice by modulating microbiota-gut-brain axis.

Summary

Researchers studied the effects of Polygonum sibiricum polysaccharides (PSP), a component of a traditional Chinese medicine, on mice with depression caused by chronic mild stress. The study aimed to determine if PSP worked through the microbiota-gut-brain (MGB) axis. Mice treated with fecal microbiota transplantation from PSP-treated mice exhibited improved depressive behaviors and increased levels of neurotransmitters 5-hydroxytryptamine and norepinephrine while reducing pro-inflammatory cytokines and corticosterone. Administration of PSP and fecal microbiota transplantation also regulated signaling pathways, indicating that PSP exerts its antidepressant effects through the MGB axis.

GastroenterologyNeuroscience
Zhang Y et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7813
PubMed:
36996849

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice.

GastroenterologyImmunology
Fan X et al (2023).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2022.10.016
PubMed:
36970196

Effects of saponins isolated from Polygonatum sibiricum on H(2)O(2)-induced oxidative damage in RIN-m5F cells and its protective effect on pancreas.

Phytochemistry
Luo J et al (2023).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2023.113724
PubMed:
36935075

To explore the best freeze-drying technology of Polygonatum sibiricum delar. Ex redoute and to establish the best HPLC method for the determination of main effective components of it from different areas in China.

Xu Y et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14156
PubMed:
36925510

Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide.

Su LL et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116351
PubMed:
36914038

Polygonati Rhizoma Polysaccharide Prolongs Lifespan and Healthspan in Caenorhabditis elegans.

Luan Y et al (2023).
Molecules.
DOI:
10.3390/molecules28052235
PubMed:
36903481

Characterization of the chloroplast genome of medicinal herb Polygonatum cyrtonema and identification of molecular markers by comparative analysis.

Genetics
Xie ZN et al (2023).
Genome.
DOI:
10.1139/gen-2022-0087
PubMed:
36763968

Review on the genus Polygonatum polysaccharides: Extraction, purification, structural characteristics and bioactivities.

Review
Gong H et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2022.12.320
PubMed:
36608864

Polygonatum sibiricum saponin Exerts Beneficial Hypoglycemic Effects in Type 2 Diabetes Mice by Improving Hepatic Insulin Resistance and Glycogen Synthesis-Related Proteins.

DiabetesPhytochemistry
Chen Z et al (2022).
Nutrients.
DOI:
10.3390/nu14245222
PubMed:
36558381

Advances in Polygonatum sibiricum polysaccharides: Extraction, purification, structure, biosynthesis, and bioactivity.

Review
Liu D et al (2022).
Front Nutr.
DOI:
10.3389/fnut.2022.1074671
PubMed:
36545471

Potential therapeutic drug targets and pathways prediction for premature ovarian insufficiency -Based on network pharmacologic method.

Endocrinology
Ju S et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116054
PubMed:
36526095

Integrated miRNA and mRNA omics reveal dioscin suppresses migration and invasion via MEK/ERK and JNK signaling pathways in human endometrial carcinoma in vivo and in vitro.

Genetics
Li XL et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116027
PubMed:
36503030

Polygonatum sibiricum ameliorated cognitive impairment of naturally aging rats through BDNF-TrkB signaling pathway.

Summary

This study found that administration of a traditional Chinese medicine called polygonatum sibiricum (PS) for 5 months effectively improved cognitive function in aging rats. PS improved the Nissl body state in the cortex and hippocampus, as well as synaptic structure and the number of synapses. PS also up-regulated the expression of BDNF-TrkB, which is important for synaptic plasticity. The study suggests that PS has the potential to be developed as a functional food for improving neurological function and anti-aging in the elderly.

Neuroscience
Zhang X et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14510
PubMed:
36373352

Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K/AKT signaling pathway in high-fat diet and streptozotocin-induced diabetic mice.

Diabetes
Wang G et al (2022).
J Food Biochem.
DOI:
10.1111/jfbc.14402
PubMed:
36226981

CO(2)-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides.

Chen J, Xu Y and Tan Z (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134301
PubMed:
36137381

Structural characterization and antioxidant activity of Polygonatum sibiricum polysaccharides.

Wang S et al (2022).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2022.119524
PubMed:
35698327

Determination of polysaccharides composition in Polygonatum sibiricum and Polygonatum odoratum by HPLC-FLD with pre-column derivatization.

Xu S et al (2022).
Heliyon.
DOI:
10.1016/j.heliyon.2022.e09363
PubMed:
35586333

Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage.

Immunology
Shen F et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114164
PubMed:
33932516

Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice.

Cardiology
Ma W et al (2021).
Biomed Res Int.
DOI:
10.1155/2021/6688855
PubMed:
33860051

Bioactive Compounds of Polygonatum sibiricum - Therapeutic Effect and Biological Activity.

Review
Zhao X et al (2022).
Endocr Metab Immune Disord Drug Targets.
DOI:
10.2174/1871530321666210208221158
PubMed:
33563164

Polygonatum sibiricum Polysaccharides Protect against MPP-Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways.

Summary

The study investigated the mechanisms behind the beneficial effects of a Chinese medicine tonic called polysaccharides (PSP) on Parkinson's disease (PD). The researchers found that PSP improved locomotor activity and protected dopaminergic neurons in a mouse model of PD. PSP also reduced oxidative stress and neuronal apoptosis, and activated signaling pathways that led to antiapoptotic and antioxidative effects. The study suggests that PSP could be a promising therapy for PD. PSP was also found to have no chronic toxicity in mice.

Neuroscience
Huang S et al (2021).
Oxid Med Cell Longev.
DOI:
10.1155/2021/8843899
PubMed:
33520086

Protective effect of Polygonatum sibiricum polysaccharide on cyclophosphamide-induced immunosuppression in chickens.

Shu G et al (2021).
Res Vet Sci.
DOI:
10.1016/j.rvsc.2020.12.025
PubMed:
33461120

A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides.

Review
Cui X et al (2018).
Molecules.
DOI:
10.3390/molecules23051170
PubMed:
29757991