Pueraria lobata

Ethnobotanical Studies

Studies

Exploring the mechanism of Pueraria lobata (Willd.) Ohwi in the regulation of obesity.

Summary

Researchers studied the plant Pueraria lobata for its potential health benefits, particularly in lowering blood sugar, improving insulin sensitivity, and inhibiting obesity. The specific mechanism of how it inhibits obesity is still unclear, making further study necessary.

Obesity
Mao J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118703
PubMed:
39154668

Puerarin Attenuates Insulin Resistance by Inhibiting Endoplasmic Reticulum Stress and Suppresses Inflammation by Modulating the JNK and IKKβ/NF-κB Pathways in Epididymal White Adipose Tissue of Mice on a High-Fat Diet.

Immunology
Sun J et al (2024).
Mol Nutr Food Res.
DOI:
10.1002/mnfr.202400003
PubMed:
39072916

Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5.

Li Z et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1423634
PubMed:
39055493

Effects and mechanisms of puerarin against neuroblastoma: insights from bioinformatics and in vitro experiments.

Sui X et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04569-0
PubMed:
38982456

Profiling of Antidiabetic Bioactive Flavonoid Compounds from an Edible Plant Kudzu (Pueraria lobata).

Summary

Researchers isolated flavonoids from kudzu plant and found they lower blood sugar levels and may treat diabetes by targeting SGLT2, PTP1B, and AG enzymes. This study provides insight into the plant's potential health benefits.

DiabetesPhytochemistry
Wang W et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c02564
PubMed:
38976778

Protein Tyrosine Phosphatase 1B Inhibitors of Pueraria lobata Based on the Spectrum-Effect Relationship by Q-Marker Selection.

Zhang Y et al (2024).
Molecules.
DOI:
10.3390/molecules29122731
PubMed:
38930797

Pueraria lobata antioxidant extract ameliorates non-alcoholic fatty liver by altering hepatic fat accumulation and oxidative stress.

Immunology
Dong H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118468
PubMed:
38906339

Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation.

Immunology
Hu Z et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155813
PubMed:
38905846

Effects of Silybum marianum, Pueraria lobate, combined with Salvia miltiorrhiza tablets on non-alcoholic fatty liver disease in adults: A triple-blind, randomized, placebo-controlled clinical trial.

Li BY et al (2024).
Clin Nutr ESPEN.
DOI:
10.1016/j.clnesp.2024.06.003
PubMed:
38879879

Preparation of Pueraria lobata Root-Derived Exosome-Like Nanovesicles and Evaluation of Their Effects on Mitigating Alcoholic Intoxication and Promoting Alcohol Metabolism in Mice.

Zhang W et al (2024).
Int J Nanomedicine.
DOI:
10.2147/IJN.S462602
PubMed:
38828197

Integrating metabolomics and network pharmacology analysis to explore mechanism of Pueraria lobata against pulmonary fibrosis: Involvement of arginine metabolism pathway.

Du H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118346
PubMed:
38782311

Interventional effects of Pueraria oral liquid on T2DM rats and metabolomics analysis.

Yang HB et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116780
PubMed:
38781864

Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases.

Review
Chauhan P et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-024-04222-4
PubMed:
38780722

Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling.

Summary

Puerarin (Pue) from Pueraria lobata protects against vascular damage induced by diabetes by reducing inflammation and oxidative stress through inactivating the ROS-NLRP3 signaling pathway. This could potentially lead to new treatments for diabetic vascular diseases.

CardiologyDiabetes
Wei H et al (2024).
J Cell Mol Med.
DOI:
10.1111/jcmm.18239
PubMed:
38774996

Benefits of Puerarin on Metabolic Syndrome and Its Associated Cardiovascular Diseases in Rats Fed a High-Fat/High-Sucrose Diet.

Summary

Puerarin from Pueraria lobata improved metabolic syndrome in rats, reducing cardiovascular damage, inflammation, and improving glucose and lipid metabolism. Dietary supplementation with PUE could be beneficial in managing and preventing MetS and CVDs.

Cardiology
Mu Y et al (2024).
Nutrients.
DOI:
10.3390/nu16091273
PubMed:
38732519

A Highly Sensitive and Rapid Colloidal Gold Immunoassay for Puerarin Detection.

Yue S et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c00644
PubMed:
38578981

Multifunctional thiolated chitosan/puerarin composite hydrogels with pH/glutathione dual responsiveness for potential drug carriers.

Yuan H et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130841
PubMed:
38553389

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review.

Summary

Herbal remedies in traditional Chinese medicine show promise in managing SCA3 by targeting oxidative stress. Preclinical studies support their therapeutic roles, suggesting potential alternative treatments to delay disease progression.

Review Immunology
Mohd Hisam NS and Wong KH (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13030375
PubMed:
38539908

Naodesheng decoction regulating vascular function via G-protein-coupled receptors: network analysis and experimental investigations.

Chen S et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1355169
PubMed:
38533257

Active Components of Pueraria lobata through the MAPK/ERK Signaling Pathway Alleviate Iron Overload in Alcoholic Liver Disease.

Immunology
Li X et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400005
PubMed:
38504590

Targeted arginine metabolomics combined with metagenomics revealed the potential mechanism of Pueraria lobata extract in treating myocardial infarction.

Summary

Researchers studied the therapeutic effects of Pueraria lobata water extract for treating myocardial infarction in rats. They found that the extract reduced cardiac injury, improved amino acid levels, and restored intestinal flora balance. This study provides new insights into the potential of Pueraria lobata in heart disease treatment.

Cardiology
Yi B et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.464732
PubMed:
38387153

A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways.

Song J et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e24842
PubMed:
38312605

Effect of Dietary Puerarin Supplementation on Growth Performance, Immune Response, Antioxidant Capacity, and Intestinal Morphology in Domestic Pigeons (Columba livia).

GastroenterologyImmunology
Wang R et al (2024).
J Poult Sci.
DOI:
10.2141/jpsa.2024003
PubMed:
38283163

Extraction and characterisation of kudzu root residue lignin based on deep eutectic solvents.

Han X et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3328
PubMed:
38279552

Glycosylation and methylation in the biosynthesis of isoflavonoids in Pueraria lobata.

Review
Li C and Zhang Y (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1330586
PubMed:
38162309

Structural elucidation of an active polysaccharide from Radix Puerariae lobatae and its protection against acute alcoholic liver disease.

Cao W et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2023.121565
PubMed:
38008472

Puerarin alleviates hyperosmotic stress-induced oxidative stress, inflammation, apoptosis and barrier damage of human corneal epithelial cells by targeting SIRT1/NLRP3 signaling.

Immunology
Dong Y, Ding YY and Gao WP (2024).
Toxicol In Vitro.
DOI:
10.1016/j.tiv.2023.105722
PubMed:
37865300

Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis.

Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117290
PubMed:
37806538

Down-regulation of human papillomavirus E6 oncogene and antiproliferative effect of Schisandra chinensis and Pueraria lobata natural extracts on Hela cell line.

Cancer
Cardona-Mendoza A et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117225
PubMed:
37797877

In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.

Diabetes
Hou B et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117281
PubMed:
37797872

Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review.

Review Phytochemistry
He H et al (2021).
Food Sci Nutr.
DOI:
10.1002/fsn3.2668
PubMed:
35035928

Botanicals and Their Bioactive Phytochemicals for Women's Health.

Review Phytochemistry
Dietz BM et al (2016).
Pharmacol Rev.
PubMed:
27677719

Puerarin: a review of pharmacological effects.

Review
Zhou YX, Zhang H and Peng C (2014).
Phytother Res.
DOI:
10.1002/ptr.5083
PubMed:
24339367

Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk.

Review
McGregor NR et al (2007).
Alcohol.
PubMed:
17980785