Pulsatilla chinensis

Ethnobotanical Studies

Studies

Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation.

Immunology
Chu S et al (2024).
Front Immunol.
DOI:
10.3389/fimmu.2024.1412022
PubMed:
38881898

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.

Summary

23-HBA from P. chinensis inhibits M2 macrophage polarization, decreasing resistance to 5-FU in colorectal cancer. Suppresses IL-10/STAT3/Bcl-2 pathway, enhancing 5-FU efficacy and reducing M2 macrophage presence in tumor tissues.

CancerGastroenterologyImmunology
Fan Z et al (2024).
Cancer Immunol Immunother.
DOI:
10.1007/s00262-024-03662-0
PubMed:
38554148

Anemoside B4 inhibits SARS-CoV-2 replication in vitro and in vivo.

Summary

AB4, a saponin from [plant], shows potential antiviral activity against SARS-CoV-2. Study aims to determine mechanism. Important for developing new treatments against COVID-19.

COVID-19
Xiao M et al (2023).
Chin Herb Med.
DOI:
10.1016/j.chmed.2023.09.005
PubMed:
38375049

Pharmacokinetics and metabolite identification of 23-hydroxybetulinic acid in rats by using liquid chromatography-mass spectrometry method.

Phytochemistry
Xue M et al (2024).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2024.124016
PubMed:
38266610

Dietary Qi-Weng-Huangbo powder enhances growth performance, diarrhoea and immune function of weaned piglets by modulating gut health and microbial profiles.

Gastroenterology
Xiao C et al (2023).
Front Immunol.
DOI:
10.3389/fimmu.2023.1342852
PubMed:
38187371

Exploration of the immuno-adjuvant effect and mechanism of Anemoside B4 through network pharmacology and experiment verification.

Shen L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155302
PubMed:
38176273

Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice.

Summary

Researchers studied the effectiveness and mechanisms of Baitouweng decoction (BD), a Traditional Chinese Medicine, in treating ulcerative colitis (UC). Understanding this could help improve UC treatment, reducing its global impact on public health.

GastroenterologyImmunology
Li X et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21869
PubMed:
38034600

A Comprehensive Review on Botany, Phytochemistry, Traditional Uses, Pharmacology, Analytical Methods, Processing Methods, Pharmacokinetics and Toxicity of Pulsatilla chinensis.

Summary

Researchers conducted a study on Pulsatilla chinensi and its potential clinical uses. They aim to support future research and advancement in this field. Importance lies in understanding the potential benefits and applications of Pulsatilla chinensi for possible use in clinical settings.

Phytochemistry
Leng D et al (2023).
Altern Ther Health Med.
PubMed:
37793336

Hederasaponin C inhibits LPS-induced acute kidney injury in mice by targeting TLR4 and regulating the PIP2/NF-κB/NLRP3 signaling pathway.

Immunology
Han S et al (2023).
Phytother Res.
DOI:
10.1002/ptr.8014
PubMed:
37778741

Anemoside B4 attenuates RANKL-induced osteoclastogenesis by upregulating Nrf2 and dampens ovariectomy-induced bone loss.

Cao Z et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115454
PubMed:
37688987

The effect of plant compartment and geographical location on shaping microbiome of Pulsatilla chinensis.

Xing Y et al (2023).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-023-12641-x
PubMed:
37436481

Qualitative and quantitative analysis of triterpenoids in different tissues of Pulsatilla chinensis.

Zhang T et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115528
PubMed:
37331205

Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository.

Ye Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116694
PubMed:
37253396

Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization.

Summary

Pulsatilla chinensis (Bge.) Regel, a traditional Chinese medicine, inhibits M2 macrophage polarization via the STAT6 pathway, reducing tumor progression and metastasis.

CancerImmunologyPhytochemistry
Yang X et al (2023).
Molecules.
DOI:
10.3390/molecules28093682
PubMed:
37175092

Pulsatilla chinensis saponins ameliorated murine depression by inhibiting intestinal inflammation mediated IDO1 overexpression and rebalancing tryptophan metabolism.

Summary

Depression may be linked with inflammatory bowel disease (IBD). Researchers have found that intestinal inflammation might be a contributing factor to depression, but the exact cause is unknown. This suggests that new treatments for depression targeting the gut may be necessary.

GastroenterologyImmunologyNeurosciencePhytochemistry
Wang T et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154852
PubMed:
37167824

Computational method for rapid screening of the metabolites of Pulsatilla chinensis in rats using UHPLC-Q-TOF/MS combined with mass spectrum-based orthogonal projection.

Su S et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115345
PubMed:
36958113

The triterpenoid saponin content difference is associated with the two type oxidosqualene cyclase gene copy numbers of Pulsatilla chinensis and Pulsatilla cernua.

GeneticsPhytochemistry
Liu X et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1144738
PubMed:
36909385

[Authenticity discrimination of Pulsatillae Radix based on dry-process REIMS fingerprinting combined with machine learning].

Shi Y et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20221017.103
PubMed:
36872262

Integrated transcriptomic and metabolomic analyses revealed the molecular mechanism of terpenoid formation for salicylic acid resistance in Pulsatilla chinensis callus.

Dong Y et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1054317
PubMed:
36684800

Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia.

Immunology
Ma H et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154431
PubMed:
36115169

Pulsatilla chinensis (Bge.) Regel: A Systematic Review on Anticancer of Its Pharmacological Properties, Clinical Researches and Pharmacokinetic Studies.

Review Cancer
Li H et al (2022).
Front Oncol.
DOI:
10.3389/fonc.2022.888075
PubMed:
35814470

Quality Evaluation of Pulsatilla chinensis Total Saponin Extracts via Quantitative Analysis of Multicomponents by Single Marker Method Combined with Systematic Quantified Fingerprint Method.

Phytochemistry
Chen L et al (2022).
J Anal Methods Chem.
DOI:
10.1155/2022/6777409
PubMed:
35309718

Identification of Pulsatilla chinensis (Bge.) Regel and look-alike species by UHPLC-TOF-MS using multivariate statistical analysis.

Zhang L et al (2022).
J Sep Sci.
DOI:
10.1002/jssc.202100732
PubMed:
35000282

The derivatives of Pulsatilla saponin A, a bioactive compound from Pulsatilla chinensis: Their synthesis, cytotoxicity, haemolytic toxicity and mechanism of action.

Phytochemistry
Tong X et al (2017).
Eur J Med Chem.
DOI:
10.1016/j.ejmech.2017.02.025
PubMed:
28237662

Triterpenoids from Pulsatilla chinensis.

Ye WC et al (1996).
Phytochemistry.
PubMed:
8768325