Common Names: pomegranate
Researchers studied lucan broad bean pod valves (BPs) rich in L-dopa and polyphenols for Parkinson's treatment. BP extracts showed higher L-dopa content than seeds, with neuroprotective polyphenols, antioxidants, and no harmful metabolites. BP extracts were more effective than synthetic L-dopa in preventing oxidative stress.
Researchers explored the benefits of mouthwashes made from medicinal plants like Punica granatum L. for gingivitis, showing positive effects on oral hygiene. Worth considering for improving oral health.
Extracts from okra, mulberry, and pomegranate leaves and peel help diabetic rats by reducing blood glucose, inflammation, and restoring brain health. Promising for treating diabetic neuropathy.
Pomegranate seed oil self-nanoemulsifying system has potent antioxidant, anti-diabetic, and anti-lipase activities. Potential for oral medications in oxidative stress, diabetes, and obesity treatment.Enhanced drug formulations in terms of pharmacokinetics and pharmacodynamics.
Scientists researched the potential benefits of pomegranate leaf (PGL) as a sustainable and bioactive compound. PGL shows promising anti-cancer, anti-diabetic, anti-inflammatory, and neuroprotective properties in studies, but more human trials are needed for confirmation and standardization.
Shading and foliar application of minerals improve pomegranate fruit quality by reducing aril whitening, increasing antioxidants, and enhancing mineral content. Helps maintain desirable fruit quality in hot climates.
This review discusses the benefits of polyphenols found in plants like olive and pomegranate, with potential applications in various industries. They can be extracted from agroindustrial waste, promoting sustainable processes.
Pomegranate has numerous health benefits, such as managing hypertension, dyslipidemia, hyperglycemia, and insulin resistance. Its antioxidant and anti-inflammatory properties also enhance wound healing and infection resistance.
Various medicinal plants show promising anticancer activity against HER2-positive breast cancer cells by reducing HER2 expression, altering proteome profile, and containing multiple anticancer compounds. Potential innovative therapies for HER2-positive breast cancer.
Review explores multifaceted pathophysiology of Alzheimer's disease, including cholinergic, tau protein, Aβ, oxidative stress, and metal ion hypotheses. Herbal interventions show potential for neuroprotection, but face limitations. DHA and Nicotine also show promise. Future research needed.
Scientists made a way to deliver pomegranate extract to breast, colon, and uterus tumors; it improves treatment effectiveness and reduces side effects.
This study used machine learning models to predict the effects of gamma-aminobutyric acid (GABA) on plant traits during drought, salinity, and combined stress conditions. These findings could help enhance crop tolerance to stress factors, benefiting food security.
Gel formulations with antimicrobials may offer new medicines for denture stomatitis treatment. It's unclear if they are more effective than antifungal drugs. (24 words)
This study evaluated the antimicrobial activity of five herbs used to treat inflammatory bowel disease (IBD) in Saudi Arabia. The herbs showed good activity against E. coli and S. aureus, suggesting their potential as natural remedies for IBD.
Pomegranate's ellagitannins can inhibit inflammation, regulate intestinal health, and serve as a dietary management resource for ulcerative colitis. Preclinical and human trial studies support these therapeutic effects.
Pomegranate extracts with high polyphenol levels can reduce oxidative stress and inflammation, manage blood sugar, and protect liver enzymes in non-alcoholic fatty liver disease (NAFLD). It is beneficial for prevention and management of NAFLD.
Scientists isolated a lectin from P. granatum fruit and discovered its potential anti-cancer properties. This could lead to new treatments or therapies for cancer.
Pomegranate peels from Jordan contain high levels of phenolic compounds, flavonoids, and tannins. The ethanol extract shows strong antimicrobial activity and the water extract has high antioxidant activity. Pomegranate peels could be utilized for medical purposes and as a source of bioactive ingredients.
In silico study found that three compounds in pomegranate peel (punicalin, punicalagin, and ellagic acid) interacted significantly with nine protein targets involved in diabetes management. These compounds show potential as antidiabetic agents, but further validation is needed.
Combining a phytoestrogens-enriched extract with citalopram (CIT) at sub-optimal doses resulted in an increased antidepressant-like effect and neuroplasticity in rats. This suggests a potential alternative therapy for reducing depressive symptoms in menopause.
Researchers prepared and studied a library of 1,000 compounds from peels to find antioxidants for Alzheimer's disease. Using computational calculations, they identified active compounds and performed molecular docking, optimization, and toxicity evaluation. Hesperidin showed promise as a potential drug for Alzheimer's treatment.
Scientists sequenced and analyzed the mitochondrial genome of Punica granatum (pomegranate). This study provides valuable insights into the organization, variation, and evolution of mitogenomes in this economically and medicinally significant fruit tree.
Study analyzes phenolic content & antioxidant activity in pomegranate parts. Petals contain highest polyphenols, placenta has highest flavonoids & punicalagin. Placenta is vital for punicalagin. Antioxidant activity highest in placenta.
Pomegranate peel has bioactive compounds with health benefits like anti-inflammation and heart protection. Extraction methods are used and it can enhance nutrition and shelf life of food products.
Pomegranate peel extract may protect against levofloxacin-induced testicular damage, reversing oxidative stress, hormonal changes, and apoptosis in rats.
Scientists investigated the combination of melatonin (an anticancer compound) with quantum dots in cancer treatment. This study pioneers the examination of ramelteon bioconjugation to quantum dots, offering new insights into using melatonin derivatives for cancer therapy.
Scientists have produced the first high-quality genome of crape myrtle, revealing its evolution and providing insights into flower and leaf color. This will benefit the study of related species and enhance breeding efforts.
52 studies on testosterone boosters were reviewed, revealing that most do not increase total testosterone. However, β-hydroxy β-methylbutyrate and betaine proved effective for male athletes, and Eurycoma longifolia and Withania somnifera may be effective for other populations. This information should be considered for lab decisions.
This study identified seven trehalose-6-phosphate phosphatase (TPP) genes in pomegranate. Some genes are involved in response to drought stress, while others show tissue-specific expression. Understanding these genes could help develop stress-resistant crops. Further research is needed for precise biological roles.
This study developed a method to synthesize magnetite nanoparticles using natural sources (grapes, blueberries, and pomegranates). These nanoparticles have a dual function, acting as reducing agents and bonding with Fe ions. They also demonstrated high heating capabilities and were found to be safe for leukemia cells.
Various bioactive metabolites found in herbs such as Rosmarinus officinalis and Punica granatum have shown impressive angiotensin converting enzyme (ACE) inhibitory activity. These natural ACE inhibitors could be a potential treatment for hypertension, respiratory distress syndrome, and chronic kidney diseases, but more clinical trials are needed.
This study in Mexico analyzed three varieties of pomegranate peel and found that extracting polyphenols using acetone produced the best antioxidant and antibacterial results in the Apaseo variety. Useful for food or drug formulation.
A systematic review found that pomegranate and its phytochemicals have an anxiolytic-like effect, potentially providing an alternative treatment for anxiety. Mechanisms of action include GABAergic receptor inhibition and modulation of oxidative stress, cytokines, and gene expression.
Scientists identified potential compounds, carpaine and punicalagin, in Carica papaya leaves and Punica granatum, that may improve cognition. These compounds were tested on rats, which showed improved memory and reduced GFAP expression in the hippocampus. Promising candidates for treating MCI and MND. (44 words, 260 characters)
A study found that a hydroalcoholic crude extract from the peels of L. increased lifespan and reduced bacterial counts in mice with lethal sepsis, suggesting antimicrobial and anti-inflammatory effects. The extract also regulated bacterial load, controlled inflammation, and reduced lung hemorrhage.
A Chinese herbal feed additive (TCM) improved egg production, quality, antioxidant capacity, immunity, and intestinal health in Roman laying hens compared to control and antibiotic groups.
This study tested the effect of pomegranate peel supplementation on obese rats. Pomegranate peel increased antioxidant capacity in the rats despite diminishing phenolic compounds after digestion.
Pomegranate contains compounds that can inhibit ACE, a enzyme involved in blood pressure regulation. These compounds also stimulate nitric oxide production, improve glucose uptake, and reduce oxidative stress.
In this study, researchers investigated the cellular mechanism behind the anti-inflammatory effects of ellagic acid, a compound found in peels of L. that has traditional uses in treating traumatic hemorrhage. They found that ellagic acid inhibited the phosphorylation of ERK and subsequent neuroinflammation induced by lipopolysaccharides (LPSs) in treated BV-2 cells. Additionally, ellagic acid attenuated LPS-induced changes in various biomarkers associated with neuroinflammation, protein aggregation, and programmed cell deaths in the infused substantia nigra. The results suggest that ellagic acid has potential as a neuroprotective agent through inhibiting MEK1-ERK signaling and promoting M2 microglial polarization.
Pomegranate's polyphenols may inhibit SARS-CoV-2 and regulate immune responses. It has potential as a COVID-19 treatment and may help replenish antioxidants during recovery.
An herbal medicine used in Japan for cancer patients was found to have a therapeutic effect on tumor growth by suppressing it through CD8 T cells. This is the first scientific evidence of its contribution to tumor immunity.
The study found that ellagic acid (EA) and punicic acid (PA) reduced pro-fibrotic proteins, reactive oxygen species, and inflammation in cardiac fibroblasts. EA and PA could be effective in reducing fibrosis.
Nutrition might have a role in preventing and worsening neurodegenerative diseases like dementia, which affect memory, perception, and problem-solving. More research is needed on the subject.
Pomegranate extract supplementation improved clinical symptoms and reduced immune cell counts in patients with allergic asthma, suggesting potential benefits for symptom management.
This article discusses the potential benefits of polyphenols in reducing age-related diseases, specifically focusing on their neuroprotective effects in Alzheimer's and Parkinson's disease. Studies show that some polyphenols play a role in maintaining neuronal homeostasis and improving cognitive function. However, inconsistencies in study design and interindividual variability impact their effectiveness. Pomegranate is highlighted as a promising treatment option, but further human clinical trials are needed.
Pomegranate extract shows potential to reduce oxidative stress and increase antioxidant activity, but more research is needed to confirm these findings.