The study aimed to investigate the antioxidant and memory protective effect of Reinwardtia indica, a plant used in Asian folk medicine. Rats were given extracts of the plant and tested for their ability to learn and remember tasks after being induced with memory impairment. The alcoholic extract at a higher dose showed the potential to reverse memory deficits and counteract the effects of scopolamine, a drug that impairs memory. The extract was also found to increase acetylcholine levels and antioxidant enzymes while decreasing acetylcholinesterase activity. Chemical profiling of the extract showed the presence of chemicals known for their neuroprotective, memory-enhancing, and antioxidant properties. These results suggest that Reinwardtia indica has the potential to be used in the treatment of memory-related disorders.