Rhodiola sacra

Ethnobotanical Studies

Studies

Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats.

Summary

Rhodiola sacra is a component with many medicinal uses, including anti-oxidation and anti-inflammation. Researchers investigated its neuroprotective effects against transient global cerebral ischemia (tGCI) in male rats. They found that pretreatment or/and post-treatment significantly reduced neuronal injury, inhibited glial activation, and improved cognitive function. Molecular docking showed that Rhodiola sacra targets adenosine monophosphate-activated protein kinase (AMPK) α2-subunit and upregulates phosphorylated AMPK and nuclear factor erythroid 2-related factor 2 (Nrf2). Additionally, Rhodiola sacra increased heme oxygenase-1 (HO-1) expression and activity and reduced malondialdehyde (MDA) content in the hippocampal CA1 region. These findings demonstrate that Rhodiola sacra prevents oxidant stress and protects neurons through activating the AMPK/Nrf2 pathway.

CardiologyNeuroscience
Li K et al (2022).
Antioxid Redox Signal.
DOI:
10.1089/ars.2020.8224
PubMed:
34714119

Treatment with the herbal formulation Eefooton slows the progression of chronic kidney disease: A case report.

Yao CA and Lin CH (2019).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000017573
PubMed:
31651859

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time-of-flight mass spectrometry.

Phytochemistry
Liu Y et al (2019).
Biomed Chromatogr.
DOI:
10.1002/bmc.4446
PubMed:
30468269

Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.

Dun Y et al (2017).
Oxid Med Cell Longev.
DOI:
10.1155/2017/8024857
PubMed:
29359009

Improved TLC Bioautographic Assay for Qualitative and Quantitative Estimation of Tyrosinase Inhibitors in Natural Products.

Zhou J et al (2017).
Phytochem Anal.
DOI:
10.1002/pca.2666
PubMed:
28028844

Microsatellite markers in Rhodiola (Crassulaceae), a medicinal herb genus widely used in traditional Chinese medicine.

You J et al (2013).
Appl Plant Sci.
DOI:
10.3732/apps.1200219
PubMed:
25202523

[Effect of Rhodiola Sacra on left ventricular remodeling and its mechanism in spontaneously hypertensive rats].

Yang R, Liu K and Chen XP (2013).
Sichuan Da Xue Xue Bao Yi Xue Ban.
PubMed:
23745255