Rhododendron molle

Ethnobotanical Studies

Studies

Rhodojaponin VI ameliorates podocyte injury related with MDM2/Notch1 pathway in rat experimental membranous nephropathy.

Song A et al (2024).
Nephrology (Carlton).
DOI:
10.1111/nep.14337
PubMed:
39011853

Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology.

Arthritis
Guo X et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118524
PubMed:
38971344

Strategies of flowering plants to avoid pollen collection by undesirable flower visitors. A commentary on 'High toxin concentration in pollen may deter collection by bees in butterfly-pollinated Rhododendron molle'.

Ruedenauer FA et al (2024).
Ann Bot.
DOI:
10.1093/aob/mcae088
PubMed:
38902985

A derivative of trihydroxynaphthalenone and a pyrone metabolite from the endophytic fungus Talaromyces purpurpgenus.

Liu Y et al (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2333359
PubMed:
38563409

High toxin concentration in pollen may deter collection by bees in butterfly-pollinated Rhododendron molle.

Feng HH et al (2024).
Ann Bot.
DOI:
10.1093/aob/mcae047
PubMed:
38507570

Structurally diverse analgesic diterpenoids from the flowers of Rhododendron molle.

Summary

Thirteen new diterpenoids were discovered in Rhododendron molle flowers extract. These compounds showed significant analgesic activities, with some exhibiting stronger effects than morphine, suggesting potential for designing new pain medications.

Pain
Zheng G et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105770
PubMed:
38056699

Discovery of highly functionalized grayanane diterpenoids from the flowers of Rhododendron molle as potent analgesics.

Zheng G et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.106928
PubMed:
37922768

Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain.

Summary

Rhodojaponin VI is a potential treatment for neuropathic pain. It targets NSF, which regulates Cav2.2 channels and reverses their effect, offering a new class of analgesic products.

Pain
Chen K et al (2023).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2023.01.021
PubMed:
36970201

Potential Anti-Inflammatory Components of Rhododendron molle G. Don Leaf Extracts in LPS-Induced RAW 264.7.

Immunology
Luo Y et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202201132
PubMed:
36843209

Anti-rheumatoid arthritis potential of Rhododendron molle G. Don leaf extract in adjuvant induced arthritis rats.

Arthritis
Luo Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116175
PubMed:
36702447

Gapless genome assembly of azalea and multi-omics investigation into divergence between two species with distinct flower color.

Genetics
Nie S et al (2022).
Hortic Res.
DOI:
10.1093/hr/uhac241
PubMed:
36643737

The regulation of T helper cell polarization by the diterpenoid fraction of Rhododendron molle based on the JAK/STAT signaling pathway.

Qin J et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1039441
PubMed:
36386123

Physical characterization and safety evaluation of folic acid-conjugated mesoporous silica nanoparticles loaded with Rhodojaponin III.

Yang Q et al (2022).
Curr Drug Deliv.
DOI:
10.2174/1567201820666221108121347
PubMed:
36366851

Rhodojaponin III-Loaded Chitosan Derivatives-Modified Solid Lipid Nanoparticles for Multimodal Antinociceptive Effects in vivo.

Summary

Researchers investigated the use of RJ-III, a bioactive compound found in a plant, in a drug delivery system to improve its release and pain-relieving effects.

Pain
Yang Q et al (2022).
Int J Nanomedicine.
DOI:
10.2147/IJN.S362443
PubMed:
35996527

The efficacy and toxicity of grayanoids as analgesics: A systematic review.

Summary

The researchers studied grayanoids, diterpenoids found in certain plants, commonly used to treat abdominal pain, headaches, and arthritis.

Review Pain
Yang J, Zhao J and Zhang J (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115581
PubMed:
35948141

Chromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis.

Genetics
Zhou GL et al (2022).
BMC Plant Biol.
DOI:
10.1186/s12870-022-03720-8
PubMed:
35836128

Evaluation of Rhodojaponin III from Rhododendron molle G. Don on oral antinociceptive activity, mechanism of action, and subacute toxicity in rodents.

Pain
Yang J et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115347
PubMed:
35533915

Rhododendron molle G. Don Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells and Potential Anticancer Components Analysis.

Cancer
Zong L et al (2021).
Molecules.
DOI:
10.3390/molecules26102990
PubMed:
34069900

Diterpenoids from the flowers of Rhododendron molle.

Zhou SZ et al (2014).
J Nat Prod.
DOI:
10.1021/np500074q
PubMed:
24787118