Rhus coriaria

Common Names: Sicilian sumac

Ethnobotanical Studies

Clinical Trials

The Comparative Effects of Rhus Coriaria and Triamcinolone in Patients with Recurrent Aphthous Stomatitis: A Single-Blinded Randomized Controlled Clinical Trial.

Lavaee F et al (2022).
Biomed Res Int.
DOI:
10.1155/2022/5855067
PubMed:
36262968

Studies

Rhus coriaria induces autophagic and apoptotic cell death in pancreatic cancer cells.

Summary

Ethanol extract (RCE) inhibits pancreatic cancer cell growth by inducing cell cycle arrest, autophagy, and apoptosis via AKT/mTOR pathway inhibition. Promising potential for anti-cancer treatment.

Cancer
El Mahi Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1412565
PubMed:
39139643

The efficacy of sumac (Rhus coriaria L.) powder supplementation in biochemical and anthropometric measurements in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.

Summary

Study found sumac supplement improved liver function and reduced markers of inflammation in obese patients with liver disease. Suggests potential non-pharmacological treatment for liver health in obese individuals.

Obesity
Mohit M et al (2024).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2024.23927
PubMed:
39086859

Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells.

Summary

Plant-extracted ZnO NPs show potential as eco-friendly cancer treatment. Biosynthesized by Rhus coriaria fruit extract, they exhibit anti-tumor effects and induce apoptosis in breast cancer cells. Exciting implications for cancer nanotechnology.

Cancer
Mongy Y and Shalaby T (2024).
Sci Rep.
DOI:
10.1038/s41598-024-63258-7
PubMed:
38866790

The incorporation of sumac seed powder (Rhus coriaria L.) into the diet of quail breeders as a novel feed additive.

Reda FM et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.103593
PubMed:
38552345

The additive effect of herbal medicines on lifestyle modification in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis.

Kim MH et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1362391
PubMed:
38464716

Phytochemical variations antioxidant, and antibacterial activities among zebaria sumac (Rhus coriaria var. zebaria) populations in Iraq.

Summary

Scientists evaluated 50 accessions of Rhus coriaria var. zebaria in Iraq for phytochemical variations and antimicrobial activity. The plant is a rich source of essential oil compounds and minerals, with potential for cultivation and medicinal use.

ImmunologyPhytochemistry
Shahrivari S et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-53635-7
PubMed:
38413642

Insights into the mechanisms of diabetic wounds: pathophysiology, molecular targets, and treatment strategies through conventional and alternative therapies.

Summary

Plants and their active constituents can potentially treat diabetic foot syndrome, promoting wound healing, reducing inflammation, and stimulating angiogenesis. These alternatives could decrease amputations and offer affordable options. Further research is needed for a better understanding.

Review Diabetes
Yadav JP et al (2024).
Inflammopharmacology.
DOI:
10.1007/s10787-023-01407-6
PubMed:
38212535

Repurposing of Rutan showed effective treatment for COVID-19 disease.

Summary

Researchers repurposed the Rutan drug from the tannic sumac plant and found that it effectively and safely treats COVID-19 by inhibiting key enzymes of the virus. Clinical studies showed reduced inflammation and shorter viremia period. Rutan can be a safe treatment and preventive measure for adults and children.

COVID-19
Salikhov SI et al (2023).
Front Med (Lausanne).
DOI:
10.3389/fmed.2023.1310129
PubMed:
38093975

Assessment of In Vitro Airway Smooth Muscle Relaxant Activity of Rhus coriaria L. Fruit Ethanolic Extract and Its Possible Mechanisms.

Uka A et al (2023).
J Med Food.
DOI:
10.1089/jmf.2022.0126
PubMed:
37902984

The effects of Rhus coriaria L. (sumac) and Cinnamomum zeylanicum L. bark on serum cytokine levels in rat mammary carcinogenesis.

Summary

The researchers investigated the effects of sumac and cinnamon bark on serum cytokine levels in a rat model of breast cancer. Both substances demonstrated anti-inflammatory effects and potential anticancer activities.

Immunology
Sadlonova V et al (2023).
Neoplasma.
DOI:
10.4149/neo_2023_230405N186
PubMed:
37789780

Element and Water-Soluble Vitamins Profile of Rhus coriaria L. (Sumac) Grown in Different Regions.

Ali HM et al (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-023-03890-y
PubMed:
37776395

The effect of high-polyphenol sumac (Rhus coriaria) on food intake using sensory and appetite analysis in younger and older adults: A randomized controlled trial.

Phytochemistry
Soleymani Majd N et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3369
PubMed:
37457172

Characterization of active Cerish fructan-sumac extract composite films: Physical, mechanical, and antioxidant properties.

Immunology
Pakseresht S, Hadree J and Sedaghat N (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3406
PubMed:
37457155

Sumac (Rhus coriaria L.) anthocyanin loaded-pectin and chitosan nanofiber matrices for real-time monitoring of shrimp freshness.

Tavassoli M et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125044
PubMed:
37224901

The Nutraceutical Properties of Rhus coriaria Linn: Potential Application on Human Health and Aging Biomedicine.

Review
Calabrò A et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24076206
PubMed:
37047178

Optimization of ultrasonic-assisted approach for synthesizing a highly stable biocompatible bismuth-coated iron oxide nanoparticles using a face-centered central composite design.

Braim FS et al (2023).
Ultrason Sonochem.
DOI:
10.1016/j.ultsonch.2023.106371
PubMed:
36934677

Sumac (Rhus coriaria L.) powder supplementation has beneficial effects on appetite in overweight/obese women with depression: A randomized controlled trial.

Summary

Summary: This study explored the impact of sumac supplementation and calorie-restricted diet on appetite in overweight and obese women with depression, highlighting the potential benefits of polyphenols in promoting satiety.

Obesity
Hariri N et al (2023).
Complement Ther Clin Pract.
DOI:
10.1016/j.ctcp.2023.101734
PubMed:
36753796

Antimicrobial Activity of Silver Nanoparticles Synthesized by the Green Method Using Rhus coriaria L. Extract Against Oral Pathogenic Microorganisms.

Antimicrobial
Nazemi Salman B et al (2022).
Med J Islam Repub Iran.
DOI:
10.47176/mjiri.36.154
PubMed:
36654848

Rhus coriaria extracts inhibit quorum sensing-related virulence and biofilm production in drug-resistant Pseudomonas aeruginosa recovered from burn wounds.

Ahmed AA, A Salih F and Yousef M (2022).
Iran J Basic Med Sci.
DOI:
10.22038/IJBMS.2022.66085.14527
PubMed:
36474566

Sumac (Rhus coriaria) Extract-Loaded Polymeric Nanosheets Efficiently Protect Human Dermal Fibroblasts from Oxidative Stress.

Emanet M et al (2022).
ACS Appl Bio Mater.
DOI:
10.1021/acsabm.2c00857
PubMed:
36426992

Pivotal Role of Copper Nanoparticles Shelled by Turmeric or Sumac on Huh-7 Cell Line Cytotoxicity, Apoptosis and Antioxidant Capacity.

Mohamed RW et al (2022).
Pak J Biol Sci.
DOI:
10.3923/pjbs.2022.952.960
PubMed:
36404749

Rhus Coriaria L. Extract: Antioxidant Effect and Modulation of Bioenergetic Capacity in Fibroblasts from Parkinson's Disease Patients and THP-1 Macrophages.

Summary

The Mediterranean plant Sumac has been found to have beneficial properties, including neuroprotection and antioxidant effects. Researchers investigated its potential neuroprotective action in Parkinson's disease (PD) by studying its effects on mitochondrial functionality. They found that Sumac extract reduced reactive oxygen species (ROS) levels, but the effect on ATP levels varied depending on the individual's genetic mutations. Sumac was also found to polarize macrophages towards an M2 phenotype, which could suggest it as a potential nutraceutical approach to PD.

ImmunologyNeuroscience
Isgrò C et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232112774
PubMed:
36361562

Effect of extraction methods on the efficiency of sumac (Rhus coriaria L.) fruit extract in soybean oil quality during accelerated conditions.

Rahmati S, Bazargani-Gilani B and Aghajani N (2022).
Food Sci Nutr.
DOI:
10.1002/fsn3.2919
PubMed:
36249969

Anti-echinococcal effects of sumac, Rhus coriaria, in a murine model of cystic echinococcosis: Parasitological and molecular evaluation.

Fotoohi S et al (2022).
Exp Parasitol.
DOI:
10.1016/j.exppara.2022.108406
PubMed:
36244447

Application of the Hurdle Technology Concept to the Fresh Za'atar (Origanum syriacum) Preservation.

Mudalal S et al (2022).
Foods.
DOI:
10.3390/foods11193002
PubMed:
36230077

Green Synthesis Magnetite (Fe₃O₄) Nanoparticles From Rhus coriaria Extract: A Characteristic Comparison With a Conventional Chemical Method.

Piro NS et al (2023).
IEEE Trans Nanobioscience.
DOI:
10.1109/TNB.2022.3187344
PubMed:
35771791

Effect of Rhus coriaria L. methanolic fruit extract on wound healing in diabetic and non-diabetic rats.

Diabetes
Alsarayreh AZ, Oran SA and Shakhanbeh JM (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.14668
PubMed:
34928525

Rhus coriaria L., a new candidate for controlling metabolic syndrome: a systematic review.

Hashem-Dabaghian F et al (2022).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgab120
PubMed:
34673978

Pharmacological and Antioxidant Activities of Rhus coriaria L. (Sumac).

Review
Alsamri H et al (2021).
Antioxidants (Basel).
DOI:
10.3390/antiox10010073
PubMed:
33430013

Repressive effect of Rhus coriaria L. fruit extracts on microglial cells-mediated inflammatory and oxidative stress responses.

Immunology
Khalil M et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2020.113748
PubMed:
33359864

Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways.

GeneticsImmunology
El Hasasna H et al (2016).
Sci Rep.
DOI:
10.1038/srep21144
PubMed:
26888313