Common Names: staghorn sumac
Researchers have found that 3,6-bis-О-di-О-galloyl-1,2,4-tri-О-galloyl-β-d-glucose, a tannin found in Rhus typhina, can strongly interact with α-synuclein, an important protein in the development of Parkinson's disease. This interaction inhibits α-synuclein aggregation, suggesting that the tannin could be a potential preventive compound against Parkinson's disease. However, the tannin also strongly interacts with human serum albumin, which reduces its bioavailability in the body. The study used fluorescence spectroscopy and circular dichroism analysis to investigate the interaction between the tannin and the proteins. This research provides insight into the possible mechanisms for preventing Parkinson's disease.