Common Names: Cherokee rose
TL;DR: Researchers optimized Rosa laevigata polysaccharide extraction with ultrasound-microwave method, studied its hypoglycemic properties. Results show potential as antioxidant/hypoglycemic drug due to improved glucose metabolism and oxidative stress reduction.
RLP from Rosa laevigata Michx. helps treat ulcerative colitis in beagles by protecting the intestinal barrier and balancing gut bacteria. This may have implications for UC treatment in humans.
Michx. polysaccharide (RLP), from Chinese herbal medicine, reduces kidney damage, inflammation, and oxidative stress in DN mice. RLP modulates metabolism and inhibits apoptosis, suggesting it as a potential treatment for DN.
Researchers have discovered a nonreversible heat-induced supramolecular gel, a gel that forms when heated, using a natural triterpenoid called fupenzic acid (FA) found in the roots of Rosa laevigata. What sets this gel apart is its unique nonreversible phase transition from liquid to gel. The entire gelation process was digitally recorded, and a mechanism for its formation was proposed through experimental methods and molecular dynamics simulation. The gel exhibited excellent injectability and stability, and it was found to have better anti-tumor activity and higher biosafety compared to its equivalent free-drug form. This opens up new possibilities for using natural product gelators in medicine.
Water-soluble particulate matter (WPM) with heavy metals triggers severe inflammation and worsens asthma. Oral and intratracheal administration of RL reduces inflammation, secretion of cytokines, and IgE, suggesting potential as an asthma treatment.
Researchers isolated two new types of selenium-containing polysaccharides from the fruits of Rosa laevigata Michx. These polysaccharides were able to protect cells from oxidative damage and had a radical scavenging effect, suggesting they have potential as a treatment for neurodegenerative diseases or as a dietary supplement. The underlying mechanism of action may be related to the Nrf2/HO-1 signaling pathway.
Researchers have developed a method for extracting and separating polysaccharides from Rosa laevigata fruit using microwave-assisted aqueous two-phase extraction. Two selenium-containing polysaccharides, Se-RLFP-1 and Se-RLFP-2, were isolated and found to have antioxidant properties, particularly at high concentrations. They were also found to have a neuroprotective effect against oxidative stress induced by HO in SH-SY5Y neuroblastoma cells, with Se-RLFP-1 exhibiting significant activity at a concentration of 100 μg/mL. These findings suggest that R. laevigata fruit and its polysaccharides may have potential health benefits.