Rosmarinus officinalis

Common Names: romero, rosemary

Ethnobotanical Studies

Studies

Compositional Optimization for Miticidal Activity, Ecotoxicity, and Phytotoxicity of Rosmarinus officinalis Essential Oils as Biorational Pesticides.

Yoon J and Tak JH (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c01592
PubMed:
39231781

Rosemary extract activates oligodendrogenesis genes in mouse brain and improves learning and memory ability.

Summary

Study found that rosemary extract improved cognitive function in aging mice by reducing inflammation and increasing neurotransmitters. Potential therapy for cognitive dysfunction and aging.

GeneticsNeuroscience
Sasaki K et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117350
PubMed:
39197189

Investigation of the knowledge, attitudes, and perceptions regarding the utilization of rosemary among the population in Jordan.

Thiab S et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0307575
PubMed:
39186547

In silico mechanistic insights of ecofriendly synthesized AgNPs, SeNPs, rGO and Ag&SeNPs@rGONM's for biological applications and its toxicity evaluation using Artemia salina.

Krishnaraj C et al (2024).
Chemosphere.
DOI:
10.1016/j.chemosphere.2024.143159
PubMed:
39178963

Green and sustainable strategies to control scaling in industrial plants: investigation of the efficacy of Rosmarinus officinalis L. Extract against CaCO(3) scale using experimental and theoretical approaches.

El Housse M et al (2024).
Environ Technol.
DOI:
10.1080/09593330.2024.2391074
PubMed:
39167056

Unusual plant-extract based media for the differentiation between species in the Candida albicans complex: A comparative study.

Morales-López S et al (2024).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202420230420
PubMed:
39166546

Essential oils loaded carboxymethylated Cassia fistula gum-based novel hydrogel films for wound healing.

Tanwar M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134682
PubMed:
39153677

Antifungal, Insecticidal, and Repellent Activities of Rosmarinus officinalis Essential Oil and Molecular Docking of Its Constituents against Acetylcholinesterase and β-Tubulin.

Summary

Study analyzed rosemary essential oil phytochemical composition, antifungal, insecticidal properties. Major components: 1,8-cineole, -pinene, camphor. Effective against fungi, kills insects, repels them. Borneol active against insect acetylcholinesterase, -caryophyllene against -tubulin. Potential eco-friendly bioinsecticide.

AntimicrobialNeurosciencePhytochemistry
Houzi G et al (2024).
Scientifica (Cairo).
DOI:
10.1155/2024/5558041
PubMed:
39135848

Ethnobotany around the Virovitica Area in NW Slavonia (Continental Croatia)-Record of Rare Edible Use of Fungus Sarccoscypha coccinea.

Ethnobotany
Vitasović-Kosić I et al (2024).
Plants (Basel).
DOI:
10.3390/plants13152153
PubMed:
39124271

Biofertilizer and biostimulant potentials of phosphate-solubilizing Bacillus subtilis subsp. subtilis M1 strain and silicon in improving low phosphorus availability tolerance in rosemary.

Msaad H et al (2024).
Lett Appl Microbiol.
DOI:
10.1093/lambio/ovae072
PubMed:
39066498

Network pharmacology-based approach to investigate the molecular targets and molecular mechanisms of Rosmarinus officinalis L. for treating aging-related disorders.

Review
Bisht A et al (2024).
Biogerontology.
DOI:
10.1007/s10522-024-10122-w
PubMed:
39017748

Investigation of the acute impact of rosemary consumption on brain activity in healthy volunteers.

Summary

Study found that consuming rosemary can improve cognitive function, measured using EEG. Rosemary is known for its anti-inflammatory and antibacterial properties. This research helps understand the potential benefits of rosemary for cognitive health.

Neuroscience
Muduroglu-Kirmizibekmez A et al (2024).
Nutr Neurosci.
DOI:
10.1080/1028415X.2024.2370729
PubMed:
38970803

Biosynthesis of TiO(2) nano particles by using Rosemary (Rosmarinus officinalis) leaf extracts and its application for crystal dye degradation under sunlight.

Saka A et al (2024).
BMC Chem.
DOI:
10.1186/s13065-024-01229-9
PubMed:
38951843

Nanostructured Mn@NiO composite for addressing multi-pollutant challenges in petroleum-contaminated water.

Hasan GG et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-34012-3
PubMed:
38943002

Rosmarinus officinalis L. essential oil enhances salt stress tolerance of durum wheat seedlings through ROS detoxification and stimulation of antioxidant defense.

Summary

Study shows Rosmarinus officinalis L. essential oil (RoEO) improves salt stress tolerance in durum wheat seedlings by enhancing growth and activating antioxidant defense genes. RoEO could be a valuable tool for increasing agricultural productivity in challenging environments.

ImmunologyPhytochemistry
Ben Saad R et al (2024).
Protoplasma.
DOI:
10.1007/s00709-024-01965-8
PubMed:
38940918

Chemical and Bioactive Evaluation of Essential Oils from Edible and Aromatic Mediterranean Lamiaceae Plants.

Spréa RM et al (2024).
Molecules.
DOI:
10.3390/molecules29122827
PubMed:
38930892

Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects.

Summary

Rosemary polyphenols have strong anti-inflammatory and antibacterial properties, potentially decreasing intestinal inflammation and lowering the risk of inflammatory bowel disease. Consider utilizing rosemary polyphenols as a preventative measure in your research.

Review Immunology
Zhang L and Lu J (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106074
PubMed:
38906386

Dietary supplementation with plant extracts for amelioration of persistent myofascial discomfort in the cervical and back regions: a randomized double-blind controlled study.

Pérez-Piñero S et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1403108
PubMed:
38887495

Application of gelatin-based zinc oxide nanoparticles bionanocomposite coatings to control Listeria monocytogenes in Talaga cheese and camel meat during refrigerated storage.

Korany AM et al (2024).
Food Microbiol.
DOI:
10.1016/j.fm.2024.104559
PubMed:
38839223

Assessment of Plant Growth Promotion Potential of Endophytic Bacterium B. subtilis KU21 Isolated from Rosmarinus officinalis.

Sharma M, Sood G and Chauhan A (2024).
Curr Microbiol.
DOI:
10.1007/s00284-024-03734-5
PubMed:
38831110

Evaluation of the mechanistic basis for the antibacterial activity of ursolic acid against Staphylococcus aureus.

Liu G et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1389242
PubMed:
38827151

Non-clinical investigations about cytotoxic and anti-platelet activities of gamma-terpinene.

Souza RP et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03173-w
PubMed:
38801455

Impact of Nanoencapsulated Rosemary Essential Oil as a Novel Feed Additive on Growth Performance, Nutrient Utilization, Carcass Traits, Meat Quality and Gene Expression of Broiler Chicken.

GeneticsPhytochemistry
Adil S et al (2024).
Foods.
DOI:
10.3390/foods13101515
PubMed:
38790815

Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis.

Zeng T et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112304
PubMed:
38776851

Metabolic profiling reveals the nutraceutical effect of Gongolaria abies-marina and Rosmarinus officinalis extracts in a type 1 diabetes animal model.

Summary

Study found R. officinalis and G. abies-marina extracts can positively impact metabolic profile in diabetic rats. G. abies-marina had stronger effect. Potential for managing diabetes-related metabolic issues.

Diabetes
Godzien J et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116731
PubMed:
38761421

Assessing the virucidal activity of essential oils against feline calicivirus, a non-enveloped virus used as surrogate of norovirus.

Lanave G et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e30492
PubMed:
38711631

Immunomodulatory Role of Rosmarinus officinalis L., Mentha x piperita L., and Lavandula angustifolia L. Essential Oils in Sheep Peripheral Blood Mononuclear Cells.

Immunology
Ciliberti MG et al (2024).
Vet Sci.
DOI:
10.3390/vetsci11040157
PubMed:
38668424

Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds.

Review
Kmail A et al (2024).
Open Life Sci.
DOI:
10.1515/biol-2022-0857
PubMed:
38645751

Ethnobotanical survey on herbal remedies for the management of type 2 diabetes in the Casablanca-Settat region, Morocco.

Summary

Study investigates the use of medicinal plants in traditional medicine in Casablanca-Settat region for managing type 2 diabetes. Essential for addressing public health challenge in Morocco.

DiabetesEthnobotany
Arraji M et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-024-04468-4
PubMed:
38622669

Analysis of Primary and Secondary Metabolites, Physical Properties, Antioxidant and Antidiabetic Activities, and Chemical Composition of Rosmarinus officinalis Essential Oils under Differential Water Stress Conditions.

Summary

Researchers found that increased water stress affects essential oil quality and bioactivity. Optimal water management can improve antioxidant and antidiabetic properties of essential oils, with implications for healthcare and agriculture.

DiabetesImmunology
Laftouhi A et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.4c00653
PubMed:
38617605

Therapeutic potential of hypnotic herbal medicines: A comprehensive review.

Review
Ghasemzadeh Rahbardar M and Hosseinzadeh H (2024).
Phytother Res.
DOI:
10.1002/ptr.8201
PubMed:
38595123

Composition and antimicrobial activity of Rosmarinus officinalis L. and Artemisia monosperma L. leaf essential oils and methanolic extracts from plants grown in normal and saline habitats in Egypt.

Summary

Researchers studied how salinity affects medicinal plants in Egypt. Salty soil boosted essential oil and antioxidant production in rosemary and Artemisia. Salty conditions altered oil components and mineral uptake, increasing plant defense against microbes.

Antimicrobial
Soliman MM et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-57301-w
PubMed:
38538682

Brain Mitochondria as a Therapeutic Target for Carnosic Acid.

Summary

CA from and is a powerful antioxidant and anti-inflammatory compound that protects mitochondria in brain cells, potentially aiding in cytoprotection and mitochondrial renewal through Nrf2 activation and regulation of mitochondrial quality control pathways.

Review Neuroscience
Infantino V et al (2024).
J Integr Neurosci.
DOI:
10.31083/j.jin2303053
PubMed:
38538219

An Aloe-Based Composition Constituting Polysaccharides and Polyphenols Protected Mice against D-Galactose-Induced Immunosenescence.

Yimam M et al (2024).
J Immunol Res.
DOI:
10.1155/2024/9307906
PubMed:
38516617

Prophylactic and Therapeutic Efficacy of Ultrasonicated Rosmarinus officinalis Ethanolic Extract and its Chitosan-Loaded Nanoparticles Against Eimeria tenella Infected Broiler Chickens.

Kasem SM et al (2024).
Acta Parasitol.
DOI:
10.1007/s11686-024-00793-3
PubMed:
38492183

Using Essential Oils to Reduce Yersinia enterocolitica in Minced Meat and in Biofilms.

Vidaković Knežević S et al (2024).
Foods.
DOI:
10.3390/foods13050806
PubMed:
38472919

Electrophysiological and Behavioral Responses of Cabbage Aphid (Brevicoryne brassicae) to Rosemary (Rosmarinus officinalis) Volatiles, a Potential push Plant for Vegetable push-pull Cropping System.

Mutua BK et al (2024).
J Chem Ecol.
DOI:
10.1007/s10886-024-01485-y
PubMed:
38470529

Alzheimer's disease: In silico study of rosemary diterpenes activities.

Summary

Researchers found that compounds from rosemary, including carnosic acid, show strong potential as inhibitors for Alzheimer's disease. Rosmanol stands out as a promising candidate for further study and potential treatment development.

Neuroscience
Abbaoui Z et al (2024).
Curr Res Toxicol.
DOI:
10.1016/j.crtox.2024.100159
PubMed:
38455759

Improvement of growth and biochemical constituents of Rosmarinus officinalis by fermented Spirulina maxima biofertilizer.

El-Sayed HS et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108452
PubMed:
38442624

Evaluation of larvicidal potential of Eritrean medicinal plants against Aedes aegypti.

Kaushik JJ et al (2024).
J Parasit Dis.
DOI:
10.1007/s12639-024-01653-7
PubMed:
38440761

Biomedical behaviors of CuO/γ-alumina/chitosan nanocomposites: Scolicidal and apoptotic effects on hydatid cysts protoscolices.

Bagherivand A et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130515
PubMed:
38423424

Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling.

Summary

Rosemary extract compound carnosic acid inhibits non-small cell lung cancer (NSCLC) cell growth and induces apoptosis by activating the Sestrin-2/LKB1/AMPK pathway, promoting autophagy. Potential novel therapy for NSCLC.

Cancer
O'Neill EJ et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25041950
PubMed:
38396629

Antibacterial Potential of Essential Oils and Silver Nanoparticles against Multidrug-Resistant Staphylococcus pseudintermedius Isolates.

Meroni G et al (2024).
Pathogens.
DOI:
10.3390/pathogens13020156
PubMed:
38392894

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study.

Peno-Mazzarino L et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46020099
PubMed:
38392217

Abietane diterpenoids with anti-neuroinflammation activity from Rosmarinus officinalis.

Summary

Tossers identified new abietane diterpenoids in Rosemary, including rosmarinusin Q, showing anti-neuroinflammatory properties. Potential for neuroprotective agents against nerve damage from inflammation.

Neuroscience
Zhou T et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.105866
PubMed:
38378134

Extraction Optimization and Qualitative/Quantitative Determination of Bioactive Abietane-Type Diterpenes from Three Salvia Species (Common Sage, Greek Sage and Rosemary) by (1)H-qNMR.

Kallimanis P et al (2024).
Molecules.
DOI:
10.3390/molecules29030625
PubMed:
38338370

Rosemary: Unrevealing an old aromatic crop as a new source of promising functional food additive-A review.

Qiu K et al (2024).
Compr Rev Food Sci Food Saf.
DOI:
10.1111/1541-4337.13273
PubMed:
38284599

Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies.

Summary

Rosemary shows neuroprotective properties in studies, inhibiting cholinesterase and modulating dopamine and oxytocin systems. It has antidepressant and anxiolytic effects and may improve memory. More research, including placebo-controlled studies, is needed. Rosemary constituents could have potential as drugs for Alzheimer's disease.

Neuroscience
Oresanya IO and Orhan IE (2024).
Curr Drug Targets.
DOI:
10.2174/0113894501255093240117092328
PubMed:
38258779

Comparing the effects of rosemary aromatherapy and music therapy on anxiety levels in patients undergoing general surgery: A randomized controlled clinical trial.

Summary

Study compared inhalation aromatherapy using rosemary essential oil and music therapy in reducing anxiety levels of general surgery patients. Results may help in managing preoperative anxiety and improving patient outcomes.

Neuroscience
Sayadi Mank-Halati M et al (2024).
Explore (NY).
DOI:
10.1016/j.explore.2024.01.002
PubMed:
38242798

Rosemary as a Potential Source of Natural Antioxidants and Anticancer Agents: A Molecular Docking Study.

Summary

The compounds CA and RA have potent antioxidant properties and exhibit antitumor effects. CA induces cancer cell death and disrupts mitochondrial function, while RA induces apoptosis and inhibits cell proliferation. Molecular docking analyses suggest these compounds may interact with the cancer-associated protein S100A8.

Review Cancer
Bouammali H et al (2023).
Plants (Basel).
DOI:
10.3390/plants13010089
PubMed:
38202397

Biogenic zinc selenide nanoparticles fabricated using Rosmarinus officinalis leaf extract with potential biological activity.

Somaghian SA et al (2024).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04329-6
PubMed:
38178178

Scolicidal and apoptotic effects of phyto- and chemically synthesized silver/boehmite nanocomposites on Echinococcus granulosus protoscoleces.

Bagherivand A et al (2023).
Biomater Adv.
DOI:
10.1016/j.bioadv.2023.213723
PubMed:
38160631

Exploring the Potential of Rosemary Derived Compounds (Rosmarinic and Carnosic Acids) as Cancer Therapeutics: Current Knowledge and Future Perspectives.

Summary

RA and CA, compounds found in rosemary extract, have shown anti-cancer properties. They inhibit tumor growth and have potential for cancer treatment.

Review Cancer
Sirajudeen F et al (2024).
Biomol Ther (Seoul).
DOI:
10.4062/biomolther.2023.054
PubMed:
38148552

Dried Herbs as an Easy-to-Use and Cost-Effective Alternative to Essential Oils to Extend the Shelf Life of Sheep Lump Cheese.

Kunová S et al (2023).
Foods.
DOI:
10.3390/foods12244487
PubMed:
38137291

Anti-nutrient contents and methane reduction potential of medicinal plants from maize stover based diet.

Chalchissa G, Nurfeta A and Andualem D (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21630
PubMed:
38027602

Evaluation of dietary rosemary leaf powder on growth, carcass composition and hemato-biochemical profiles of common carp (Cyprinus carpio) reared in cage system.

S Omar S et al (2023).
Cell Mol Biol (Noisy-le-grand).
DOI:
10.14715/cmb/2023.69.11.21
PubMed:
38015529

Role of Nitric Oxide, TNF-α and Caspase-3 in Lead Acetate-Exposed Rats Pretreated with Aqueous Rosmarinus officinalis Leaf Extract.

Enogieru AB and Iyoha EN (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-023-03974-9
PubMed:
38012512

The Expression of Selected Cytokine Genes in the Livers of Young Castrated Bucks after Supplementation with a Mixture of Dry Curcuma longa and Rosmarinus officinalis Extracts.

GeneticsImmunology
Urbańska DM et al (2023).
Animals (Basel).
DOI:
10.3390/ani13223489
PubMed:
38003107

Chemical Composition of Rosemary (Rosmarinus officinalis L.) Extract and Its Inhibitory Effects on SARS-CoV-2 Spike Protein-ACE2 Interaction and ACE2 Activity and Free Radical Scavenging Capacities.

Summary

Rosemary water extract contains compounds that inhibit the interaction between the SARS-CoV-2 spike protein and ACE2, as well as reduce ACE2 activity. This suggests that rosemary may lower the risk of COVID-19 infection and development.

COVID-19
Yao Y et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c02301
PubMed:
37988686

Sustainable Pest Management Using Novel Nanoemulsions of Honeysuckle and Patchouli Essential Oils against the West Nile Virus Vector, Culex pipiens, under Laboratory and Field Conditions.

Hikal WM et al (2023).
Plants (Basel).
DOI:
10.3390/plants12213682
PubMed:
37960039

The Effect of Plasma-Activated Water Combined with Rosemary Extract (Rosmarinus officinalis L.) on the Physicochemical Properties of Frankfurter Sausage during Storage.

Phytochemistry
Zeraat Pisheh F et al (2023).
Foods.
DOI:
10.3390/foods12214022
PubMed:
37959142

Chemical composition and antioxidant activity of petroleum ether fraction of Rosmarinus officinalis.

Summary

In this study, the researchers analyzed the chemical composition and antioxidant activity of a petroleum ether fraction. They identified 82 chemical components and found that the fraction displayed good antioxidant activity. This information can be used for the development and utilization of the fraction.

Immunology
Shen X et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21316
PubMed:
37942163

Antibacterial Activity of Essential Oils Combinations based on Thymus broussonnetii, and Their Synergism with some Antibiotics.

Amassmoud O et al (2023).
Curr Microbiol.
DOI:
10.1007/s00284-023-03510-x
PubMed:
37910319

In Vitro Antioxidant and Antifungal Activities of Four Essential Oils and Their Major Compounds against Post-Harvest Fungi Associated with Chickpea in Storage.

Summary

This study evaluated the antifungal and antioxidant properties of essential oils derived from four plants. The EO with the highest antioxidant and antifungal activity was found to contain a high concentration of eugenol. Combining eugenol and carvacrol in a 1:3 ratio showed promising potential for grain protection during storage.

AntimicrobialImmunology
Et-Tazy L et al (2023).
Plants (Basel).
DOI:
10.3390/plants12203587
PubMed:
37896050

Effect of Supplementation with Curcuma longa and Rosmarinus officinalis Extract Mixture on Acute Phase Protein, Cathelicidin, Defensin and Cytolytic Protein Gene Expression in the Livers of Young Castrated Polish White Improved Bucks.

Genetics
Urbańska DM et al (2023).
Genes (Basel).
DOI:
10.3390/genes14101932
PubMed:
37895281

Plant Extracts as Skin Care and Therapeutic Agents.

Review
Michalak M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015444
PubMed:
37895122

Development of Essential Oil-Loaded Polymeric Nanocapsules as Skin Delivery Systems: Biophysical Parameters and Dermatokinetics Ex Vivo Evaluation.

Phytochemistry
Silva-Flores PG et al (2023).
Molecules.
DOI:
10.3390/molecules28207142
PubMed:
37894621

The JAK/STAT/NF-κB signaling pathway can be regulated by rosemary essential oil, thereby providing a potential treatment for DNCB-induced in mice.

Summary

This study explores how rosemary essential oil helps treat atopic dermatitis, offering insights for potential therapeutic applications in managing the condition.

ImmunologyPhytochemistry
Li J et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115727
PubMed:
37879216

Interaction of Rosmarinus officinalis L. with UV-A radiation by preserving its morphological traits and modifying its phenolic composition.

Summary

Exposing greenhouse plants to UV-A radiation changes their chlorophyll content and antioxidant activity, making it potentially beneficial for pharmaceutical industry use.

Phytochemistry
Rahimi-Rizi M et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2273921
PubMed:
37876221

Antifungal activity of volatile organic compounds from essential oils against the postharvest pathogens Botrytis cinerea, Monilinia fructicola, Monilinia fructigena, and Monilinia laxa.

Summary

Plant essential oils (EOs) were tested for their antifungal activity against gray mold and brown rot. Results showed that certain EOs inhibited the growth of the fungi, suggesting their potential use for controlling these diseases in fruit and vegetable storage.

Antimicrobial
Álvarez-García S, Moumni M and Romanazzi G (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1274770
PubMed:
37860258

Use of medicinal plants during COVID-19 pandemic in Brazil.

Summary

Study finds 40.2% of participants in a Brazilian city use medicinal plants, primarily for anxiety. Females, non-whites, and lower-educated with higher income and comorbidities were more likely to use. No reported use for treating COVID-19.

COVID-19
da Silva AM et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-43673-y
PubMed:
37783716

Optimisation of three essential oils against Salmonella spp. and Escherichia coli by mixture design.

Kachkoul R et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202301221
PubMed:
37783668

New selective and sustainable ultrasound-assisted extraction procedure to recover carnosic and rosmarinic acids from Rosmarinus officinalis by sequential use of bio-based solvents.

Pizani RS et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137540
PubMed:
37778266

Excito-repellent and Pesticide-Likeness Properties of Essential Oils on Carpophilus dimidiatus (Fabricius) (Nitidulidae) and Oryzaephilus mercator (L.) (Silvanidae).

Comelli NC et al (2023).
J Chem Inf Model.
DOI:
10.1021/acs.jcim.3c01198
PubMed:
37774492

Unravelling Effects of Rosemary (Rosmarinus officinalis L.) Extract on Hepatic Fat Accumulation and Plasma Lipid Profile in Rats Fed a High-Fat Western-Style Diet.

Madsen S et al (2023).
Metabolites.
DOI:
10.3390/metabo13090974
PubMed:
37755254

Biochemical typing and evaluation of pathogenicity in vulvovaginal isolates of Candida albicans complex.

Morales-López S et al (2023).
Biomedica.
DOI:
10.7705/biomedica.6861
PubMed:
37721915

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases.

Summary

Various bioactive metabolites found in herbs such as Rosmarinus officinalis and Punica granatum have shown impressive angiotensin converting enzyme (ACE) inhibitory activity. These natural ACE inhibitors could be a potential treatment for hypertension, respiratory distress syndrome, and chronic kidney diseases, but more clinical trials are needed.

Review Cardiology
Khaled A et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7987
PubMed:
37675925

Effect of rosemary (Rosmarinus officinalis) leaf meal supplementation on production performance and egg quality of laying hens.

Kedir S et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e19124
PubMed:
37649844

Efficiency of Recovery of the Bioactive Principles of Plants by Comparison between Solid-Liquid Extraction in Mixture and Single-Vegetable Matrices via Maceration and RSLDE.

Naviglio D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12162900
PubMed:
37631112

Phytochemical Constituents and Biological Activity of Wild and Cultivated Rosmarinus officinalis Hydroalcoholic Extracts.

Phytochemistry
Francolino R et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12081633
PubMed:
37627628

Evaluation of Marketed Rosemary Essential Oils (Rosmarinus officinalis L.) in Terms of European Pharmacopoeia 10.0 Criteria.

Barak TH, Bölükbaş E and Bardakcı H (2023).
Turk J Pharm Sci.
DOI:
10.4274/tjps.galenos.2022.78010
PubMed:
37606010

Eco-friendly management strategies of insect pests: long-term performance of rosemary essential oil encapsulated into chitosan and gum Arabic.

Summary

This study tested the effectiveness of encapsulating Rosmarinus officinalis essential oil to control insect pests in stored products. Encapsulation showed high efficiency and effectively killed pests during storage.

Phytochemistry
Soltani A et al (2023).
Int J Environ Health Res.
DOI:
10.1080/09603123.2023.2245775
PubMed:
37584334

Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia.

Li T et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116984
PubMed:
37532071

The Selective Separation of Carnosic Acid and Rosmarinic Acid by Solid-Phase Extraction and Liquid-Liquid Extraction: A Comparative Study.

Zhu C, Fan Y and Wu H (2023).
Molecules.
DOI:
10.3390/molecules28145493
PubMed:
37513364

Implications of the Cultivation of Rosemary and Thyme (Lamiaceae) in Plant Communities for the Development of Antioxidant Therapies.

Immunology
Luță EA et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241411670
PubMed:
37511428

Immunological and Histological Studies of Different Concentrations of Rosmarinus officinalis and Thymus vulgaris Extracts on Thymus Gland of Chick Embryos.

Alzahri RY, Al-Ghamdi FA and Al-Harbi SS (2023).
Toxics.
DOI:
10.3390/toxics11070625
PubMed:
37505590

Genkwanin: An emerging natural compound with multifaceted pharmacological effects.

Review
El Menyiy N et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115159
PubMed:
37481929

The impact of arbuscular mycorrhizal symbiosis, Funneliformis mosseae, on rosemary phytoremediation ability under urban traffic.

Alinejad Z et al (2023).
Int J Phytoremediation.
DOI:
10.1080/15226514.2023.2236729
PubMed:
37469110

Plectranthus amboinicus and rosemary (Rosmarinus officinalis L.) essential oils effects on performance, antioxidant activity, intestinal health, immune response, and plasma biochemistry in broiler chickens.

GastroenterologyImmunology
Hosseinzadeh S et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3380
PubMed:
37457190

Virtual screening of natural ligands from five resources to target Ralstonia solanacearum polygalacturonase and endoglucanase.

Etminani F and Barzegari E (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03683-z
PubMed:
37404365

Control of Listeria monocytogenes in a fresh cheese using aromatic and medicinal plants and enterocin: a comparative study.

Ananou S et al (2023).
Lett Appl Microbiol.
DOI:
10.1093/lambio/ovad076
PubMed:
37401169

Investigating the pollution of irrigated plants (Rosmarinus officinalis) with polluted water in different growth stages using spectrometer and K-means method.

Fard KG and Mokarram M (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-28217-1
PubMed:
37351746

Melatonin enhances biomass, phenolic accumulation, and bioactivities of rosemary (Rosmarinus officinalis) in vitro shoots under UV-B stress.

Phytochemistry
Zhao Z et al (2023).
Physiol Plant.
DOI:
10.1111/ppl.13956
PubMed:
37327069

Incorporation of fresh leaves of wormwood (Artemisia herba alba) and/or rosemary (Rosmarinus officinalis) in the diet of rams: Effect on testicular function, sexual behavior, and blood parameters.

Khnissi S et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3293
PubMed:
37324835

Reduction of oral pathogens and oxidative damage in the CAL 27 cell line by Rosmarinus officinalis L. and Taraxacum officinale Web. Extracts.

Huđek Turković A et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116761
PubMed:
37301304

Protection Function and Mechanism of Rosemary (Rosmarinus officinalis L.) Extract on the Thermal Oxidative Stability of Vegetable Oils.

Song X, Sui X and Jiang L (2023).
Foods.
DOI:
10.3390/foods12112177
PubMed:
37297422

Rosmarinus officinalis L. Essential Oils Impact on the Microbiological and Oxidative Stability of Sarshir (Kaymak).

Hashemi SMB, Gholamhosseinpour A and Barba FJ (2023).
Molecules.
DOI:
10.3390/molecules28104206
PubMed:
37241946

Spirulina platensis improves growth, oil content, and antioxidant activitiy of rosemary plant under cadmium and lead stress.

Immunology
Gharib FAEL and Ahmed EZ (2023).
Sci Rep.
DOI:
10.1038/s41598-023-35063-1
PubMed:
37198296

Investigating the Effect of Rosemary Essential Oil, Supercritical CO(2) Processing and Their Synergism on the Quality and Microbial Inactivation of Chicken Breast Meat.

Phytochemistry
Santi F et al (2023).
Foods.
DOI:
10.3390/foods12091786
PubMed:
37174324

A Green and Effective Polyethylene Glycols-Based Microwave-Assisted Extraction of Carnosic and Rosmarinic Acids from Rosmarinus officinalis Leaves.

Zhu C, Fan Y and Bai X (2023).
Foods.
DOI:
10.3390/foods12091761
PubMed:
37174298

The biochemical properties of Rosmarinus officinalis L. affected by irrigation water amount and quality.

Rigi Karvandri A et al (2023).
Environ Geochem Health.
DOI:
10.1007/s10653-023-01584-x
PubMed:
37145240

Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (M(pro)): a computational study.

Summary

Researchers seek alternative therapies for COVID-19, exploring the potential of targeting the main protease (M) to control viral replication and prevent infections, amid concerns over vaccine effectiveness.

COVID-19
Patel U et al (2023).
J Mol Model.
DOI:
10.1007/s00894-023-05569-6
PubMed:
37115321

Insight into the Antifungal Effects of Propolis and Carnosic Acid-Extension to the Pathogenic Yeast Candida glabrata: New Propolis Fractionation and Potential Synergistic Applications.

Antimicrobial
Argüelles A et al (2023).
J Fungi (Basel).
DOI:
10.3390/jof9040442
PubMed:
37108897

The Effect of Aromatic Plant Extracts Encapsulated in Alginate on the Bioactivity, Textural Characteristics and Shelf Life of Yogurt.

Popescu L et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12040893
PubMed:
37107268

Effective Improvement of the Oxidative Stability of Acer truncatum Bunge Seed Oil, a New Woody Oil Food Resource, by Rosemary Extract.

Qi Y et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12040889
PubMed:
37107264

Anti-inflammatory activity of essential oils from Tunisian aromatic and medicinal plants and their major constituents in THP-1 macrophages.

Immunology
Pereira RB et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112678
PubMed:
37087210

Rosmarinus officinalis essential oils' eradication of beta-lactamase and multidrug resistant clinical bacterial pathogens from hospital settings.

Guellouma FZ et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2201884
PubMed:
37074231

Enhanced Bioactivity of Rosemary, Sage, Lavender, and Chamomile Essential Oils by Fractionation, Combination, and Emulsification.

Karaca N et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.2c07508
PubMed:
37008100

In silico and in vitro elastase inhibition assessment assays of rosmarinic acid natural product from Rosmarinus officinalis Linn.

Jesus EG et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2196077
PubMed:
37004998

Priming crop plants with rosemary (Salvia rosmarinus Spenn, syn Rosmarinus officinalis L.) extract triggers protective defense response against pathogens.

Martin AP et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107644
PubMed:
36996636

Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition.

Summary

Peppermint and rosemary oils were shown to have nootropic and anti-amnesic effects in rats with scopolamine-induced amnesia-like Alzheimer's disease (AD). The oils were orally administered to rats, and in the nootropic phase, both oils showed a decrease in latency times and memory errors. In the therapeutic phase, the oils enhanced memory processing. The hippocampus exhibited elevated BDNF levels, and immunohistochemistry findings showed increased hippocampal neurogenesis. Gas chromatography-mass spectrometry analysis of the oils revealed compounds with potential efficacy in memory and cognition. The combination of the two oils produced more anti-amnesic activity and had possible therapeutic activity for memory enhancement in AD patients.

Neuroscience
Al-Tawarah NM et al (2023).
Nutrients.
DOI:
10.3390/nu15061547
PubMed:
36986277

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases.

Review Immunology
Li Pomi F et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12030680
PubMed:
36978928

Rosemary (Rosmarinus officinalis L.) Glycolic Extract Protects Liver Mitochondria from Oxidative Damage and Prevents Acetaminophen-Induced Hepatotoxicity.

Guimarães NSS et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12030628
PubMed:
36978874

System network analysis of Rosmarinus officinalis transcriptome and metabolome-Key genes in biosynthesis of secondary metabolites.

Genetics
Moghadam A et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0282316
PubMed:
36862714

Impact of the Extraction Method on the Chemical Composition and Antioxidant Potency of Rosmarinus officinalis L. Extracts.

Dhouibi N et al (2023).
Metabolites.
DOI:
10.3390/metabo13020290
PubMed:
36837909

Encapsulation of Rosmarinus officinalis essential oil and of its main components in cyclodextrin: Application to the control of the date moth Ectomyelois ceratoniae (Pyralidae).

Phytochemistry
Ben Abada M et al (2023).
Pest Manag Sci.
DOI:
10.1002/ps.7418
PubMed:
36811278

Effect of the Addition of Selected Herbal Extracts on the Quality Characteristics of Flavored Cream and Butter.

Ziarno M et al (2023).
Foods.
DOI:
10.3390/foods12030471
PubMed:
36765999

Involvement of the NO/cGMP/K ATP pathway in the antinociceptive effect of rosemary ( Rosmarinus officinalis ) essential oil in mice.

Summary

Rosemary essential oil was tested for its pain-relieving properties in mice. The study found that the antinociceptive effect of the oil may be mediated through the NO/cGMP/K ATP pathway.

PainPhytochemistry
Hajhashemi V, Salimian M and Hajihashemi O (2023).
Behav Pharmacol.
DOI:
10.1097/FBP.0000000000000709
PubMed:
36730811

The effect of irrigation with treated and untreated wastewater on the yield and chemical composition of essential oil of Mentha spicata L. and Rosmarinus officinalis L.

Phytochemistry
Asadzadeh M, Ghavam M and Mirzaei R (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25398-7
PubMed:
36715796

Anticandidal effect of Eucalyptus oil and three isolated compounds on cutaneous wound healing in rats.

El-Sakhawy MA et al (2023).
Eur Rev Med Pharmacol Sci.
DOI:
10.26355/eurrev_202301_30850
PubMed:
36647849

Green synthesis of spermine coated iron nanoparticles and its effect on biochemical properties of Rosmarinus officinalis.

Afrouz M et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-27844-5
PubMed:
36641537

Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer's rat model.

Summary

A study tested the effects of extracts from Rosemary and Saffron, given individually and combined, on Alzheimer's neuroinflammation in rats. The rats were given extracts over 15 days and then tested for cognitive impairment, amyloid neuroproteins, oxidative stress, and other markers. The extracts showed significant improvement in all parameters compared to the control group and a better morphological appearance in the cortex and hippocampus. Computational analysis found the extracts may impede the activity of proteins regulating disease progression, suggesting these extracts could help treat Alzeheimer's.

Neuroscience
Hassan M et al (2023).
Biomarkers.
DOI:
10.1080/1354750X.2022.2164617
PubMed:
36594248

Stable C and N isotope variation during anaerobic digestate composting and in the compost-amended soil-plant system.

Nogués I et al (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2022.117063
PubMed:
36584515

Carnosic acid suppressed the formation of NETs in alcoholic hepatosteatosis based on P2X7R-NLRP3 axis.

Zuo RM et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154599
PubMed:
36577209

SnO(2) and CuO anchored on zeolite as an efficient heterojunction photocatalyst for sunlight-assisted degradation of cefixime.

Khoshdel K, Honarmand M and Hassani H (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-24635-9
PubMed:
36564689

Resistance profile and biofilm production capacity of Staphylococcus spp. beef slaughterhouse isolates and their sensitivity to Rosmarinus officinalis essential oil.

Phytochemistry
Bezerra K et al (2023).
Vet Res Commun.
DOI:
10.1007/s11259-022-10057-y
PubMed:
36547797

Investigation on the molecular, electronic and spectroscopic properties of rosmarinic acid: an intuition from an experimental and computational perspective.

Eno EA et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2154841
PubMed:
36546691

Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP.

Summary

Researchers evaluated the potential neuroprotective effects of rosmarinic acid (RA) in a murine model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). RA was found to prevent hyperlocomotion behavior in MPTP-treated animals and improve the monoaminergic system in healthy animals. RA also increased dopaminergic signaling in the parkinsonian mice, indicating potential neuroprotective properties for RA in preventing behavioral features observed in PD and improving neurotransmission in the healthy brain.

Neuroscience
Presti-Silva SM et al (2023).
Behav Brain Res.
DOI:
10.1016/j.bbr.2022.114257
PubMed:
36526017

Fumigant toxicity of four essential oils against the carob moth Ectomyelois ceratoniae Zeller and the Mediterranean flour moth Ephestia kuehniella.

Phytochemistry
Chaaban SB et al (2022).
Int J Environ Health Res.
DOI:
10.1080/09603123.2022.2152431
PubMed:
36463575

Ethyl lauroyl arginate-based hydrophobic ion pair complex in lipid nanocapsules: A novel oral delivery approach of rosmarinic acid for enhanced permeability and bioavailability.

Gad HA et al (2023).
Int J Pharm.
DOI:
10.1016/j.ijpharm.2022.122388
PubMed:
36375682

Chemical characterization and evaluation of acaricidal potential of rosemary essential oil and its main compound α-pinene on the two-spotted spider mite, Tetranychus urticae.

Phytochemistry
Lopes RP et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2137799
PubMed:
36287579

Photo-catalytic and biomedical applications of one-step, plant extract-mediated green-synthesized cobalt oxide nanoparticles.

Sani A et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-23645-x
PubMed:
36255577

Insights for the control of dried-fruit beetle Carpophilus hemipterus (Nitidulidae) using rosemary essential oil loaded in chitosan nanoparticles.

Phytochemistry
Soltani A et al (2023).
Int J Environ Health Res.
DOI:
10.1080/09603123.2022.2083089
PubMed:
35652908

Biotransformation of eugenol by an endophytic fungus Daldinia sp. IIIMF4010 isolated from Rosmarinus officinalis.

Lone BA et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2066101
PubMed:
35468012

Hydrosols from Rosmarinus officinalis, Salvia officinalis, and Cupressus sempervirens: Phytochemical Analysis and Bioactivity Evaluation.

Phytochemistry
Politi M et al (2022).
Plants (Basel).
DOI:
10.3390/plants11030349
PubMed:
35161330

Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders.

Summary

Rosemary is an evergreen shrub used in folk medicine to treat various conditions. Studies highlight that it has significant neuropharmacological properties, including antimicrobial, anti-inflammatory, anti-oxidant, and neuroprotective effects. It also shows clinical benefits for mood, memory, pain, anxiety, and sleep. The aim of this review is to evaluate the preclinical potential of rosemary extracts and its active constituents on nervous system disorders. The study includes various sources from PubMed, Scopus, Google Scholar, and Web of Science without any time limitation. The review finds rosemary as a potential source for inflammation, analgesic, anti-anxiety, and memory-boosting therapeutics. The study recommends further research on isolated constituents such as carnosic acid, rosmarinic acid, and essential oil to help people with nervous system disorders.

Review Neuroscience
Ghasemzadeh Rahbardar M and Hosseinzadeh H (2020).
Iran J Basic Med Sci.
DOI:
10.22038/ijbms.2020.45269.10541
PubMed:
32963731

Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review.

Review
de Macedo LM et al (2020).
Plants (Basel).
DOI:
10.3390/plants9050651
PubMed:
32455585

Investigation of rosemary herbal extracts (Rosmarinus officinalis) and their potential effects on immunity.

Review
Ahmed HM and Babakir-Mina M (2020).
Phytother Res.
DOI:
10.1002/ptr.6648
PubMed:
32086980

Hypolipidemic effects of Rosmarinus officinalis L.

Review
Farkhondeh T, Samarghandian S and Pourbagher-Shahri AM (2019).
J Cell Physiol.
DOI:
10.1002/jcp.28221
PubMed:
30693502

Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent.

Review
de Oliveira JR, Camargo SEA and de Oliveira LD (2019).
J Biomed Sci.
DOI:
10.1186/s12929-019-0499-8
PubMed:
30621719

Promotion of hair growth by Rosmarinus officinalis leaf extract.

Murata K et al (2013).
Phytother Res.
DOI:
10.1002/ptr.4712
PubMed:
22517595