Rubia cordifolia

Ethnobotanical Studies

Studies

Cytotoxic and Antitumor Agents from Genus Rubia.

Summary

Rubia species in traditional Chinese medicine have cytotoxic and antitumor effects, containing specific antitumor agents. Review focuses on 71 chemical substances in Genus Rubia with structures and mechanisms of action.

Cancer
Xu G et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202401498
PubMed:
39183172

Phytochemicals-based investigation of Rubia cordifolia pharmacological potential against letrozole-induced polycystic ovarian syndrome in female adult rats: In vitro, in vivo and mechanistic approach.

Summary

Study formulated and tested a plant-based extract in PCOS-induced rats. Extract improved ovulation, hormone levels, liver function, and inflammation in ovaries. Potential treatment for PCOS.

Endocrinology
Zhang J et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e34298
PubMed:
39108850

Towards environmentally-friendly solutions for real textile-dyeing wastewater with energy recovery: Effluent recirculation and Rubia plant-derived purpurin electron mediator in microbial fuel cell.

Tan SM et al (2024).
J Environ Manage.
DOI:
10.1016/j.jenvman.2024.121905
PubMed:
39067334

Effects of geographical, soil and climatic factors on the two marker secondary metabolites contents in the roots of Rubia cordifolia L.

Wang Y et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1419392
PubMed:
38919816

The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence.

Immunology
Qian YW et al (2024).
Life Sci.
DOI:
10.1016/j.lfs.2024.122862
PubMed:
38917872

Formulation of Phytosomes Containing Rubia cordifolia Extract for Neuropathic Pain: In Vitro and In Vivo Evaluation.

Summary

Researchers developed a phytosome delivery system for a plant extract with strong antioxidant properties. Formulation improved bioavailability of key compound, leading to increased neuroprotective effects and pain relief potential in nerve damage. Encapsulation may enhance treatment for neuropathic pain.

Pain
Kumar N et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.4c03774
PubMed:
38882167

First Report of Anthracnose on Wurfbainia villosa var. villosa Caused by Colletotrichum gloeosporioides in China.

Deng Q et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-04-24-0717-PDN
PubMed:
38764344

Isolation of anthraquinone derivatives from Rubia cordifolia (Rubiaceae) and their bioactivities against plant pathogenic microorganisms.

Wang W et al (2024).
Pest Manag Sci.
DOI:
10.1002/ps.8177
PubMed:
38747671

[Syntheses and Structure-Activity Relationship Studies of Antitumor Bicyclic Hexapeptide RA-VII Analogues].

Summary

Scientists synthesized modified analogues of RA-VII peptides from Rubia cordifolia roots, testing them against various cancer cell lines. They found that certain modifications were crucial for potent cytotoxic activity, highlighting potential new treatment strategies.

Review Cancer
Hitotsuyanagi Y et al (2024).
Yakugaku Zasshi.
DOI:
10.1248/yakushi.23-00208
PubMed:
38692932

A Prenyltransferase Participates in the Biosynthesis of Anthraquinones in Rubia cordifolia.

Liu C et al (2024).
Plant Physiol.
DOI:
10.1093/plphys/kiae171
PubMed:
38502063

Fungal, but not bacterial, diversity and network complexity promote network stability during roadside slope restoration.

Wang M et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.171007
PubMed:
38401731

Sustained silencing peanut allergy by xanthopurpurin is associated with suppression of peripheral and bone marrow IgE-producing B cell.

Yang N et al (2024).
Front Immunol.
DOI:
10.3389/fimmu.2024.1299484
PubMed:
38380329

Mollugin prevents CLP-induced sepsis in mice by inhibiting TAK1-NF-κB/MAPKs pathways and activating Keap1-Nrf2 pathway in macrophages.

Immunology
Liu X et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.111079
PubMed:
38149576

The Theoretical and Experimental Insights into the Radical Scavenging Activity of Rubiadin.

Hieu LT et al (2023).
J Phys Chem B.
DOI:
10.1021/acs.jpcb.3c06366
PubMed:
38103025

Rubia cordifolia L. Attenuates Diabetic Neuropathy by Inhibiting Apoptosis and Oxidative Stress in Rats.

Summary

The study investigated the impact of L. (L.) roots in diabetic neuropathy using a rat model. It examined potential neuroprotective, antidiabetic, and analgesic mechanisms. This research is relevant for understanding diabetic neuropathy treatment options.

DiabetesImmunology
Bana S et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16111586
PubMed:
38004451

YIV-818-A: a novel therapeutic agent in prostate cancer management through androgen receptor downregulation, glucocorticoid receptor inhibition, epigenetic regulation, and enhancement of apalutamide, darolutamide, and enzalutamide efficacy.

Summary

YIV-818-A, a botanical drug derived from Rubia cordifolia extracts, effectively inhibits castration-resistant prostate cancer (CRPC) and shows synergy with existing drugs. It has potential as an anti-prostate cancer drug with chemopreventive properties.

CancerEndocrinology
Lam W et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1244655
PubMed:
37860121

Changes in marker secondary metabolites revealed the medicinal parts, harvest time, and possible synthetic sites of Rubia cordifolia L.

Wang Y et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108024
PubMed:
37699290

Mollugin suppresses proliferation and drives ferroptosis of colorectal cancer cells through inhibition of insulin-like growth factor 2 mRNA binding protein 3/glutathione peroxidase 4 axis.

Summary

Mollugin, a compound from Rubia cordifolia, induces ferroptosis in colorectal cancer (CRC) cells by reducing GSH and increasing ROS, Fe, and MDA levels. Inhibition of ferroptosis reverses the antitumor effects of mollugin. High expression of IGF2BP3 in CRC suggests poor prognosis. Mollugin may be a promising CRC therapy by targeting the IGF2BP3/GPX4 axis.

CancerGastroenterologyGenetics
Wang W et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115427
PubMed:
37677963

On the Role of ROS and Glutathione in the Mode of Action Underlying Nrf2 Activation by the Hydroxyanthraquinone Purpurin.

Ren Q et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12081544
PubMed:
37627539

Auxin-dependent regulation of growth via rolB-induced modulation of the ROS metabolism in the long-term cultivated pRiA4-transformed Rubiacordifolia L. calli.

Veremeichik GN et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107932
PubMed:
37557016

Analysis of active components and molecular mechanism of action of Rubia cordifolia L. in the treatment of nasopharyngeal carcinoma based on network pharmacology and experimental verification.

Yang X et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e17078
PubMed:
37484327

TLC-MS-Bioautographic identification of antityrosinase compounds and preparation of a topical gel formulation from bioactive fraction of RSM optimized alcoholic extract of Rubia cordifolia L. stem.

Insaf A et al (2023).
J AOAC Int.
DOI:
10.1093/jaoacint/qsad076
PubMed:
37471690

Induction of Nrf2-EpRE-mediated gene expression by hydroxyanthraquinones present in extracts from traditional Chinese medicine and herbs.

Genetics
Ren Q et al (2023).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2023.113802
PubMed:
37116774

Chemical constituents from the aerial parts of Rubia cordifolia L. with their NO inhibitory activity.

Zhang H et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2192491
PubMed:
36971058

Madder (Rubia cordifolia L.) Alleviates Myocardial Ischemia-Reperfusion Injury by Protecting Endothelial Cells from Apoptosis and Inflammation.

CardiologyImmunology
Gao J, Wang Z and Ye Z (2023).
Mediators Inflamm.
DOI:
10.1155/2023/5015039
PubMed:
36875688

The Underling Mechanisms Exploration of Rubia cordifolia L. Extract Against Rheumatoid Arthritis by Integrating Network Pharmacology and Metabolomics.

Arthritis
Zeng W et al (2023).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S388932
PubMed:
36818604

Anthraquinone Production from Cell and Organ Cultures of Rubia Species: An Overview.

Review
Murthy HN et al (2022).
Metabolites.
DOI:
10.3390/metabo13010039
PubMed:
36676964

Research Note: Effect of Rubia cordifolia L. processed Terminalia chebula Retz polysaccharide on the histological structure and apoptosis in the spleen in immunosuppressed Chinese yellow quail.

He M et al (2023).
Poult Sci.
DOI:
10.1016/j.psj.2022.102416
PubMed:
36566656

Biodegradable Sodium Alginate/Carrageenan/Cellulose Composite Hydrogel Wound Dressings Containing Herbal Extracts for Promoting Blood Coagulation and Wound Healing.

Li Z et al (2023).
Macromol Biosci.
DOI:
10.1002/mabi.202200235
PubMed:
36239160

A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications.

Review Phytochemistry
Wen M et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.965390
PubMed:
36160419

Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression.

Hussain Y et al (2022).
Life Sci.
DOI:
10.1016/j.lfs.2022.120964
PubMed:
36115584

Rubia cordifolia L. ameliorates DSS-induced ulcerative colitis in mice through dual inhibition of NLRP3 inflammasome and IL-6/JAK2/STAT3 pathways.

Immunology
Qin W et al (2022).
Heliyon.
DOI:
10.1016/j.heliyon.2022.e10314
PubMed:
36082330

SERS detection of anthraquinone dyes: Using solvothermal silver colloid as the substrate.

Zhu J et al (2022).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2022.121646
PubMed:
35926284

Protective activity of purpurin against d-galactosamine and lipopolysaccharide-induced hepatorenal injury by upregulation of heme oxygenase-1 in the RBC degradation cycle.

Rakshit S et al (2022).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23168
PubMed:
35838105

Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract.

Chandraker SK et al (2022).
Sci Rep.
DOI:
10.1038/s41598-022-12878-y
PubMed:
35614187

Biosynthesis of copper oxide nanoparticles using Rubia cordifolia bark extract: characterization, antibacterial, antioxidant, larvicidal and photocatalytic activities.

Immunology
Vinothkanna A et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-18996-4
PubMed:
35175521