Ruta graveolens

Common Names: common rue

Ethnobotanical Studies

Central Europe

DOI:: 10.3390/plants12010135
PubMed:: 36616265

Viesca and Parras Coahuila, northeast Mexico

Uses: Gastro-intestinal system diseases, Obstetrics, Gynecology, and Urinary tract Diseases, Central nervous system diseases, Skin, Eye, Ear, Nose, and Oropharynx Diseases

DOI:: 10.1016/j.jsps.2022.11.003
PubMed:: 36685306

Huacareta, Chuquisaca, Bolivia

Uses: Neck pain, ear pain

DOI:: 10.1186/1746-4269-8-29
PubMed:: 22856877

Ecuador

Uses: To treat headaches, bad air c, fainting during childbirth, gastrointestinal and neurological problems; pain relief (joints, head, throat).

DOI:: 10.3390/plants11121590
PubMed:: 35736741

Javadhu Hills, Tiruvannamalai district, Tamil Nadu, India

Uses: Mosquito repellent

DOI:: 10.1016/j.heliyon.2023.e15607
PubMed:: 37305490

Studies

An Evaluation of Sex-Specific Pharmacokinetics and Bioavailability of Kokusaginine: An In Vitro and In Vivo Investigation.

Shang K et al (2024).; Pharmaceuticals (Basel).
DOI:: 10.3390/ph17081053
PubMed:: 39204158

New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants.

Review

Grosu Dumitrescu C et al (2024).; Life (Basel).
DOI:: 10.3390/life14081019
PubMed:: 39202761

Antifungal Mechanism of Ruta graveolens Essential Oil: A Colombian Traditional Alternative against Anthracnose Caused by Colletotrichum gloeosporioides.

Summary

Study showed essential oil of (REO) affects hyphal morphology, fatty acid profile, fungal metabolism, and triggers apoptosis in . Potential as antifungal surface disinfectant and fungicide replacement for anthracnose control postharvest.

Antimicrobial Phytochemistry

Peralta-Ruiz Y et al (2024).; Molecules.
DOI:: 10.3390/molecules29153516
PubMed:: 39124920

Rutin reduces inflammation and fibrosis via TGF-β/SMAD pathways in IgA nephropathy induced rats.

Immunology

Jash R et al (2024).; Nephrology (Carlton).
DOI:: 10.1111/nep.14378
PubMed:: 39113164

Graveoline attenuates D-GalN/LPS-induced acute liver injury via inhibition of JAK1/STAT3 signaling pathway.

Immunology

He J et al (2024).; Biomed Pharmacother.
DOI:: 10.1016/j.biopha.2024.117163
PubMed:: 39018876

Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway.

Wang Y et al (2024).; Biomed Pharmacother.
DOI:: 10.1016/j.biopha.2024.116695
PubMed:: 38713950

Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation.

Summary

Study finds extract with anti-asthmatic effects, reducing symptoms and improving lung function in rats. Extract shows antioxidant, anti-inflammatory activities and induces autophagy while inhibiting apoptosis. Could be developed as anti-allergic asthma drug.

Asthma Immunology

Alyami MH et al (2024).; Saudi Pharm J.
DOI:: 10.1016/j.jsps.2024.101968
PubMed:: 38352238

Antifungal Activity of Rue Essential Oil and Commercial Chitosan on Native Corn Foliar Diseases.

Summary

Researchers studied the incidence of fungal diseases in native corn in Cherán, Mexico. They found that rue essential oil inhibited 100% of the mycelial growth of the fungi, while chitosan inhibited 89-90%. The main compound in rue essential oil was 2-(3-phenylprop-2-enoyl)chromen-4-one.

Antimicrobial Phytochemistry

Ceja-Torres LF et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12193416
PubMed:: 37836155

Ruta graveolens: Boost Melanogenic Effects and Protection against Oxidative Damage in Melanocytes.

Ainiwaer P et al (2023).; Antioxidants (Basel).
DOI:: 10.3390/antiox12081580
PubMed:: 37627575

10.

THE EFFECT OF RUTA GRAVEOLENS L. ETHANOLIC EXTRACTS ON SKIN ISOLATES OF STAPHYLOCOCCI AND PROPIONIBACTERIUM ACNES.

Dermatology

Makevych N, Kutsyk R and Kurovets L (2023).; Wiad Lek.
DOI:: 10.36740/WLek202307119
PubMed:: 37622509

11.

(+)-/(-)-Rutabenzofuran a and (+)-/(-)- Rutabenzofuran b: Two unprecedented pairs of Z/E isomeric benzofuran enantiomers from the aerial part of Ruta graveolens L.

Liu Y et al (2023).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2023.113677
PubMed:: 37059286

12.

Spectrum-effect relationship between UPLC fingerprints and melanogenic effect of Ruta graveolens L.

Wubuli A et al (2023).; J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:: 10.1016/j.jchromb.2023.123683
PubMed:: 36965451

13.

Parasiticides: Weapons for Controlling Microbial Vector-Borne Diseases in Veterinary Medicine; The Potential of Ethnobotanic/Phytoparasiticides: An Asset to One Health.

Review Ethnobotany

Carvalho da Silva R et al (2023).; Antibiotics (Basel).
DOI:: 10.3390/antibiotics12020341
PubMed:: 36830252

14.

Chemical composition, antioxidant, and antimicrobial activities of six commercial essential oils.

Antimicrobial Phytochemistry

Coimbra A et al (2023).; Lett Appl Microbiol.
DOI:: 10.1093/lambio/ovac042
PubMed:: 36688786

15.

The Influence of Exogenous Phenylalanine on the Accumulation of Secondary Metabolites in Agitated Shoot Cultures of Ruta graveolens L.

Szewczyk A, Paździora W and Ekiert H (2023).; Molecules.
DOI:: 10.3390/molecules28020727
PubMed:: 36677781

16.

Quantitative assessment of antioxidant potential of selected homeopathic preparations in clinical practice.

Kumar A et al (2022).; Drug Metab Pers Ther.
DOI:: 10.1515/dmpt-2022-0169
PubMed:: 36577508

17.

Effect of Ruta graveolens Extract on the Major Virulence Factors in Methicillin Resistant Staphylococcus aureus.

Rezk S et al (2022).; Infect Drug Resist.
DOI:: 10.2147/IDR.S393912
PubMed:: 36510590

18.

Dynamized ultra-low dilution of Ruta graveolens disrupts plasma membrane organization and decreases migration of melanoma cancer cell.

Cancer

Fuselier C et al (2023).; Cell Adh Migr.
DOI:: 10.1080/19336918.2022.2154732
PubMed:: 36503402

19.

Chemical Composition and Antifungal Activity of Zanthoxylum armatum Fruit Essential Oil against Phytophthora capsici.

Antimicrobial Phytochemistry

Yang J et al (2022).; Molecules.
DOI:: 10.3390/molecules27238636
PubMed:: 36500729

20.

Exploring Contact Toxicity of Essential Oils against Sitophilus zeamais through a Meta-Analysis Approach.

Review Phytochemistry

Achimón F et al (2022).; Plants (Basel).
DOI:: 10.3390/plants11223070
PubMed:: 36432799

21.

Cinnamomum verum J. Presl. Bark essential oil: in vitro investigation of anti-cholinesterase, anti-BACE1, and neuroprotective activity.

Summary

Six plant essential oils commonly used in Iranian Traditional Medicine for memory improvement were tested for their ability to inhibit cholinesterase, an enzyme whose inhibition is a key target in the treatment of Alzheimer's disease. The plants tested were cinnamon, myrtle, rue, dill, nutmeg, and saffron. These findings may support the continued use of these natural remedies for memory improvement and suggest the potential of using these plants for developing drugs to treat AD.

Neuroscience Phytochemistry

Saeedi M et al (2022).; BMC Complement Med Ther.
DOI:: 10.1186/s12906-022-03767-y
PubMed:: 36401242

22.

A high-resolution accurate mass approach to identification of graveoline metabolites using ultra-high-performance liquid chromatography combined with a photo diode array detector and quadrupole/time-of-flight tandem mass spectrometry.

Phytochemistry

Liu H, Guo S and Xi S (2023).; Biomed Chromatogr.
DOI:: 10.1002/bmc.5511
PubMed:: 36100977

23.

In Vivo Therapeutic Effect of Some Medicinal Plants' Methanolic Extracts on the Growth and Development of Secondary Hydatid Cyst Infection.

Al Qaisi YT et al (2022).; Acta Parasitol.
DOI:: 10.1007/s11686-022-00605-6
PubMed:: 35960491

24.

Ruta graveolens, Peganum harmala, and Citrullus colocynthis methanolic extracts have in vitro protoscolocidal effects and act against bacteria isolated from echinococcal hydatid cyst fluid.

Al Qaisi YT et al (2022).; Arch Microbiol.
DOI:: 10.1007/s00203-022-02844-7
PubMed:: 35353289

25.

Phytochemical Characterization, and Antioxidant and Antimicrobial Properties of Agitated Cultures of Three Rue Species: Ruta chalepensis, Ruta corsica, and Ruta graveolens.

Antimicrobial Phytochemistry

Szewczyk A et al (2022).; Antioxidants (Basel).
DOI:: 10.3390/antiox11030592
PubMed:: 35326242

26.

Chemical constituents of Ruta graveolens L. and their melanogenic effects and action mechanism.

Ainiwaer P et al (2022).; Fitoterapia.
DOI:: 10.1016/j.fitote.2021.105094
PubMed:: 34861325

27.

Ruta Essential Oils: Composition and Bioactivities.

Review Phytochemistry

Nahar L et al (2021).; Molecules.
DOI:: 10.3390/molecules26164766
PubMed:: 34443352

28.

Ruta graveolens phytophotodermatitis.

Dermatology

Avallone G et al (2021).; Dermatol Online J.
DOI:: 10.5070/D327754382
PubMed:: 34391344

29.

Is it safe to consume traditional medicinal plants during pregnancy?

Review

Bernstein N et al (2021).; Phytother Res.
DOI:: 10.1002/ptr.6935
PubMed:: 33164294

30.

Ruta graveolens as a potential source of neuroactive compounds to promote and restore neural functions.

Review

Colucci-D'Amato L and Cimaglia G (2020).; J Tradit Complement Med.
DOI:: 10.1016/j.jtcme.2020.05.002
PubMed:: 32670826

31.

HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis.

Genetics

Gentile MT et al (2019).; J Vis Exp.
DOI:: 10.3791/58591
PubMed:: 31282895

32.

Ruta Graveolens intoxication.

Seak CJ and Lin CC (2007).; Clin Toxicol (Phila).
PubMed:: 17364636