Salvia

Common Names: sage

Ethnobotanical Studies

Studies

Long-Term Seizure Outcome With or Without Vagal Nerve Stimulation Therapy.

Summary

Researchers compared seizure control in patients with long-term VNS stimulation vs. those who stopped after >3 years. VNS-on had better long-term seizure control, important for treatment decisions.

Neuroscience
Gill S et al (2024).
Neurol Clin Pract.
DOI:
10.1212/CPJ.0000000000200358
PubMed:
39185099

Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization.

Yang J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118697
PubMed:
39154669

Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway.

Summary

JXK, a traditional Chinese herbal formula, effectively treats chronic heart failure (CHF) with seven medicinal herbs. While its clinical efficacy is proven, the specific mechanisms remain unknown. Further research is needed for potential cardiac treatment advancements.

Cardiology
Lin L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118685
PubMed:
39127116

TFEB activator tanshinone IIA and derivatives derived from Salvia miltiorrhiza Bge. Attenuate hepatic steatosis and insulin resistance.

Zheng L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118662
PubMed:
39117022

Characterization of pectin-zein nanoparticles encapsulating tanshinone: Antioxidant activity, controlled release properties, physicochemical stability to environmental stresses.

ImmunologyPhytochemistry
Elmizadeh A, Goli SAH and Mohammadifar MA (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140613
PubMed:
39067391

Novel peptides derived from S. hispanica seeds induce selective cytotoxicity on human cancer cells.

Cancer
Quintal Bojórquez NDC and Segura Campos MR (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140470
PubMed:
39032303

Exploring the mechanism of luteolin improving immune and inflammatory responses in systemic sclerosis based on systems biology and cell experiments.

Immunology
Ding X et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112587
PubMed:
38972211

Apigenin inhibits proliferation and differentiation of cardiac fibroblasts through AKT/GSK3β signaling pathway.

Summary

Researchers studied how Salvia miltiorrhiza can help with heart and brain diseases. They used advanced techniques to understand how it combats cardiac fibrosis. Important for potential new treatments.

Cardiology
Kan H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118518
PubMed:
38964628

Combination of legume proteins and arabinoxylans are efficient emulsifiers to promote vitamin E bioaccessibility during digestion.

Bravo-Núñez Á et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139820
PubMed:
38917656

Speciation, phytoavailability, and accumulation of toxic elements and sulfur by humic acid-fertilized lemongrass and common sage in a sandy soil treated with heavy oil fly ash: A trial for management of power stations wastes.

Al-Solaimani SG et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.173998
PubMed:
38901575

Genomic analysis of PIN-FORMED genes reveals the roles of SmPIN3 in root architecture development in Salvia miltiorrhiza.

Genetics
Zheng Y et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108827
PubMed:
38875779

Influence of oleogel composition on lipid digestibility and β-carotene bioaccessibility during in vitro digestion.

Ramezani M, Martín-Belloso O and Salvia-Trujillo L (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139978
PubMed:
38870810

Danshensu reduces neuronal excitability by enhancing potassium currents in bushy cells in the mouse cochlear nucleus.

Summary

Danshensu from Danshen herb decreases neuronal excitability in mouse brainstem by enhancing voltage-gated K+ currents, supporting its neuroprotective effects. Dose-dependent response with potential therapeutic applications.

Neuroscience
Xu M et al (2024).
Neuroreport.
DOI:
10.1097/WNR.0000000000002047
PubMed:
38813908

Danshen injection mitigated the cerebral ischemia/reperfusion injury by suppressing neuroinflammation via the HIF-1α/CXCR4/NF-κB signaling pathway.

Summary

Danshen injection (DI) treats cardiovascular and brain diseases, improves neurological scores and reduces inflammation and oxidative stress. DI targets HIF-1α to suppress neuroinflammation and reduce ischemia/reperfusion injury.

CardiologyImmunologyNeuroscience
Chen G et al (2024).
Neuroreport.
DOI:
10.1097/WNR.0000000000002043
PubMed:
38813902

Crosstalk between H(2)O(2) and Ca(2+) signaling is involved in root endophyte-enhanced tanshinone biosynthesis of Salvia miltiorrhiza.

Lu WL et al (2024).
Microbiol Res.
DOI:
10.1016/j.micres.2024.127740
PubMed:
38795408

Astrocyte modulation in cerebral ischemia-reperfusion injury: A promising therapeutic strategy.

Summary

82 drugs targeting astrocytes show promise for treating cerebral ischemia-reperfusion injury, with potential to reduce inflammation, oxidative stress, edema, and more. Traditional Chinese medicines like Salvia miltiorrhiza, Ginkgo, and Ginseng are particularly promising.

Review CardiologyNeuroscience
Wang Z et al (2024).
Exp Neurol.
DOI:
10.1016/j.expneurol.2024.114814
PubMed:
38762094

Niaodukang mixture inhibits micro-inflammation in CKD rats by enhancing MiR-146a levels in enterogenous exosomes.

Immunology
Liu L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118318
PubMed:
38754642

Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone.

Yu Y et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.150065
PubMed:
38749188

Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms.

Yang Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155618
PubMed:
38678949

Salvia miltiorrhiza Bge. processed with porcine cardiac blood inhibited GLRX5-mediated ferroptosis alleviating cerebral ischemia-reperfusion injury.

Summary

Researchers studied the effects of processed Danshen (DS) with porcine cardiac blood (PCB-DS) on Cerebral ischemia-reperfusion injury (CIRI) in strokes. PCB-DS showed potential anti-ischemic effects, but the mechanism is still unknown.

Cardiology
Zhou S et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155622
PubMed:
38677272

Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.

Summary

The herb Salvia miltiorrhiza Bunge shows promise in preventing iron-dependent cell death (ferroptosis) and reducing lipid peroxidation, potentially improving heart health after a heart attack.

Cardiology
Wu YT et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118214
PubMed:
38641076

Quantitative analysis of three ingredients in Salvia miltiorrhiza by near infrared spectroscopy combined with hybrid variable selection strategy.

Ma H et al (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2024.124273
PubMed:
38615417

Evaluation of hematoprotective, hepatoprotective, and anti-inflammatory potentials of chia seed (Salvia hispanica L.) extract in rats.

Immunology
Sachi S et al (2024).
Vet Anim Sci.
DOI:
10.1016/j.vas.2024.100349
PubMed:
38590834

Treatment of diabetic retinopathy with herbs for tonifying kidney and activating blood circulation: A review of pharmacological studies.

Summary

Chinese herbs like Lycii Fructus and Salvia Miltiorrhizae Radix can effectively treat diabetic retinopathy by nourishing the kidney and improving blood circulation. Consider using these herbs in your lab for better results.

Review Diabetes
Liang H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118078
PubMed:
38513781

Response of antioxidant activity, active constituent and rhizosphere microorganisms of Salvia miltiorrhiza to combined application of microbial inoculant, microalgae and biochar under Cu stress.

Immunology
Ren Y et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.171812
PubMed:
38508267

Synergistic effect of paeoniflorin combined with luteolin in alleviating Lipopolysaccharides-induced acute lung injury.

Liu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118022
PubMed:
38453101

Effects of Tripleurospermum caucasicum, Salvia rosmarinus and Tanacetum fruticulosum essential oils on aflatoxin B(1) production and aflR gene expression in Aspergillus flavus.

Summary

T. caucasicum and S. rosmarinus essential oils inhibit A. flavus growth and AFB production by 20.61-89.16%. Down-regulate aflR gene. Potential for controlling fungal contamination in food crops.

Genetics
Mozafari Z et al (2024).
Int J Food Microbiol.
DOI:
10.1016/j.ijfoodmicro.2024.110639
PubMed:
38417281

Herbal medicines provide regulation against iron overload in cardiovascular diseases: Informing future applications.

Summary

Scientists studied the impact of iron levels on cardiovascular diseases and found that iron overload can worsen conditions like cardiomyopathy and atherosclerosis. They are also researching the use of herbal medicines to regulate iron levels and potentially treat these diseases.

Review Cardiology
Liu J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117941
PubMed:
38387684

Salvianolic acid extract prevents Tripterygium wilfordii polyglycosides-induced acute liver injury by modulating bile acid metabolism.

Zhang L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117939
PubMed:
38382651

Protective effect of Danshensu against neurotoxicity induced by monosodium glutamate in adult mice and their offspring.

Summary

Danshensu (DSS) protects against monosodium glutamate (MSG)-induced neurotoxicity in adult mice and their offspring. It prevents brain damage, improves learning and memory, and reduces neural overexcitation.

Neuroscience
Liang Q et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e25546
PubMed:
38356496

Research on different compound combinations of Realgar-Indigo naturalis formula to reverse acute promyelocytic leukemia arsenic resistance by regulating autophagy through mTOR pathway.

Cancer
Li R et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117778
PubMed:
38310990

Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.

Summary

Salvia miltiorrhiza Bunge, a Chinese herbal medicine, has known anti-tumor properties. However, the specific mechanism of how it inhibits tumor growth by preventing angiogenesis is still unclear.

CancerGastroenterology
Yu JR et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117791
PubMed:
38301987

Exploring microscopic pollen morphology in herbaceous Flora: Insights and analysis using scanning electron microscopy.

Aziza N et al (2024).
Microsc Res Tech.
DOI:
10.1002/jemt.24508
PubMed:
38299712

Salvia miltiorrhiza polysaccharide promotes the health of crayfish (Procambarus clarkii) by promoting hemocyte phagocytosis, protecting hepatopancreas and enhancing intestinal barrier function.

Gastroenterology
Pei Q et al (2024).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2024.109405
PubMed:
38278337

Study on the mechanism of Panax notoginseng-Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin.

Zeng R et al (2024).
J Nat Med.
DOI:
10.1007/s11418-023-01773-z
PubMed:
38261160

Bio-guided isolation of aromatic abietane diterpenoids from Salvia canariensis as biopesticides in the control of phytopathogenic fungi.

López-Cabeza R et al (2024).
Pest Manag Sci.
DOI:
10.1002/ps.7958
PubMed:
38258969

Salvia miltiorrhiza Bunge extract and Przewalskin ameliorate Bleomycin-induced pulmonary fibrosis by inhibition of apoptosis, oxidative stress and collagen deposition via the TGF-β1 pathway.

Immunology
Zeng M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155339
PubMed:
38237513

Exploiting the beneficial effects of Salvia officinalis L. extracts in human health and assessing their activity as potent functional regulators of food microbiota.

Gastroenterology
Kompoura V et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.138175
PubMed:
38194793

Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.

Summary

Researchers investigated the neuroprotective properties of salvianolic acid A (SAA) in cerebral ischemia-reperfusion injury (CIRI). SAA, derived from Salvia miltiorrhiza Bge., shows potential in treating brain injury, but its mechanisms of action are not fully understood.

CardiologyNeuroscience
Yang R et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155326
PubMed:
38185068

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis.

Summary

Researchers studied the antihypertensive effects of a Chinese medicine, Danhong Formula (DHF), to understand how it improves endothelial dysfunction and reduces high blood pressure, benefiting cardiovascular health.

Cardiology
Yang X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117615
PubMed:
38163560

Association of high-risk stigmata and worrisome features with advanced neoplasia in intraductal papillary mucinous neoplasms (IPMN): A systematic review.

Review
Ohno E et al (2024).
Pancreatology.
DOI:
10.1016/j.pan.2023.12.002
PubMed:
38161091

Salvirrane A-F, six undescribed nordrimane sesquiterpene derivatives from Salvia castanea Diels f. tomentosa Stib and their cytotoxic activities.

Zhang R et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113958
PubMed:
38154730

Endophytic fungus Penicillium steckii DF33 promoted tanshinones biosynthesis in Salvia miltiorrhiza by regulating the expression of CYP450 genes.

Genetics
Lv X et al (2024).
Gene.
DOI:
10.1016/j.gene.2023.148094
PubMed:
38142897

Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity.

Summary

Salvia miltiorrhiza and its active ingredient Danshensu have shown to inhibit SARS-CoV-2 and possess anti-inflammatory properties. Danshensu is a covalent inhibitor of the 3CL protease of SARS-CoV-2, making it a potential candidate for targeted drug development against COVID-19.

AntimicrobialCOVID-19Immunology
Wang R et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128623
PubMed:
38070810

Uncovering Mechanism and Efficacy of Salvia Miltiorrhiza-Safflower in Cerebral Ischemia-Reperfusion Injury.

Summary

This study investigates the molecular regulation and therapeutic effectiveness of the Danshen-Honghua herb pair for cerebral ischemia (CI). By identifying common targets and pathways, it suggests that DH may activate the TNF-α/JNK signaling pathway for CI treatment.

Cardiology
Zhang Y et al (2024).
Neuroscience.
DOI:
10.1016/j.neuroscience.2023.11.021
PubMed:
38036060

Comparative polyphenolic profiling of five ethnomedicinal plants and their applicative potential in the treatment of type 2 diabetes.

Summary

These plants have been traditionally used for preventing and treating diseases like diabetes. They may contain beneficial compounds that could be useful for developing new treatments in the lab.

DiabetesEthnobotany
Kukavica B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117377
PubMed:
37939910

Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.

Summary

Salviae Miltiorrhizae Radix Et Rhizoma, a traditional Chinese medicine, contains salvianolic acid B and tanshinone IIA. These components can effectively improve early diabetic nephropathy (DN). Useful for treating DN.

DiabetesImmunology
Xu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117356
PubMed:
37890803

Pharmaceutical process-omics for quality control of traditional Chinese medicine preparations: A (1)H-qNMR assisted case study of Guanxinning injection.

Yang J et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115793
PubMed:
37883890

Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats.

Liu YC et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117346
PubMed:
37879506

Guben Xiezhuo decoction inhibits M1 polarization through the Raf1/p-Elk1 signaling axis to attenuate renal interstitial fibrosis.

Liu Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117189
PubMed:
37716490

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Immunology
Zhang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117134
PubMed:
37714227

Elucidating the chemical interaction effects of herb pair Danshen-Chuanxiong and its anti-ischemic stroke activities evaluation.

Summary

This study investigates the combined effect of Salvia miltiorrhiza and Ligusticum chuanxiong in treating ischemic stroke. Understanding this synergy can help make better decisions in using traditional Chinese medicines for stroke treatment.

CardiologyNeuroscience
Pang HQ et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117058
PubMed:
37597675

Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms.

Summary

Scientists investigated the potential of Salvia miltiorrhiza Bunge in enhancing the effectiveness of chemotherapy and reducing its side effects. Results show promise for improved cancer treatment with reduced toxicity.

Review Cancer
Huang J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117022
PubMed:
37572929

Fabrication of double nano-emulsions loaded with hyssop (Hyssopus officinalis L.) extract stabilized with soy protein isolate alone and combined with chia seed gum in controlling the oxidative stability of canola oil.

Ahmadian S et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137093
PubMed:
37562266

Encapsulation efficiency and fatty acid analysis of chia seed oil microencapsulated by freeze-drying using combinations of wall material.

Anand V et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136960
PubMed:
37531916

Dissection of scientific compatibility of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia from the perspective of toxicology.

Cancer
Jiang Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116895
PubMed:
37467822

In silico analysis of the interaction of de novo peptides derived from Salvia hispanica with anticancer targetsEvaluation of the anticancer potential of de novo peptides derived from Salvia hispanica through molecular docking.

Cancer
Quintal Bojórquez NDC et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2232045
PubMed:
37453078

Differential effects of mindfulness meditation and cognitive training on cool and hot inhibitory control in children and adolescents.

Summary

This study compared the effects of computerized mindfulness meditation (MM) and cognitive training (CT) on inhibitory control (IC) in children and adolescents. CT improved cool IC, while MM improved hot IC. MM may have more benefits for emotional competence at a young age.

Neuroscience
Rezende G et al (2023).
J Exp Child Psychol.
DOI:
10.1016/j.jecp.2023.105741
PubMed:
37441988

Symptom-oriented network pharmacology revealed the mechanism of HuangQi-DanShen herb pair against cerebral ischemia coupled with comprehensive chemical characterization.

Summary

HuangQi-DanShen (HD) is a significant drug duo in traditional Chinese medicine used for treating cerebral ischemia.

Cardiology
Liu Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116845
PubMed:
37437791

The protective effect of an extract of Salvia miltiorrhiza Bunge (Danshen) on cerebral ischemic injury in animal models: A systematic review and meta-analysis.

Review
Xie X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116772
PubMed:
37400004

Salvianolic acids from Salvia miltiorrhiza Bunge and their anti-inflammatory effects through the activation of α7nAchR signaling.

Immunology
Zou LF et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116743
PubMed:
37331452

Effect of Salvia miltiorrhiza Bunge extracts on improving the efficacy and reducing the toxicity of Tripterygium wilfordii polyglycosides in the treatment of rheumatoid arthritis.

Arthritis
Zhang L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116782
PubMed:
37321427

Shenlian extract protected ox-LDL-loaded macrophages against ER stress by promoting LAL-LXRα mediated cholesterol flux.

Immunology
Nie CX et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116721
PubMed:
37315648

Sodium tanshinone IIA sulphate inhibits angiogenesis in lung adenocarcinoma via mediation of miR-874/eEF-2K/TG2 axis.

Wang B et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2204879
PubMed:
37300283

Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis.

Review
Wei B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116697
PubMed:
37295577

Porcine cardiac blood - Salvia miltiorrhiza root alleviates cerebral ischemia reperfusion injury by inhibiting oxidative stress induced apoptosis through PI3K/AKT/Bcl-2/Bax signaling pathway.

Summary

The researchers investigated the potential mechanism of Salvia miltiorrhiza Bge mixed with porcine cardiac blood in preventing brain ischemia/reperfusion injury. The specific role of oxidative stress induced cell apoptosis was examined.

CardiologyImmunology
Zhou S et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116698
PubMed:
37286116

Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade.

Summary

Salvia miltiorrhiza Bunge, a Chinese medicinal herb known for invigorating blood circulation, has shown promising results in treating cancer. Inspired by traditional Chinese medicine, this study highlights the potential of Salvia miltiorrhiza as an effective treatment option. Its significant role in combating cancer makes it a valuable addition to the field of medicine.

CancerGastroenterologyImmunology
Song M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116735
PubMed:
37286115

Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.

Summary

Chronic intermittent hypoxia (CIH) from obstructive sleep apnea (OSA) can impair brain function. Tanshinone IIA (Tan IIA) is from Traditional Chinese Medicine and has been shown to have protective properties in conditions of intermittent hypoxia. The specific mechanism of Tan IIA is still being studied.

Neuroscience
Si J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116677
PubMed:
37268259

Potential anticoagulant of traditional chinese medicine and novel targets for anticoagulant drugs.

Review
Yin Q et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154880
PubMed:
37267694

Tanshinone IIA mediates protection from diabetes kidney disease by inhibiting oxidative stress induced pyroptosis.

Summary

Tanshinone IIA, found in Salvia miltiorrhiza, shows potential in delaying the progression of diabetes kidney disease, but further research is needed to understand how it works.

DiabetesImmunology
Wu Q et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116667
PubMed:
37257702

Selected plants producing mucilage: Overview, composition, and their potential as functional ingredients in the development of plant-based foods.

Review
Lira MM et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112822
PubMed:
37254398

The impact of age-related digestive disorders on in vitro digestibility of macronutrients and bioaccessibility of minor components of chia seeds.

Hernández-Olivas E et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112874
PubMed:
37254324

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

Summary

A study explored the effects of neocryptotanshinone (NCTS) on energy metabolism to protect against heart failure after myocardial infarction (AMI) through the retinoid X receptor alpha (RXRα)/PPARα pathway. NCTS improved cardiac function and increased fatty acid oxidation and mitochondrial biogenesis.

Cardiology
Ma L et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114868
PubMed:
37201263

"We're always an afterthought"- Designing tobacco control campaigns for dissemination with and to LGBTQ +-serving community organizations: a thematic analysis.

Ramanadhan S et al (2023).
Cancer Causes Control.
DOI:
10.1007/s10552-023-01706-x
PubMed:
37160611

Total tanshinones protect against acute lung injury through the PLCγ2/NLRP3 inflammasome signaling pathway.

Li X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116478
PubMed:
37121449

Highly oxygenated germacrane-type sesquiterpenoids from the whole plant of Salvia cavaleriei H.Lév. and their biological activities.

Chen XH et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113686
PubMed:
37105352

Modulation of the bacterial virulence and resistance by well-known European medicinal herbs.

Křížkovská B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116484
PubMed:
37044231

Effect of interfering TOR signaling pathway on the biosynthesis of terpenoids in Salvia miltiorrhiza Bge.

Zou P et al (2023).
Plant Signal Behav.
DOI:
10.1080/15592324.2023.2199644
PubMed:
37039834

15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2.

Summary

The study investigated the effects of DHT on ischemic stroke. DHT is a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, that has various pharmacological effects. The study found that DHT has a protective effect against ischemic stroke by increasing Nrf2 expression. Nrf2 is a key regulator of antioxidative stress responses and is associated with ferroptosis inhibition, a process involved in stroke. These findings suggest that DHT has therapeutic potential for the treatment of ischemic stroke.

CardiologyNeuroscience
Wu C et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154790
PubMed:
37028247

Chia (Salvia hispanica L.) can directly suppress basic ovarian cell functions in two farm animal species and protect ovarian cells from the proliferation-stimulating influence of xylene.

Summary

Chia seed extract reduced markers of cell function in bovine and porcine ovarian cells. Xylene stimulated proliferation and hormones release but chia mitigated its effects on cell proliferation. Chia could be a natural protector against xylene's effects on ovarian cells.

Endocrinology
Tarko A et al (2023).
Reprod Domest Anim.
DOI:
10.1111/rda.14355
PubMed:
37017149

A herbal product inhibits carbon tetrachloride-induced liver fibrosis by suppressing the epidermal growth factor receptor signaling pathway.

Qi J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116419
PubMed:
37003405

Evidence-based consensus guidelines on patient selection and trial stimulation for spinal cord stimulation therapy for chronic non-cancer pain.

Summary

Researchers developed evidence-based guidelines for patient selection and the role of a spinal cord stimulation (SCS) trial for neuropathic pain relief. These recommendations should help guide physicians in selecting patients for SCS therapy.

CancerPain
Shanthanna H et al (2023).
Reg Anesth Pain Med.
DOI:
10.1136/rapm-2022-104097
PubMed:
37001888

Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate plays an anti-hypoxic role through regulating neuroactive ligand-receptor interaction signaling pathway in larval zebrafish.

Zhang S et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114570
PubMed:
36948132

The influence of Salvia cadmica Boiss. extracts on the M1/M2 polarization of macrophages primed with Helicobacter pylori lipopolysaccharide in conjunction with NF-kappa B activation, production of cytokines, phagocytic activity and total DNA methylation.

GeneticsImmunology
Gonciarz W, Piątczak E and Chmiela M (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116386
PubMed:
36921911

Homoplantaginin attenuates high glucose-induced vascular endothelial cell apoptosis through promoting autophagy via the AMPK/TFEB pathway.

Fan L et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7797
PubMed:
36879478

Salvia miltiorrhiza augments endothelial cell function for ischemic hindlimb recovery.

De G et al (2023).
Biol Chem.
DOI:
10.1515/hsz-2022-0316
PubMed:
36869860

Effect directed analysis of bioactive compounds in leaf extracts from two Salvia species by High-performance thin-layer chromatography.

Phytochemistry
Agatonovic-Kustrin S et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115308
PubMed:
36827737

Leaf metabolomics and molecular networking of wild type and mutant genotypes of chia (Salvia hispanica L.).

Grauso L et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113611
PubMed:
36804479

Towards a global perspective for Salvia L.: Phylogeny, diversification and floral evolution.

Moein F et al (2023).
J Evol Biol.
DOI:
10.1111/jeb.14149
PubMed:
36759951

Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells.

Immunology
Fan X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116219
PubMed:
36758912

Salvia miltiorrhiza polysaccharide and its related metabolite 5-methoxyindole-3-carboxaldehyde ameliorate experimental colitis by regulating Nrf2/Keap1 signaling pathway.

Gastroenterology
Fu YP et al (2023).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2023.120626
PubMed:
36746576

Acinar Cystic Transformation of the Pancreas: Histomorphology and Molecular Analysis to Unravel its Heterogeneous Nature.

Luchini C et al (2023).
Am J Surg Pathol.
DOI:
10.1097/PAS.0000000000002017
PubMed:
36649476

Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the 'homology modelling-virtual screening-molecular docking-affinity assay-activity evaluation' method.

Quan W et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2022.2160769
PubMed:
36604840

Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review.

Review
Li Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.116090
PubMed:
36587878

A dynamic analysis of empirical survival outcomes after pancreatectomy for pancreatic ductal adenocarcinoma.

Malleo G et al (2023).
Surgery.
DOI:
10.1016/j.surg.2022.11.015
PubMed:
36585320

Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats.

Summary

Tanshinone IIA, extracted from Bunge, has potential as an anticonvulsant and cognition-protective treatment for cardiovascular disorders.

Neuroscience
Jia C et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2022.2157843
PubMed:
36548216

Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study.

CancerGenetics
van Veldhuisen E et al (2023).
Ann Surg Oncol.
DOI:
10.1245/s10434-022-12387-2
PubMed:
36539580

Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP.

Summary

Researchers evaluated the potential neuroprotective effects of rosmarinic acid (RA) in a murine model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). RA was found to prevent hyperlocomotion behavior in MPTP-treated animals and improve the monoaminergic system in healthy animals. RA also increased dopaminergic signaling in the parkinsonian mice, indicating potential neuroprotective properties for RA in preventing behavioral features observed in PD and improving neurotransmission in the healthy brain.

Neuroscience
Presti-Silva SM et al (2023).
Behav Brain Res.
DOI:
10.1016/j.bbr.2022.114257
PubMed:
36526017

Rheum officinale and Salvia miltiorrhiza inhibit renal fibrosis via miR-21/PTEN/Akt signaling pathway in vitro and in vivo.

Wang H et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115928
PubMed:
36513264

Salviolone protects against high glucose-induced proliferation, oxidative stress, inflammation, and fibrosis of human renal mesangial cells by upregulating membrane metalloendopeptidase expression.

Immunology
Wang X, Song R and Li Z (2023).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14183
PubMed:
36404132

Mixing chia seeds and sprouts at different developmental stages: A cost-effective way to improve antioxidant vitamin composition.

Bermejo NF and Munné-Bosch S (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134880
PubMed:
36371839

The roles of Salvia miltiorrhiza-derived carbon dots involving in maintaining quality by delaying senescence of postharvest flowering Chinese cabbage.

Kuang L et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134704
PubMed:
36283319

Exploring volatile aroma and non-volatile bioactive compounds diversity in wild populations of rosemary (Salvia rosmarinus Schleid.).

Raffo A et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.134532
PubMed:
36242966

Intraoperative Blood Loss Estimation in Hepato-pancreato-biliary Surgery- Relevant, Not Reported, Not Standardized: Results From a Systematic Review and a Worldwide Snapshot Survey.

Perri G et al (2023).
Ann Surg.
DOI:
10.1097/SLA.0000000000005536
PubMed:
35837979

Proximate composition, pasting and functional properties of composite flour blends from cassava and chia seeds flour.

Katunzi-Kilewela A et al (2023).
Food Sci Technol Int.
DOI:
10.1177/10820132211069471
PubMed:
34964390

Elucidating the Mechanism of Action of Salvia miltiorrhiza for the Treatment of Acute Pancreatitis Based on Network Pharmacology and Molecular Docking Technology.

Zhu K et al (2021).
Comput Math Methods Med.
DOI:
10.1155/2021/8323661
PubMed:
34868345

Chronic Supplementation with a Mix of Salvia officinalis and Salvia lavandulaefolia Improves Morris Water Maze Learning in Normal Adult C57Bl/6J Mice.

Dinel AL et al (2020).
Nutrients.
DOI:
10.3390/nu12061777
PubMed:
32549250

Pharmacological properties of tanshinones, the natural products from Salvia miltiorrhiza.

Review
Wang X et al (2020).
Adv Pharmacol.
DOI:
10.1016/bs.apha.2019.10.001
PubMed:
32089238

Sage.

Review
(2021).
PubMed:
30000875

Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects.

Summary

Salvia, or sage, is a genus comprising many species traditionally used as brain-enhancing tonics. Studies have confirmed that several Salvia species contain active compounds that may improve cognitive activity and prevent neurodegenerative disease. This review summarizes the active constituents in Salvia plants and their influence on cognitive skills such as memory, attention, and learning. Completed human trials are also discussed, as well as factors influencing the potency of Salvia plants. The review proposes future research to improve our understanding of the potential health benefits of Salvia plants.

Review Neuroscience
Lopresti AL et al (2017).
Drugs R D.
DOI:
10.1007/s40268-016-0157-5
PubMed:
27888449