Salvia miltiorrhiza

Ethnobotanical Studies

Studies

Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.

Immunology
Fan Y et al (2024).
Cell Signal.
DOI:
10.1016/j.cellsig.2024.111348
PubMed:
39153586

Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway.

Summary

JXK, a traditional Chinese herbal formula, effectively treats chronic heart failure (CHF) with seven medicinal herbs. While its clinical efficacy is proven, the specific mechanisms remain unknown. Further research is needed for potential cardiac treatment advancements.

Cardiology
Lin L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118685
PubMed:
39127116

TFEB activator tanshinone IIA and derivatives derived from Salvia miltiorrhiza Bge. Attenuate hepatic steatosis and insulin resistance.

Zheng L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118662
PubMed:
39117022

Salvianolic acid A attenuates non-alcoholic fatty liver disease by regulating the AMPK-IGFBP1 pathway.

Zhu J et al (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.111162
PubMed:
39047806

The methyl jasmonate-responsive transcription factor SmERF106 promotes tanshinone accumulation in Salvia miltiorrhiza.

Li Y et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108932
PubMed:
39018777

Structural analysis of Salvia miltiorrhiza polysaccharide and its regulatory functions on T cells subsets in tumor-bearing mice combined with thymopentin.

Cancer
Ji H et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133832
PubMed:
39002910

Physiological and molecular mechanisms of carbon quantum dots alleviating Cu(2+) toxicity in Salvia miltiorrhiza bunge.

Zhong M et al (2024).
Environ Pollut.
DOI:
10.1016/j.envpol.2024.124521
PubMed:
38986761

Exploring the mechanism of luteolin improving immune and inflammatory responses in systemic sclerosis based on systems biology and cell experiments.

Immunology
Ding X et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112587
PubMed:
38972211

Apigenin inhibits proliferation and differentiation of cardiac fibroblasts through AKT/GSK3β signaling pathway.

Summary

Researchers studied how Salvia miltiorrhiza can help with heart and brain diseases. They used advanced techniques to understand how it combats cardiac fibrosis. Important for potential new treatments.

Cardiology
Kan H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118518
PubMed:
38964628

Genomic analysis of PIN-FORMED genes reveals the roles of SmPIN3 in root architecture development in Salvia miltiorrhiza.

Genetics
Zheng Y et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108827
PubMed:
38875779

Research of the dynamic regulatory mechanism of Compound Danshen Dripping Pills on myocardial infarction based on metabolic trajectory analysis.

Summary

Tossers studied CDDP for MI treatment, but focused on endpoints, neglecting dynamic changes in disease. Establishing dynamic research strategy for precise clinical medication guidance is crucial.

Cardiology
Zhang CJ et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155626
PubMed:
38850631

Dihydrotanshinone I targets ESR1 to induce DNA double-strand breaks and proliferation inhibition in hepatocellular carcinoma.

Genetics
Nie Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155767
PubMed:
38833789

Danshensu reduces neuronal excitability by enhancing potassium currents in bushy cells in the mouse cochlear nucleus.

Summary

Danshensu from Danshen herb decreases neuronal excitability in mouse brainstem by enhancing voltage-gated K+ currents, supporting its neuroprotective effects. Dose-dependent response with potential therapeutic applications.

Neuroscience
Xu M et al (2024).
Neuroreport.
DOI:
10.1097/WNR.0000000000002047
PubMed:
38813908

Danshen injection mitigated the cerebral ischemia/reperfusion injury by suppressing neuroinflammation via the HIF-1α/CXCR4/NF-κB signaling pathway.

Summary

Danshen injection (DI) treats cardiovascular and brain diseases, improves neurological scores and reduces inflammation and oxidative stress. DI targets HIF-1α to suppress neuroinflammation and reduce ischemia/reperfusion injury.

CardiologyImmunologyNeuroscience
Chen G et al (2024).
Neuroreport.
DOI:
10.1097/WNR.0000000000002043
PubMed:
38813902

Crosstalk between H(2)O(2) and Ca(2+) signaling is involved in root endophyte-enhanced tanshinone biosynthesis of Salvia miltiorrhiza.

Lu WL et al (2024).
Microbiol Res.
DOI:
10.1016/j.micres.2024.127740
PubMed:
38795408

Astrocyte modulation in cerebral ischemia-reperfusion injury: A promising therapeutic strategy.

Summary

82 drugs targeting astrocytes show promise for treating cerebral ischemia-reperfusion injury, with potential to reduce inflammation, oxidative stress, edema, and more. Traditional Chinese medicines like Salvia miltiorrhiza, Ginkgo, and Ginseng are particularly promising.

Review CardiologyNeuroscience
Wang Z et al (2024).
Exp Neurol.
DOI:
10.1016/j.expneurol.2024.114814
PubMed:
38762094

Niaodukang mixture inhibits micro-inflammation in CKD rats by enhancing MiR-146a levels in enterogenous exosomes.

Immunology
Liu L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118318
PubMed:
38754642

Suppression of retinal neovascularization by intravitreal injection of cryptotanshinone.

Yu Y et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2024.150065
PubMed:
38749188

Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms.

Yang Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155618
PubMed:
38678949

Salvia miltiorrhiza Bge. processed with porcine cardiac blood inhibited GLRX5-mediated ferroptosis alleviating cerebral ischemia-reperfusion injury.

Summary

Researchers studied the effects of processed Danshen (DS) with porcine cardiac blood (PCB-DS) on Cerebral ischemia-reperfusion injury (CIRI) in strokes. PCB-DS showed potential anti-ischemic effects, but the mechanism is still unknown.

Cardiology
Zhou S et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155622
PubMed:
38677272

Salvia miltiorrhiza suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling.

Summary

The herb Salvia miltiorrhiza Bunge shows promise in preventing iron-dependent cell death (ferroptosis) and reducing lipid peroxidation, potentially improving heart health after a heart attack.

Cardiology
Wu YT et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118214
PubMed:
38641076

Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits.

Zhang L et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116344
PubMed:
38636259

Quantitative analysis of three ingredients in Salvia miltiorrhiza by near infrared spectroscopy combined with hybrid variable selection strategy.

Ma H et al (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2024.124273
PubMed:
38615417

Physiological and molecular mechanisms of ZnO quantum dots mitigating cadmium stress in Salvia miltiorrhiza.

Chai S et al (2024).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2024.134245
PubMed:
38603910

Response of antioxidant activity, active constituent and rhizosphere microorganisms of Salvia miltiorrhiza to combined application of microbial inoculant, microalgae and biochar under Cu stress.

Immunology
Ren Y et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.171812
PubMed:
38508267

Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation.

Summary

Researchers investigated how Danshen injection (DSI) can help reduce anthracycline-induced cardiotoxicity (AIC). Understanding this mechanism could lead to safer and more effective cancer therapies using anthracyclines.

Genetics
Dai Q et al (2024).
Curr Pharm Des.
DOI:
10.2174/0113816128289845240305070522
PubMed:
38482629

Synergistic effect of paeoniflorin combined with luteolin in alleviating Lipopolysaccharides-induced acute lung injury.

Liu Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118022
PubMed:
38453101

Herbal medicines provide regulation against iron overload in cardiovascular diseases: Informing future applications.

Summary

Scientists studied the impact of iron levels on cardiovascular diseases and found that iron overload can worsen conditions like cardiomyopathy and atherosclerosis. They are also researching the use of herbal medicines to regulate iron levels and potentially treat these diseases.

Review Cardiology
Liu J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117941
PubMed:
38387684

Salvianolic acid extract prevents Tripterygium wilfordii polyglycosides-induced acute liver injury by modulating bile acid metabolism.

Zhang L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117939
PubMed:
38382651

Research on different compound combinations of Realgar-Indigo naturalis formula to reverse acute promyelocytic leukemia arsenic resistance by regulating autophagy through mTOR pathway.

Cancer
Li R et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117778
PubMed:
38310990

Diterpenoid tanshinones inhibit gastric cancer angiogenesis through the PI3K/Akt/mTOR signaling pathway.

Summary

Salvia miltiorrhiza Bunge, a Chinese herbal medicine, has known anti-tumor properties. However, the specific mechanism of how it inhibits tumor growth by preventing angiogenesis is still unclear.

CancerGastroenterology
Yu JR et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117791
PubMed:
38301987

Salvia miltiorrhiza polysaccharide promotes the health of crayfish (Procambarus clarkii) by promoting hemocyte phagocytosis, protecting hepatopancreas and enhancing intestinal barrier function.

Gastroenterology
Pei Q et al (2024).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2024.109405
PubMed:
38278337

Study on the mechanism of Panax notoginseng-Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin.

Zeng R et al (2024).
J Nat Med.
DOI:
10.1007/s11418-023-01773-z
PubMed:
38261160

Tanshinone IIA attenuates osteoarthritis via inhibiting aberrant angiogenesis in subchondral bone.

Li HZ et al (2024).
Arch Biochem Biophys.
DOI:
10.1016/j.abb.2024.109904
PubMed:
38253247

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis.

Summary

Researchers studied the antihypertensive effects of a Chinese medicine, Danhong Formula (DHF), to understand how it improves endothelial dysfunction and reduces high blood pressure, benefiting cardiovascular health.

Cardiology
Yang X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117615
PubMed:
38163560

Endophytic fungus Penicillium steckii DF33 promoted tanshinones biosynthesis in Salvia miltiorrhiza by regulating the expression of CYP450 genes.

Genetics
Lv X et al (2024).
Gene.
DOI:
10.1016/j.gene.2023.148094
PubMed:
38142897

Salvia miltiorrhiza-Containing Chinese Herbal Medicine Combined With GnRH Agonist for Postoperative Treatment of Endometriosis: A Systematic Review and meta-Analysis.

Review Endocrinology
Gao Q et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.831850
PubMed:
35250579

Salvia miltiorrhiza: an ancient Chinese herbal medicine as a source for anti-osteoporotic drugs.

Review
Guo Y et al (2014).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2014.07.058
PubMed:
25109459