Sanguinaria canadensis

Common Names: bloodroot

Ethnobotanical Studies

Boreal Forest, Canada

Uses: Circulatory system disorders, Cough, cold and sore throat, Dermatological infections, Gastro-intestinal disorders, Injuries, Mental disorders, Nutritional disorders, Pregnancy, child birth, puerperium, Respiratory system disorders

DOI:: 10.1186/1746-4269-8-7
PubMed:: 22289509

Cherokee Nation

Uses: root decoction for cough

ISBN:: 0881924539

Studies

Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ.

Gastroenterology

Sun W et al (2024).; Toxicol Mech Methods.
DOI:: 10.1080/15376516.2024.2383366
PubMed:: 39087424

Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.

Summary

Sanguinarine chloride (S.C), a compound found in certain plants, has been shown to have antioxidant, anti-inflammatory, and anti-cancer properties. Recent research suggests it may induce ferroptosis in some cancers, but more studies are needed to understand the exact mechanism.

Cancer

Liu S et al (2024).; Chin Med.
DOI:: 10.1186/s13020-024-00881-6
PubMed:: 38195593

Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells.

Cancer Phytochemistry

Tuzimski T et al (2023).; Int J Mol Sci.
DOI:: 10.3390/ijms24076360
PubMed:: 37047332

Serious Skin Injuries Following Exposure to Unapproved Mole and Skin Tag Removers.

Konkel K et al (2023).; J Clin Aesthet Dermatol.
PubMed:: 36743972

Understanding of black salve toxicity by multi-compound cytotoxicity assays.

Croaker A et al (2022).; BMC Complement Med Ther.
DOI:: 10.1186/s12906-022-03721-y
PubMed:: 36127674

Sanguinarine Induces H(2)O(2)-Dependent Apoptosis and Ferroptosis in Human Cervical Cancer.

Cancer

Alakkal A et al (2022).; Biomedicines.
DOI:: 10.3390/biomedicines10081795
PubMed:: 35892694

Sanguinarine Represses the Growth and Metastasis of Non-small Cell Lung Cancer by Facilitating Ferroptosis.

Cancer

Xu R et al (2022).; Curr Pharm Des.
DOI:: 10.2174/1381612828666220217124542
PubMed:: 35176976

Botanical Briefs: Bloodroot (Sanguinaria canadensis).

Schwartzberg L, Osswald SS and Elston DM (2021).; Cutis.
DOI:: 10.12788/cutis.0345
PubMed:: 34847001

Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition.

Tian S et al (2021).; Molecules.
DOI:: 10.3390/molecules26196012
PubMed:: 34641558

10.

Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways.

Yang X et al (2021).; Toxicol Lett.
DOI:: 10.1016/j.toxlet.2021.07.001
PubMed:: 34252508

11.

Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes.

Alfhili MA, Alsughayyir J and Basudan AB (2021).; Toxicon.
DOI:: 10.1016/j.toxicon.2021.05.013
PubMed:: 34081931

12.

Determination of Cytotoxic Activity of Sanguinaria canadensis Extracts against Human Melanoma Cells and Comparison of Their Cytotoxicity with Cytotoxicity of Some Anticancer Drugs.

Cancer

Tuzimski T et al (2021).; Molecules.
DOI:: 10.3390/molecules26061738
PubMed:: 33804614

13.

Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts.

Summary

This study explored the potential of certain plant extracts to inhibit acetylcholinesterase, an enzyme linked to neurodegenerative disorders. The extracts were obtained from plants collected before, during and after flowering, and were analyzed using a high performance liquid chromatography method. The results showed that most alkaloids in the extracts exhibited very high acetylcholinesterase activity inhibition, with IC values ranging from 0.36 to 89.14 µg/mL. The study suggests that these plant extracts have potential for further investigation as a treatment for neurodegenerative disorders such as Alzheimer's disease.

Neuroscience Phytochemistry

Tuzimski T and Petruczynik A (2021).; Molecules.
DOI:: 10.3390/molecules26010230
PubMed:: 33466254

14.

The complete plastome of bloodroot (Sanguinaria canadensis, Papaveraceae), a spring ephemeral from eastern North America.

Liu Z et al (2019).; Mitochondrial DNA B Resour.
DOI:: 10.1080/23802359.2019.1662747
PubMed:: 33365804

15.

Dermatologic uses of bloodroot: a review and reappraisal.

Review

Fravor L and Khachemoune A (2021).; Int J Dermatol.
DOI:: 10.1111/ijd.15273
PubMed:: 33128472

16.

Development and characterization of SSR markers for Sanguinaria canadensis based on genome skimming.

Genetics

Liao R et al (2019).; Appl Plant Sci.
DOI:: 10.1002/aps3.11289
PubMed:: 31572630

17.

Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses.

Review Phytochemistry

Croaker A et al (2016).; Int J Mol Sci.
DOI:: 10.3390/ijms17091414
PubMed:: 27618894

18.

Bloodroot.

Review

Wang MZ and Warshaw EM (2012).; Dermatitis.
DOI:: 10.1097/DER.0b013e318273a4dd
PubMed:: 23169210

19.

The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.

Review

Newton SM et al (2002).; J Ethnopharmacol.
PubMed:: 11744296

20.

Antimicrobial action of sanguinarine.

Review Antimicrobial

Godowski KC et al (1989).; J Clin Dent.
PubMed:: 2700895