Sanguisorba officinalis

Common Names: official burnet

Ethnobotanical Studies

Gongcheng County, Guangxi, China

Uses: Bruise, infantile diarrhea, scald, hemorrhoids, enteritis, stomachache, stone

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

Bairin Area, Inner Mongolia

Uses: Joint pain

DOI:: 10.1186/s13002-019-0300-9
PubMed:: 31269968

Yi people, Mile, Yunnan, China

Uses: Burn and scald

DOI:: 10.1186/s13002-024-00656-1
PubMed:: 38395900

Clinical Trials

Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling.

Yoshida H et al (2019).; Int J Cosmet Sci.
DOI:: 10.1111/ics.12505
PubMed:: 30485450

Studies

Identification of octyl gallate, a novel apoptosis-inducing compound for colon cancer therapy, from Sanguisorba officinalis L. by cell membrane chromatography and UHPLC-(Q)TOF-MS/MS.

Summary

Scientists identified octyl gallate from L. extract using advanced chromatography techniques. OG showed significant anti-colon cancer effects in cell lines and mouse models by inhibiting proliferation, inducing apoptosis, and suppressing migration. This research presents a promising approach for developing novel colon cancer therapies.

Cancer Gastroenterology Phytochemistry

Ni C et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e32230
PubMed:: 38933948

Ziyuglycoside II, a triterpene glycoside compound in Sanguisorbae officinalis l. extract, suppresses metastasis in osteosarcoma via CBX4-mediated Wnt/β-catenin signal pathway.

Summary

"ZGS II from Sanguisorba officinalis l. shows promise in treating aggressive osteosarcoma, inhibiting growth and metastasis. Potential new therapy for challenging bone cancer."

Cancer Phytochemistry

Deng Z et al (2024).; Phytomedicine.
DOI:: 10.1016/j.phymed.2024.155716
PubMed:: 38924929

Revealing microbial diversity in buffalo milk with high somatic cell counts: implications for mastitis diagnosis and treatment.

Jiang H et al (2024).; Vet Res Commun.
DOI:: 10.1007/s11259-024-10438-5
PubMed:: 38874832

Natural Phytochemical and Visible Light at Different Wavelengths Show Synergistic Antibacterial Activity against Staphylococcus aureus.

Phytochemistry

Jeong JY and Hwang YJ (2024).; Pharmaceutics.
DOI:: 10.3390/pharmaceutics16050612
PubMed:: 38794274

Niaodukang mixture inhibits micro-inflammation in CKD rats by enhancing MiR-146a levels in enterogenous exosomes.

Immunology

Liu L et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118318
PubMed:: 38754642

Ziyuglycoside II attenuated OVX mice bone loss via inflammatory responses and regulation of gut microbiota and SCFAs.

Gastroenterology Immunology

Zhou Y et al (2024).; Int Immunopharmacol.
DOI:: 10.1016/j.intimp.2024.112027
PubMed:: 38603860

Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS.

Shen X et al (2024).; Int J Anal Chem.
DOI:: 10.1155/2024/7971021
PubMed:: 38463657

Pharmacokinetics of four tannin compounds from Sanguisorba officinalis L. before and after processing by ultra-high-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry

Wei Y et al (2024).; J Sep Sci.
DOI:: 10.1002/jssc.202300803
PubMed:: 38403460

Stability in the leaf functional traits of understory herbaceous species after 12-yr of nitrogen addition in temperate larch plantations.

Yan T et al (2023).; Front Plant Sci.
DOI:: 10.3389/fpls.2023.1282884
PubMed:: 38116147

10.

Hypotensive and Vasorelaxant Effects of Sanguisorbae Radix Ethanol Extract in Spontaneously Hypertensive and Sprague Dawley Rats.

Jung J et al (2023).; Nutrients.
DOI:: 10.3390/nu15214510
PubMed:: 37960162

11.

In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus.

Jeong JY et al (2023).; Pharmaceuticals (Basel).
DOI:: 10.3390/ph16101491
PubMed:: 37895962

12.

Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT/NF-κB/ STAT3 pathway uncovered by single-cell RNA sequencing.

Summary

Researchers investigated the potential of S. officinalis as a treatment for UC, a serious and incurable illness causing bloody stools. Understanding its molecular mechanism and disease basis could lead to improved treatments with fewer side effects.

Gastroenterology Genetics Immunology

Li C et al (2023).; Phytomedicine.
DOI:: 10.1016/j.phymed.2023.155052
PubMed:: 37717310

13.

An antiviral optimized extract from Sanguisorba officinalis L. roots using response surface methodology, and its efficacy in controlling viral hemorrhagic septicemia of olive flounder (Paralichthys olivaceus).

Summary

Scientists have created an optimized extract from Sanguisorba officinalis L. roots that effectively combats viral hemorrhagic septicemia virus in olive flounder, improving their survival and immune response. This extract could be used as an alternative for controlling the virus in fish farms.

Antimicrobial

Lim JW et al (2023).; Fish Shellfish Immunol.
DOI:: 10.1016/j.fsi.2023.109066
PubMed:: 37689225

14.

Sanguisorba officinalis L. Ameliorates Hepatic Steatosis and Fibrosis by Modulating Oxidative Stress, Fatty Acid Oxidation, and Gut Microbiota in CDAHFD-Induced Mice.

Summary

A study found that a 95% ethanolic Sweet Orange (SO) extract (SOEE) has potential in inhibiting hepatic steatosis and fibrosis by regulating oxidative stress, fatty acid oxidation, and gut microbiota composition. This could be beneficial for treating non-alcoholic fatty liver disease (NAFLD).

Gastroenterology Immunology

Nam Y et al (2023).; Nutrients.
DOI:: 10.3390/nu15173779
PubMed:: 37686810

15.

In vitro anti-bactrical activity and its preliminary mechanism of action of the non-medicinal parts of Sanguisorba officinalis L. against Helicobacter pylori infection.

Chen P et al (2023).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.116981
PubMed:: 37574016

16.

Triterpenoids from the roots of Sanguisorba officinalis and their Nrf2 stimulation activity.

Wu L et al (2023).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2023.113803
PubMed:: 37516332

17.

Sanguisorba officinalis L. enhances the 5-fluorouracil sensitivity and overcomes chemoresistance in 5-fluorouracil-resistant colorectal cancer cells via Ras/MEK/ERK and PI3K/Akt pathways.

Summary

This study investigated the potential of the traditional Chinese medicine DiYu (DY) to improve the sensitivity and overcome drug resistance in colorectal cancer cells. The results could help identify alternative therapies for drug-resistant cancer.

Cancer Gastroenterology

Zhang W et al (2023).; Heliyon.
DOI:: 10.1016/j.heliyon.2023.e16798
PubMed:: 37484409

18.

Sanguisorba minor Scop.: An Overview of Its Phytochemistry and Biological Effects.

Summary

This study explores the history, taxonomy, habitat, bioactive components, and biological activities of the genus . It specifically investigates Scop and its potential chemical composition and biological effects. The research also considers electron microscopy and mentions pests and beneficial insects. This study lays the groundwork for further research on Scop.

Review Phytochemistry

Tocai Moţoc AC et al (2023).; Plants (Basel).
DOI:: 10.3390/plants12112128
PubMed:: 37299107

19.

Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.

Summary

Chinese medicine Sanguisorba officinalis L. extract (ESO) accelerates diabetic wound healing by reducing inflammation through blocking NF-κB/NLRP3 signaling pathway. Promising treatment option.

Diabetes Immunology

Song J et al (2023).; Phytother Res.
DOI:: 10.1002/ptr.7906
PubMed:: 37260161

20.

Insights into Q-markers and molecular mechanism of Sanguisorba saponins in treating ulcerative colitis based on lipid metabolism regulation.

Gastroenterology Phytochemistry

Yu T et al (2023).; Phytomedicine.
DOI:: 10.1016/j.phymed.2023.154870
PubMed:: 37207387

21.

Standardized Sanguisorba officinalis L. Extract Inhibits Adipogenesis and Promotes Thermogenesis via Reducing Oxidative Stress.

Immunology

Zheng Y et al (2023).; Antioxidants (Basel).
DOI:: 10.3390/antiox12040882
PubMed:: 37107257

22.

Gold Nanoparticles Coated with SH-PEG-NH(2) and Loaded with Ziyuglycoside I for Promoting Autophagy in Hematopoietic Stem Cells.

Xiong Y et al (2023).; Int J Nanomedicine.
DOI:: 10.2147/IJN.S399568
PubMed:: 36974074

23.

Novel chemical-structure TPOR agonist, TMEA, promotes megakaryocytes differentiation and thrombopoiesis via mTOR and ERK signalings.

Jiang X et al (2023).; Phytomedicine.
DOI:: 10.1016/j.phymed.2022.154637
PubMed:: 36610353

24.

Evaluation of Polyphenolic Composition and Antimicrobial Properties of Sanguisorba officinalis L. and Sanguisorba minor Scop.

Antimicrobial Phytochemistry

Tocai Moţoc AC et al (2022).; Plants (Basel).
DOI:: 10.3390/plants11243561
PubMed:: 36559673

25.

Variation of Saponins in Sanguisorba officinalis L. before and after Processing (Paozhi) and Its Effects on Colon Cancer Cells In Vitro.

Cancer Phytochemistry

Wang Z et al (2022).; Molecules.
DOI:: 10.3390/molecules27249046
PubMed:: 36558181

26.

Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and experimental investigation.

Cancer

Li H et al (2022).; Front Pharmacol.
DOI:: 10.3389/fphar.2022.1054803
PubMed:: 36506573

27.

Inhibitory Effects of Selected Medicinal Plants on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus.

Jung IG et al (2022).; Molecules.
DOI:: 10.3390/molecules27227780
PubMed:: 36431886

28.

Methyl Gallate Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Inhibiting TLR4/NF-κB Pathway.

Gastroenterology

Zhou P et al (2022).; Int J Mol Sci.
DOI:: 10.3390/ijms232214024
PubMed:: 36430509

29.

Rapid Profiling of Metabolites Combined with Network Pharmacology to Explore the Potential Mechanism of Sanguisorba officinalis L. against Thrombocytopenia.

Dai Y et al (2022).; Metabolites.
DOI:: 10.3390/metabo12111074
PubMed:: 36355157

30.

Dietary supplementation of probiotics fermented Chinese herbal medicine Sanguisorba officinalis cultures enhanced immune response and disease resistance of crucian carp (Carassius auratus) against Aeromonas hydrophila.

Wang T et al (2022).; Fish Shellfish Immunol.
DOI:: 10.1016/j.fsi.2022.10.046
PubMed:: 36341871

31.

Sod translocation to restore habitats of the myrmecophilous butterfly Phengaris (Maculinea) teleius on former agricultural fields.

Sevilleja CG et al (2022).; Ecol Evol.
DOI:: 10.1002/ece3.9293
PubMed:: 36177109

32.

Simultaneous Determination and Pharmacokinetics Study of Three Triterpenes from Sanguisorba officinalis L. in Rats by UHPLC-MS/MS.

Phytochemistry

Wei F et al (2022).; Molecules.
DOI:: 10.3390/molecules27175412
PubMed:: 36080179

33.

Sanguisorba officinalis L. suppresses 5-fluorouracil-sensitive and-resistant colorectal cancer growth and metastasis via inhibition of the Wnt/β-catenin pathway.

Cancer

Zhang W et al (2022).; Phytomedicine.
DOI:: 10.1016/j.phymed.2021.153844
PubMed:: 34785413

34.

Determination of Triterpenoids and Phenolic Acids from Sanguisorba officinalis L. by HPLC-ELSD and Its Application.

Phytochemistry

Sun J et al (2021).; Molecules.
DOI:: 10.3390/molecules26154505
PubMed:: 34361658

35.

Network Pharmacology and Pharmacological Evaluation Reveals the Mechanism of the Sanguisorba Officinalis in Suppressing Hepatocellular Carcinoma.

Jiang N et al (2021).; Front Pharmacol.
DOI:: 10.3389/fphar.2021.618522
PubMed:: 33746755

36.

Phenolic glycosides from Sanguisorba officinalis and their anti-inflammatory effects.

Immunology Phytochemistry

Chen JF et al (2022).; Nat Prod Res.
DOI:: 10.1080/14786419.2020.1849202
PubMed:: 33205667

37.

A new triterpenoid and other constituents with cytotoxic activity from the roots of Sanguisorba officinalis L.

Wang R et al (2021).; Nat Prod Res.
DOI:: 10.1080/14786419.2019.1693569
PubMed:: 31795750

38.

Aryl-tetralin-type lignan isolated from Sanguisorba officinalis.

Wang LN et al (2019).; J Asian Nat Prod Res.
DOI:: 10.1080/10286020.2018.1487957
PubMed:: 29945462

39.

Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review.

Review

Jang E et al (2018).; Am J Chin Med.
DOI:: 10.1142/S0192415X18500155
PubMed:: 29433389