Sarcococca ruscifolia

Ethnobotanical Studies

Studies

Synthesis, biological activities and mechanistic studies of C(20)-ketone pachysandra alkaloids as anti-hepatocellular carcinoma agents.

Summary

Researchers designed and synthesized 23 novel C-ketone pachysandra alkaloids to combat liver cancer, showing stronger anticancer activity with low toxicity. Compound 6k inhibits liver cancer cell proliferation and migration through the JAK2/STAT3 pathway, making it a promising treatment option.

Zhao J et al (2024).
Mol Divers.
PubMed:
39158620