Researchers identified potential inhibitors from Dehydrocostus lactone and Mokkolactone for EGFR L858R mutant lung cancer. These compounds showed anti-proliferative activity and stable binding in molecular simulations. Further in vivo studies are needed for efficacy assessment.
Flower extracts were used to synthesize copper nanoparticles with potential applications in stabilizing compounds, antimicrobial activity, and anti-obesity/anti-diabetic effects. This study demonstrates the versatility and benefits of using plant-synthesized nanoparticles in various fields.
Dehy, a compound from Saussurea lappa Clarke, effectively treats cancer and gastrointestinal disorders. However, its specific impact on gastric cancer is not well-known.
Researchers developed a nanoformulation of costunolide (COST) to improve its anti-proliferative effects in colon cancer cells. The optimized formulation showed increased cytotoxicity, enhanced apoptosis, and altered gene expression compared to raw COST, making it more effective in killing cancer cells.
Researchers found that a plant extract from Saussurea lappa roots could potentially be used as a food supplement to combat SARS-CoV-2, as it showed some ability to inhibit the virus. Further research is needed to establish its effectiveness as a treatment for COVID-19.
Scientists have discovered that HDL, a protein responsible for various functions in the body, is affected by alterations in its structure caused by SARS-CoV-2. This discovery sheds light on the increased risk of severe COVID-19 in older adults, obese individuals, and those with chronic illnesses. The study's findings could potentially lead to new treatments that target HDL to improve outcomes for these vulnerable populations.