Schisandra chinensis

Ethnobotanical Studies

Studies

Schisandra chinensis lignans improve insulin resistance by targeting TLR4 and activating IRS-1/PI3K/AKT and NF-κB signaling pathways.

Summary

Schisandra chinensis compounds 2 and 4 improve insulin resistance by targeting TLR4, modulating NF-κB and IRS-1/PI3K/AKT pathways, offering potential as T2DM treatments.

ImmunologyPhytochemistry
Zhao SL et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.113069
PubMed:
39241520

Schisandra chinensis (Turcz.) Baill neutral polysaccharides alleviate Parkinson's disease via effectively activating MCL-1 expression regulation of autophagy signaling.

Summary

SBP-1 polysaccharide from Schisandra chinensis may protect against Parkinson's disease by enhancing autophagy and targeting MCL-1 to improve neuronal survival. Potential treatment for PD.

Neuroscience
Wang SY et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134952
PubMed:
39197630

Correction to: A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high‑sucrose diet.

Lee H et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01480-1
PubMed:
39184977

Anti-pneumoconiosis effect of schisantherin A in PMA-induced A549 cells and SiO(2)/TiO(2)nanoparticles-induced acute pulmonary injury in mice.

Lim JJ, Choi HS and Kim H (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176938
PubMed:
39181224

CKD-497 inhibits NF-kB signaling and ameliorates inflammation and pulmonary fibrosis in ovalbumin-induced asthma and particulate matter-induced airway inflammatory diseases.

Summary

CKD-497, derived from rhizome and fruits, reduces inflammation and mucus production in asthma and pollution-induced lung inflammation. It inhibits proinflammatory cytokines and NF-kB pathway, potentially protecting against respiratory diseases.

AsthmaImmunology
Kim H et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1428567
PubMed:
39170711

Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.

Summary

Schisandrin C activates the cGAS-STING pathway, inhibiting tumor growth in breast and colon cancer models. It enhances type I IFN response and antitumor immunity, improving chemotherapy efficacy. Important for future cancer treatment strategies.

Cancer
Yang H et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1369563
PubMed:
39170700

Schisandra chinensis lignans regulate and cooperate with endogenous cannabinoid systems to ameliorate intestinal barrier injury associated with depression.

Summary

SCL from Schisandra chinensis helps with depression by repairing gut barrier, reducing inflammation, protecting nerves, and modulating the endocannabinoid system. Important for understanding depression treatment.

GastroenterologyNeurosciencePhytochemistry
Wang J et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155929
PubMed:
39126923

Molecular mechanisms of Schisandra chinensis in treating depression-neuropathic pain comorbidity by network pharmacology and molecular docking analysis.

Summary

Study identified bioactive components in Schisandra chinensis for treating neuropathic pain/depressive disorder comorbidity. Components regulate pathways involving TNF, VEGF, and GH, providing insights into molecular mechanisms for potential novel therapies.

NeurosciencePain
Mokhtari T and El-Meghawry El-Kenawy A (2024).
Neuroscience.
DOI:
10.1016/j.neuroscience.2024.07.023
PubMed:
39032805

Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes.

Summary

Schisandrin B from Schisandra fruit inhibits Angiotensin II-induced cardiac inflammation and remodeling by targeting MyD88. Potential novel therapy for myocardial inflammatory diseases.

COVID-19CardiologyImmunology
Xu S et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112660
PubMed:
39018688

Exploring the diversity and potential functional characteristics of microbiota associated with different compartments of Schisandra chinensis.

Summary

Researchers studied the relationship between microbes and medicinal plants, focusing on a specific herb with potential health benefits. Understanding these interactions could improve plant growth and utilization for medicinal purposes.

Gastroenterology
Hou W et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1419943
PubMed:
38939187

Interfamily Grafted Hybrids Vitis vinifera/Schisandra chinensis Resulted in Transcriptomic, Phenotypic, and Metabolic Changes.

Zhang S et al (2024).
Plants (Basel).
DOI:
10.3390/plants13121676
PubMed:
38931108

Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathway.

Summary

Gomisin N from Schisandra chinensis has neuroprotective effects in Alzheimer's disease by upregulating antioxidant proteins and improving cognitive function in AD models through the GSK3β/Nrf2 signaling pathway. Potentially promising therapeutic agent.

Neuroscience
Song M et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155811
PubMed:
38924927

The regulation of GSH/GPX4-mediated lipid accumulation confirms that schisandra polysaccharides should be valued equally as lignans.

Phytochemistry
Xue L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118483
PubMed:
38914150

Tracking Chlamydia - Host interactions and antichlamydial activity in Caenorhabditis elegans.

Reigada I et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116956
PubMed:
38901202

The influence of storage conditions on the quality of Schisandra chinensis fruits: A integrated investigation of constituent and antioxidant activity.

Immunology
Sheng Y et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e32194
PubMed:
38882346

Integrated spatial metabolomics and network pharmacology to explore the pharmacodynamic substances and mechanism of Radix ginseng-Schisandra chinensis Herb Couple on Alzheimer's disease.

Summary

Study using AFADESI-MSI & network pharmacology analyzed RS effects in AD mice. RS attenuated hippocampal damage, impacting 28 biomarkers linked to AD pathophysiology. Shows potential of TCM in understanding herbal formulas for AD treatment.

Neuroscience
Fan Y et al (2024).
Anal Bioanal Chem.
DOI:
10.1007/s00216-024-05364-z
PubMed:
38853180

Multi-omics analysis reveals mechanism of Schisandra chinensis lignans and acteoside on EMT in hepatoma cells via ERK1/2 pathway.

Summary

Scientists found that traditional Chinese medicine components have anti-cancer properties against Hepatocellular carcinoma, a common and chemo-resistant cancer. This research may lead to more effective treatments for late-stage HCC.

Phytochemistry
Jiang J et al (2024).
Funct Integr Genomics.
DOI:
10.1007/s10142-024-01351-w
PubMed:
38849609

Investigation of the efficacy of Dengzhan Shengmai capsule against heart failure with preserved ejection fraction.

Summary

Chinese medicine DZSMC may treat HFpEF effectively. Research on its mechanism is growing. Potential safe and effective treatment worth exploring further for high mortality condition.

Cardiology
Kang Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118419
PubMed:
38838924

Extraction, purification, structural characterization, and biological activity of polysaccharides from Schisandra chinensis: A review.

Review
Ji R, Wang Z and Kuang H (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132590
PubMed:
38788881

Triterpenoids with α-glucosidase inhibitory and cytotoxic activities from the fruits of Schisandra chinensis.

Sun P et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106029
PubMed:
38768792

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects.

Li A et al (2024).
Arch Microbiol.
DOI:
10.1007/s00203-024-03988-4
PubMed:
38739151

A versatile economic strategy by HPLC-CAD for quantification of structurally diverse markers in quality control of Shengmai Formula from raw materials to preparations.

Liu L et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155625
PubMed:
38692077

Synthetic consortia of four strains promote Schisandra chinensis growth by regulating soil microbial community and improving soil fertility.

Li Y et al (2024).
Planta.
DOI:
10.1007/s00425-024-04410-5
PubMed:
38678496

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed.

Sun B et al (2024).
Molecules.
DOI:
10.3390/molecules29081893
PubMed:
38675712

State-of-the-Art Review on Botanical Hybrid Preparations in Phytomedicine and Phytotherapy Research: Background and Perspectives.

Review
Panossian A, Lemerond T and Efferth T (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17040483
PubMed:
38675443

Effect and mechanism of gomisin D on the isoproterenol induced myocardial injury in H9C2 cells and mice.

Summary

Gomisin D protects heart cells from damage caused by stress, making it a potential treatment for heart disease. It works by reducing cell death, decreasing heart enzyme levels, and improving energy production in mitochondria.

Cardiology
Chen ZH et al (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2336152
PubMed:
38634612

A combined extract containing Schisandra chinensis (SCE) reduced hepatic triglyceride accumulation in rats fed a high-sucrose diet.

Lee H et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01464-1
PubMed:
38585559

Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice.

Summary

Wine-processed Schisandra chinensis polysaccharide improves memory, reduces neuronal damage, and decreases Aβ deposition in AD mice. It also regulates metabolic disorders and shows potential as a treatment for Alzheimer's Disease.

Neuroscience
Lun W et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130804
PubMed:
38565361

Simultaneous separation and determination of seven biphenyl cyclooctene lignans in Schisandra chinensis and its preparations by micellar electrokinetic chromatography with dual organic solvent system.

Summary

Gomisin, a natural compound from Magnoliaceae, has various health benefits including anti-inflammatory, antioxidant, anti-tumor, anti-aging, and hypoglycemic effects. It can be used in medicine, supplements, food, and cosmetics.

Phytochemistry
Wang M et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3349
PubMed:
38558474

Lignan contents of Schisandra chinensis (Turcz.) Baill. from different origins-A new model for evaluating the content of prominent components of Chinese herbs.

Phytochemistry
He D et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155361
PubMed:
38552434

Establishment of cluster of differentiation 20 immobilized cell membrane chromatography for the screening of active antitumor components in traditional Chinese medicine.

Summary

Researchers developed a model to study a small molecule's interaction with CD20 protein in lymphoma cells. Compounds from Schisandra chinensis and Lysionotus pauciflorus were found to target CD20, with potential for improving non-Hodgkin lymphoma treatment.

CancerPhytochemistry
Ding Y et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.464845
PubMed:
38552371

The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.

Immunology
Wu Z et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00888-z
PubMed:
38500179

Simultaneous Quantification of Nine Target Compounds in Traditional Korean Medicine, Bopyeo-Tang, Using High-Performance Liquid Chromatography-Photodiode Array Detector and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry.

Phytochemistry
Seo CS et al (2024).
Molecules.
DOI:
10.3390/molecules29051171
PubMed:
38474683

Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels.

Summary

Scientists studied Schisandra chinensis for its analgesic properties. The extract showed analgesic activity but the active component and mechanisms are unknown. Important for potential pain management discoveries.

Pain
Zhao M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117996
PubMed:
38431110

Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review.

Summary

Adaptogens are plants that help the body adapt to stress and promote resilience. They have anti-inflammatory effects and may improve conditions in central nervous system disorders. Research aims to understand their benefits on neuroinflammation.

Review Neuroscience
Wróbel-Biedrawa D and Podolak I (2024).
Molecules.
DOI:
10.3390/molecules29040866
PubMed:
38398618

Network pharmacology and experimental validation to investigate the mechanism of Nao-Ling-Su capsule in the treatment of ischemia/reperfusion-induced acute kidney injury.

Summary

NLSC, a traditional herbal capsule, may have potential in treating acute kidney injury. Its ingredients have brain-strengthening and kidney-protecting effects, showing promise in clinical use.

Cardiology
Lin Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117958
PubMed:
38395179

Application of three-dimensional material CZIF-8/CS-MS as adsorbents for the determination of plant growth regulators in Schisandra chinensis.

Zhang DX et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.464727
PubMed:
38359689

Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells.

Jin M et al (2024).
iScience.
DOI:
10.1016/j.isci.2024.108912
PubMed:
38323006

Transcriptome-wide analysis of PIP reductase gene family identified a phenylpropene synthase crucial for the biosynthesis of dibenzocyclooctadiene lignans in Schisandra chinensis.

GeneticsPhytochemistry
Qiang T et al (2023).
Synth Syst Biotechnol.
DOI:
10.1016/j.synbio.2023.11.011
PubMed:
38283950

Effect of vinegar steaming on the composition and structure of Schisandra chinensis polysaccharide and its anti-colitis activity.

Gastroenterology
Guo ZJ et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5811
PubMed:
38191780

A comprehensive study of Ephedra sinica Stapf-Schisandra chinensis (Turcz.) Baill herb pair on airway protection in asthma.

Summary

Mahuang and Wuweizi herbs, commonly used in traditional Chinese medicine for respiratory symptoms, work together to improve efficacy in treating cough and asthma. The mechanism against asthma is still unknown.

Asthma
Zhuo Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117614
PubMed:
38113990

Schisandrin B, a dual positive allosteric modulator of GABA(A) and glycine receptors, alleviates seizures in multiple mouse models.

Neuroscience
Wu J et al (2024).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-023-01195-3
PubMed:
38017298

Schisandrin A in Schisandra chinensis Upregulates the LDL Receptor by Inhibiting PCSK9 Protein Stabilization in Steatotic Model.

Kim HJ et al (2024).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2306.06049
PubMed:
37997262

Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.

DiabetesImmunology
Guo X et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-023-03725-w
PubMed:
37910285

Protection of schisantherin A against dictamnine-induced hepatotoxicity: Pharmacokinetic insights.

Chang X et al (2024).
J Appl Toxicol.
DOI:
10.1002/jat.4557
PubMed:
37873635

Schisandrin A from Schisandra chinensis Attenuates Ferroptosis and NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy through Mitochondrial Damage by AdipoR1 Ubiquitination.

Diabetes
Wang X et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/5411462
PubMed:
35996380

Plant Adaptogens-History and Future Perspectives.

Meta-Analysis
Todorova V et al (2021).
Nutrients.
DOI:
10.3390/nu13082861
PubMed:
34445021

Antioxidant Effects of Schisandra chinensis Fruits and Their Active Constituents.

Review Immunology
Kopustinskiene DM and Bernatoniene J (2021).
Antioxidants (Basel).
DOI:
10.3390/antiox10040620
PubMed:
33919588

Cough Inhibition Activity of Schisandra chinensis in Guinea Pigs.

Zhong S et al (2021).
J Med Food.
DOI:
10.1089/jmf.2020.4824
PubMed:
33861937

Schisandra chinensis and its phytotherapeutical applications.

Review
Rybnikář M, Šmejkal K and Žemlička M (2019).
Ceska Slov Farm.
PubMed:
31431019

Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases.

Review
Zhang M, Xu L and Yang H (2018).
Int J Mol Sci.
DOI:
10.3390/ijms19071970
PubMed:
29986408

Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress.

Immunology
Yuan R et al (2018).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.01.079
PubMed:
29902864

A review of polysaccharides from Schisandra chinensis and Schisandra sphenanthera: Properties, functions and applications.

Review
Li Z et al (2018).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2017.12.058
PubMed:
29352909