Schizocapsa plantaginea

Ethnobotanical Studies

Gongcheng County, Guangxi, China

Uses: Sore throat, toothache, infantile pharyngitis, sprain swelling, lymphadenopathy

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

Studies

A systematic review of spirostanol saponins and anticancer natural products isolated from Tacca plantaginea (Hance) Drenth.

Summary

Scientists studied bioactive molecules in Tacca plantaginea, including taccanolides and taccaosides, which show potential as anticancer agents by targeting cancer stem cells and immune response. Further research on saponins from this plant may lead to new immuno-active treatments.

Review Cancer Phytochemistry

Bailly C et al (2024).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2024.114252
PubMed:: 39173698

SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/mTOR Signaling Pathways.

Summary

SSPH I, a saponin found in Schizocapsa plantaginea, has anti-proliferative and antimetastatic effects on lung cancer. This research suggests potential for developing new treatments.

Cancer Immunology Phytochemistry

Zhou J et al (2024).; Recent Pat Anticancer Drug Discov.
DOI:: 10.2174/0115748928283132240103073039
PubMed:: 38305308

Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism.

Phytochemistry

Huang D et al (2023).; Med Oncol.
DOI:: 10.1007/s12032-023-02000-1
PubMed:: 36977862

SSPH I, a Novel Anti-Cancer Saponin, Inhibits Autophagy and Induces Apoptosis via ROS Accumulation and ERK1/2 Signaling Pathway in Hepatocellular Carcinoma Cells.

Cancer Phytochemistry

Zhou JL et al (2020).; Onco Targets Ther.
DOI:: 10.2147/OTT.S253234
PubMed:: 32606806

Saponins isolated from Schizocapsa plantaginea inhibit human hepatocellular carcinoma cell growth in vivo and in vitro via mitogen-activated protein kinase signaling.

Phytochemistry

Sun YW et al (2018).; Chin J Nat Med.
DOI:: 10.1016/S1875-5364(18)30027-X
PubMed:: 29425588