Oroxylin A (OA) inhibits glycolytic enzymes to treat liver cancer; it also decreases pulmonary arterial hypertension (PAH) in rats by reducing the Warburg effect of abnormal glucose metabolism. OA shows potential as a protective treatment for PAH.
Baicalin from Scutellaria baicalensis helps lower blood pressure and protects the heart. Targets related to cardiac hypertrophy and signaling pathways were identified, showing improved cardiac function in mice and cells by reducing cardiac hypertrophy markers and MAPK pathway activation. It can be beneficial for hypertension-related heart issues.
"Wogonin inhibits pulmonary vascular remodeling in pulmonary hypertension by suppressing EndMT via the TGF-β1/Smad pathway, showing potential as a promising therapeutic drug for PH."
Baicalein from Scutellaria baicalensis has potential anti-inflammatory and antitumor effects, but its therapeutic mechanisms in endometriosis are not fully understood. Endometriosis is a painful gynecological condition with limited treatment options and high recurrence rates.
Researchers studied how baicalin, a compound in Radix scutellariae, can help reduce inflammation in metabolic disorders like obesity. Baicalin can potentially improve insulin resistance in obesity by modulating macrophages.
TL;DR: Interaction between ritonavir and S. baicalensis boosts flavones in blood/brain, helping treat SARS-CoV-2. Important for understanding herb-drug interactions in COVID-19 treatment.
Baicalin from Scutellaria baicalensis helps treat diabetic osteoporosis by promoting bone formation and inhibiting fat accumulation. Its effects may be mediated through the P38-MAPK pathway, offering a potential new treatment approach.
Baicalin, a compound from Georgi, inhibits lung cancer progression by reducing inflammation and targeting SOCS1/NF-κB/STAT3 pathway. Potential novel treatment for lung cancer.
BS drug pair is effective for depression and tumor treatment, but simultaneous targeting mechanism remains unclear. Understanding could lead to new treatment approaches for both conditions.
This study explores using Traditional Chinese Medicine to target the interaction between SARS-CoV-2 variants and human cells, finding baicalein and baicalin from () to be effective inhibitors. Further research on these compounds is warranted for potential COVID-19 treatment.
TREM2 upregulation by Baicalin reduces inflammation and oxidative stress in acute ischemic stroke, showing promise for treatment efficacy in both in vitro and in vivo models.
Research reviewed nutraceuticals from Traditional Chinese Medicine for relieving Long COVID-19 gastrointestinal symptoms. Identified plants such as Cinnamomum cassia and Salvia miltiorrhiza show promise in reducing inflammation and oxidative stress. These natural remedies may offer multi-target therapeutic benefits for Long COVID-19 complications.
Research shows Oroxylin A from traditional Chinese medicine has potent anti-tumor effects through various biological mechanisms. Its safety and effectiveness warrant further clinical trials for potential cancer treatment.
Baicalein from Scutellaria baicalensis roots protects against obesity-induced heart damage by activating the mitochondrial unfolded protein response. Important for treating metabolic and cardiovascular diseases.
Baicalin-preteated BMSC-derived exosomes reduce hepatic I/R injury by suppressing inflammation, improving cell balance, and inducing FGF21 expression. Baicalin enhances therapeutic potential of exosomes for liver damage.
Scientists developed a yeast-based platform to produce pharmaceutical components found in rare plants. This method reduces environmental impact and allows for the synthesis of multiple compounds. The study provides insight into biosynthesizing plant-derived components for therapeutic use.
Huangqin decoction inhibits growth of dermatophyte, and damages its cell membrane and enzyme activities, revealing significant anti-dermatophyte potential.
This study investigated the antioxidant, anti-inflammatory, and intestinal protective properties of and Georgi extracts. Results showed potential health benefits on body weight, intestinal microbiota, and short-chain fatty acid concentrations. Useful for clinical and animal production applications.
This study investigated the use of baicalein, a flavonoid with multiple therapeutic properties, for the treatment of diabetes. Aquasomes were used to enhance its solubility, potentially facilitating its delivery as a drug. This research is important as it explores a promising approach to effectively treat metabolic abnormalities induced by diabetes.
Wogonin, a natural flavonoid, protects against cerebral ischemia-reperfusion (IR) injury by reducing inflammation through the AMPK/SIRT1/NLRP3 inflammasome pathway. It improves neurological function and reduces brain damage.
Baicalein, a component in traditional Chinese medicine, induces pyroptosis in gastric cancer cells through the NF-κB-NLRP3 signaling axis. This could be an effective and novel therapeutic approach for treating gastric cancer, providing hope for improved outcomes.
Baicalin and baicalein, derived from a Chinese medicinal plant, have low toxicity to normal cells and exhibit anticancer activities. They regulate tumor microenvironmental cells and extracellular matrix, inhibiting tumor angiogenesis, progression, and metastasis. Further research is needed to improve their bioavailability and clinical applications.
Baicalin, a compound derived from Scutellaria baicalensis, has been found to protect against oxidative stress and inflammation in Parkinson's disease. It activates Nrf2 to increase antioxidant enzymes and suppresses NLRP3 inflammasome activation.
Researchers studied the therapeutic effects of baicalein (BAI), a compound in Scutellaria baicalensis Georgi, for cataract treatment. BAI has antioxidant, anti-apoptotic, and anti-inflammatory properties. Care about this because it could potentially lead to a new treatment for cataracts.
This study found that the natural compound wogonin can reverse radioresistance in breast cancer cells by inhibiting the Nrf2/HIF-1 pathway. This offers potential strategies to improve the effectiveness of radiotherapy in breast cancer treatment.
Scientists studied Scutellaria baicalensis Georgi, a traditional Chinese medicine often used in East Asia. They explored its active compounds in aqueous extracts and their effects on lowering blood sugar and lipids. The results may uncover the mechanisms behind its therapeutic properties.
Baicalin, found in Scutellaria baicalensis Georgi, shows promise in treating metabolic dysfunction-associated fatty liver disease (MAFLD). It reduces lipid accumulation, cirrhosis, and apoptosis in the liver by enhancing antioxidant enzymes through the p62-Keap1-Nrf2 pathway.
Wogonin, derived from Scutellaria baicalensis Georgi, can mitigate the progression of pulmonary hypertension (PH) in mice. A noninvasive prediction method using feature selection (BSCDWOA-KELM) can accurately screen key indicators in PH datasets. This method can be used to predict wogonin therapy for PH.
The researchers studied the effects of Sanhuang Xiexin Decoction (SHXD) on rat NK-cell phenotypes and its mechanism in treating inflammation induced by lipopolysaccharides (LPS).
Baicalein and baicalin, compounds from plants, show potential as drugs to treat COVID-19. They exhibit antiviral and anti-inflammatory properties, suppressing viral infection and reducing organ damage. More research is needed to determine their safety and effectiveness in patients. This offers hope for new antiviral treatments.
The effectiveness of the Qinzhizhudan Formula (QZZD) in treating vascular dementia (VD) is still unclear, requiring further research to understand its potential therapeutic effects and mechanism of action.
Scientists investigated the protective effects of Wogonoside (Wog) from Scutellaria baicalensis Georgi (SBG) on acute myocardial ischemia (AMI). Understanding these mechanisms could lead to potential treatments for cardiovascular diseases.
Researchers investigated the effects of Scutellaria baicalensis Georgi (SGE) on inflammatory pain. SGE extracted from the herb showed anti-inflammatory and analgesic properties, potentially making it useful for treating inflammation-related diseases. However, more research is needed to fully understand its mechanisms.
Baicalin, a compound found in certain plants, has shown potential in improving polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder in women.
Baicalin, found in Scutellaria baicalensis Georgi plant, has been shown to have kidney-protective properties. However, its impact on mesangial proliferative glomerulonephritis (MPGN) is not well understood. This study aimed to explore the effect of Baicalin on MPGN and uncover the mechanisms involved. By understanding how Baicalin affects MPGN, we can potentially develop new therapies for this prevalent form of primary glomerulonephritis.
Baicalin, a compound found in Scutellaria baicalensis Georgi, has been reported to have antidepressant effects. In this study, the researchers investigated how it works by exploring the role of the PARP1 signaling pathway in depression. They found that administration of baicalin alleviated depressive-like behaviors induced by chronic stress in mice by reducing neuronal damage in the hippocampus and increasing anti-apoptotic proteins while decreasing pro-apoptotic proteins. They also found that baicalin works by regulating the SIRT1/PARP1 signaling pathway. These findings suggest that baicalin may be a potential therapeutic option for depression.
Researchers investigated the differences between two specifications of Scutellaria baicalensis, a traditional Chinese medicine. The Chinese Pharmacopoeia Commission no longer distinguishes between them, but they are still sold separately.
Flavonoids in have been studied for their effects on lung cancer and asthma. This review explores the mechanisms by which these compounds work.
Researchers investigated the effectiveness of using an herb extract and its component, baicalein, to inhibit the 3C protease of SARS-CoV-2, a preferred target for anti-coronavirus drug development. The ethanol extract and baicalein displayed anti-SARS-CoV-2 activity and inhibited viral replication in Vero cells. The herb extract also inhibited viral entry. Four baicalein analogues from other herbs were identified to also inhibit SARS-CoV-2 3CL activity. The study suggests that the herb extract and baicalein have the potential to be developed as broad-spectrum anti-coronavirus drugs.
A review article suggests that natural products like plants and herbs could be used as potential treatments for COVID-19 based on their antiviral activities against other coronaviruses. The authors searched through multiple scientific databases and found that certain plants and herbs, such as Allium sativum, Zingiber officinale, and Glycyrrhiza glabra, have been shown to improve immune response and inhibit viral replication. The study also identified specific compounds, such as terpenoids and alkaloids, with promising effects against coronavirus targets like the S protein and viral enzymes. Overall, the article suggests that natural products could be used as preventive and therapeutic agents in the fight against COVID-19.