Scutellaria barbata

Ethnobotanical Studies

Studies

Scutellaria barbata D.Don and Scleromitrion diffusum (Willd.) R.J.Wang inhibits the progression of triple negative breast cancer though the activation inhibition of NF-κB triggered by CAFs-derived IL6.

Summary

Researchers studied the herb pair Scutellaria barbata and Scleromitrion diffusum for their anti-tumor effects on triple-negative breast cancer. Understanding their molecular mechanisms can lead to new treatment options.

CancerImmunology
Pan Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118656
PubMed:
39121924

Corrigendum to "Dissecting the antitumor effects of Scutellaria barbata: Initial insights into the metabolism of scutellarin and luteolin by gut microbiota" [J. Pharm. Biomed. Anal. 248 (2024) 116325].

CancerGastroenterology
Zhang X et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116393
PubMed:
39106746

Dissecting the antitumor effects of Scutellaria barbata: Initial insights into the metabolism of scutellarin and luteolin by gut microbiota.

Summary

Study investigated how gut microbiota metabolizes flavonoids in Scutellaria barbata, elucidating potential anti-tumor effects. Results inform future studies optimizing cancer treatment with SBD.

CancerGastroenterology
Zhang X et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116325
PubMed:
38959755

Research progress on anti-tumor mechanisms of scutellarin.

Summary

Scutellarin, a flavonoid, shows promising anti-tumor effects by inhibiting growth/metastasis, inducing apoptosis/autophagy, and enhancing sensitivity to chemotherapy. Further research can explore its potential in cancer treatment.

Review Cancer
Ge HC and Zhong XH (2024).
J Asian Nat Prod Res.
DOI:
10.1080/10286020.2024.2362375
PubMed:
38910315

Identification of Scutebarbatine B metabolites in rats using UHPLC-Q-Orbitrap-MS/MS and exploration of its mechanism of reversal multidrug resistance in breast cancer by network pharmacology and molecular docking studies.

Summary

"SBT-B from S. barbata inhibits P-gp, reversing MDR in breast cancer. Identified 18 novel metabolites, mainly through oxidization and acetylation. Targets p27 phosphorylation, p53 signaling, and inhibits P-gp expression. Provides new insight for P-gp inhibitor development."

Cancer
Zhang H et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116207
PubMed:
38744199

Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies.

Ye Z et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8232
PubMed:
38695125

Study on the Mechanism of Competing Endogenous Network of 'Scutellaria barbata D.Don-Houttuynia cordata- Radix Scutellariae' in the Treatment of NSCLC based on Bioinformatics, Molecular Dynamics and Experimental Verification.

Wu L et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099288771240419110716
PubMed:
38685811

Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

Summary

Researchers developed lipid nanocarriers using ultrasonic waves to encapsulate Scutellaria barbata for anticancer and antibacterial benefits. Green technology synthesis enhances bioavailability, controlled release, and stability. Potential for eco-friendly drug delivery advancements.

Cancer
Jetti R et al (2024).
Bioprocess Biosyst Eng.
DOI:
10.1007/s00449-024-03021-4
PubMed:
38647679

Scutellaria barbata D.Don extract regulates Ezrin-mediated triple negative breast cancer progress via suppressing the RhoA /ROCK1 signaling.

Summary

Researchers investigated the anti-cancer effects of Scutellaria barbata D.Don (SB) extract on triple-negative breast cancer (TNBC). Understanding its mechanism could lead to potential new treatment targets for TNBC.

Cancer
Niu J, Hu J and Wang Z (2024).
Toxicol Res (Camb).
DOI:
10.1093/toxres/tfae033
PubMed:
38525246

Scutellarin, a flavonoid compound from Scutellaria barbata, suppresses growth of breast cancer stem cells in vitro and in tumor-bearing mice.

Summary

Scientists studied Scutellaria barbata to explore its potential as a natural treatment for various types of cancer. The compound scutellarin showed promise for its anti-tumor effects.

CancerPhytochemistry
Ma H et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155418
PubMed:
38518647

Network-based pharmacology-based research on the effect and mechanism of the Hedyotis diffusa-Scutellaria Barbata pair in the treatment of hepatocellular carcinoma.

Hou C et al (2024).
Sci Rep.
DOI:
10.1038/s41598-023-50696-y
PubMed:
38200019

Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification.

Summary

Scutellaria barbata D. Don (SBD) contains bioactive ingredients that inhibit ovarian cancer development. Quercetin, luteolin, and wogonin are key components that inhibit cancer growth by targeting the PI3K/Akt signaling pathway. SBD could be a potential drug for ovarian cancer treatment.

CancerEndocrinology
Zhang J et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000036656
PubMed:
38134066

Determination and mechanism of Xiao-Ai Jie-Du decoction against diffuse large B-cell lymphoma: In silico and In vitro studies.

Summary

Xiao-Ai Jie-Du decoction is a treatment for DLBCL with varying prescriptions. It has shown effectiveness in clinical practice.

Immunology
Zhan XZ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117271
PubMed:
37838296

The complete chloroplast genome of Scutellaria barbata D. Don 1825 revealed the phylogenetic relationships of the Scutellaria genus.

Summary

The researchers analyzed the chloroplast genome of D. Don 1825, a medicinal plant used to treat various diseases. They found 131 genes and determined its phylogenetic relationship with other plants. This study provides a potential reference for important medicinal plants in the genus.

Genetics
Pan S et al (2023).
Mitochondrial DNA B Resour.
DOI:
10.1080/23802359.2023.2261564
PubMed:
37799449

Hedyotis Diffusa-Scutellaria Barbata inhibits Breast Cancer Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata inhibits the Progression of Breast Cancer via Targeting LMO1 and AKT/Mtor Signaling Pathway.

Summary

Scutellaria barbata and Hedyotis diffusa herb pair (SH) has anticancer effects in various cancers, including breast cancer, but the precise mechanism is unknown.

Cancer
Li Z et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230913105858
PubMed:
37711008

Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.

Summary

Combination of Hedyotis diffusa and Scutellaria barbata inhibits colorectal cancer through downregulation of hsa_circ_0039933, a molecule that promotes cancer progression via the Wnt signaling pathway.

CancerGastroenterology
Zhu D, Yuan S and Chen C (2023).
Sci Rep.
DOI:
10.1038/s41598-023-40393-1
PubMed:
37587207

Evaluation of therapeutic mechanism of Hedyotis diffusa Willd (HDW)‒Scutellaria barbata (SB) in clear cell renal cell carcinoma via single-cell RNA sequencing and network pharmacology.

Genetics
Bai Y et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230731155309
PubMed:
37526191

The signaling pathways of traditional Chinese medicine in treating diabetic retinopathy.

Summary

Traditional Chinese medicine (TCM) shows promise for treating diabetic retinopathy (DR) by targeting inflammation, angiogenesis, and oxidative stress pathways. TCM components like curcumolide, quercetin, blueberry anthocyanins, and more have potential for DR treatment, aiding in the development of new drugs. (35 words)

Review Diabetes
Li W et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1165649
PubMed:
37405050

Tandem duplication and sub-functionalization of clerodane diterpene synthase originates the blooming of clerodane diterpenoids in Scutellaria barbata.

Qiu T et al (2023).
Plant J.
DOI:
10.1111/tpj.16377
PubMed:
37395679

Identification of Flavonoids from Scutellaria barbata D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships.

Phytochemistry
Tang TT et al (2023).
Molecules.
DOI:
10.3390/molecules28114476
PubMed:
37298951

Editorial: The inaugural Monash international health science and technology conference: pharmacology perspectives.

Khaw KY et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1208546
PubMed:
37229254

Study on the mechanism of action of Scutellaria barbata on hepatocellular carcinoma based on network pharmacology and bioinformatics.

Yang AY, Liu HL and Yang YF (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1072547
PubMed:
36699068

Stepwise Diagnostic Product Ions Filtering Strategy for Rapid Discovery of Diterpenoids in Scutellaria barbata Based on UHPLC-Q-Exactive-Orbitrap-MS.

Zhou X et al (2022).
Molecules.
DOI:
10.3390/molecules27238185
PubMed:
36500290

Scutellaria barbata D. Don inhibits cervical cancer cell proliferation, migration, and invasion via miR-195-5p/LOXL2 axis.

Cancer
Xue S et al (2022).
Toxicol Res (Camb).
DOI:
10.1093/toxres/tfac058
PubMed:
36337243

The Characteristics and Mortality of Chinese Herbal Medicine Users among Newly Diagnosed Inoperable Huge Hepatocellular Carcinoma (≥10 cm) Patients: A Retrospective Cohort Study with Exploration of Core Herbs.

Chen SL et al (2022).
Int J Environ Res Public Health.
DOI:
10.3390/ijerph191912480
PubMed:
36231778

Network pharmacology-based investigation and experimental validation of the mechanism of scutellarin in the treatment of acute myeloid leukemia.

Cancer
Huang Z et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.952677
PubMed:
36160389

Integrating network pharmacology and experimental models to investigate the efficacy of QYHJ on pancreatic cancer.

Cancer
Yang PW et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115516
PubMed:
35817247

A strategy integrating parent ions list-modified mass defect filtering-diagnostic product ions for rapid screening and systematic characterization of flavonoids in Scutellaria barbata using hybrid quadrupole-orbitrap high-resolution mass spectrometry.

Phytochemistry
Zhou X et al (2022).
J Chromatogr A.
DOI:
10.1016/j.chroma.2022.463149
PubMed:
35597199

Scutellaria barbata Inhibits Hepatocellular Carcinoma Tumorigenicity by Inducing Ferroptosis of Hepatocellular Carcinoma Cells.

Cancer
Li Y et al (2022).
Front Oncol.
DOI:
10.3389/fonc.2022.693395
PubMed:
35321425

Scutellarin potentiates the skin regenerative function of self growth colony, an optimized platelet-rich plasma extract, in cultured keratinocytes through VEGF receptor and MAPK signaling.

Guo MS et al (2022).
J Cosmet Dermatol.
DOI:
10.1111/jocd.14800
PubMed:
35080332

Network pharmacology-based strategy to investigate the active ingredients and molecular mechanisms of Scutellaria Barbata D. Don against radiation pneumonitis.

Sun PY et al (2021).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000027957
PubMed:
34964782

Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways.

Cancer
Lv YX et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/6666499
PubMed:
34239588

Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.

Cancer
Zeng S et al (2021).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2021.174253
PubMed:
34118224

Scutellaria barbata D. Don Polysaccharides Inhibit High Glucose-Induced Proliferation and Angiogenesis of Retinal Vascular Endothelial Cells.

Genetics
Li W and Xiao H (2021).
Diabetes Metab Syndr Obes.
DOI:
10.2147/DMSO.S296164
PubMed:
34103952

Comparative Genome Analysis of Scutellaria baicalensis and Scutellaria barbata Reveals the Evolution of Active Flavonoid Biosynthesis.

Genetics
Xu Z et al (2020).
Genomics Proteomics Bioinformatics.
DOI:
10.1016/j.gpb.2020.06.002
PubMed:
33157301

Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications.

Review
Chen Q et al (2020).
Curr Pharm Des.
DOI:
10.2174/1381612825666191216124310
PubMed:
31840605

Cytotoxic Neo-Clerodane Diterpenoids from Scutellaria barbata D.Don.

Wang M et al (2019).
Chem Biodivers.
DOI:
10.1002/cbdv.201800499
PubMed:
30444060