Selaginella doederleinii

Ethnobotanical Studies

Studies

Amentoflavone reverses epithelial-mesenchymal transition in hepatocellular carcinoma cells by targeting p53 signalling pathway axis.

Summary

Amentoflavone from Selaginella doederleinii reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting core genes and blocking the p53 signaling pathway, leading to reduced cell migration, invasion, and apoptosis. Important for potential cancer treatment strategies.

Cancer
Jian HY et al (2024).
J Cell Mol Med.
DOI:
10.1111/jcmm.18442
PubMed:
38842135

Anti-tumor effect and mechanism of the total biflavonoid extract from S doederleinii on human cervical cancer cells in vitro and in vivo.

Summary

SDTBE, a biflavonoid extract from Hieron, inhibits cervical cancer cell proliferation, induces apoptosis, autophagy, and cell cycle arrest, and suppresses tumor growth in mice. The mechanism involves activating the Caspase-dependent mitochondrial apoptosis pathway.

Cancer
Lin S et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e24778
PubMed:
38304845

Corrigendum to "Disclosing targets and pharmacological mechanisms of total bioflavonoids extracted from Selaginella doederleinii against non-small cell lung cancer by combination of network pharmacology and proteomics" [J. Ethnopharmacol. 286 (2022) 114836].

Cancer
Xu D et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116441
PubMed:
36997372

A Biflavonoid-Rich Extract from Selaginella doederleinii Hieron. against Throat Carcinoma via Akt/Bad and IKKβ/NF-κB/COX-2 Pathways.

Immunology
Wang S et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15121505
PubMed:
36558956

Delicaflavone reactivates anti-tumor immune responses by abrogating monocytic myeloid cell-mediated immunosuppression.

Cancer
Li L et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154508
PubMed:
36332384

Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles.

Zhang F et al (2022).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2708229
PubMed:
36042169

Delicaflavone Represses Lung Cancer Growth by Activating Antitumor Immune Response through N6-Methyladenosine Transferases and Oxidative Stress.

Cancer
Wang X et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/8619275
PubMed:
35979397

Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract From Selaginella doederleinii.

Chen B et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.849110
PubMed:
35571075

Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe(3)O(4) nanoparticles.

Summary

This study developed a new screening tool to find drugs to treat Alzheimer's disease by inhibiting acetylcholinesterase (AChE), an enzyme that deactivates the cognitive chemical acetylcholine. The researchers immobilized AChE on magnetic nanoparticles and optimized the process to maximize enzyme immobilization yield. They then used this tool to screen natural products and found four compounds that successfully inhibited AChE - one of which was more potent than the current treatment, tacrine. This approach could be useful for discovering target drugs from complex matrices.

Neuroscience
Zhang F et al (2022).
Talanta.
DOI:
10.1016/j.talanta.2022.123284
PubMed:
35255433

Disclosing targets and pharmacological mechanisms of total bioflavonoids extracted from Selaginella doederleinii against non-small cell lung cancer by combination of network pharmacology and proteomics.

CancerPhytochemistry
Xu D et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114836
PubMed:
34793885