Common Names: sickle senna
Researchers identified natural compounds that can inhibit the activity of the SARS-CoV-2 main protease, which plays a critical role in viral replication. Through computational methods such as molecular docking and simulations, four compounds were identified with good pharmacokinetics and toxicity properties: PubChem CID 70825, CID 25247358, CID 54685836, and CID 1983. Experimental validation is still needed, but these compounds show promise as potential therapeutics for COVID-19.
Senna tora sprouts were found to have increased antioxidant and neuroprotective properties compared to seeds due to their higher levels of phenolic compounds, specifically compounds 1 and 3-6. Two new naphthopyrone glycosides were isolated from the sprouts. These compounds were found to protect neuronal cells against oxidative stress. Sprouts and their constituents could potentially be developed as natural neuroprotective agents.