Postoperative cognitive dysfunction (POCD) is a condition where patients experience cognitive impairment after surgery. This study investigated whether pretreatment with extract, a Chinese herbal medicine used for chronic inflammation, could reduce inflammation and improve cognitive performance in postoperative animals. Male mice were fed different doses of the extract for 14 days before laparotomy. Results showed that animals with extract pretreatment demonstrated memory improvement in a dose-dependent manner compared with control. Evidence for the attenuation of systemic and neuroinflammation was also found, indicating a therapeutic potential of in reducing POCD and the possibility of using this traditional Chinese medicine during surgery.