Common Names: blessed milk-thistle, spotted thistle, variegated thistle, milk thistle, blessed milkthistle
Study showed nutraceutical formulations with prebiotics, minerals, and silymarin improved gut microbiota, sleep, quality of life, and metabolic markers in overweight/obese individuals. NSupple_Silybum had significant positive effects on microbiota composition.
This study aims to explore the effectiveness of a new nutraceutical supplement in improving metabolic and endocrine parameters related to obesity.
Silymarin from Silybum marianum plant is a potent antioxidant, liver protective, and potential neuroprotective agent with immunomodulatory properties. It shows promise for treating liver diseases, Alzheimer's, Parkinson's, and cerebral ischemia.
Silymarin can help prevent chemotherapy-induced liver damage in breast cancer patients on doxorubicin-containing regimens. Consider adding silymarin to treatment plans to protect liver function.
Endophytic fungi from medicinal plants produce bioactive compounds with potential for drug development. Aspergillus flavus showed antibiofilm and antioxidant activity, with compounds identified for anti-cancer properties. Further research is warranted on these promising findings.
Silibinin from milk thistle improves diabetes by reducing insulin resistance, oxidative stress, and inflammation. It also protects against diabetic complications like liver damage and neuropathy. Clinical studies support its potential as a treatment, but more research is needed.
Study shows natural products from plants have potential in cancer therapy. Phytochemicals regulate molecular pathways, offering chemo-preventive benefits. Literature review highlights medicinal plants' anticancer effects and mechanisms. Important for developing targeted treatments.
Silibinin from milk thistle improves insulin secretion and sensitivity, reduces hyperglycemia in diabetic rats. Also improves anxiety-like behaviors and learning, and protects liver function.
Silymarin from milk thistle inhibits skin inflammation by targeting gelatinases, with potential for treating skin disorders. It also reduces ear edema by 74%.
Silibinin, a compound from milk thistle seeds, has anti-tumor effects in adenoid cystic carcinoma cells and mice. It inhibits cell growth, induces apoptosis, and alters protein expression related to cancer pathways. Potential key targets include CASP3, SRC, and JAK. Use of silibinin in cancer treatment is supported.
Silymarin protects against paracetamol-induced liver and heart damage by reducing oxidative stress markers and restoring antioxidant enzyme activity. Potentially valuable therapeutic agent for liver and heart diseases.
Tossers studied binding between HCQ/SM and HSA, inducing conformational changes, with potential therapeutic relevance for COVID-19 due to strong interaction with virus proteases. Valuable insights for pharmaceutical and biological properties.
Researchers tested a plant extract's protective properties against cancer medications. Results show the extract reduces genotoxicity and enhances cytotoxic effects of the medications. This research could lead to improved treatment strategies.
Silybum marianum (milk thistle) has potent antiviral properties, making it a crucial medicinal plant for combating various viruses.
This study looked at the effect of a supplement on liver functions and gut microbiota in overweight dogs. Results showed improvements in inflammation and metabolic status, but individual variability in the microbiome may impact supplement effectiveness. Further research is needed.
Researchers screened Middle Eastern plants for cytotoxic effects against lung cancer cell lines. Some extracts showed potent efficacy in inducing apoptosis in cancer cells, suggesting potential as alternative cancer treatments. Additional research into these plant extracts could lead to new cancer therapies.
Researchers investigated the effects of combining cisplatin (a chemotherapy drug) with silymarin (an extract from milk thistle) on ovarian cancer cells. Silymarin enhanced the anticancer effects of cisplatin, offering potential for improved treatment options. Important for developing effective ovarian cancer therapies.
Researchers used a model to identify four potential EGFR antagonists in Silybum marianum, showing potential for new, efficient, and less toxic cancer treatment.
Silibinin, derived from milk thistle, effectively inhibits macrophage activation by preventing morphological changes and reducing phagocytosis. It targets key inflammatory pathways, making it a potential anti-inflammatory agent with promising therapeutic properties.
Herbal extracts like Moringa oleifera and Boswellia serrata have been shown to improve liver function in diabetes. They contain phenolic compounds that protect the liver through various mechanisms, including improving glucose metabolism and antioxidant defense.
Researchers conducted a trial to study the impact of growing conditions on milk thistle quality. They found that weather conditions and row spacing significantly influenced the yields of health-beneficial compounds. Highest yields were obtained in the 2021 growing season with a spacing of 37 cm.
Scientists studied the biotransformation of milk thistle flavonolignans by gut microorganisms. They identified metabolites and potential pharmacological activities. This information is important for understanding the oral bioavailability and potential health benefits of milk thistle.
Silibinin, extracted from Silybum marianum, protects against ferroptotic damage and neuroinflammation in a sporadic AD model by regulating key proteins and pathways.
This study tested a polyherbal emulsion on diabetic rats and found that it reduced blood glucose and lipid levels, increased insulin, and protected pancreas and kidney tissues. It suggests that the formulation could be used as a remedy or alongside traditional diabetes medication.
Insulin resistance (IR) leads to diabetes and cardiovascular issues. Natural substances like berberine, quercetin, and silymarin combat this by targeting insulin signaling and reducing inflammation. Further research on human usage is needed.
Silibinin, a natural product found in Silybum marianum, has been used for liver diseases and shows neuroprotective activities in animal studies. Studies suggest it alters several cellular and molecular signaling pathways, including BDNF and mTOR, exhibiting antioxidant effects. This review summarizes the pharmacology, side effects, and potential therapeutic effects of silibinin for neurodegenerative disorders. Silibinin may serve as a therapeutic alternative for neurodegenerative disorders and requires further preclinical and clinical research.
Silibinin, a compound extracted from milk thistle, has traditionally been used to treat liver disease. This study evaluated the potential of silibinin as an antipsychotic drug and assessed its potential toxicity. Animal studies showed that the LD of silibinin was greater than 2,000mg/kg, indicating low toxicity. Silibinin was found to prevent and reverse symptoms of schizophrenia, including stereotypy and behavioral despair. These findings suggest that silibinin is a safe drug with significant antipsychotic activity against schizophrenia.
The study looked at the effects of Silibinin, a natural compound, on N-methyl-D-aspartate receptors (NMDARs) in Alzheimer's disease. The experimenters found that Silibinin has neuroprotective effects on Alzheimer's disease models. The study suggests that Silibinin has potential as a treatment for Alzheimer's disease, and further research is needed.