Smilax glabra

Ethnobotanical Studies

Studies

Therapeutic Effect of Smilax glabra Roxb. on Weaning Rats Against Pb-Induced Nephrotoxicity Based on Network Pharmacology.

Tian C et al (2024).
Biol Trace Elem Res.
DOI:
10.1007/s12011-024-04366-3
PubMed:
39240306

Treating chronic atrophic gastritis: identifying sub-population based on real-world TCM electronic medical records.

Wang YM et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1444733
PubMed:
39170704

Investigation of the molecular mechanism of Smilax glabra Roxb. in treating hypertension based on proteomics and bioinformatics.

Summary

Study explored protein expression in hypertension treated with Roxb. (SGR), showing potential for anti-inflammatory and immune system disease treatment. Important for developing SGR-based therapies.

Cardiology
Yang X et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1360829
PubMed:
38783958

Rapid evaluation of the quality of Smilax glabra Roxb. using QADS based on FT-NIR combined with multiple intelligent algorithms.

Zhan GZ et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139633
PubMed:
38781896

20 potentially new compounds and 11 new bioactive constituents found in Smilacis Glabrae Rhizoma utilizing HPLC-DAD-ESI-IT-TOF-MS(n).

Gegentana et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3352
PubMed:
38639052

Chaetoxylariones A-G: undescribed chromone-derived polyketides from co-culture of Chaetomium virescens and Xylaria grammica enabled via the molecular networking strategy.

Zhang S et al (2024).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2024.107329
PubMed:
38608410

Engeletin alleviates depressive-like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway.

Summary

Engeletin from Smilax glabra rhizomilax alleviates depression in mice by modulating microglial polarization and suppressing inflammatory pathways. Potential new avenue for antidepressant treatment targeting microglia.

Neuroscience
Zhang J et al (2024).
J Cell Mol Med.
DOI:
10.1111/jcmm.18285
PubMed:
38597406

The safety and efficacy of Compound Kushen Injection with chemoradiotherapy for the outcomes of lung and gastrointestinal cancers: A PRIMSA-compliant meta-analysis.

Meta-Analysis
Chen Y, Ma M and Xu F (2024).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000036758
PubMed:
38579051

First Report of Colletotrichum fructicola Causing Leaf Spot on Smilax glabra Roxb in China.

Liu Z et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-09-23-1933-PDN
PubMed:
38386302

Integrated network pharmacological analysis revealed that Smilax glabra Roxb. alleviates IMQ-induced psoriatic skin inflammation through regulating T cell immune response.

Immunology
Guo Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117836
PubMed:
38301985

Determination and mechanism of Xiao-Ai Jie-Du decoction against diffuse large B-cell lymphoma: In silico and In vitro studies.

Summary

Xiao-Ai Jie-Du decoction is a treatment for DLBCL with varying prescriptions. It has shown effectiveness in clinical practice.

Immunology
Zhan XZ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117271
PubMed:
37838296

Polysaccharide from Smilax glabra Roxb Mitigates Intestinal Mucosal Damage by Therapeutically Restoring the Interactions between Gut Microbiota and Innate Immune Functions.

Summary

Chinese medicine Roxb has bioactive polysaccharides (SGPs) that protect the gut from inflammation. SGPs increase goblet cells, reduce apoptosis, improve tight junction proteins, and enhance mucin production, while promoting probiotic bacteria and blocking pro-inflammatory pathways. Potential treatment for inflammatory bowel disease.

Gastroenterology
Abaidullah M et al (2023).
Nutrients.
DOI:
10.3390/nu15194102
PubMed:
37836386

Engeletin alleviates depression-like phenotype by increasing synaptic plasticity via the BDNF-TrkB-mTORC1 signalling pathway.

Summary

Engeletin from Smilax glabra shows antidepressant-like effects in mice by activating the BDNF-TrkB-mTORC1 pathway, enhancing synaptic plasticity in the prefrontal cortex. Promising as a new antidepressant.

Neuroscience
Xu Y et al (2023).
J Cell Mol Med.
DOI:
10.1111/jcmm.17975
PubMed:
37799103

Effect of Smilax spp. and Phellinus linteus combination on cytotoxicity and cell proliferation of breast cancer cells.

Summary

In the pursuit of reducing the mortality rate of breast cancer, researchers investigated the effects of combining PL with extracts from Smilax corbularia and S. glabra (PSS) on various breast cancer cell lines. The study aimed to uncover a more effective therapeutic regimen for breast cancer treatment. By observing the effects of PSS on MCF7, T47D, MDA-MB-231, and MDA-MB-468 cell lines, the researchers hope to contribute to the development of improved treatment options for this prevalent disease.

Cancer
Chalertpet K et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04003-x
PubMed:
37264344

The potential of Chinese medicines in the treatment of hyperuricemia.

Review
Tang J et al (2023).
Am J Transl Res.
PubMed:
37193181

Design, syntheses and biological evaluation of natural product aiphanol derivatives and analogues: Discovery of potent anticancer agents.

Summary

A recent study investigated the anticancer properties of aiphanol, a natural product found in traditional Chinese medicine. The researchers discovered that aiphanol can inhibit angiogenesis and tumor growth by blocking the VEGF/VEGFRs and COX2 signaling pathways. They designed and synthesized 40 derivatives and analogues of aiphanol, and two of them, 10j and 14c, showed the strongest inhibition of tumor cell growth across various cell lines. These analogues had 80 times greater potency than the original compound. The study also revealed that the presence of a specific substrate at the 7-position of benzo 1,4-dioxane is crucial for the anticancer activity. Molecular docking experiments showed that compound 14c binds tightly to both VEGFR2 and COX2. Overall, compounds 10j and 14c hold promise as potential candidates for future development of anticancer agents.

Cancer
Yao L et al (2023).
Bioorg Med Chem Lett.
DOI:
10.1016/j.bmcl.2023.129326
PubMed:
37182611

Engeletin alleviates cerebral ischemia reperfusion-induced neuroinflammation via the HMGB1/TLR4/NF-κB network.

Summary

Engeletin, derived from Smilax glabra rhizomilax, has neuroprotective effects in rats with cerebral ischemia reperfusion injury, reducing deficits, infarct size, inflammation, and apoptosis. It suppresses the HMGB1/TLR4/NF-κB inflammatory network.

CardiologyImmunologyNeuroscience
Xu Y et al (2023).
J Cell Mol Med.
DOI:
10.1111/jcmm.17758
PubMed:
37132060

Component identification of modified sanmiao pills by UPLC-Xevo G2-XS QTOF and its anti-gouty arthritis mechanism based on network pharmacology and experimental verification.

Arthritis
Chen R et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116394
PubMed:
36940736

Study on the Mechanism of Qing-Fei-Shen-Shi Decoction on Asthma Based on Integrated 16S rRNA Sequencing and Untargeted Metabolomics.

Summary

QFSS, a Chinese herbal formula, showed promising results in treating asthma in mice by regulating gut microbiota and metabolism. Potential mechanism for further research.

AsthmaGenetics
Hu H et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/1456844
PubMed:
36846048

Preparation and characterization of zein-lecithin-total flavonoids from Smilax glabra complex nanoparticles and the study of their antioxidant activity on HepG2 cells.

Phytochemistry
Li J et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.100579
PubMed:
36845521

Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4/NF-κB signaling pathway.

GastroenterologyImmunology
Lv S et al (2023).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2022.1106875
PubMed:
36743916

A comprehensive quality control evaluation for standard decoction of Smilax glabra Roxb based on HPLC-MS-UV/CAD methods combined with chemometrics analysis and network pharmacology.

Shi W et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.135371
PubMed:
36608559

A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis.

Cancer
Chen SM et al (2022).
Am J Cancer Res.
PubMed:
36504899

Smilax glabra Roxb.: A Review of Its Traditional Usages, Phytochemical Constituents, Pharmacological Properties, and Clinical Applications.

Review Phytochemistry
Wu H et al (2022).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S374439
PubMed:
36277602

Tentative Identification of Phytochemicals from Smilax glabra and Smilax corbularia Extracts by LC-QTOF/MS and Their Bioactive Potential.

Phytochemistry
Jeeno P et al (2022).
Plants (Basel).
DOI:
10.3390/plants11162089
PubMed:
36015393

Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis.

DermatologyGenetics
Hu X et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154384
PubMed:
35963195

Flavonoid Group of Smilax glabra Roxb. Regulates the Anti-Tumor Immune Response Through the STAT3/HIF-1 Signaling Pathway.

Immunology
Guo Y et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.918975
PubMed:
35935838

Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction.

Wang T et al (2022).
Food Funct.
DOI:
10.1039/d2fo00060a
PubMed:
35388843

Engeletin protects against cerebral ischemia/reperfusion injury by modulating the VEGF/vasohibin and Ang-1/Tie-2 pathways.

Cardiology
Liu H et al (2021).
Braz J Med Biol Res.
DOI:
10.1590/1414-431X2020e11028
PubMed:
34287581

Distinguishing Smilax glabra and Smilax china rhizomes by flow-injection mass spectrometry combined with principal component analysis.

Liang J et al (2018).
Acta Pharm.
DOI:
10.2478/acph-2018-0003
PubMed:
29453916