Solanum incanum

Common Names: nightshade

Ethnobotanical Studies

Asagirt District, Northeastern Ethiopia

Uses: Epistaxis, tonsillitis, leech, abdominal pain

DOI:: 10.1186/s41182-023-00493-0
PubMed:: 36617576

Aswa River catchment, northern Uganda

Uses: ear; eye; eye (vet); wound; toothache; diarrhea; stomach

DOI:: 10.1186/s13002-023-00620-5
PubMed:: 37884931

Clinical Trials

Efficacy of Strychnos spinosa (Lam.) and Solanum incanum L. aqueous fruit extracts against cattle ticks.

Madzimure J et al (2013).; Trop Anim Health Prod.
DOI:: 10.1007/s11250-013-0367-6
PubMed:: 23456785

Studies

Activitybudget and foraging patterns ofNubian giraffe (Giraffa camelopardalis camelopardalis) in Lake Nakuru National Park, Kenya.

Gitau CG et al (2024).; Ecol Evol.
DOI:: 10.1002/ece3.11463
PubMed:: 38826174

Evaluation of the antimalarial properties of Solanum incanum L. leaf extract fractions and its ability to downregulate delta aminolevulinate dehydratase to prevent the establishment of malaria infection.

Chiamah OC et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2023.117613
PubMed:: 38185259

Medicinal Plants in Treating Hepatitis B Among Communities of Central Region of Ethiopia.

Beykaso G et al (2023).; Hepat Med.
DOI:: 10.2147/HMER.S440351
PubMed:: 38170153

Medicinal plants for treatment of diarrhoeal diseases among under-five children: experience from traditional healers in North-eastern Tanzania.

Liheluka E et al (2023).; BMC Complement Med Ther.
DOI:: 10.1186/s12906-023-04216-0
PubMed:: 37880735

Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis.

Summary

Saudi scientists identify potential anti-epileptic compounds from local flora using network pharmacology and bioinformatics, supported by molecular docking experiments. This research informs future development of epilepsy treatments.

Genetics Neuroscience

Falah Alshehri F et al (2023).; Saudi Pharm J.
DOI:: 10.1016/j.jsps.2023.101732
PubMed:: 37638220

Optically amended biosynthesized crystalline copper-doped ZnO for enhanced antibacterial activity.

Mengistu A, Naimuddin M and Abebe B (2023).; RSC Adv.
DOI:: 10.1039/d3ra04488b
PubMed:: 37608973

Integrating defense and leaf economic spectrum traits in a tropical savanna plant.

Mohanbabu N et al (2023).; Front Plant Sci.
DOI:: 10.3389/fpls.2023.1185616
PubMed:: 37342149

Khasianine Affects the Expression of Sugar-Sensitive Proteins in Pancreatic Cancer Cells, Which Are Altered in Data from the Rat Model and Patients.

Summary

Summary: This study investigated the antiproliferative activity of khasianine on pancreatic cancer cells. Khasianine, extracted from fruits, inhibited the growth of human and rat pancreatic cancer cell lines. The researchers identified sugar-sensitive proteins and found that khasianine downregulated lactose-sensitive proteins the most. Rhamnose-sensitive proteins were upregulated in pancreatic cancer patients and a rat model. The study also identified the Ras homolog family member A (RhoA) as a key signaling pathway. Overall, this research suggests that khasianine has potential as a treatment for pancreatic cancer.

Cancer

Sagini MN et al (2023).; ACS Pharmacol Transl Sci.
DOI:: 10.1021/acsptsci.3c00013
PubMed:: 37200805

Solasodine suppress MCF7 breast cancer stem-like cells via targeting Hedgehog/Gli1.

Cancer

Chen J et al (2022).; Phytomedicine.
DOI:: 10.1016/j.phymed.2022.154448
PubMed:: 36116198

10.

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice.

Diabetes

Andargie Y et al (2022).; Evid Based Complement Alternat Med.
DOI:: 10.1155/2022/4454881
PubMed:: 35774744

11.

Assessment of morphological and molecular variability of some Solanum melongena L. cultivars and wild Solanum incanum L. in Saudi Arabia.

Al-Rowaily SL et al (2021).; Biol Futur.
DOI:: 10.1007/s42977-020-00052-2
PubMed:: 34554472

12.

Evaluation of the antiulcerogenic activity of hydromethanol extracts of Solanum incanum L. (Solanaceae) leaves and roots in mice; single and repeated dose study.

Belayneh YM et al (2021).; Metabol Open.
DOI:: 10.1016/j.metop.2021.100119
PubMed:: 34485890

13.

Vegetation zonation along the desert-wetland ecosystem of Taif Highland, Saudi Arabia.

Galal TM, Al-Yasi HM and Fadl MA (2021).; Saudi J Biol Sci.
DOI:: 10.1016/j.sjbs.2021.02.086
PubMed:: 34121875

14.

Improved genome assembly and pan-genome provide key insights into eggplant domestication and breeding.

Genetics

Barchi L et al (2021).; Plant J.
DOI:: 10.1111/tpj.15313
PubMed:: 33964091

15.

Traditional knowledge, use and conservation of plants by the communities of Tharaka-Nithi County, Kenya.

Kathambi V et al (2020).; Plant Divers.
DOI:: 10.1016/j.pld.2020.12.004
PubMed:: 33733015

16.

Antimicrobial and In Vitro Cytotoxic Efficacy of Biogenic Silver Nanoparticles (Ag-NPs) Fabricated by Callus Extract of Solanum incanum L.

Antimicrobial

Lashin I et al (2021).; Biomolecules.
DOI:: 10.3390/biom11030341
PubMed:: 33668378

17.

Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis.

Genetics

Yang CC et al (2021).; J Dermatol.
DOI:: 10.1111/1346-8138.15703
PubMed:: 33458860

18.

Plants Used in Antivenom Therapy in Rural Kenya: Ethnobotany and Future Perspectives.

Review Ethnobotany

Omara T et al (2020).; J Toxicol.
DOI:: 10.1155/2020/1828521
PubMed:: 32612650

19.

Application of Ficus carica L. and Solanum incanum L. Extracts in Coagulation of Milk: The Case of Traditional Practice in Ab'ala Area, Afar Regional State, Ethiopia.

Desta W, Shumbahri M and Gebrehiwot S (2020).; Biochem Res Int.
DOI:: 10.1155/2020/9874949
PubMed:: 32322421

20.

Preliminary Antimicrobial Profile of Solanum incanum L.: A Common Medicinal Plant.

Antimicrobial

Sbhatu DB and Abraha HB (2020).; Evid Based Complement Alternat Med.
DOI:: 10.1155/2020/3647065
PubMed:: 32063983

21.

Solanum incanum extract (SR-T100) induces melanoma cell apoptosis and inhibits established lung metastasis.

Cancer

Yu S, Sheu HM and Lee CH (2017).; Oncotarget.
DOI:: 10.18632/oncotarget.21508
PubMed:: 29262580

22.

Transcriptome analysis and molecular marker discovery in Solanum incanum and S. aethiopicum, two close relatives of the common eggplant (Solanum melongena) with interest for breeding.

Genetics

Gramazio P et al (2016).; BMC Genomics.
DOI:: 10.1186/s12864-016-2631-4
PubMed:: 27108408

23.

Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells.

Cancer

Wu YH et al (2015).; J Cancer.
DOI:: 10.7150/jca.12738
PubMed:: 26366215

24.

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

Phytochemistry

Manase MJ et al (2012).; Fitoterapia.
DOI:: 10.1016/j.fitote.2012.04.024
PubMed:: 22579841

25.

The cytotoxic principles of Solanum incanum.

Lin CN et al (1990).; J Nat Prod.
PubMed:: 2380724

26.

Antibiotic action of Solanum incanum Linnaeus.

Antimicrobial

Beaman-Mbaya V and Muhammed SI (1976).; Antimicrob Agents Chemother.
PubMed:: 945715