Researchers discovered four new steroidal compounds and isolated twenty known compounds from Solanum lyratum Thunb plants. Some of these compounds showed significant cytotoxic effects against human colon and hepatoma cells, offering potential for cancer treatment. This study also provides chemical markers to help differentiate Solanum plants.
Researchers isolated and identified several new compounds from a plant, and studied their effects on neuroprotection and inhibition of AchE. Compound 4a showed significant neuroprotective effects, and compound 1a exhibited strong inhibition of AchE.
Researchers extracted and isolated seven new alkaloids and 13 known alkaloids from the herb Solanum lyratum Thunb. They determined the structure of the new compounds and found that two of them, (-)-(7'S)-N-feruloyltyramine A and (+)-(7'R)-N-feruloyltyramine A, provided neuroprotective effects against cell damage and acetylcholinesterase inhibitory effects. The findings suggest that S. lyratum has potential as a source of new functional components for the pharmaceutical industry.
Researchers discovered two new lignans and 11 known lignan analogues from the Thumb. They separated two pairs of enantiomers and determined their structures using various methods. All compounds were tested for their acetylcholinesterase inhibitory activity. Two compounds showed clear AChE inhibition compared to the positive control. These findings suggest that the Thumb may potentially have therapeutic uses for treating diseases related to acetylcholinesterase dysfunction.
Solanum lyratum contains four new terpenoids (solanoids F-I) and eleven known compounds that were characterized using spectroscopic techniques. Compounds 1-6, 8, and 12-15 showed neuroprotective effects against oxidative damage in human cells. The study also used gene and pathway analyses to identify potential targets for these compounds in Alzheimer's disease.