Uses: Diuretic, chronic liver enlargement, diarrhea, and piles; also effective against skin illness and anthrax. Fruits are used to treat a variety of ailments, including heart disease, hiccups, asthma, fever, bronchitis, and diarrhea. Ringworm can be treated using green fruit pastes. Fruit juice is an expectorant and cooling drink that can be used to treat fevers, gonorrhea, giddiness, and inflammations
Progesterone in the environment harms humans and wildlife. This study shows L. plants can effectively remove progesterone with the help of 24-EBL, reducing oxidative damage and enhancing antioxidant system activity.
Research on Solanum nigrum L. shows it has potential anti-tumor effects due to its various bioactive components. Consider using SNL in clinical applications for its therapeutic benefits.
Researchers studied antiviral properties of medicinal plants in Egypt, showing potential for treating serious viral diseases. Important due to high mortality rates, lack of cures, and emergence of resistant strains.
Researchers identified enzymes in Solanum nigrum and eggplant that produce bioactive steroidal molecules with potential anti-cancer and anti-inflammatory properties. This discovery can be used for engineering the production of these molecules in other organisms.
Researchers investigated the neuroprotective effects of extract on retinal ganglion cells in a glaucoma rat model. Results show potential for novel neurotherapeutics to treat glaucoma by reducing oxidative stress and remodeling matrix metalloproteinases.
Chinese medicine Solanum nigrum L contains solasonine, an effective anti-tumor component. It stops tumor growth, induces cell death, ferroptosis, and prevents metastasis. Understanding its mechanisms helps develop its applications.
Researchers have found that plant-based herbal medicines, specifically [name], have strong anti-tumor properties. This review discusses the progress made in understanding the active constituents and their mechanisms, offering insights for the development of new clinical anticancer drugs.
Researchers isolated and analyzed plant-derived exosome-like nanoparticles (PDENs) from black nightshade berries. PDENs showed anti-inflammatory properties by decreasing IL-6 expression in stimulated cells. PDENs are easier and cheaper to obtain than animal cell-derived exosomes, offering a potential alternative treatment for inflammation.
Researchers developed a plant-based nanosponge that effectively treated breast cancer by inducing DNA damage, cell cycle arrest, and reducing tumor weight in mice, showcasing the potential of nanosponges as drug delivery systems in cancer treatment.
Scientists studied pollen tube growth in a plant species and found that successful seed germination depends on fertilization. Proximity between ovules and pollen tubes increases fertilization chances. Fertilized ovules show structural changes and impact seed germination rate. Unfertilized ovules have low germination success.
The researchers collected plants with mosaic, enation, and leaf curl symptoms. They confirmed begomovirus infection and identified a novel betasatellite. These plants could serve as reservoir hosts for infecting chili plants.
Solanum nigrum water extract (SNWE) showed significant anticancer effects against MCF-7 and MDA-MB-231 breast cancer cells by inducing apoptotic cell death. This suggests that SNWE could be a potential non-toxic treatment option for breast cancer, but more research is needed.
The study evaluated the anti-arthritic effects of Solanum nigrum L. extracts. Results showed significant pain relief and reduction in inflammation. Extracts regulated inflammatory markers and improved oxidative stress, suggesting potential in treating arthritis.
Solamargine (SM) inhibits tumor cell proliferation and induces apoptosis in human renal carcinoma cells. It downregulates p-STAT3 expression and activates caspase proteins, promoting cell death. SM also inhibits tumor growth in mice without causing organ toxicity.
Solasonine, a compound found in L., has shown anticancer effects on various cancers, including non-small cell lung cancer (NSCLC). This study aims to uncover its biological target and mechanism in NSCLC.
S. nigrum Linn., a traditional Chinese herb, has proven anti-cancer activity against digestive system tumors. Its components include solanine, solasonine, and solamargine. The herb induces apoptosis, cell cycle arrest, autophagy, and more, making it a potential standardized anti-tumor drug for further clinical trials.
Scientists studied Solanum nigrum L., a plant used to treat tumors, and found that its steroidal alkaloid Solasonin (SS) has anti-colorectal cancer (CRC) activity. SS induced apoptosis and cell cycle arrest in CRC cells by downregulating HDAC and increasing P53 acetylation. SS could effectively inhibit CRC growth, making it a potential treatment option.
Solasonine (SS), the main ingredient in Solanum nigrum L., shows neuroprotective effects in vitro and in vivo models of cerebral ischemia/reperfusion injury (CIRI). It reduces inflammation, oxidative stress, and apoptosis in neurons, and improves neurological outcomes in rats. Mechanistically, it targets the TLR4/MyD88/NF-κB and AMPK/Nrf2/HO-1 pathways.
Study found that water extract (SNWE) can potentially kill MCF-7 and MDA-MB-231 cancer cells by causing mitochondrial dysfunction. Promising natural agent for cancer treatment.
The researchers investigated the effects of Astragali Radix and Solanum nigrum L. on the polarization of glioma-associated microglia/macrophages (GAMs). Understanding their roles and mechanisms could be useful in treating glioma, a type of brain tumor.
Complications from COVID-19 have been well-documented, but less attention has been given to post-COVID complications which can last for more than 6 months. Available drugs tackle the issue but new interventions are required. An edible plant, Solanum nigrum, shows potential in treating COVID-19 symptoms. It demonstrates anti-inflammatory, immunomodulatory, and antiviral action to treat the infection and its post-complications, protecting various organs. Further experiments are needed to validate the hypothesis.
The experimenters isolated 10 compounds from a source and determined their structures through various analytical techniques. They then tested the compounds for neuroprotective effects in cells and found that three showed moderate effectiveness. The study highlights potential compounds for future development of neuroprotective treatments.