Common Names: Canada goldenrod
Researchers tested a collection of natural product extracts from popular botanical dietary supplements for their efficacy against SARS-CoV-2, the virus causing COVID-19. Out of 1867 extracts and 18 compounds, 310 extracts from 188 species were identified as having ≥ 50% viral entry inhibition activity at 20 µg/mL, with three extracts showing potent antiviral activity against both pseudotyped variants and infectious SARS-CoV-2. Two of these extracts were from Solidago altissima L. (Asteraceae) flowers and Pteridium aquilinum (L.) Kuhn (Dennstaedtiaceae) rhizomes. These findings could have important implications for the development of treatments for COVID-19 using botanical dietary supplements.